NO20035696D0 - Crystalline anti-cholinergic, process for its preparation and use thereof for the manufacture of a drug - Google Patents

Crystalline anti-cholinergic, process for its preparation and use thereof for the manufacture of a drug

Info

Publication number
NO20035696D0
NO20035696D0 NO20035696A NO20035696A NO20035696D0 NO 20035696 D0 NO20035696 D0 NO 20035696D0 NO 20035696 A NO20035696 A NO 20035696A NO 20035696 A NO20035696 A NO 20035696A NO 20035696 D0 NO20035696 D0 NO 20035696D0
Authority
NO
Norway
Prior art keywords
cholinergic
drug
manufacture
preparation
crystalline anti
Prior art date
Application number
NO20035696A
Other languages
Norwegian (no)
Other versions
NO334301B1 (en
Inventor
Ulrike Werthmann
Peter Sieger
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20035696D0 publication Critical patent/NO20035696D0/en
Publication of NO334301B1 publication Critical patent/NO334301B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
NO20035696A 2001-06-22 2003-12-19 Anhydrous crystalline tiotropium bromide, process for the preparation thereof, drug thereof and use thereof for the manufacture of a medicament for the treatment of diseases NO334301B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10215436 2002-04-08
PCT/EP2002/006291 WO2003000265A1 (en) 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Publications (2)

Publication Number Publication Date
NO20035696D0 true NO20035696D0 (en) 2003-12-19
NO334301B1 NO334301B1 (en) 2014-02-03

Family

ID=26009556

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20035696A NO334301B1 (en) 2001-06-22 2003-12-19 Anhydrous crystalline tiotropium bromide, process for the preparation thereof, drug thereof and use thereof for the manufacture of a medicament for the treatment of diseases

Country Status (38)

Country Link
EP (1) EP1401445B1 (en)
JP (1) JP2005504015A (en)
KR (2) KR100971616B1 (en)
CN (1) CN100586948C (en)
AR (1) AR037491A1 (en)
AT (1) ATE337006T1 (en)
AU (1) AU2002345016B2 (en)
BG (1) BG66303B1 (en)
BR (1) BR0210537A (en)
CA (1) CA2450961C (en)
CO (1) CO5550423A2 (en)
CY (1) CY1105223T1 (en)
CZ (1) CZ302786B6 (en)
DE (1) DE50207943D1 (en)
DK (1) DK1401445T3 (en)
EA (1) EA005813B1 (en)
EE (1) EE05316B1 (en)
EG (1) EG24851A (en)
ES (1) ES2271280T3 (en)
HK (1) HK1068540A1 (en)
HR (1) HRP20031066B1 (en)
HU (1) HUP0400333A3 (en)
IL (2) IL159238A0 (en)
ME (1) ME00412B (en)
MX (1) MXPA03011718A (en)
MY (1) MY122779A (en)
NO (1) NO334301B1 (en)
NZ (1) NZ530690A (en)
PE (2) PE20030130A1 (en)
PL (1) PL208137B1 (en)
PT (1) PT1401445E (en)
RS (1) RS50441B (en)
SA (1) SA02230255B1 (en)
SI (1) SI1401445T1 (en)
SK (1) SK287262B6 (en)
TW (2) TWI261589B (en)
UY (1) UY27342A1 (en)
WO (1) WO2003000265A1 (en)

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UY30550A1 (en) 2006-08-22 2008-03-31 Boehringer Ingelheim Int NEW BETA-AGANISTAS ENANTIOMÉRICAMENTE PUROS, PROCEDURES FOR ITS PREPARATION AND ITS USE AS MEDICATIONS
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
EP2610258B1 (en) 2007-10-19 2014-08-27 Boehringer Ingelheim International Gmbh Substituted piperidino dihydrothieno pyrimidines
EP2093219A1 (en) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Crystalline enantiomer free salt form of a betamimetic and its use as medicine
US20120053164A1 (en) 2008-12-19 2012-03-01 Boehringer Ingelheim International Gmbh Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
US20130143905A1 (en) 2009-12-17 2013-06-06 Boehringer Ingelheim International Gmbh Novel antagonists for ccr2 and uses thereof
KR101530234B1 (en) 2009-12-17 2015-06-19 베링거 인겔하임 인터내셔날 게엠베하 New ccr2 receptor antagonists and uses thereof
BR112012018865A2 (en) 2010-01-29 2016-04-12 Boehringer Ingelheim Int substituted naphthyridines and their use as syk kinase inhibitors
JP5646736B2 (en) 2010-05-12 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel CCR2 receptor antagonists, methods for their preparation, and their use as drugs
EP2569298B1 (en) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
EP2576542B1 (en) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
JP5721242B2 (en) 2010-06-01 2015-05-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel CCR2 antagonist
TR201007108A2 (en) * 2010-08-25 2012-03-21 B�Lg�� Mahmut New tiotropium bromide crystal and production method.
JP5959537B2 (en) 2011-01-28 2016-08-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Substituted pyridinyl-pyrimidines and their use as pharmaceuticals
TR201101897A2 (en) 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Crystal material containing tiotropium bromide
TR201102068A2 (en) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Crystalline substances containing tiotropium bromide
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BR112014001898A2 (en) 2011-07-26 2017-02-21 Boehringer Ingelheim Int substituted quinolines and their use as medicines
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
EA031602B1 (en) 2011-11-25 2019-01-31 Адверио Фарма Гмбх Processes for preraring aldehydes
CZ304368B6 (en) 2011-11-28 2014-04-02 Zentiva, K.S. Tiotropium bromide mixed solvate and process for preparing thereof
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (en) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A PROCESS FOR THE PREPARATION OF TIOTROPE BROMIDE
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Also Published As

Publication number Publication date
BG66303B1 (en) 2013-03-29
JP2005504015A (en) 2005-02-10
EE200400029A (en) 2004-04-15
PE20030130A1 (en) 2003-04-02
RS50441B (en) 2010-03-02
PE20081305A1 (en) 2008-10-01
SA02230255B1 (en) 2006-10-31
HUP0400333A2 (en) 2004-12-28
KR20090031638A (en) 2009-03-26
CZ2004120A3 (en) 2004-05-12
SK522004A3 (en) 2004-06-08
TW200617007A (en) 2006-06-01
TWI261589B (en) 2006-09-11
EG24851A (en) 2010-10-27
CN100586948C (en) 2010-02-03
YU99703A (en) 2006-05-25
AR037491A1 (en) 2004-11-17
HRP20031066B1 (en) 2011-10-31
WO2003000265A1 (en) 2003-01-03
SK287262B6 (en) 2010-04-07
EP1401445A1 (en) 2004-03-31
CN1520294A (en) 2004-08-11
HUP0400333A3 (en) 2012-10-29
IL159238A0 (en) 2004-06-01
NZ530690A (en) 2005-05-27
EP1401445B1 (en) 2006-08-23
SI1401445T1 (en) 2007-02-28
CZ302786B6 (en) 2011-11-09
DK1401445T3 (en) 2006-11-27
CA2450961C (en) 2010-03-30
AU2002345016B2 (en) 2008-04-17
ME00412B (en) 2011-10-10
CY1105223T1 (en) 2010-03-03
UY27342A1 (en) 2003-02-28
PL208137B1 (en) 2011-03-31
MY122779A (en) 2006-05-31
MEP62008A (en) 2011-05-10
CO5550423A2 (en) 2005-08-31
ATE337006T1 (en) 2006-09-15
HRP20031066A2 (en) 2004-04-30
EA005813B1 (en) 2005-06-30
PT1401445E (en) 2006-10-31
CA2450961A1 (en) 2003-01-03
ES2271280T3 (en) 2007-04-16
IL159238A (en) 2010-04-15
NO334301B1 (en) 2014-02-03
MXPA03011718A (en) 2004-12-06
BG108440A (en) 2004-08-31
KR101011353B1 (en) 2011-01-28
EA200301293A1 (en) 2004-08-26
DE50207943D1 (en) 2006-10-05
BR0210537A (en) 2004-06-22
PL364489A1 (en) 2004-12-13
HK1068540A1 (en) 2005-04-29
KR20040018285A (en) 2004-03-02
EE05316B1 (en) 2010-08-16
KR100971616B1 (en) 2010-07-22

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