NO20010121L - Fremgangsmåte for fremstilling av (1R,4S)-2- azabicyklo[2.2.1]hept-5-en-3-on-derivater - Google Patents

Fremgangsmåte for fremstilling av (1R,4S)-2- azabicyklo[2.2.1]hept-5-en-3-on-derivater

Info

Publication number
NO20010121L
NO20010121L NO20010121A NO20010121A NO20010121L NO 20010121 L NO20010121 L NO 20010121L NO 20010121 A NO20010121 A NO 20010121A NO 20010121 A NO20010121 A NO 20010121A NO 20010121 L NO20010121 L NO 20010121L
Authority
NO
Norway
Prior art keywords
general formula
azabicyclo
hept
derivatives
preparation
Prior art date
Application number
NO20010121A
Other languages
English (en)
Other versions
NO20010121D0 (no
Inventor
Christine Bernegger-Egli
Frank Brux
Jean Paul
Oleg Werbitzky
Yves Guggisberg
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26149414&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20010121(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of NO20010121D0 publication Critical patent/NO20010121D0/no
Publication of NO20010121L publication Critical patent/NO20010121L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det beskrives en bioteknologisk fremgangsmåte for fremstilling av forbindelser med den generelle formel. hvori Rbetyr acyl eller acyloksy og Ret hydrogenatom eller C-alkyl, omfattende omsetning av et lactam med den generelle formel. ved hjelp av en hydrolase i nærvær av en nukleofil og i nærvær av en base i et konstant pH-område.Dertil beskrives den videre omsetning av forbindelsen med den generelle formel I til det optisk aktive l-amino-4-(hydroksymetly)-2-cyklopenten med formelen
NO20010121A 1998-07-09 2001-01-08 Fremgangsmåte for fremstilling av (1R,4S)-2- azabicyklo[2.2.1]hept-5-en-3-on-derivater NO20010121L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98112719 1998-07-09
EP98123949 1998-12-17
PCT/EP1999/004814 WO2000003032A1 (de) 1998-07-09 1999-07-08 Verfahren zur herstellung von (1r,4s)-2-azabicyclo[2.2.1]hept-5-en-3-on-derivaten

Publications (2)

Publication Number Publication Date
NO20010121D0 NO20010121D0 (no) 2001-01-08
NO20010121L true NO20010121L (no) 2001-01-08

Family

ID=26149414

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20010121A NO20010121L (no) 1998-07-09 2001-01-08 Fremgangsmåte for fremstilling av (1R,4S)-2- azabicyklo[2.2.1]hept-5-en-3-on-derivater

Country Status (11)

Country Link
US (2) US6780634B1 (no)
EP (1) EP1095160B1 (no)
JP (1) JP2002520027A (no)
AT (1) ATE258605T1 (no)
AU (1) AU5280399A (no)
DE (1) DE59908429D1 (no)
DK (1) DK1095160T3 (no)
ES (1) ES2214876T3 (no)
NO (1) NO20010121L (no)
PT (1) PT1095160E (no)
WO (1) WO2000003032A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780635B2 (en) 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
EP1574508A1 (de) * 2004-01-30 2005-09-14 Lonza AG Verfahren zur Herstellung von Acetalen und Ketalen von 3-Amino-5-(hydroxymethyl)-cyclopentan-1,2-diolen, sowie deren Derivaten und Salzen
WO2005118544A2 (en) 2004-05-18 2005-12-15 Rigel Pharmaceuticals, Inc. Cycloalkyl substituted pyrimidinediamine compounds and their uses
DK1812581T3 (da) * 2004-11-15 2009-05-11 Rigel Pharmaceuticals Inc Fremgangsmåde til fremstilling af optisk aktive N-carbamat-beskyttede beta-lactamer ved optisk oplösning under anvendelse af en candida antarctica lipase
GB2420559B (en) 2004-11-15 2008-08-06 Rigel Pharmaceuticals Inc Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
EP2448916B1 (en) 2009-07-02 2014-09-03 Dr. Reddy's Laboratories, Ltd. Production of trans-4-aminocyclopent-2-ene-1-carboxylic acid derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0424064T3 (da) * 1989-10-16 1995-06-26 Chiroscience Ltd Chirale azabicycloheptanoner og fremgangsmåde til fremstilling deraf
GB9618340D0 (en) 1996-09-03 1996-10-16 Chiroscience Ltd Microorganism and its use
GB9717928D0 (en) 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams

Also Published As

Publication number Publication date
EP1095160B1 (de) 2004-01-28
JP2002520027A (ja) 2002-07-09
US20040167351A1 (en) 2004-08-26
ATE258605T1 (de) 2004-02-15
ES2214876T3 (es) 2004-09-16
NO20010121D0 (no) 2001-01-08
US6780634B1 (en) 2004-08-24
EP1095160A1 (de) 2001-05-02
WO2000003032A1 (de) 2000-01-20
AU5280399A (en) 2000-02-01
DE59908429D1 (de) 2004-03-04
DK1095160T3 (da) 2004-05-17
PT1095160E (pt) 2004-06-30

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