NO20005023L - Fremgangsmåter for å hemme MRP1 - Google Patents

Fremgangsmåter for å hemme MRP1

Info

Publication number
NO20005023L
NO20005023L NO20005023A NO20005023A NO20005023L NO 20005023 L NO20005023 L NO 20005023L NO 20005023 A NO20005023 A NO 20005023A NO 20005023 A NO20005023 A NO 20005023A NO 20005023 L NO20005023 L NO 20005023L
Authority
NO
Norway
Prior art keywords
methods
mrp1
inhibit
inhibit mrp1
useful
Prior art date
Application number
NO20005023A
Other languages
English (en)
Other versions
NO20005023D0 (no
Inventor
Joseph Michael Gruber
Julian Stanley Kroin
Bryan Hurst Norman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20005023D0 publication Critical patent/NO20005023D0/no
Publication of NO20005023L publication Critical patent/NO20005023L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Magnetically Actuated Valves (AREA)
  • Control Of The Air-Fuel Ratio Of Carburetors (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse vedrører en forbindelse som har formel (I), som er nyttig for å inhibere resistente neoplasmer hvor resistensen er helt eller delvis overført av MRP1.
NO20005023A 1998-04-08 2000-10-05 Fremgangsmåter for å hemme MRP1 NO20005023L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8108098P 1998-04-08 1998-04-08
PCT/US1999/007613 WO1999051228A1 (en) 1998-04-08 1999-04-07 Methods for inhibiting mrp1

Publications (2)

Publication Number Publication Date
NO20005023D0 NO20005023D0 (no) 2000-10-05
NO20005023L true NO20005023L (no) 2000-12-05

Family

ID=22161981

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005023A NO20005023L (no) 1998-04-08 2000-10-05 Fremgangsmåter for å hemme MRP1

Country Status (18)

Country Link
US (1) US6369070B1 (no)
EP (1) EP1067928A4 (no)
JP (1) JP2002510625A (no)
KR (1) KR20010042471A (no)
CN (1) CN1304306A (no)
AU (1) AU3476999A (no)
BR (1) BR9910112A (no)
CA (1) CA2327617A1 (no)
EA (1) EA200001034A1 (no)
HR (1) HRP20000646A2 (no)
HU (1) HUP0101508A3 (no)
ID (1) ID27364A (no)
IL (1) IL138389A0 (no)
NO (1) NO20005023L (no)
PL (1) PL343313A1 (no)
SK (1) SK14982000A3 (no)
TR (1) TR200002851T2 (no)
WO (1) WO1999051228A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE316531T1 (de) * 1999-10-07 2006-02-15 Lilly Co Eli Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
WO2001046199A1 (en) * 1999-12-22 2001-06-28 Eli Lilly And Company Methods and compounds for inhibiting mrp1
WO2001096346A1 (en) * 2000-06-14 2001-12-20 Eli Lilly And Company Tricyclic compounds as mrp1-inhibitors
JP2004509897A (ja) * 2000-09-22 2004-04-02 イーライ・リリー・アンド・カンパニー シクロヘキシルアミン誘導体の立体選択的製造方法
EP1392702B1 (en) 2001-04-09 2005-11-30 Eli Lilly And Company Compounds and methods for inhibiting mrp1
CA2442141A1 (en) 2001-04-09 2002-10-17 Eli Lilly And Company Compounds and pharmaceutical compositions for inhibiting mrp1
ES2243709T3 (es) * 2001-04-09 2005-12-01 Eli Lilly And Company Compuestos y procedimientos para inhibir la mrp1.
CA2545711A1 (en) * 2003-11-13 2005-06-02 Ambit Biosciences Corporation Urea derivatives as kinase modulators
KR20070034993A (ko) * 2004-05-14 2007-03-29 아이알엠 엘엘씨 Ｐｐａｒ 조절제로서의 화합물 및 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588731A (en) * 1985-06-21 1986-05-13 Roussel Uclaf Derivatives of isoxazolo[4,5-c]quinoline(2H)-3-one and method of preparation and use as anxiolytic agents
US5744485A (en) 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US5717092A (en) * 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity

Also Published As

Publication number Publication date
BR9910112A (pt) 2000-12-26
ID27364A (id) 2001-04-05
JP2002510625A (ja) 2002-04-09
SK14982000A3 (sk) 2001-05-10
WO1999051228A1 (en) 1999-10-14
KR20010042471A (ko) 2001-05-25
US6369070B1 (en) 2002-04-09
TR200002851T2 (tr) 2000-12-21
HUP0101508A3 (en) 2002-04-29
EA200001034A1 (ru) 2001-04-23
HRP20000646A2 (en) 2001-06-30
AU3476999A (en) 1999-10-25
CN1304306A (zh) 2001-07-18
IL138389A0 (en) 2001-10-31
EP1067928A4 (en) 2001-11-14
HUP0101508A2 (hu) 2001-10-28
PL343313A1 (en) 2001-08-13
EP1067928A1 (en) 2001-01-17
NO20005023D0 (no) 2000-10-05
CA2327617A1 (en) 1999-10-14

Similar Documents

Publication Publication Date Title
AU7824900A (en) Compounds and methods for inhibiting mrp1
CY1108567T1 (el) Αντιθρομβωτικες ενωσεις
DK1485359T3 (da) Natriumkanalblokkere
NO20054856L (no) 4-anilino-kinazolinderivater som antiproliferative midler
NO20061321L (no) Kinazolinderivater som tyrosin kinase inhibitorer
NO20061320L (no) Kinazolinderivater som antitumor agenter
NO2012021I1 (no) Perampanel eller salter eller hydrater derav
WO2002062792A1 (en) Jnk inhibitor
NO20030637L (no) 2-aminopyridinforbindelser og anvendelse derav som legemidler
NO20005023L (no) Fremgangsmåter for å hemme MRP1
NO20062353L (no) Kinazolinderivater
EA200301317A1 (ru) Производные аминохинолина и его применение в качестве лигандов аденозина a3
TR200002803T2 (tr) MRP1 inhibe etmek için yöntemler.
ATE360612T1 (de) In 4-stellung substituierte piperidinderivate
TR200002804T2 (tr) MRP1 inhibe etmek için yöntemler
IL166164A0 (en) 6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
NO20022977L (no) Substituerte homopiperidinylbenzimidazolanaloger som fundiske relaksanter
TR200402754T4 (tr) Yeni benzosultam oksazolidinon antibakteriyel maddeler.
ATE423171T1 (de) Verwendung von chinaldin-und naphthalinderivaten als kristallisationsmodifikatoren
ATE206125T1 (de) Furoindolizine
SE0003026D0 (sv) Use for conifer sapling protection
MY117662A (en) Organic compounds
NO974233L (no) Aminofenolderivater
SE0402461D0 (sv) New process
DE60207709D1 (de) Verbindungen und methoden zur inhibierung von mrp1

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application