NO158781B - MEASURES FOR TREATMENT OF SARS. - Google Patents

Description

The present invention relates to an agent for the treatment of wounds.

Agents for the treatment of wounds are previously known. Thus, among the conventional textile dressings there are i.a. a dextran-based product for the treatment of wounds (US patent 4,225,580). However, this material has the disadvantage that it is relatively difficult to apply, and in particular the disadvantage that it is relatively difficult to remove from the wounds,

as the small dextran grains easily stick to the edge of the wounds.

The agent according to the invention is characterized in that

it consists of 2 to 20% by weight of a graft copolymer of starch and hydrolyzed polyacrylonitrile, whose carboxyl group hydrogen is replaced by aluminum in an amount of 5 to 90%, suspended in a lipophilic liquid or paste containing 1-3 surfactants in a concentration of a maximum of 5% by weight.

This wound treatment agent has significantly more favorable properties compared to previously known agents for the same application.

The grafted copolymer of starch and hydrolyzed polyacrylonitrile used for the agent according to the invention, where 5 to 90% of the carboxyl group hydrogen is replaced by aluminium, can for example be produced according to US patent 4 302 369, by reacting a starch suspension with acetonitrile under the conditions specified there in the presence of a chemical initiator such as ceramic ammonium nitrate, hydrolyzes the formed graft copolymer with strong bases and then reacts with aluminum salts. The product formed can then be dried, washed with an alcoholic ammonia solution and adjusted with hydrochloric acid to the desired pH value of 6.0 to 7.5. On the other hand, however, it is also possible to get this product, e.g. from Henkel Corporation, Minneapolis, under the designation SGP 157 M. For the production of the agent according to the invention, such graft copolymers are suitable which exhibit the following characteristics: The ratio between the starch component and the acrylate and acrylamide component is preferably 1:3 to 1:0.9 , the ratio of carboxyl groups to amide groups is preferably 2:1 to 9:1,

and in the polymer is preferably 25 to 75% of carboxyl

the groups replaced with aluminium.

As lipophilic liquids, hydrocarbons, such as e.g. paraffins, vaseline, stearin, but also vegetable and animal oils, waxes or fats, such as e.g. jojoba oil, olive oil, peanut oil, coconut oil, almond oil, sunflower oil, lanolin, fine bone oil, beeswax, wool grease, etc., are used.

Both non-ionic and ionic surfactants are suitable as physiologically acceptable surfactants. As non-ionic surfactants can be mentioned: lecithins, lecithin fractions and their breakdown products, polyethylene fatty acid esters such as polyoxy-ethylene fatty alcohol ether, polyoxyethylated sorbitan fatty acid esters, glycerol polyethylene glycol oxystearate, glycerol poly-ethylene glycol ricinolate, ethoxylated soy stearins, ethoxylated castor oil and their hydrogenated derivatives, cholesterol, poly- oxyethylene polyoxypropylene polymers, such as polyoxyethylene polyoxypropylene polymers having a molecular weight of 6800 - 8975, e.g. Pluronic<®>F 68.

The compounds specified in claims 2-4 have proven to be particularly suitable surfactants for use in the agents according to the invention.

Polyethylene group-containing surfactants which are suitable for the production of the agents are, for example, polyethylene glycols with a molecular weight above approx. 1000, water sparingly soluble polypropylene glycols and block polymers of both compounds, which are common in the trade under the names Pluroni J8>. Particularly suitable is the surfactant Pluronic<®> F 68 which is used in the agents according to the invention in a concentration of up to 5% by weight calculated on the agent itself. Other surfactants containing polyethylene groups which are suitable for the production of the agent according to the invention are, for example, the commercial products Cremophor<®>.

Fatty alcohol sulphates are also suitable as surfactants, such as e.g. the commercially available Lanette<®> E or N preparations.

Like fatty alcohol or cholesterol-containing surfactants such as

are suitable for the production of the agents according to the invention, mention may be made of: stearyl alcohol, palmityl alcohol, mixtures of these, which are for example commercially available under the name Lanette<®>0 or the cholesterol contained in lanolin.

As it only depends on the properties, but not on the chemical structure of the surfactant, mixtures of several surfactants are just as suitable as a single defined surfactant. In addition to the surfactants, the agent according to the invention also contains lipophilic liquids or pastes which preferably consist of the components specified in claims 5 and 6.

High-boiling paraffins that are suitable as components of the agents according to the invention are the thin-flowing, viscous, waxy or solid paraffins commonly used in galenics, e.g. also those sold under the name Vaseline<®>. Suitable substances are also such paraffins which are emulsified with wool fatty alcohols which are sold under the name Eucerin".

The suitable components for the agent according to the invention

are, for example, the vegetable or animal oils, waxes or fats, which have already been mentioned in the description.

Of the individual components which, alongside the grafted copolymers, are used in the agent according to the invention, mixtures are prepared using the conditions well known to the galenician, which in each case are matched to the desired application area for the agent according to the invention.

For the preparation of the agent, the components are e.g. ground evenly on a suitable mill and sterilized by heat.

The agent according to the invention for the treatment of wounds is, with regard to its application, not only suitable for the treatment of wounds in the narrower sense, but is as those in the "Rote Liste" published by the Bundesverband der pharmazeutischen Industrie e.v., D-6000 Frankfurt/Main - 1980", listed wound treatment agents suitable for the treatment of numerous secretion-related inflammations or damage to the skin or mucous membrane. Such disorders or injuries are e.g. cuts, shocks, lacerations, crush injuries, burns, frostbite, scrapes, sunburn, eczema, haemorrhoids, etc.

The agent according to the invention for the treatment of injuries can also contain the additives or auxiliary substances common to such agents (e.g. fragrances) as well as also active substances that are often used in such agents.

The agent according to the invention is applied to the place on the body to be treated and possibly covered with gas.

The agent according to the invention is distinguished by an unusual suction pressure and therefore favors rapid healing of the wound due to water extraction.

The lipophilic components and surfactants contained in the agent according to the invention ensure that the agent according to the invention does not dry out due to its low vapor pressure. This prevents adhesion to the wound, or the edge of the wound, so that the agent can be removed again without problems. In addition, these ingredients cause the preparations to become pasty and can thus be easily applied.

The following design examples serve to explain the agent according to the invention in more detail.

Example 1

2 g of graft copolymer SGP 157 M from the company Henkel Corporation, Minneapolis, is ground with 0.8 g of Pluronic<®>F 68 and 10 g of Pur-oba oil for 30 minutes in a ball mill whereby a homogeneous dispersion is formed.

Example 2

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, is ground with 1 g of thin liquid paraffin for 5 minutes in a ball mill. 3 g of paraffin are then added, which is further ground for 5 minutes, another 6 g of paraffin and 1 g of Pluronic®F 68 are added, and further ground is continued for 20 minutes until a homogeneous dispersion is formed.

Example 3

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, with a grain size of less than 0.063 mm and 5 g of Pluronic<®>F 68 with a grain size of less than 0.075 mm are ground with 20 g of thin liquid paraffin. 50 g of white vaseline and 25 g of viscous paraffin are then added to the mixture, and the mixture is ground until a smooth, homogeneous dispersion is obtained.

Example 4

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, is ground with 10 g of Cremophor® EL. Add 90 g of white vaseline in portions to the mixture and grind until a homogeneous dispersion is formed.

Example 5

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, is ground with 10 g of Cremopho EL and 10 g of polyethylene glycol (MV 400). Then add 80 g of white vaseline in portions, and grind until a homogeneous dispersion is formed.

Example 6

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, with a grain size below 0.063 mm and 0.8 g of Pluronic® with a grain size below 0.075 mm are ground with 6 g of Cremophor® EL. Then add 36 g of white vaseline in portions, and grind until a homogeneous dispersion is formed.

Example 7

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, with a grain size below 0.036 mm and 0.8 g of Pluroni 68 with a grain size below 0.075 mm are ground with 4 g of Cremopho EL and 4 g of polyethylene glycol (MV 400). 4.8 g of white vaseline are then added in portions, and ground until a homogeneous dispersion is formed.

Example 8

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, with a grain size below 0.063 mm and 0.8 g of Pluronic® F 68 with a grain size below 0.075 mm are ground with 20 g of "Eucerin" until a homogeneous dispersion is formed.

Example 9

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, with a grain size below 0.063 mm and 0.8 g of Pluronic<®>F 68 with a grain size below 0.075 mm are ground with 4 g of Cremophor<®>EL. 16 g of "Eucerin" is then added in portions and ground until a homogeneous dispersion is formed.

Example IO

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, with a grain size of less than 0.063 mm and 0.8 g of Pluronic® F 68 with a grain size of less than 0.075 mm are ground with 4 g of Cremopho EL and 4 g of polyethylene glycol (MV -40b) . 4.8 g of "Eucerin" is then added in portions and ground until a homogeneous dispersion is formed.

Example 11

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, with a grain size below 0.063 mm and 0.8 g of Pluron 68 are rubbed together with 20 g of ointment base to a homogeneous dispersion.

The ointment base used is prepared as follows: 35 g

(s)

viscous paraffin, 35 g of white vaseline and 30 g of Lanette^N are melted at 90°C and stirred until the mixture has cooled.

Example 12

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, with a grain size below 0.063 mm and 0.8 g of Pluroni 68 are mixed with 20 g of ointment base to a homogeneous dispersion.

The ointment base used is prepared as follows:

6.0 g of wool wax, 0.5 Lanette<®>0, 10.0 g of viscous paraffin and 83.5 g of white vaseline are melted at 90°C and stirred until the mixture has cooled.

Example 13

2 g of graft copolymer SGP 157 M from Henkel Corporation, Minneapolis, is mixed with 0.8 g of Pluroni 68 with a grain size below 0.075 mm and 4 g of Cremopho EL. 16 g of the ointment base prepared according to example 11 is then added in portions, and mixed until a homogeneous dispersion is obtained.

Example 14

Under the conditions of example 13, but using the ointment base prepared according to example 12, a homogeneous dispersion is produced.

Example 15

Procedure for determining suction pressure

1. Experimental device

A schematic drawing of the apparatus used to determine the suction pressure is shown in the following fig. 1.

A vertically attached U-tube with a leg length of approx. 70 cm was filled with so much mercury that the height was approx. 30 cm.

One leg of the U-tube is open and somewhat longer than the other leg, which carries a mounting device for a funnel equipped with a fritted bottom. So much water was then placed on the mercury column in both tube halves that the frit plate was just filled with water.

To carry out the measurement, an accurately weighed amount of polymer material (5 g) was placed on the frit covered with a filter.

During swelling, the polymer absorbs as much water until the difference in the hydrostatic pressure in the two pipe halves is equal to the suction pressure.

2. Theoretical basis

As can be seen from the test device, the suction pressure (SP) is measured by a force comparison. In the equilibrium state, the difference in hydrostatic pressure in the two pipe halves is exactly equal to the suction pressure.

Sketch of the apparatus for determining the suction pressure.

la) Before measurement: h^ = h_

lb) In equilibrium state: AhHg = 2 { h1 - h£)

In the equilibrium state:

S„ respectively. n is the specific gravity of mercury and water.

some ten

Results:

Claims (6)

1. Means for the treatment of wounds, characterized in that it consists of 2 to 20% by weight of a graft copolymer of starch and hydrolyzed polyacrylonitrile, whose carboxyl group hydrogen is replaced by aluminum in an amount of 5 to 90%, suspended in a lipophilic liquid or paste containing 1-3, surfactants in a concentration of a maximum of 5% by weight. 2. Means for treating wounds according to claim 1/ characterized in that it contains a polyethylene group-containing surfactant. 3. Means for treating wounds according to claim 1 or 2, characterized in that it contains a fatty alcohol sulfate as a surfactant. 4. Means for treating wounds according to claim 1 or 2, characterized in that it contains a fatty alcohol or cholesterol as a surfactant. 5. Means for treating wounds according to claim 1 - .it, characterized in that it contains a high-boiling paraffin. 6. Means for treating wounds according to claims 1-5, characterized in that it contains a vegetable or animal oil, wax or fat.