NO20012544D0 - Substituted benzo [de] isoquinoline-1,3-dione - Google Patents

Substituted benzo [de] isoquinoline-1,3-dione

Info

Publication number
NO20012544D0
NO20012544D0 NO20012544A NO20012544A NO20012544D0 NO 20012544 D0 NO20012544 D0 NO 20012544D0 NO 20012544 A NO20012544 A NO 20012544A NO 20012544 A NO20012544 A NO 20012544A NO 20012544 D0 NO20012544 D0 NO 20012544D0
Authority
NO
Norway
Prior art keywords
isoquinoline
dione
substituted benzo
benzo
substituted
Prior art date
Application number
NO20012544A
Other languages
Norwegian (no)
Other versions
NO20012544L (en
Inventor
Werner Mederski
Ralf Devant
Gerhard Barnickel
Sabine Bernotat-Danielowski
Guido Melzer
Peter Raddatz
Zhengdong Wu
Daljit Dhanoa
Richard M Soll
James Rinker
Todd L Graybill
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20012544L publication Critical patent/NO20012544L/en
Publication of NO20012544D0 publication Critical patent/NO20012544D0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/14Aza-phenalenes, e.g. 1,8-naphthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20012544A 1998-11-25 2001-05-23 Substituted benzo [de] isoquinoline-1,3-dione NO20012544D0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19941398A 1998-11-25 1998-11-25
US39878399A 1999-09-20 1999-09-20
PCT/EP1999/008561 WO2000032577A2 (en) 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones

Publications (2)

Publication Number Publication Date
NO20012544L NO20012544L (en) 2001-05-23
NO20012544D0 true NO20012544D0 (en) 2001-05-23

Family

ID=26894745

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012544A NO20012544D0 (en) 1998-11-25 2001-05-23 Substituted benzo [de] isoquinoline-1,3-dione

Country Status (15)

Country Link
EP (1) EP1144381A2 (en)
JP (1) JP2002537225A (en)
KR (1) KR20010080569A (en)
CN (1) CN1330638A (en)
AU (1) AU760136B2 (en)
BR (1) BR9915648A (en)
CA (1) CA2352045A1 (en)
CZ (1) CZ20011782A3 (en)
HU (1) HUP0104520A3 (en)
ID (1) ID28982A (en)
NO (1) NO20012544D0 (en)
PL (1) PL348204A1 (en)
SK (1) SK7022001A3 (en)
TW (1) TW473474B (en)
WO (1) WO2000032577A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6429212B1 (en) * 1996-08-16 2002-08-06 Ishihara Sangyo Kaisha Ltd. Medicinal composition
EP1088821A1 (en) * 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives
US7547716B2 (en) 2001-06-08 2009-06-16 Institute Of Medicinal Molecular Design, Inc. Sulfonamide derivatives
US6693198B2 (en) * 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts
US8097725B2 (en) * 2004-12-03 2012-01-17 Roche Diagnostics Operations, Inc. Luminescent indicator dye and optical sensor
FR2915685A1 (en) * 2007-05-02 2008-11-07 Thales Sa New fluorescent compounds of solid state in water, with naphthalimide base, useful for allowing the grafting on transducer, which is a biological substance, in biosensor and security or explosive detectors, and as markers
EP3348555B1 (en) 2013-03-15 2020-11-25 Alumend, LLC Compositions and methods of using the compositions for plaque softening
US9662324B2 (en) 2013-05-01 2017-05-30 Academia Sinica Methods and compositions for treating β-thalassemia and sickle cell disease
CN103450176B (en) * 2013-08-15 2016-07-06 大连理工大学 One class is containing 2-(4-aminophenyl) benzothiazole naphthalimide compound and application thereof
WO2016041511A1 (en) 2014-09-19 2016-03-24 Yen-Ta Lu Benzo-heterocyclic compounds and their applications
CN106905237B (en) * 2017-02-08 2019-05-14 上海师范大学 A kind of pH and weary oxygen double-bang firecracker answer the naphthalimide ratio fluorescent probe and its synthetic method of positioning tumor cell
CN110283123B (en) * 2019-07-08 2022-06-17 桂林医学院 4-p-toluenesulfonyl piperazine-3-nitro-1, 8-naphthalimide derivative and synthesis method and application thereof
CN110272388B (en) * 2019-07-08 2022-06-17 桂林医学院 4-dithioformic acid piperazine-3-nitro-1, 8-naphthalimide derivative and synthesis method and application thereof
CN110407865B (en) * 2019-08-02 2022-04-15 山东师范大学 Benzene sulfonamide structure-based compound shown as formula (I) and preparation method and application thereof
CN111518075B (en) * 2020-04-17 2023-03-28 西南大学 Naphthalimide piperazine triazole compound and preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2423546C2 (en) * 1974-05-15 1983-01-27 Hoechst Ag, 6000 Frankfurt Process for the preparation of 4-amino-1,8-naphthalic acid-N-arylimide compounds
ES459497A1 (en) * 1977-06-04 1978-04-16 Made Labor Sa N(Aminoalkyl)-naphthalimides and their derivatives
DE3635711A1 (en) * 1986-10-21 1988-04-28 Knoll Ag 5-NITROBENZO (DE) ISOCHINOLIN-1,3-DIONE, THEIR PRODUCTION AND USE
EP0930883B1 (en) * 1996-10-21 2006-01-11 Allelix Biopharmaceuticals Inc. Neurotrophin antagonists for the treatment of epilepsy, alzheimer's disease and pain
AU4946697A (en) * 1996-10-28 1998-05-22 Merck Patent Gmbh Dihydrobenzoanthracenone, -pyrimidinone or dihydronaphtoquinolinone

Also Published As

Publication number Publication date
PL348204A1 (en) 2002-05-06
HUP0104520A2 (en) 2002-04-29
BR9915648A (en) 2001-08-14
SK7022001A3 (en) 2002-09-10
WO2000032577A3 (en) 2000-09-21
AU760136B2 (en) 2003-05-08
AU2660300A (en) 2000-06-19
EP1144381A2 (en) 2001-10-17
HUP0104520A3 (en) 2002-10-28
WO2000032577A2 (en) 2000-06-08
TW473474B (en) 2002-01-21
JP2002537225A (en) 2002-11-05
CA2352045A1 (en) 2000-06-08
CN1330638A (en) 2002-01-09
ID28982A (en) 2001-07-19
NO20012544L (en) 2001-05-23
KR20010080569A (en) 2001-08-22
CZ20011782A3 (en) 2001-09-12

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