NO1998016I1 - Lepirudin - Google Patents
LepirudinInfo
- Publication number
- NO1998016I1 NO1998016I1 NO1998016C NO1998016C NO1998016I1 NO 1998016 I1 NO1998016 I1 NO 1998016I1 NO 1998016 C NO1998016 C NO 1998016C NO 1998016 C NO1998016 C NO 1998016C NO 1998016 I1 NO1998016 I1 NO 1998016I1
- Authority
- NO
- Norway
- Prior art keywords
- lepirudin
- Prior art date
Links
- OTQCKZUSUGYWBD-BRHMIFOHSA-N lepirudin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C)[C@@H](C)O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C1=CC=C(O)C=C1 OTQCKZUSUGYWBD-BRHMIFOHSA-N 0.000 title 1
- 229960004408 lepirudin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3805540 | 1988-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO1998016I1 true NO1998016I1 (no) | 1998-05-26 |
Family
ID=6347932
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO890758A NO176915C (no) | 1988-02-23 | 1989-02-22 | Fremgangsmåte for fremstilling av et hirudin-derivat |
| NO1998016C NO1998016I1 (no) | 1988-02-23 | 1998-05-26 | Lepirudin |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO890758A NO176915C (no) | 1988-02-23 | 1989-02-22 | Fremgangsmåte for fremstilling av et hirudin-derivat |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5180668A (no) |
| JP (1) | JPH0649719B2 (no) |
| KR (1) | KR970009950B1 (no) |
| AU (1) | AU604925B2 (no) |
| CA (1) | CA1339104C (no) |
| HU (2) | HU210439B (no) |
| IE (1) | IE65354B1 (no) |
| NO (2) | NO176915C (no) |
| NZ (1) | NZ228064A (no) |
| PH (1) | PH25937A (no) |
| PT (1) | PT89778B (no) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3835815A1 (de) * | 1988-10-21 | 1990-04-26 | Hoechst Ag | Neue isohirudine |
| DE4009268A1 (de) * | 1990-03-22 | 1991-09-26 | Consortium Elektrochem Ind | Sekretion von hirudinderivaten |
| AU648124B2 (en) * | 1990-11-08 | 1994-04-14 | Japan Energy Corporation | Hirudine mutant, production thereof, anticoagulant, secretory vector, microorganism transformed by said vector, and production of product from said microorganism |
| DE4140381A1 (de) * | 1991-12-07 | 1993-06-09 | Hoechst Ag, 6230 Frankfurt, De | Neue synthetische isohirudine mit verbesserter stabilitaet |
| DE4404168A1 (de) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudinderivate und Verfahren zu deren Herstellung |
| DE19543737A1 (de) * | 1995-11-24 | 1997-05-28 | Hoechst Ag | Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices |
| DE19544233A1 (de) * | 1995-11-28 | 1997-06-05 | Hoechst Ag | Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten |
| DE19944870A1 (de) | 1999-09-18 | 2001-03-29 | Aventis Pharma Gmbh | Signalsequenzen zur Herstellung von Leu-Hirudin über Sekretion durch E. coli in das Kulturmedium |
| US7795205B2 (en) * | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3445532A1 (de) * | 1984-12-13 | 1986-06-19 | Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn | Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten |
| DE3445517C2 (de) * | 1984-12-13 | 1993-11-18 | Ciba Geigy | Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins |
-
1988
- 1988-06-23 AU AU18284/88A patent/AU604925B2/en not_active Expired
-
1989
- 1989-01-10 US US07/295,422 patent/US5180668A/en not_active Expired - Lifetime
- 1989-02-21 PH PH38226A patent/PH25937A/en unknown
- 1989-02-21 NZ NZ228064A patent/NZ228064A/en unknown
- 1989-02-21 KR KR89002002A patent/KR970009950B1/ko not_active IP Right Cessation
- 1989-02-22 IE IE55989A patent/IE65354B1/en not_active IP Right Cessation
- 1989-02-22 NO NO890758A patent/NO176915C/no not_active IP Right Cessation
- 1989-02-22 CA CA000591790A patent/CA1339104C/en not_active Expired - Fee Related
- 1989-02-22 HU HU89854A patent/HU210439B/hu unknown
- 1989-02-22 PT PT89778A patent/PT89778B/pt not_active IP Right Cessation
- 1989-02-23 JP JP1044980A patent/JPH0649719B2/ja not_active Expired - Lifetime
-
1995
- 1995-06-29 HU HU95P/P00596P patent/HU211828A9/hu unknown
-
1998
- 1998-05-26 NO NO1998016C patent/NO1998016I1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT89778A (pt) | 1989-10-04 |
| HU211828A9 (en) | 1995-12-28 |
| US5180668A (en) | 1993-01-19 |
| NO890758L (no) | 1989-08-24 |
| IE65354B1 (en) | 1995-10-18 |
| KR970009950B1 (en) | 1997-06-19 |
| NO176915C (no) | 1995-06-21 |
| HU210439B (en) | 1995-04-28 |
| IE890559L (en) | 1989-08-23 |
| NO890758D0 (no) | 1989-02-22 |
| CA1339104C (en) | 1997-07-29 |
| JPH0649719B2 (ja) | 1994-06-29 |
| NZ228064A (en) | 1990-12-21 |
| NO176915B (no) | 1995-03-13 |
| HUT50502A (en) | 1990-02-28 |
| PT89778B (pt) | 1994-03-31 |
| AU604925B2 (en) | 1991-01-03 |
| PH25937A (en) | 1991-12-19 |
| JPH025891A (ja) | 1990-01-10 |
| AU1828488A (en) | 1989-08-24 |
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