NO175312C - Fremgangsmåte for rensing av et polypeptid med en del av den strukturelle oppbygning til blodplate-avledet vekstfaktor, samt monoklonalt antistoff som er spesifikt for en epitop derav - Google Patents

Fremgangsmåte for rensing av et polypeptid med en del av den strukturelle oppbygning til blodplate-avledet vekstfaktor, samt monoklonalt antistoff som er spesifikt for en epitop derav

Info

Publication number
NO175312C
NO175312C NO885055A NO885055A NO175312C NO 175312 C NO175312 C NO 175312C NO 885055 A NO885055 A NO 885055A NO 885055 A NO885055 A NO 885055A NO 175312 C NO175312 C NO 175312C
Authority
NO
Norway
Prior art keywords
epitope
platelet
polypeptide
purifying
well
Prior art date
Application number
NO885055A
Other languages
English (en)
Norwegian (no)
Other versions
NO885055L (no
NO175312B (no
NO885055D0 (no
Inventor
Arlen R Thomason
Margery A Nicolson
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/025,344 external-priority patent/US5175255A/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of NO885055D0 publication Critical patent/NO885055D0/no
Publication of NO885055L publication Critical patent/NO885055L/no
Publication of NO175312B publication Critical patent/NO175312B/no
Publication of NO175312C publication Critical patent/NO175312C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
NO885055A 1987-03-23 1988-11-11 Fremgangsmåte for rensing av et polypeptid med en del av den strukturelle oppbygning til blodplate-avledet vekstfaktor, samt monoklonalt antistoff som er spesifikt for en epitop derav NO175312C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/025,344 US5175255A (en) 1987-03-23 1987-03-23 Methods for purification of platelet-derived growth factor
US15204588A 1988-02-19 1988-02-19
PCT/US1988/000701 WO1988007057A1 (en) 1987-03-13 1988-03-07 Purified platelet-derived growth factor and methods for purification thereof

Publications (4)

Publication Number Publication Date
NO885055D0 NO885055D0 (no) 1988-11-11
NO885055L NO885055L (no) 1989-01-12
NO175312B NO175312B (no) 1994-06-20
NO175312C true NO175312C (no) 1994-09-28

Family

ID=26699628

Family Applications (1)

Application Number Title Priority Date Filing Date
NO885055A NO175312C (no) 1987-03-23 1988-11-11 Fremgangsmåte for rensing av et polypeptid med en del av den strukturelle oppbygning til blodplate-avledet vekstfaktor, samt monoklonalt antistoff som er spesifikt for en epitop derav

Country Status (8)

Country Link
EP (3) EP0622456A1 (xx)
JP (1) JPH01502669A (xx)
KR (1) KR890700609A (xx)
AU (1) AU624789B2 (xx)
FI (1) FI885224A (xx)
NO (1) NO175312C (xx)
NZ (1) NZ223867A (xx)
WO (1) WO1988007057A1 (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849407A (en) * 1986-08-13 1989-07-18 Zymogenetics, Inc. Biologically active mosaic proteins
US5474982A (en) * 1986-08-13 1995-12-12 Zymogenetics, Inc. PDGF analogs and methods of use
JP2887325B2 (ja) * 1988-06-28 1999-04-26 ラ ホヤ キャンサー リサーチ ファウンデーション デコリンによる細胞増殖の抑制
US5583103A (en) * 1988-06-28 1996-12-10 La Jolla Cancer Research Foundation Inhibition of transforming growth factor beta activity
US5654270A (en) * 1988-06-28 1997-08-05 La Jolla Cancer Research Foundation Use of fibromodulin to prevent or reduce dermal scarring
US5654267A (en) * 1988-12-20 1997-08-05 La Jolla Cancer Research Center Cooperative combinations of ligands contained within a matrix
US7214375B1 (en) 1989-09-29 2007-05-08 La Jolla Cancer Research Foundation Methods of decreasing the accumulation of extracellular matrix associated with glomerulonephritis with anti-TGF-β-specific antibodies
IL96682A0 (en) * 1989-12-15 1991-09-16 Amgen Inc Production of biologically active platelet-derived growth factor from high expression host cell systems
WO1992001716A1 (en) * 1990-07-23 1992-02-06 Zymogenetics, Inc. Protease resistant pdgf and methods of use
GB9101645D0 (en) * 1991-01-25 1991-03-06 British Bio Technology Compounds
GB9106678D0 (en) * 1991-03-28 1991-05-15 Ferguson Mark W J Wound healing
AU3062392A (en) * 1991-11-04 1993-06-07 Novo Nordisk A/S Pdgf gel formulation
DE69535976D1 (de) * 1994-03-29 2009-08-13 Renovo Ltd Heilung von Wunden oder fibrotischen Krankheiten unter Verwendung von wenigstens einem Agens gegen einen Wachstumsfaktor
GB2288118A (en) * 1994-03-29 1995-10-11 Univ Manchester Wound healing composition
US7597886B2 (en) 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7820798B2 (en) 1994-11-07 2010-10-26 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7429646B1 (en) 1995-06-05 2008-09-30 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor-like 2
US7964190B2 (en) 1996-03-22 2011-06-21 Human Genome Sciences, Inc. Methods and compositions for decreasing T-cell activity
US6635743B1 (en) 1996-03-22 2003-10-21 Human Genome Sciences, Inc. Apoptosis inducing molecule II and methods of use
JP2002537769A (ja) 1999-02-26 2002-11-12 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ヒトエンドカインαおよび使用方法
CA2405557C (en) 2000-04-12 2013-09-24 Human Genome Sciences, Inc. Albumin fusion proteins
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
WO2004045531A2 (en) * 2002-11-14 2004-06-03 Cornell Research Foundation, Inc. Protection of cardiac myocardium
CN108949870B (zh) * 2018-08-06 2021-05-28 智享生物(苏州)有限公司 一种生产重组血小板源生长因子的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479896A (en) 1981-12-11 1984-10-30 Antoniades Harry N Method for extraction localization and direct recovery of platelet derived growth factor
US4543439A (en) * 1982-12-13 1985-09-24 Massachusetts Institute Of Technology Production and use of monoclonal antibodies to phosphotyrosine-containing proteins
CA1219232A (en) * 1983-08-17 1987-03-17 Richard A. Lerner Polypeptide-induced monoclonal receptors to protein ligands
US4801542A (en) 1984-10-12 1989-01-31 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
DE3751632T2 (de) * 1986-08-13 1996-06-13 Zymogenetics Inc Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen
AU2451988A (en) * 1988-10-28 1990-05-03 Jewish Hospital Of St. Louis, The Recombinant platelet-derived growth factor a-chain derived from endothelial cells

Also Published As

Publication number Publication date
EP0282317A3 (en) 1990-05-30
FI885224A0 (fi) 1988-11-11
WO1988007057A1 (en) 1988-09-22
FI885224A (fi) 1988-11-11
EP0622456A1 (en) 1994-11-02
JPH01502669A (ja) 1989-09-14
AU1715388A (en) 1988-10-10
KR890700609A (ko) 1989-04-26
NO885055L (no) 1989-01-12
AU624789B2 (en) 1992-06-25
EP0282317A2 (en) 1988-09-14
NO175312B (no) 1994-06-20
NO885055D0 (no) 1988-11-11
NZ223867A (en) 1991-08-27
EP0559234A1 (en) 1993-09-08

Similar Documents

Publication Publication Date Title
NO175312C (no) Fremgangsmåte for rensing av et polypeptid med en del av den strukturelle oppbygning til blodplate-avledet vekstfaktor, samt monoklonalt antistoff som er spesifikt for en epitop derav
IT8319234A0 (it) Procedimento per la produzione di anticorpi monoclonali umani.
IL73883A (en) Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
ES2196002T3 (es) Anticuerpos recombinantes para terapia humana.
NO884771L (no) Fremgangsmaate for fremstilling av et kimerisk antistoffmolekyl.
NO864139L (no) Polypeptid virksomt ved dannelse av aids-antistoff.
NO870770L (no) FremgangsmŸte for fremstilling av monoklonale antistoffer.
NO843293L (no) Monoklonale antistoffer, samt fremgangsmaate for fremstilling av slike
ES498300A0 (es) Un metodo de fabricacion de un componente de peso ligero,por ejemplo, brazos de control inferior en automoviles.
DE3684211D1 (xx)
EP0198086A4 (en) MAN-MOUSE HYBRIDOMA PRODUCING HUMAN ANTIVIRAL ANTIBODY, PREPARATION METHOD AND HUMAN ANTIVIRAL MONOCLONAL ANTIBODY.
AR242986A1 (es) Un metodo de reduccion de la heterogeneidad de anticuerpos secretados por celulas productoras de anticuerpo.
DE3581288D1 (de) Antileishmania monoklonale antikoerper, diese antikoerper ausscheidende hybridomas, von diesen antikoerpern erkannte leishmaniaantigene, verfahren zur herstellung und verwendung von diesen monoklonalen antikoerpern und antigenen.
DK407987D0 (da) Apolipoprotein b-specifikke monoklonale antistoffer og hybridomer, som producerer disse antistoffer
DE3682491D1 (de) Immobilisierter c-peptid-antikoerper, seine herstellung und verwendung.
DE68907735D1 (de) Genfragmente, die die variable region eines anti-hiv-antikoerpers codieren, von diesen exprimierte chimaere anti-hiv-antikoerper und verfahren zu deren herstellung.
NO873774D0 (no) Monoklonale eller polyklonale antistoffer.
FI862978A (fi) Onkofetaalisia spesifisiä monoklonaalisia vasta-aineita, menetelmä niiden valmistamiseksi ja niiden käyttö.
DK717888D0 (da) Monoklonale antistoffer
DE3586808D1 (de) L-thyroxin erkennende monoklonale antikoerper.
ATE109834T1 (de) Monoklonaler antikörper spezifisch gegen humane pankreas-phospholipase-a2.
DE3886545D1 (de) Monoklonale human-antikörper, spezifisch für rh(d).
DK276185D0 (da) Monoklonale antistoffer,fremgangsmaade til fremstilling af disse samt deres diagnostiske anvendelse
IL92312A0 (en) Monoclonal antibody specifically recognizing n-glycolyl type gm2,hybridoma producing the antibody and method for preparing the hybridoma
ATE144286T1 (de) Monoklonale antikörper gegen den plasmin- antiplasmin komplex, verfahren zu ihrer herstellung sowie ihre verwendung