AU5914490A - N,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides, preparation and their use - Google Patents

N,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides, preparation and their use

Info

Publication number
AU5914490A
AU5914490A AU59144/90A AU5914490A AU5914490A AU 5914490 A AU5914490 A AU 5914490A AU 59144/90 A AU59144/90 A AU 59144/90A AU 5914490 A AU5914490 A AU 5914490A AU 5914490 A AU5914490 A AU 5914490A
Authority
AU
Australia
Prior art keywords
pyridine
bis
dicarboxylic acid
alkoxyalkyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU59144/90A
Other versions
AU624978B2 (en
Inventor
Ekkehard Baader
Martin Bickel
Volkmar Gunzler-Pukall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU5914490A publication Critical patent/AU5914490A/en
Application granted granted Critical
Publication of AU624978B2 publication Critical patent/AU624978B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboxylic acid diamides of the formula I <IMAGE> where R<1> is linear or branched C1-C4-alkanediyl, R<2> is unbranched C1-C4-alkyl or hydrogen and n is 1 or 2 and R<1'>, R<2'> and n' have the same meanings as R<1>, R<2> and n, where R<1> and R<1'>, R<2> and R<2'>, and n and n' are identical or different, and their physiologically acceptable salts with the exception of N,N'-bis(2-methoxyethyl)pyridine-2,4-dicarboxylic acid diamide and N,N'-bis(2-hydroxyethyl)pyridine-2,4-dicarboxylic acid diamide. The compounds of the formula I inhibit prolin hydroxylase and lysin hydroxylase and are suitable as fibrosuppressants and immunosuppressants.
AU59144/90A 1989-07-20 1990-07-19 N,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides, preparation and their use Ceased AU624978B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3924093 1989-07-20
DE3924093A DE3924093A1 (en) 1989-07-20 1989-07-20 N, N'-BIS (ALKOXY-ALKYL) -PYRIDINE-2,4-DICARBONESAUREDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF

Publications (2)

Publication Number Publication Date
AU5914490A true AU5914490A (en) 1991-01-24
AU624978B2 AU624978B2 (en) 1992-06-25

Family

ID=6385494

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59144/90A Ceased AU624978B2 (en) 1989-07-20 1990-07-19 N,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides, preparation and their use

Country Status (26)

Country Link
EP (1) EP0409119B1 (en)
JP (1) JPH0776213B2 (en)
KR (1) KR0181945B1 (en)
AT (1) ATE104280T1 (en)
AU (1) AU624978B2 (en)
CA (1) CA2021529C (en)
CY (1) CY1997A (en)
CZ (1) CZ280129B6 (en)
DD (1) DD300429A5 (en)
DE (2) DE3924093A1 (en)
DK (1) DK0409119T3 (en)
ES (1) ES2052112T3 (en)
FI (1) FI94630C (en)
HU (1) HU218274B (en)
IE (1) IE64438B1 (en)
IL (1) IL95121A (en)
LT (1) LT3798B (en)
LV (1) LV10430B (en)
NO (1) NO177187C (en)
NZ (1) NZ234563A (en)
PL (1) PL166307B1 (en)
PT (1) PT94779B (en)
RU (1) RU1836350C (en)
SK (1) SK279199B6 (en)
UA (1) UA19056A (en)
ZA (1) ZA905680B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU615324B2 (en) * 1988-08-04 1991-09-26 Hoechst Aktiengesellschaft An improved process for the preparation of n,n'-bis- (alkoxyalkyl)-pyridine-2,4-dicarboxamides
US5482953A (en) * 1991-02-05 1996-01-09 Hoechst Aktiengesellschaft 2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharmaceuticals

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3707429A1 (en) * 1987-03-07 1988-09-15 Hoechst Ag SUBSTITUTED PYRIDINE-2,4-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE4020570A1 (en) 1990-06-28 1992-01-02 Hoechst Ag 2,4- AND 2,5-SUBSTITUTED PYRIDINE-N-OXIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
DE4030999A1 (en) * 1990-10-01 1992-04-09 Hoechst Ag 4- OR 5-SUBSTITUTED PYRIDINE-2-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
TW199147B (en) * 1991-03-18 1993-02-01 Hoechst Ag
EP0541042A1 (en) * 1991-11-05 1993-05-12 Hoechst Aktiengesellschaft 2,4- and 2,5-pyridine-dicarboxylic acid derivatives, process for their preparation and their use
TW222585B (en) * 1992-09-11 1994-04-21 Hoechst Ag
DOP2002000332A (en) 2001-02-14 2002-08-30 Warner Lambert Co MATRIX METALOPROTEINAS PYRIDINE INHIBITORS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3432094A1 (en) 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt ESTER OF PYRIDINE-2,4- AND -2,5-DICARBONIC ACID AS A MEDICINAL PRODUCT FOR INHIBITING PROLIN AND LYSINE HYDROXYLASE
DE3703963A1 (en) 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,, 5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF, AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3703962A1 (en) * 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3703959A1 (en) 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3826471A1 (en) 1988-08-04 1990-02-22 Hoechst Ag Improved process for the preparation of N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboximides
DE3828140A1 (en) 1988-08-19 1990-03-01 Hoechst Ag Improved process for the preparation of N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboxamides and use of these compounds for the preparation of orally administrable medicaments
DE58908519D1 (en) * 1988-08-04 1994-11-24 Hoechst Ag Improved process for the preparation of N, N-bis (alkoxyalkyl) pyridine -2,4-dicarboxylic acid diamides.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU615324B2 (en) * 1988-08-04 1991-09-26 Hoechst Aktiengesellschaft An improved process for the preparation of n,n'-bis- (alkoxyalkyl)-pyridine-2,4-dicarboxamides
US5482953A (en) * 1991-02-05 1996-01-09 Hoechst Aktiengesellschaft 2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharmaceuticals
US5614537A (en) * 1991-02-05 1997-03-25 Hoechst Aktiengesellschaft 2,4-and 2,5-bistetrazolylpyridines, a process for the preparation thereof and the use thereof as pharmaceuticals

Also Published As

Publication number Publication date
IE902642A1 (en) 1991-02-27
DD300429A5 (en) 1992-06-11
PT94779A (en) 1991-03-20
ATE104280T1 (en) 1994-04-15
ZA905680B (en) 1991-04-24
EP0409119B1 (en) 1994-04-13
IL95121A (en) 1994-08-26
IL95121A0 (en) 1991-06-10
EP0409119A1 (en) 1991-01-23
KR910002799A (en) 1991-02-26
LT3798B (en) 1996-03-25
KR0181945B1 (en) 1999-05-01
PL166307B1 (en) 1995-05-31
FI94630C (en) 1995-10-10
ES2052112T3 (en) 1994-07-01
NO177187B (en) 1995-04-24
LTIP1462A (en) 1995-05-25
UA19056A (en) 1997-12-25
LV10430B (en) 1996-02-20
CY1997A (en) 1997-09-05
NO177187C (en) 1995-08-02
CA2021529A1 (en) 1991-01-21
JPH0776213B2 (en) 1995-08-16
HU904549D0 (en) 1990-12-28
RU1836350C (en) 1993-08-23
FI94630B (en) 1995-06-30
CZ280129B6 (en) 1995-11-15
NO903235L (en) 1991-01-21
CZ357690A3 (en) 1995-06-14
NZ234563A (en) 1992-12-23
DE3924093A1 (en) 1991-02-07
CA2021529C (en) 1997-12-30
AU624978B2 (en) 1992-06-25
PT94779B (en) 1997-04-30
IE64438B1 (en) 1995-08-09
SK357690A3 (en) 1998-07-08
DE59005328D1 (en) 1994-05-19
HU218274B (en) 2000-07-28
SK279199B6 (en) 1998-07-08
LV10430A (en) 1995-02-20
DK0409119T3 (en) 1994-08-08
JPH0358973A (en) 1991-03-14
NO903235D0 (en) 1990-07-19
HUT54653A (en) 1991-03-28
PL286132A1 (en) 1991-07-29
FI903624A0 (en) 1990-07-18

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired