NO20044814L - Process for the preparation of combretastanines - Google Patents

Process for the preparation of combretastanines

Info

Publication number
NO20044814L
NO20044814L NO20044814A NO20044814A NO20044814L NO 20044814 L NO20044814 L NO 20044814L NO 20044814 A NO20044814 A NO 20044814A NO 20044814 A NO20044814 A NO 20044814A NO 20044814 L NO20044814 L NO 20044814L
Authority
NO
Norway
Prior art keywords
combretastanines
preparation
Prior art date
Application number
NO20044814A
Other languages
Norwegian (no)
Other versions
NO329701B1 (en
Inventor
Michel Lavigne
Jean-Paul Casimir
Stephane Mutti
Irina Malejonock
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20044814L publication Critical patent/NO20044814L/en
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of NO329701B1 publication Critical patent/NO329701B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
NO20044814A 2002-04-11 2004-11-05 Process for the preparation of combretastanines and intermediate for the process NO329701B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0204499A FR2838437B1 (en) 2002-04-11 2002-04-11 PROCESSES FOR THE PREPARATION OF COMBRETASTATINS
PCT/FR2003/001117 WO2003084919A2 (en) 2002-04-11 2003-04-09 Method for preparing combretastatins

Publications (2)

Publication Number Publication Date
NO20044814L true NO20044814L (en) 2004-01-07
NO329701B1 NO329701B1 (en) 2010-12-06

Family

ID=28459732

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20044814A NO329701B1 (en) 2002-04-11 2004-11-05 Process for the preparation of combretastanines and intermediate for the process
NO20101215A NO331372B1 (en) 2002-04-11 2010-09-01 Process for the preparation of combretastatin

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20101215A NO331372B1 (en) 2002-04-11 2010-09-01 Process for the preparation of combretastatin

Country Status (28)

Country Link
EP (3) EP1497255A2 (en)
JP (1) JP4299677B2 (en)
KR (1) KR101018983B1 (en)
CN (1) CN1291970C (en)
AR (2) AR039198A1 (en)
AU (1) AU2003260026B2 (en)
BR (1) BR0309087A (en)
CA (1) CA2481742C (en)
CR (1) CR7481A (en)
EA (1) EA007965B1 (en)
EC (1) ECSP045348A (en)
FR (1) FR2838437B1 (en)
HK (1) HK1075651A1 (en)
HR (1) HRP20040935A2 (en)
IL (1) IL164247A0 (en)
MA (1) MA26407A1 (en)
ME (1) MEP91508A (en)
MX (1) MXPA04009112A (en)
NO (2) NO329701B1 (en)
NZ (1) NZ535318A (en)
OA (1) OA12804A (en)
PL (3) PL213708B1 (en)
RS (3) RS20110562A3 (en)
TN (1) TNSN04201A1 (en)
TW (1) TWI262179B (en)
UA (1) UA76079C2 (en)
WO (1) WO2003084919A2 (en)
ZA (1) ZA200407417B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235688B1 (en) 2004-11-04 2007-06-26 University Of Notre Dame Du Lac Process for preparing histone deacetylase inhibitors and intermediates thereof
FR2928148B1 (en) * 2008-02-28 2013-01-18 Sanofi Aventis PROCESS FOR PREPARING COMBRETASTATIN
FR2939665B1 (en) 2008-12-12 2011-10-07 Sanofi Aventis ANTITUMOR COMBINATION ASSOCIATING WITH AVE8062A AND DOCETAXEL
FR2945210B1 (en) 2009-05-07 2011-07-01 Sanofi Aventis ANTITUMOR COMBINATION COMPRISING AVE8062 AND SORAFENIB
FR2953518B1 (en) 2009-12-03 2012-01-20 Sanofi Aventis PROCESS FOR PREPARING A COMBRETASTATIN DERIVATIVE
EP2481404A1 (en) 2010-11-15 2012-08-01 Sanofi An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
MX2012014732A (en) 2010-06-18 2013-01-22 Sanofi Sa An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative.
EP2397135A1 (en) 2010-06-18 2011-12-21 Sanofi An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
EP2407161A1 (en) 2010-07-13 2012-01-18 Sanofi An antitumoral combination comprising ombrabulin and bevacizumab
FR2968557A1 (en) 2010-12-09 2012-06-15 Sanofi Aventis ANTITUMOR COMBINATION COMPRISING A DRIFT OF THE COMBRETASTATIN FAMILY AND THE CETUXIMAB
FR2978663A1 (en) 2011-08-01 2013-02-08 Sanofi Sa ANTITUMOR COMBINATION COMPRISING OMBRABULIN AND CETUXIMAB ASSOCIATED WITH RADIOTHERAPY
FR2978662A1 (en) 2011-08-01 2013-02-08 Sanofi Sa ANTITUMOR COMBINATION COMPRISING OMBRABULIN AND CISPLATIN ASSOCIATED WITH RADIOTHERAPY
CN103012248B (en) * 2013-01-11 2014-11-05 浙江大德药业集团有限公司 Synthesis of amino combretastatin derivative and application of amino combretastatin derivative as oral antitumour drug
EP3184095A1 (en) 2013-05-23 2017-06-28 IP Gesellschaft für Management mbH Administration units comprising polymorph 1 of 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
EP4079327A1 (en) 2021-04-22 2022-10-26 Centaurus Polytherapeutics Payloads for drug-conjugates and their use for treating cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996237A (en) 1987-01-06 1991-02-26 Arizona Board Of Regents Combretastatin A-4
SU1766257A3 (en) * 1988-02-24 1992-09-30 Ф.Хоффманн-Ля Рош Аг (Фирма) Method of obtaining stilbene derivatives
NZ232897A (en) * 1989-04-03 1992-12-23 Squibb & Sons Inc Interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogues, preparation and pharmaceutical compositions thereof
TW325458B (en) 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
US5731353A (en) * 1993-09-08 1998-03-24 Ajinomoto Co., Inc. Stilbene derivatives and pharmaceutical compositions containing them
JP3080405B2 (en) * 1994-04-06 2000-08-28 日本新薬株式会社 Aminostilbazole derivatives and pharmaceuticals
TW334418B (en) * 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
JP4551514B2 (en) * 1999-07-23 2010-09-29 住友化学株式会社 Process for producing unsaturated hydrocarbon residue-substituted anilines
GB9918912D0 (en) 1999-08-12 1999-10-13 Angiogene Pharm Ltd New stilbenes with vascular damaging activity

Also Published As

Publication number Publication date
CA2481742A1 (en) 2003-10-16
CR7481A (en) 2008-11-25
WO2003084919A3 (en) 2004-04-08
PL213967B1 (en) 2013-05-31
RS20110562A2 (en) 2012-10-31
PL371629A1 (en) 2005-06-27
RS86504A (en) 2007-02-05
NZ535318A (en) 2007-02-23
AR082581A2 (en) 2012-12-19
FR2838437B1 (en) 2004-06-04
RS52331B (en) 2012-12-31
ZA200407417B (en) 2006-04-26
HK1075651A1 (en) 2005-12-23
UA76079C2 (en) 2006-06-15
PL214129B1 (en) 2013-06-28
JP4299677B2 (en) 2009-07-22
KR101018983B1 (en) 2011-03-07
WO2003084919A2 (en) 2003-10-16
IL164247A0 (en) 2005-12-18
TNSN04201A1 (en) 2007-03-12
NO20101215L (en) 2004-01-07
BR0309087A (en) 2005-02-09
EP2348012A1 (en) 2011-07-27
PL394821A1 (en) 2011-09-12
AR039198A1 (en) 2005-02-09
PL394820A1 (en) 2011-09-12
OA12804A (en) 2006-07-11
ECSP045348A (en) 2004-11-26
AU2003260026A1 (en) 2003-10-20
CN1291970C (en) 2006-12-27
KR20040108717A (en) 2004-12-24
EP2354118A1 (en) 2011-08-10
MA26407A1 (en) 2004-12-01
CN1646476A (en) 2005-07-27
RS20110562A3 (en) 2013-12-31
AU2003260026B2 (en) 2008-01-03
RS20110561A3 (en) 2013-10-31
NO329701B1 (en) 2010-12-06
PL213708B1 (en) 2013-04-30
FR2838437A1 (en) 2003-10-17
JP2005522478A (en) 2005-07-28
EP1497255A2 (en) 2005-01-19
CA2481742C (en) 2012-06-19
MXPA04009112A (en) 2004-12-07
MEP91508A (en) 2011-12-20
NO331372B1 (en) 2011-12-12
HRP20040935A2 (en) 2005-10-31
TW200401762A (en) 2004-02-01
EA200401350A1 (en) 2005-02-24
TWI262179B (en) 2006-09-21
RS20110561A2 (en) 2012-10-31
EA007965B1 (en) 2007-02-27

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