NO20062316L - Nye CXCL8 antagonister - Google Patents
Nye CXCL8 antagonisterInfo
- Publication number
- NO20062316L NO20062316L NO20062316A NO20062316A NO20062316L NO 20062316 L NO20062316 L NO 20062316L NO 20062316 A NO20062316 A NO 20062316A NO 20062316 A NO20062316 A NO 20062316A NO 20062316 L NO20062316 L NO 20062316L
- Authority
- NO
- Norway
- Prior art keywords
- cxcl8
- new
- antagonists
- cxcl8 antagonists
- cxcl
- Prior art date
Links
- 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 title abstract 2
- 102100026236 Interleukin-8 Human genes 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000004890 Interleukin-8 Human genes 0.000 abstract 2
- 108090001007 Interleukin-8 Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 1
- 229940096397 interleukin-8 Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5421—IL-8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nye antagonister av kjemokinet CXCL8 (også kjent som interleukin-8) kan oppnås ved å danne mutanter med spesifikke kombinasjoner av ikke-konserverte substitusjoner av basiske aminosyrer lokalisert i den C-terminale region. Forbindelser fremstilt i henhold til den foreliggende oppfinnelse kan anvendes for å blokkere CXCL8-aktivitet in vivo for derved å tilveiebringe terapeutiske preparater for anvendelse i behandlingen eller forebyggingen av CXCL-8-relaterte sykdommer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03103909 | 2003-10-22 | ||
PCT/EP2004/052637 WO2005040210A2 (en) | 2003-10-22 | 2004-10-22 | Novel cxcl8 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20062316L true NO20062316L (no) | 2006-06-23 |
Family
ID=34486342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20062316A NO20062316L (no) | 2003-10-22 | 2006-05-22 | Nye CXCL8 antagonister |
Country Status (10)
Country | Link |
---|---|
US (1) | US20090022657A1 (no) |
EP (1) | EP1673388B1 (no) |
JP (1) | JP2007533300A (no) |
AT (1) | ATE415420T1 (no) |
AU (1) | AU2004283910A1 (no) |
CA (1) | CA2534828A1 (no) |
DE (1) | DE602004018014D1 (no) |
IL (1) | IL175019A0 (no) |
NO (1) | NO20062316L (no) |
WO (1) | WO2005040210A2 (no) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2583852B (en) * | 2018-01-18 | 2022-12-21 | Third Wave Bioactives Llc | Fruit and vegetable-based fermentate compositions and methods of making and using the same |
TR201811689A2 (tr) * | 2018-08-10 | 2018-09-21 | Hacettepe Ueniversitesi | Cxcl8 ami̇no ucu öncül di̇zi̇si̇nden türevlenen i̇mmünmodülatör pepti̇t |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69226649D1 (de) * | 1991-12-04 | 1998-09-17 | Biomedical Research Centre Ltd | Analoge des menschlichen Interleukin-8. |
WO1996009062A1 (en) * | 1994-09-23 | 1996-03-28 | University Of Nebraska Board Of Regents | Polypeptide agonists and antagonists of human interleukin-8 |
UA77950C2 (en) * | 2000-10-04 | 2007-02-15 | Applied Research Systems | Use of mutants of cc chemokines for treatment of multiple sclerosis |
-
2004
- 2004-10-22 CA CA002534828A patent/CA2534828A1/en not_active Abandoned
- 2004-10-22 DE DE602004018014T patent/DE602004018014D1/de not_active Expired - Fee Related
- 2004-10-22 WO PCT/EP2004/052637 patent/WO2005040210A2/en active Application Filing
- 2004-10-22 EP EP04791294A patent/EP1673388B1/en active Active
- 2004-10-22 US US10/573,726 patent/US20090022657A1/en not_active Abandoned
- 2004-10-22 AU AU2004283910A patent/AU2004283910A1/en not_active Abandoned
- 2004-10-22 AT AT04791294T patent/ATE415420T1/de not_active IP Right Cessation
- 2004-10-22 JP JP2006536095A patent/JP2007533300A/ja active Pending
-
2006
- 2006-04-20 IL IL175019A patent/IL175019A0/en unknown
- 2006-05-22 NO NO20062316A patent/NO20062316L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL175019A0 (en) | 2006-08-20 |
EP1673388A2 (en) | 2006-06-28 |
ATE415420T1 (de) | 2008-12-15 |
DE602004018014D1 (de) | 2009-01-08 |
WO2005040210A3 (en) | 2005-06-23 |
EP1673388B1 (en) | 2008-11-26 |
US20090022657A1 (en) | 2009-01-22 |
AU2004283910A1 (en) | 2005-05-06 |
CA2534828A1 (en) | 2005-05-06 |
JP2007533300A (ja) | 2007-11-22 |
WO2005040210A2 (en) | 2005-05-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE548363T1 (de) | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen | |
ATE451376T1 (de) | Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen | |
ATE446313T1 (de) | Muteine von tränen-lipocalin | |
DE602004014117D1 (de) | Thiazole zur verwendung als inhibitoren von protein-kinasen | |
DE60327999D1 (de) | Azolylaminoazine als inhibitoren von proteinkinasen | |
ATE528302T1 (de) | 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind | |
ATE482213T1 (de) | Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine | |
ATE466580T1 (de) | Azolylaminoazine als proteinkinasehemmer | |
ATE468336T1 (de) | Azolylaminoazine als proteinkinasehemmer | |
ATE365733T1 (de) | Zusammensetzungen brauchbar als protein-kinase- inhibitoren | |
HK1131167A1 (zh) | 淚液脂質運載蛋白的突變蛋白及其獲得方法 | |
NO20084652L (no) | Deazapuriner anvendelige som inhibitorer av januskinaser | |
NO20082476L (no) | Bicykliske forbindelser med kinaseinhiberende aktivitet | |
ATE506951T1 (de) | Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer- krankheit | |
DE602006004844D1 (de) | Pyrrolopyrimidine verwendbar als protein kinase inhibitoren | |
NO20070489L (no) | 3-aminocyklopentankarboksamider som modulatorer av kjemokinreseptorer. | |
EA200501710A1 (ru) | Замещённые карбоновые кислоты | |
DE602004024374D1 (de) | Zusammensetzungen zur verwendung als protein-kinase-inhibitoren | |
DE602006017574D1 (de) | Als protein-kinase-inhibitoren nutzbare benzimidazole | |
ATE389651T1 (de) | Als inhibitoren von c-met geeignete pyrrolzusammensetzungen | |
MXPA05009014A (es) | Antagonistas del receptor ccr-3. | |
DE602006020293D1 (de) | 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin-kinasen nützlich sind | |
ATE402958T1 (de) | Antagonisten des ige-rezeptors | |
NO20062316L (no) | Nye CXCL8 antagonister | |
ATE410415T1 (de) | Neue verbindungen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
CREP | Change of representative |
Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS |
|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |