FI903624A0 - Analogous process for the preparation of therapeutically useful N, N'-bis (alkoxy and hydroxyalkyl) pyridine-2,4-dicarboxylic acid diamides - Google Patents
Analogous process for the preparation of therapeutically useful N, N'-bis (alkoxy and hydroxyalkyl) pyridine-2,4-dicarboxylic acid diamidesInfo
- Publication number
- FI903624A0 FI903624A0 FI903624A FI903624A FI903624A0 FI 903624 A0 FI903624 A0 FI 903624A0 FI 903624 A FI903624 A FI 903624A FI 903624 A FI903624 A FI 903624A FI 903624 A0 FI903624 A0 FI 903624A0
- Authority
- FI
- Finland
- Prior art keywords
- pyridine
- bis
- dicarboxylic acid
- hydroxyalkyl
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Abstract
N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboxylic acid diamides of the formula I <IMAGE> where R<1> is linear or branched C1-C4-alkanediyl, R<2> is unbranched C1-C4-alkyl or hydrogen and n is 1 or 2 and R<1'>, R<2'> and n' have the same meanings as R<1>, R<2> and n, where R<1> and R<1'>, R<2> and R<2'>, and n and n' are identical or different, and their physiologically acceptable salts with the exception of N,N'-bis(2-methoxyethyl)pyridine-2,4-dicarboxylic acid diamide and N,N'-bis(2-hydroxyethyl)pyridine-2,4-dicarboxylic acid diamide. The compounds of the formula I inhibit prolin hydroxylase and lysin hydroxylase and are suitable as fibrosuppressants and immunosuppressants.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3924093 | 1989-07-20 | ||
DE3924093A DE3924093A1 (en) | 1989-07-20 | 1989-07-20 | N, N'-BIS (ALKOXY-ALKYL) -PYRIDINE-2,4-DICARBONESAUREDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF |
Publications (3)
Publication Number | Publication Date |
---|---|
FI903624A0 true FI903624A0 (en) | 1990-07-18 |
FI94630B FI94630B (en) | 1995-06-30 |
FI94630C FI94630C (en) | 1995-10-10 |
Family
ID=6385494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI903624A FI94630C (en) | 1989-07-20 | 1990-07-18 | Analogous process for the preparation of therapeutically useful N, N'-bis (alkoxy and hydroxyalkyl) pyridine-2,4-dicarboxylic acid diamides |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0409119B1 (en) |
JP (1) | JPH0776213B2 (en) |
KR (1) | KR0181945B1 (en) |
AT (1) | ATE104280T1 (en) |
AU (1) | AU624978B2 (en) |
CA (1) | CA2021529C (en) |
CY (1) | CY1997A (en) |
CZ (1) | CZ280129B6 (en) |
DD (1) | DD300429A5 (en) |
DE (2) | DE3924093A1 (en) |
DK (1) | DK0409119T3 (en) |
ES (1) | ES2052112T3 (en) |
FI (1) | FI94630C (en) |
HU (1) | HU218274B (en) |
IE (1) | IE64438B1 (en) |
IL (1) | IL95121A (en) |
LT (1) | LT3798B (en) |
LV (1) | LV10430B (en) |
NO (1) | NO177187C (en) |
NZ (1) | NZ234563A (en) |
PL (1) | PL166307B1 (en) |
PT (1) | PT94779B (en) |
RU (1) | RU1836350C (en) |
SK (1) | SK279199B6 (en) |
UA (1) | UA19056A (en) |
ZA (1) | ZA905680B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3707429A1 (en) * | 1987-03-07 | 1988-09-15 | Hoechst Ag | SUBSTITUTED PYRIDINE-2,4-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS |
DE58908519D1 (en) * | 1988-08-04 | 1994-11-24 | Hoechst Ag | Improved process for the preparation of N, N-bis (alkoxyalkyl) pyridine -2,4-dicarboxylic acid diamides. |
DE4020570A1 (en) | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- AND 2,5-SUBSTITUTED PYRIDINE-N-OXIDES, METHOD FOR THE PRODUCTION AND USE THEREOF |
DE4030999A1 (en) * | 1990-10-01 | 1992-04-09 | Hoechst Ag | 4- OR 5-SUBSTITUTED PYRIDINE-2-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT |
YU9492A (en) * | 1991-02-05 | 1995-03-27 | Hoechst Ag. | 2,4- and 2,5-BIS-TETRAZOLYL pyridines and the process for their preparation |
TW199147B (en) * | 1991-03-18 | 1993-02-01 | Hoechst Ag | |
EP0541042A1 (en) * | 1991-11-05 | 1993-05-12 | Hoechst Aktiengesellschaft | 2,4- and 2,5-pyridine-dicarboxylic acid derivatives, process for their preparation and their use |
TW222585B (en) * | 1992-09-11 | 1994-04-21 | Hoechst Ag | |
DOP2002000332A (en) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | MATRIX METALOPROTEINAS PYRIDINE INHIBITORS |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3432094A1 (en) | 1984-08-31 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | ESTER OF PYRIDINE-2,4- AND -2,5-DICARBONIC ACID AS A MEDICINAL PRODUCT FOR INHIBITING PROLIN AND LYSINE HYDROXYLASE |
DE3703963A1 (en) | 1987-02-10 | 1988-08-18 | Hoechst Ag | PYRIDINE-2,4- AND 2,, 5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF, AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS |
DE3703962A1 (en) * | 1987-02-10 | 1988-08-18 | Hoechst Ag | PYRIDINE-2,4- AND 2,5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS |
DE3703959A1 (en) | 1987-02-10 | 1988-08-18 | Hoechst Ag | PYRIDINE-2,4- AND 2,5-DICARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS |
DE3826471A1 (en) | 1988-08-04 | 1990-02-22 | Hoechst Ag | Improved process for the preparation of N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboximides |
DE3828140A1 (en) | 1988-08-19 | 1990-03-01 | Hoechst Ag | Improved process for the preparation of N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboxamides and use of these compounds for the preparation of orally administrable medicaments |
DE58908519D1 (en) * | 1988-08-04 | 1994-11-24 | Hoechst Ag | Improved process for the preparation of N, N-bis (alkoxyalkyl) pyridine -2,4-dicarboxylic acid diamides. |
-
1989
- 1989-07-20 DE DE3924093A patent/DE3924093A1/en not_active Withdrawn
-
1990
- 1990-07-14 AT AT90113528T patent/ATE104280T1/en not_active IP Right Cessation
- 1990-07-14 DK DK90113528.5T patent/DK0409119T3/en active
- 1990-07-14 DE DE59005328T patent/DE59005328D1/en not_active Expired - Fee Related
- 1990-07-14 ES ES90113528T patent/ES2052112T3/en not_active Expired - Lifetime
- 1990-07-14 EP EP90113528A patent/EP0409119B1/en not_active Expired - Lifetime
- 1990-07-18 CZ CS903576A patent/CZ280129B6/en not_active IP Right Cessation
- 1990-07-18 IL IL9512190A patent/IL95121A/en not_active IP Right Cessation
- 1990-07-18 FI FI903624A patent/FI94630C/en not_active IP Right Cessation
- 1990-07-18 DD DD342874A patent/DD300429A5/en not_active IP Right Cessation
- 1990-07-18 NZ NZ234563A patent/NZ234563A/en unknown
- 1990-07-18 SK SK3576-90A patent/SK279199B6/en unknown
- 1990-07-19 ZA ZA905680A patent/ZA905680B/en unknown
- 1990-07-19 KR KR1019900010938A patent/KR0181945B1/en not_active IP Right Cessation
- 1990-07-19 IE IE264290A patent/IE64438B1/en not_active IP Right Cessation
- 1990-07-19 PL PL90286132A patent/PL166307B1/en unknown
- 1990-07-19 AU AU59144/90A patent/AU624978B2/en not_active Ceased
- 1990-07-19 CA CA002021529A patent/CA2021529C/en not_active Expired - Fee Related
- 1990-07-19 UA UA4830947A patent/UA19056A/en unknown
- 1990-07-19 HU HU549/90A patent/HU218274B/en not_active IP Right Cessation
- 1990-07-19 NO NO903235A patent/NO177187C/en not_active IP Right Cessation
- 1990-07-19 JP JP2189620A patent/JPH0776213B2/en not_active Expired - Lifetime
- 1990-07-19 RU SU904830947A patent/RU1836350C/en active
- 1990-07-20 PT PT94779A patent/PT94779B/en not_active IP Right Cessation
-
1993
- 1993-05-07 LV LVP-93-301A patent/LV10430B/en unknown
- 1993-11-12 LT LTIP1462A patent/LT3798B/en not_active IP Right Cessation
-
1997
- 1997-09-05 CY CY199797A patent/CY1997A/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
MM | Patent lapsed |
Owner name: HOECHST AKTIENGESELLSCHAFT |