JPH02152920A - Composition for skin disinfection and cleansing - Google Patents

Abstract

PURPOSE:To obtain a composition for skin disinfection and cleansing which is a W/O type emulsion, and suitably used for disinfecting and cleansing the skin parts which are difficult to be washed by using specific amounts of synthetic oil, nonionic surface active agent, amphoteric surface active agent and a disinfectant and purified water. CONSTITUTION:The subject composition is composed of 20 to 70wt.%, preferably 40 to 60wt.% of synthetic oil such as glycerol trioctanoate and/or mineral oil, 1 to 25wt.% of a nonionic surface active agent such as a water-soluble silicone oil, 0 to 2wt.% of an amphoteric surface active agent such as 2-akkyl-N- carboxymethylhydroxyethylimidazolium betaine, 0.001 to 1wt.% of a disinfectant such as alkyldiaminoethylglycine hydrochloride or benzalkonium chloride and purified water. The composition ensures the prevention of formation and aggravation of rash and itching.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a composition for disinfecting and cleaning the skin, more specifically, for cleaning and cleaning the skin in daily life, especially around the anus, around the genitals, around the axilla, etc. The present invention relates to a new composition that is suitable for sterilizing and wiping skin areas that are difficult to wipe, and that can be kept clean by wiping secondary areas and prevent the occurrence of symptoms such as rashes and itchiness.

Chronic - Kome Ichigoichi Niraichio Traditionally, sanitary napkins, tampons, etc. have been used to treat menstrual blood and secretions during menstruation, and blood and dirt remaining on the skin around the female genital area can be removed by using the toilet. paper,
It is common to wipe it off with tissue paper, etc.
Stains such as blood and secretions stuck to the skin cannot be removed sufficiently by the wiping operation described above, which is not only uncomfortable, but also causes rashes, itching, etc. Even though most women are concerned about these stains, the current situation is that they have no choice but to give up.

It is most appropriate to remove fixed stains such as menstrual blood, secretions, proteins, viscous solutions containing polysaccharides, etc. by washing with water, but in reality washing with water is not possible in most cases. . In addition, some cleaning tools such as clean cotton have been developed and attempts are being made to use them, but these have drawbacks such as high cost per use and not being able to be flushed down the toilet. There is room for practical improvement. Furthermore, foam-like cleaning agents that are applied to toilet paper and the like are also known, but these are water-soluble and have disadvantages such as the paper being torn when applied.

Oil-based cleaning agents do not have such adverse effects and can maintain the strength of the paper, but as mentioned above, proteins such as menstrual blood and secretions, etc.
A fatal drawback is that the wiping effect of viscous solutions containing polysaccharides and their adhered substances is not sufficient.

1. The purpose of the present invention is to apply to skin areas that are difficult to clean and wipe in daily life, such as the area around the anus, the area around the genitals, and the area around the axilla, especially the skin around the genital area of women during menstruation. It is suitable for cleaning stubborn stains such as residual menstrual blood, proteins such as secretions, viscous solutions containing polysaccharides, etc., and can be used with cleaning paper such as toilet paper. To provide a new composition that is highly effective and does not irritate or damage the skin when wiped off, and that can keep the skin area clean and prevent the occurrence of symptoms such as rash and itching. be.

As a result of extensive research, the present inventors have found that the above object can be achieved by a composition in the form of a W/O emulsion having the following composition, and have now completed the present invention.

That is, the present invention relates to a composition for sterilizing and wiping the skin, which contains components (1> to (4)) in the following composition range and purified water, and is in the form of a W/O emulsion.

(1) Synthetic oil and/or mineral oil 20-70% (2
) Nonionic surfactant 1 to 25% (3) Amphoteric surfactant 0 to 2% (4) ff
1 bactericidal agent 0.001 to 1 F1% The composition of the present invention combines the wiping effect of water and the paper strength retaining effect of oil based on the W/O type emulsion having the above-mentioned specific composition. It can be put to practical use by applying it to toilet paper, etc., and can thus provide exceptional wiping and sterilizing effects that are not possible with conventional methods. However, such emulsion and practical sterilizing and wiping compositions have not been known at all.

In the composition of the present invention, it is essential to use a specific oil as component (1). The components include, for example, medium-chain fatty acid triglycerides having 4 to 10 carbon atoms, such as glyceryl trioctanoate, glycerin tricaprylate, and glycerin tricaprate; 30 fatty acids and monohydric alcohols having 1 to 20 carbon atoms Chain silicone oils such as dimethylpolysiloxane and methylphenylpolysiloxane; Cyclic silicone oils such as octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane, etc. synthetic oils, and mineral oils such as hydrocarbons such as liquid paraffin and liquid isoparaffin. Among these, synthetic oils such as isopropyl myristate and dimethylpolysiloxane, and mineral oils such as liquid isoparaffin are particularly preferred in view of their low viscosity.

The above component (1) is blended singly or in combination of two or more in an amount of 20 to 70% by weight, preferably 40 to 60% by weight, and thereby obtained. The excellent effects intended by the present invention can be imparted to the composition.

In the composition of the present invention, the nonionic surfactant as the component (2) and the amphoteric surfactant as the component (3) are such that the composition of the present invention, which is finally prepared by blending them, can be sprayed. The composition of the present invention can be applied to particularly sensitive areas of the skin, although it is not particularly limited and can be used by appropriately selecting from various known products on the premise that it will be in the form of a W/O emulsion. Considering that it is
It is desirable to have as little irritation to the skin as possible. The above-mentioned nonionic surfactant satisfying such properties is
It is classified into those belonging to the following (2-1) to (2-4).

(2-1) Water-soluble silicones Nidimethylpolysiloxane polyethylene glycol copolymer, dimethylpolysiloxane polypropylene glycol copolymer, etc. alone or in combination, or a mixture of several types of silicones, such as Toray An example is DCQ2-3225 manufactured by Silicone Co., Ltd.

(2-2) Polyglycerin fatty acid esters such as didecaglyceryl pentaoleate, decaglyceryl heptaoleate, decaglyceryl decaoleate, hexaglyceryl pentaoleate, hexaglyceryl polyresilate, etc. alone or in rough combinations.

(2-3) Polyoxyethylene alkyl ethers: polyoxyethylene lauryl ether, polyoxyethylene oleyl ether, etc. alone or in combination.

[2-4) Others: Polyoxyethylene hydrogenated castor oil, etc.

Among the above (2-1) to (2-4), especially (2-1)
Water-soluble silicones belonging to the following can be suitably used.

The above component (2) is blended alone or in an appropriate combination of two or more in the composition of the present invention in an amount of 1 to 25% by weight or 1 to 15% by weight. The excellent effects intended by the present invention can be imparted to the composition.

Further, as an amphoteric surfactant satisfying the above properties, specifically, for example, 2-alkyl-N-carboxymethylhydroxyethylimidazolium betaine (alkyl=C1
1-C1□), lauryldimethylaminoacetic acid betaine,
Wfm alkyldiaminoethylglycine (alkyl=0
12 to C14), among which 2-alkyl-N-carboxymethylhydroxyethylimidazolium betaine is preferred. Although the above component (3) is not an essential component of the composition of the present invention, it is usually used alone or in combination of two or more types in the composition of the present invention up to 2% by weight, preferably 0.1 to 1%. It is preferable to add and blend the compound in an amount of 4 to 40% by weight, thereby making it possible to further improve the emulsified state of the composition of the present invention.

Furthermore, the composition of the present invention contains 0.00% of a bactericide as component (4).
It is essential to add and blend in the range of 0.01 to 1% by weight, preferably 0.01 to 0.2% by weight. Examples of the bactericide used as component (4) include alkyldiaminoethylglycine hydrochloride (alkyl-mainly C1□ to C14), benzalkonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, benzethonium chloride, triclocarpan, triclosan. , halocarpan and the like.

Among the above, alkyldiaminoethylglycine hydrochloride can also be used as an amphoteric surfactant as the component (3), and in this case, the amount used is the same as that of the component (3).
4) The total amount of the ingredients can be ranged.

Among the compositions of the present invention, preferred are those having particularly low viscosity, preferably the viscosity of the entire composition at 20°C of 5QC3 or less, and excellent stability in the WIO emulsion state, for example, (1) Chain silicone oil such as dimethylpolysiloxane as a component and (2) as a component.
−1) in combination with water-soluble silicones belonging to
and (1) mineral oil such as liquid paraffin as a component (
As the 2) component, a combination with a polyglycerol fatty acid ester belonging to (2-2) can be exemplified.

The composition of the present invention may further contain medicinal agents such as various known anti-inflammatory agents, preservatives such as parabens, stabilizers such as butyl didroxytoluene (BHT), vitamin E, edetic acid, fragrances, etc., as necessary. Appropriate amounts of deodorants, etc. can be added and blended, and lower alcohols such as ethanol, Q-menthol, etc. can be added and blended for the purpose of increasing the cooling sensation, and olive oil, jojoba oil, castor oil, palm oil, etc. can be added as emollients. Oil, vegetable oils such as almond oil and coconut oil, and animal oils such as lanolin and squalane may also be added.

The composition of the present invention uses predetermined amounts of the above components (1) to (4) and other additives as necessary, and the remaining purified water.
It can be easily prepared into a W/O type emulsion according to a conventional method. For example, the emulsion is most basically prepared by separately mixing the oily component and aqueous component of each component, and adding the latter little by little to the former while stirring and mixing using a suitable device such as a homomixer. It is implemented by

The composition of the present invention in the form of a W/O emulsion thus prepared is made into a product by filling it into a suitable container, and is generally applied in an appropriate amount onto cleaning paper such as toilet paper by spraying, dropping, etc. Afterwards, it is put to practical use by wiping the skin area with the wiping paper. Therefore, it is suitable and preferable for the above-mentioned product to be used in a conventional pressure accumulating pump bottle or in the form of a spray using various propellants. The practical use of the above product is, for example, to remove pre-fixed menstrual blood, secretions, filth, etc. from the genital area during menstruation, the anal area after defecation, the genital area when bathing is not possible, the axillary area, etc. After wiping with tissue paper, etc., it is appropriate to finish by wiping with a cleaning paper sprayed with this product several times.This provides a sufficient wiping effect and keeps the skin area clean. This can reliably prevent the occurrence and aggravation of rashes, itching, and other symptoms. In addition, this product can be applied directly to the genital area, anal area, axillary area, etc., and then wiped off with toilet paper, tissue paper, etc. This application also achieves the intended effect of the present invention. Get 1 no.

The sterilizing and wiping composition of the present invention can be applied to skin areas that are difficult to clean and wipe in daily life, for example by applying it to wiping paper such as toilet paper. It is particularly effective in wiping away menstrual blood, secretions, etc. that adhere to the female genital area during menstruation, and has a bactericidal effect on the skin area. keep it clean and
It can prevent itching and rashes. Moreover, during the above-mentioned practical use, there is no risk of the wiping paper being torn, the wiping feeling is very good, there is no discomfort such as stickiness, and there is no risk of causing pain or irritation.

EXAMPLES Examples and comparative examples are given below to explain the present invention in more detail, but the present invention is not limited thereto.

The reagents used on each side are as follows.

○Silicone-based nonionic surfactant: rDc-02-3225CJ (manufactured by Torre Silicone) O polyglycerin fatty acid ester; hexaglycerin polyresilate (llexag Iy
n: Nikko Chemicals Co., Ltd.) 0 Medium-chain fatty acid triglyceride: Panacet 8/OJ (Nippon Oil & Fats Co., Ltd.) 02-Furkyl-N-ruboxymethylhydroxyethylimidazolinium betaine: rHIRANOL C2) I J (Milanol Co., Ltd.) ) 0 alkyldiaminoethylglycine hydrochloride: rTEGo
-51J (manufactured by Nippon Shoji Co., Ltd.) Example 1 A phase (S/W Koma dimethylpolysiloxane 35 Medium chain fatty acid triglyceride 5 Silicone nonionic surfactant /OB phase 2-Alkyl- hydroxyedylimidazolinium betaine alkyl hydrochloride Diaminoethylglycine 0.05 Purified water
After heating appropriate amounts of the above phases A and B to 70°C or higher, add phase A little by little to phase B and cool to 30°C while stirring at 3000 1'pm with a homomixer. A sterilizing and wiping composition of the present invention in the form of a W/O type lotion was obtained.

Example 2 Phase A (W/W%) Dimethylpolysiloxane 35 Medium chain fatty acid triglyceride 5 Silicoline nonionic surfactant /OB phase 2-Alkyl-N-hydroxymethyl 0.5 Hydroxyethyl imidazolinium betaine chloride Benzalkonium 0. 05 Purified water
Using appropriate amounts of the above phase A and phase B, the present invention was sterilized in the form of a W/O type lotion in the same manner as in Example 1.
A cleaning composition was obtained.

Example 3 Phase A (W/cocoon) Light liquid isoparaffin 40 Isopropyl myristate 8 Polyglycerin fatty acid ester 2B phase Alkyl diaminoethyl glycine hydrochloride 0.2 Purified water
A sterilizing and wiping composition of the present invention in the form of a W/O type lotion was obtained in the same manner as in Example 1 using appropriate amounts of the above Phases A and B.

Example 4 Phase A (W/W%) Dimethylpolysiloxane 25 Medium chain fatty acid triglyceride 5 Silicoline nonionic surfactant 20 Phase B 2-Alkyl-N-carboxymethylhydroxyethylimidazolinium betaine Alkyldiaminoethylglycine hydrochloride o. oi purified water
A sterilizing and wiping composition of the present invention in the form of a W/O type lotion was obtained in the same manner as in Example 1 using appropriate amounts of the above Phases A and B.

Example 5 At'th
(W/-
%) Dimethylpolysiloxane 40 Isopropyl myristate 5 Silicoline nonionic surfactant 5B phase Alkyldiaminoethyl glycine hydrochloride 0.3 Purified water
A sterilizing and wiping composition of the present invention in the form of a W/O type lotion was obtained in the same manner as in Example 1 using appropriate amounts of the above Phases A and B.

Example 6 Phase A (14/related) Dimethylpolysiloxane 35 Isopropyl myristate 5 Silicoline nonionic surfactant /O triclocarpane
0.1B phase 2-alkyl-N-carboxymethylhydroxyethylimidazolinium betaine purified water
A sterilizing/wiping composition of the present invention in the form of a W/O type lotion was obtained in the same manner as in Example 1 using the above Phases A and B.

Example 7 Phase A (W/river grade liquid isoparaffin 35 isopropyl myristate 5 polyglycerin fatty acid ester 5 triclosan
0.2B phase 2-alkyl-N-carboxymethyl 1-hydroxyethylimidazolinium betaine purified water
A sterilizing and wiping composition of the present invention in the form of a W/O type lotion was obtained in the same manner as in Example 1 using appropriate amounts of the above Phases A and B.

Example 8 Phase A (%) Dimethylpolysiloxane 35 Medium chain fatty acid triglyceride 5 Silicoline nonionic surfactant /OB phase Alkyldiaminoethylglycine hydrochloride 1.0 Alkyldiaminoethylglycine hydrochloride 0.05 Purification water
Using appropriate amounts of the above phase A and phase B (however, 1.0% of alkyl diaminoethylglycine hydrochloride is used as an amphoteric surfactant and 0.05% of the same is used as a bactericide), W/O was prepared in the same manner as in Example 1. A sterilizing and wiping composition of the present invention in the form of a mold lotion was obtained.

Example 9 Phase A (W/W%) Light liquid isoparaffin 40 Isopropyl myristate 8 Polyglycerin fatty acid ester 2B phase Chlorhexidine gluconate 0.2 Purified water
A sterilizing/wiping composition of the present invention in the form of a W/O type lotion was obtained in the same manner as in Example 1 using appropriate amounts of the above Phases A and B.

Example/O Phase A Dimethylpolysiloxane 25 Neutral fatty acid triglyceride 5 Silicoline nonionic surfactant 20 Phase B 2-Alkyl-N-carboxymethylhydroxyethylimidazolinium betaine Benzethonium chloride 0.2 Purification water
A sterilizing and wiping composition of the present invention in the form of a W/O type lotion was obtained in the same manner as in Example 1 using appropriate amounts of the above Phases A and B.

Comparative Example 1 Phase A (-/side) Dimethylpolysiloxane 35 Medium chain fatty acid triglyceride /O Sorbitan monooleate 2 Polyoxyethylene sorbitan monooleate (IOE.O) Phase 3 Cetyl vr Sodium L 0.1 Purified water Appropriate amount. A comparative cleaning composition in the form of an O/W type lotion was obtained in the same manner as in Example using the above Phase A and Phase B.

Comparative Example 2 (W/W%) Dimethylpolysiloxane 70 medium chain fatty acid triglyceride /O squalane
20 Each of the above components was stirred at room temperature until uniform, to obtain a comparative wiping composition.

<Efficacy Test> In order to confirm the effects of the composition of the present invention, tests were conducted on the following items.

(2) Paper strength The following tests were carried out using the composition of the present invention obtained in Example 1, the comparative composition (comparative example 1), and purified water as samples. That is, the upper end of a 11.5 x 20 cm toilet paper was fixed, the lower end was pulled with a weight, and 0.1 m1 of each sample was
2 was sprayed onto toilet paper, and the weight (c[) of the weight when the paper was cut was measured.

The results are shown in Table 1 below.

Table 1 From Table 1 above, it can be seen that the composition sample of the present invention (Example 1) has a remarkable increase in paper strength compared to purified water, and has a paper strength sufficient for practical use. On the other hand, although the sample of Comparative Example 1 had the same amount of water as that of Example 1, it was found that the paper strength was only about the same as that of purified water and could not be put to practical use.

In addition, as a result of the same test, the compositions of the present invention shown in Examples 2 to 2/O were also found to have an increase in paper strength that was approximately the same as that of Example 1.

(2) Blood removal ability test The following tests were conducted using the composition of the present invention obtained in Example 1 and the comparative composition obtained in Comparative Example 2 as samples. That is, 20 μQ of human blood was applied to the skin on the crooked side of a human forearm and completely dried with a hair dryer. Then, using toilet paper sprayed with each sample (approximately 0.1 m12) and untreated toilet paper to which no drug was applied as a control, the dry surface was wiped /0 times with equal force, The removal rate (%) was determined and the cleaning effect of each sample was investigated. The blood removal rate was determined by hemolyzing blood wiped onto toilet paper and measuring its absorbance in the visible region.

The results obtained are shown in Table 2 below.

Table 2 From Table 2 above, the comparative sample (Comparative Example 2) and the control have no blood removing effect, while the composition sample of the present invention (Example 1) has a significant blood removing effect. That is clear.

As a result of the same test as above, it was found that the compositions of the present invention described in Examples 2 to 2/O had substantially the same blood removal effect as that of Example 1.

■ Sterilizing effect test: Sterilizing and wiping composition of the present invention 0.5ml 12. /O0mg/
Peng's human serum albumin 0.511112 and bacterial fluid 25
Put μQ (approximately 5 bacteria) into a test tube and
, 3 and 5 hours), and then the number of viable bacteria was measured to examine the bactericidal effect of the composition of the present invention.

As a comparative control, similar effects were investigated using physiological saline and the formulations of Examples 1 and 2 in which the alkyl diaminoethyl glycine hydrochloride and benzalkonium chloride as disinfectant components were removed, respectively.

The results are shown in FIGS. 1 to 4.

In each figure, the horizontal axis represents time (hr), and the vertical axis represents the logarithm of the number of viable bacteria (I
Figures 1 and 2 show the number of E. coli bacteria, and Figures 3 and 4 show the number of viable bacteria in each test solution. The figure shows the results of examining the number of Pseudomonas aeruginosa.

In addition, FIGS. 1 and 3 show the results of using the composition of the present invention which was actually overwhelmingly 1 (indicated as (1) in the figure).
Figures 2 and 4 show the results of using the composition of Example 2 as the composition of the present invention (shown as (1) in the figures), and (2) in each figure shows the composition shown as (1). These are the results with the bactericidal component removed, and (3) is the result of physiological saline as a control.

From the second and second figures, it is clear that the composition of the present invention has a remarkable bactericidal effect.

BRIEF DESCRIPTION OF THE DRAWINGS FIGS. 1 to 4 are graphs showing the results of examining the sterilizing effect of the sterilizing and wiping composition of the present invention.

(that's all) No. figure Gin Between (h ``) Between (h ``) No. figure ,Time while (h ``) No. figure Time while (h ``)

Claims (1)

[Scope of Claims] [1] A composition for sterilizing and wiping the skin, which contains components (1) to (4) in the following composition range and purified water, and has a W/O emulsion form. thing. (1) 20 to 70% by weight of synthetic oil and/or mineral oil (2) 1 to 25% by weight of nonionic surfactant (3) 0 to 2% by weight of amphoteric surfactant (4) 0.001 to 1% of bactericide weight%