NO177187C - Analogous Process for Preparing Therapeutically Active N, N'-Bis (Alkoxy-alkyl) -pyridine-2,4-dicarboxylic Acid Diamides - Google Patents

Analogous Process for Preparing Therapeutically Active N, N'-Bis (Alkoxy-alkyl) -pyridine-2,4-dicarboxylic Acid Diamides

Info

Publication number
NO177187C
NO177187C NO903235A NO903235A NO177187C NO 177187 C NO177187 C NO 177187C NO 903235 A NO903235 A NO 903235A NO 903235 A NO903235 A NO 903235A NO 177187 C NO177187 C NO 177187C
Authority
NO
Norway
Prior art keywords
pyridine
bis
dicarboxylic acid
alkyl
alkoxy
Prior art date
Application number
NO903235A
Other languages
Norwegian (no)
Other versions
NO177187B (en
NO903235L (en
NO903235D0 (en
Inventor
Ekkehard Baader
Martin Bickel
Volkmar Gunzler-Pukall
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO903235D0 publication Critical patent/NO903235D0/en
Publication of NO903235L publication Critical patent/NO903235L/en
Publication of NO177187B publication Critical patent/NO177187B/en
Publication of NO177187C publication Critical patent/NO177187C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboxylic acid diamides of the formula I <IMAGE> where R<1> is linear or branched C1-C4-alkanediyl, R<2> is unbranched C1-C4-alkyl or hydrogen and n is 1 or 2 and R<1'>, R<2'> and n' have the same meanings as R<1>, R<2> and n, where R<1> and R<1'>, R<2> and R<2'>, and n and n' are identical or different, and their physiologically acceptable salts with the exception of N,N'-bis(2-methoxyethyl)pyridine-2,4-dicarboxylic acid diamide and N,N'-bis(2-hydroxyethyl)pyridine-2,4-dicarboxylic acid diamide. The compounds of the formula I inhibit prolin hydroxylase and lysin hydroxylase and are suitable as fibrosuppressants and immunosuppressants.
NO903235A 1989-07-20 1990-07-19 Analogous Process for Preparing Therapeutically Active N, N'-Bis (Alkoxy-alkyl) -pyridine-2,4-dicarboxylic Acid Diamides NO177187C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3924093A DE3924093A1 (en) 1989-07-20 1989-07-20 N, N'-BIS (ALKOXY-ALKYL) -PYRIDINE-2,4-DICARBONESAUREDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF

Publications (4)

Publication Number Publication Date
NO903235D0 NO903235D0 (en) 1990-07-19
NO903235L NO903235L (en) 1991-01-21
NO177187B NO177187B (en) 1995-04-24
NO177187C true NO177187C (en) 1995-08-02

Family

ID=6385494

Family Applications (1)

Application Number Title Priority Date Filing Date
NO903235A NO177187C (en) 1989-07-20 1990-07-19 Analogous Process for Preparing Therapeutically Active N, N'-Bis (Alkoxy-alkyl) -pyridine-2,4-dicarboxylic Acid Diamides

Country Status (26)

Country Link
EP (1) EP0409119B1 (en)
JP (1) JPH0776213B2 (en)
KR (1) KR0181945B1 (en)
AT (1) ATE104280T1 (en)
AU (1) AU624978B2 (en)
CA (1) CA2021529C (en)
CY (1) CY1997A (en)
CZ (1) CZ280129B6 (en)
DD (1) DD300429A5 (en)
DE (2) DE3924093A1 (en)
DK (1) DK0409119T3 (en)
ES (1) ES2052112T3 (en)
FI (1) FI94630C (en)
HU (1) HU218274B (en)
IE (1) IE64438B1 (en)
IL (1) IL95121A (en)
LT (1) LT3798B (en)
LV (1) LV10430B (en)
NO (1) NO177187C (en)
NZ (1) NZ234563A (en)
PL (1) PL166307B1 (en)
PT (1) PT94779B (en)
RU (1) RU1836350C (en)
SK (1) SK279199B6 (en)
UA (1) UA19056A (en)
ZA (1) ZA905680B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3707429A1 (en) * 1987-03-07 1988-09-15 Hoechst Ag SUBSTITUTED PYRIDINE-2,4-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE58908519D1 (en) * 1988-08-04 1994-11-24 Hoechst Ag Improved process for the preparation of N, N-bis (alkoxyalkyl) pyridine -2,4-dicarboxylic acid diamides.
DE4020570A1 (en) 1990-06-28 1992-01-02 Hoechst Ag 2,4- AND 2,5-SUBSTITUTED PYRIDINE-N-OXIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
DE4030999A1 (en) * 1990-10-01 1992-04-09 Hoechst Ag 4- OR 5-SUBSTITUTED PYRIDINE-2-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
YU9492A (en) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- and 2,5-BIS-TETRAZOLYL pyridines and the process for their preparation
TW199147B (en) * 1991-03-18 1993-02-01 Hoechst Ag
EP0541042A1 (en) * 1991-11-05 1993-05-12 Hoechst Aktiengesellschaft 2,4- and 2,5-pyridine-dicarboxylic acid derivatives, process for their preparation and their use
TW222585B (en) * 1992-09-11 1994-04-21 Hoechst Ag
DOP2002000332A (en) 2001-02-14 2002-08-30 Warner Lambert Co MATRIX METALOPROTEINAS PYRIDINE INHIBITORS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3432094A1 (en) 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt ESTER OF PYRIDINE-2,4- AND -2,5-DICARBONIC ACID AS A MEDICINAL PRODUCT FOR INHIBITING PROLIN AND LYSINE HYDROXYLASE
DE3703963A1 (en) 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,, 5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF, AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3703962A1 (en) * 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3703959A1 (en) 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3826471A1 (en) 1988-08-04 1990-02-22 Hoechst Ag Improved process for the preparation of N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboximides
DE3828140A1 (en) 1988-08-19 1990-03-01 Hoechst Ag Improved process for the preparation of N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboxamides and use of these compounds for the preparation of orally administrable medicaments
DE58908519D1 (en) * 1988-08-04 1994-11-24 Hoechst Ag Improved process for the preparation of N, N-bis (alkoxyalkyl) pyridine -2,4-dicarboxylic acid diamides.

Also Published As

Publication number Publication date
IE902642A1 (en) 1991-02-27
DD300429A5 (en) 1992-06-11
PT94779A (en) 1991-03-20
ATE104280T1 (en) 1994-04-15
ZA905680B (en) 1991-04-24
EP0409119B1 (en) 1994-04-13
IL95121A (en) 1994-08-26
IL95121A0 (en) 1991-06-10
AU5914490A (en) 1991-01-24
EP0409119A1 (en) 1991-01-23
KR910002799A (en) 1991-02-26
LT3798B (en) 1996-03-25
KR0181945B1 (en) 1999-05-01
PL166307B1 (en) 1995-05-31
FI94630C (en) 1995-10-10
ES2052112T3 (en) 1994-07-01
NO177187B (en) 1995-04-24
LTIP1462A (en) 1995-05-25
UA19056A (en) 1997-12-25
LV10430B (en) 1996-02-20
CY1997A (en) 1997-09-05
CA2021529A1 (en) 1991-01-21
JPH0776213B2 (en) 1995-08-16
HU904549D0 (en) 1990-12-28
RU1836350C (en) 1993-08-23
FI94630B (en) 1995-06-30
CZ280129B6 (en) 1995-11-15
NO903235L (en) 1991-01-21
CZ357690A3 (en) 1995-06-14
NZ234563A (en) 1992-12-23
DE3924093A1 (en) 1991-02-07
CA2021529C (en) 1997-12-30
AU624978B2 (en) 1992-06-25
PT94779B (en) 1997-04-30
IE64438B1 (en) 1995-08-09
SK357690A3 (en) 1998-07-08
DE59005328D1 (en) 1994-05-19
HU218274B (en) 2000-07-28
SK279199B6 (en) 1998-07-08
LV10430A (en) 1995-02-20
DK0409119T3 (en) 1994-08-08
JPH0358973A (en) 1991-03-14
NO903235D0 (en) 1990-07-19
HUT54653A (en) 1991-03-28
PL286132A1 (en) 1991-07-29
FI903624A0 (en) 1990-07-18

Similar Documents

Publication Publication Date Title
HUT58322A (en) Process for producing new n-(3-hydroxy-4-piperidinyl)-dihydro-benzofurane-, -dihydro-2h-penzopyrane- and -dihydro-benzodioxine-carboxamide derivatives and pharmaceutical compositions containing them
ES2000185A6 (en) Pyridonecarboxylic acid derivatives and process for their preparation.
HUT61004A (en) Process for producing quinoxaline derivatives and pharmaceutical compositions comprising such compounds as active ingredient
ATE411309T1 (en) PYRIDONE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIBACTERIAL ACTIVE INGREDIENTS
NO177187C (en) Analogous Process for Preparing Therapeutically Active N, N&#39;-Bis (Alkoxy-alkyl) -pyridine-2,4-dicarboxylic Acid Diamides
NO161619C (en) ANALOGY PROCEDURES FOR THE PREPARATION OF THERAPEUTIC ACTIVE SUBSTITUTED 5,11-DIHYDRO-6-DIBENZ (B, E) -AZEPIN-6-ON DERIVATIVES.
ES2001703A6 (en) Imidazolinyl derivatives, process for their preparation and agents with herbicidal activity containing them.
ATE32221T1 (en) 3 N-SUBSTITUTED 3,4-DIHYDROPYRIMIDI DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS.
NO913391L (en) PROCEDURE FOR THE PREPARATION OF NEW HETRAZEPINOID ACIDAMIDS.
CA2014062A1 (en) Pyridine derivatives
KR960004860B1 (en) Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments
ES2082882T3 (en) PROCEDURE FOR THE MANUFACTURE OF ACID-3-AMINO-2- (HET) AROIL-ACRYLIC DERIVATIVES.
IL74800A (en) Esters of 4-aryl-1,4,5,7-tetrahydro-5-oxothieno(3,4-b)-pyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
ATE158576T1 (en) ALPHA-ARYL-ALPHA-HYDROXY-BETA-IMIDAZOLINYLPROPIONIC ACID AMIDE
ATE78154T1 (en) SALT OF 6-(1-PIPERIDINYL)2,4-DIAMINOPYRIMIDIN-3-OXIDE AND ACETYLAMINOACETIC ACID THEIR PRODUCTION AND DERMATOCOSMETIC USE.
MX9201156A (en) MIXED DIAMIDES OF PIRIDINE ACIDS -2,4- AND 2,5 DICARBOXYLICS, PROCEDURE FOR THEIR PREPARATION, USE OF THE SAME AS WELL AS MEDICINES BASED ON THESE COMPOUNDS.

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN JANUARY 2003