NO130779B - - Google Patents

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Publication number
NO130779B
NO130779B NO713601A NO360171A NO130779B NO 130779 B NO130779 B NO 130779B NO 713601 A NO713601 A NO 713601A NO 360171 A NO360171 A NO 360171A NO 130779 B NO130779 B NO 130779B
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Norway
Prior art keywords
ester
addition
poultry
lining
agent
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NO713601A
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Norwegian (no)
Inventor
Patrick Eberhard
Konrad Hammacher
Wolfgang Mindt
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Hoffmann La Roche
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Publication of NO130779B publication Critical patent/NO130779B/no

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14542Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1477Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/404Cells with anode, cathode and cell electrolyte on the same side of a permeable membrane which separates them from the sample fluid, e.g. Clark-type oxygen sensors

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Electrochemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Fodder In General (AREA)

Description

Fjærkrefor. Poultry feed.

Foreliggende oppfinnelse vedrører et formiddel med farvende virkning såvel på eggeplommen som også på ben, nebb, hud, fett og kjøtt på fjærkre. The present invention relates to a means with a coloring effect both on the yolk and also on the bones, beak, skin, fat and meat of poultry.

Det er kjent at konsumentene nå for tiden ønsker et stadig hyppigere gjødd fjærkre med hud og ben med sterkt gul-pigmentert farve, såvel som egg med dyp gul plomme. Dessuten kreves ved unge oppdrettingsdyr av bestemte raser en ster-kest mulig pimentering, særlig hva ben og nebb angår. På den annen side fratas fjærkreet på grunn av den økede intensifisering stadig mere av det grønnfor som er nød-vendig for en normal pigmentering. Det er derfor forsøkt å kompensere bortfallet av grønnfor ved foringen med tørket grønt-mel. Ved dette viser det seg at kvalitets-forskjellen i det tørkede grøntmelet er så betydelig at ofte kunne bare meget util-fredsstillende resultater oppnås. It is known that consumers nowadays increasingly want fertilized poultry with skin and bones with a strong yellow-pigmented colour, as well as eggs with a deep yellow yolk. In addition, in the case of young breeding animals of certain breeds, the strongest possible seasoning is required, especially where legs and beaks are concerned. On the other hand, due to the increased intensification, the poultry is increasingly deprived of the green fodder that is necessary for normal pigmentation. Attempts have therefore been made to compensate for the loss of green fodder when lining with dried green meal. This shows that the difference in quality in the dried vegetable meal is so significant that often only very unsatisfactory results could be achieved.

Det er allerede også forsøkt ved til-leggsforing med karotinoider å oppå den ønskede pigmentering. De hittil gjennom-førte forsøk med p-karotin, dihydro-(3-karotin og lykopin ble imidlertid uten resul-tat. Andre karotinoider virket riktignok pigmenterende, men enten er den oppnådde farvetone ikke ønsket eller farveintensiteten for liten. Attempts have already been made to increase the desired pigmentation by adding carotenoids. However, the trials carried out so far with β-carotene, dihydro-(3-carotene and lycopene) were without result. Other carotenoids did have a pigmenting effect, but either the color tone obtained is not desired or the color intensity is too low.

Ifølge nærværende oppfinnelse er det nå overraskende lykkes å fremstille et karotinoidholdig formiddel, med hvis hjelp oppnåelsen av den ønskede farve lykkes, såvel med hensyn til farvetonen som også med hensyn til farveintensiteten og ved bruk av små konsentrasjoner. Formidlet ifølge oppfinnelsen karakteriseres ved en tilsetning av en alkylester av 17-(2,6,6-tri-metyl-cycloheksen-(1 )-yl) -2,6,11,15-tetra-metyl-heptadecaoctaen-(2,4,6,8,10,12,14, 16)-syre-(1) (kalt C:i<> ester). Som alkyl-estere kommer frem for alt slike i betrakt-ning med inntil 20 carbonatomer i alkohol-resten, f. eks. etyl-, propyl-, butyl-, cetyl-esteren. Fortrinnsvis består formidlet ifølge oppfinnelsen av en blanding av vanlig fjærkrefor (enkeltfor eller blandingsfor som avgis med tilsetning av korn) med C.ioesteren. Med fordel er doseringen 0,5— 30 mg karotinoid pr. kg for. According to the present invention, it has now surprisingly succeeded in producing a carotenoid-containing agent, with the help of which the desired color is achieved successfully, both with regard to the color tone and also with regard to the color intensity and when using small concentrations. The agent according to the invention is characterized by the addition of an alkyl ester of 17-(2,6,6-tri-methyl-cyclohexen-(1)-yl)-2,6,11,15-tetra-methyl-heptadecaoctaene-(2, 4,6,8,10,12,14, 16)-acid-(1) (called C:i<> ester). Alkyl esters are primarily those with up to 20 carbon atoms in the alcohol residue, e.g. the ethyl, propyl, butyl, cetyl ester. Preferably, the product according to the invention consists of a mixture of ordinary poultry feed (single feed or mixed feed which is dispensed with the addition of grain) with the C. ioester. Advantageously, the dosage is 0.5-30 mg carotenoid per kg for.

Det for fremkalling av farve egnede formiddel kan fremstilles ved en blanding av Cnoesteren med et basisfor eller med van-ningsvannet. C:ii>esteren kan tilsettes i vil-kårlig form, f. eks. som et tørt pulver i ren form, som tørt pulver i stabilisert, fortyn-net form (innlagt i beskyttelsesmasse som absorbat eller som enkelt blanding), som oppløsning, f. eks. i planteolje (under even-tuell tilsetning av stabiliseringsmiddel), som emulsjon eller dispersjon (f. eks. for anvendelse i vanningsvann. The agent suitable for color development can be prepared by mixing the Cnoester with a base liner or with the irrigation water. The C:ii>ester can be added in any form, e.g. as a dry powder in pure form, as dry powder in stabilized, diluted form (embedded in a protective compound as an absorbate or as a simple mixture), as a solution, e.g. in vegetable oil (with the possible addition of a stabilizer), as an emulsion or dispersion (e.g. for use in irrigation water.

Ifølge en utførelsesform for oppfinnelsen tilblandes C.ioesteren i form av et even-tuelt stabilisert tørt pulver til basisforet. Tilsetningen kan også skje ved å sprøyte en oljelignende oppløsning som inneholder esteren på et formiddel. For å forhindre en delvis nedbrytning av den tilsatte esteren, er det ved anvendelse av ikke stabiliserte produkter gunstig først å foreta tilsetningen umiddelbart før foringen. Denne for-anstaltning er særdeles å anbefale når anvendelsen skjer i forbindelse med van-ningsvannet. According to one embodiment of the invention, the C.ioester is mixed in the form of an optionally stabilized dry powder to the base lining. The addition can also take place by spraying an oil-like solution containing the ester onto a vehicle. In order to prevent a partial breakdown of the added ester, when using non-stabilized products, it is advantageous to first make the addition immediately before the lining. This measure is particularly recommended when it is used in connection with the irrigation water.

Et ifølge foranstående angivelse oppnådd formiddel kan fores som vanlig. Ved foringen av verpehøns oppnås en tiltalen-de, alt etter konsentrasjonen av C30 esteren i foret, mere eller mindre sterk gulfarving av eggeplommen. Ved foring av gjødd fjærkre under utviklingsperioden oppnås en gulfarving av ben, nebb, hud og kjøtt. Denne f arving er særlig intens på ben og nebb, mindre intens i fettet og i huden og ennå mindre utpreget i muskel-vevet. A product obtained according to the above description can be fed as usual. When feeding laying hens, depending on the concentration of the C30 ester in the feed, a more or less strong yellowing of the yolk is achieved. When feeding fertilized poultry during the development period, a yellowing of the legs, beak, skin and meat is achieved. This coloring is particularly intense on the legs and beak, less intense in the fat and in the skin and even less pronounced in the muscle tissue.

Særlig gode resultater oppnås når foret som inneholder C™-esteren gis fjærkreet fra klekkingen til slutten av gjødningen, henholdsvis oppdrettingen. Det er imidlertid også mulig å begynne med tilsetningen av esteren først etter noen tid, f. eks. etter dyrenes femte leveuke. Ved lenger varende anvendelse er det på sin plass å anvende et for som er fattig på Cwesteren, mens ved Particularly good results are achieved when the feed containing the C™ ester is given to the poultry from hatching to the end of fertilisation, respectively rearing. However, it is also possible to start with the addition of the ester only after some time, e.g. after the animals' fifth week of life. For longer-term use, it is appropriate to use a lining that is poor in Cwesteren, while wood

Dette basisfor blir daglig ved tilsetning av følgende tilsetninger i oljeaktig form over-ført i det for foringen bestemte formiddel: Formiddel Tilsetninger This basic lining is transferred daily by the addition of the following additives in oily form into the medium specified for the lining: Medium Additives

I 1 mg C:m-metylester i 10 ccm arachiolje/ kg for In 1 mg C:m-methyl ester in 10 ccm arachi oil/kg for

II 3 mg C.TO-metylester i 10 ccm arachiolje/ kg for II 3 mg C.TO-methyl ester in 10 ccm arachi oil/kg for

III 6 mg CMo-metylester i 10 ccm arachiolje/ kg for III 6 mg CMo-methyl ester in 10 ccm arachi oil/kg for

Eksempel 2: Anvendelse av formidlet. a) Det ifølge eksempel 1 fremstilte formiddel ble gitt til en gruppe verpehøner. Tre dager etter begynnelsen av foringen lot en mørkere farve på eggeplommene seg allerede fastslå. Etter ca. 14 dager ble den endelige farveverdi oppnådd Det viste seg at formiddel 1 bevirket en lys, formiddel 2 en midlere, og formiddel 3 en mørkere gulfarving av eggeplommene. Example 2: Application of conveyed. a) The agent prepared according to example 1 was given to a group of laying hens. Three days after the beginning of the lining, a darker color of the yolks was already evident. After approx. 14 days, the final color value was achieved. It turned out that medium 1 caused a light, medium 2 a medium, and medium 3 a darker yellowing of the yolks.

b) Det ifølge eksempel 1 fremstilte formiddel III ble foret til en gruppe gjød-ningshaner over en tidsperiode på 82 dager. Foringen ble begynt umiddelbart etter at dyrene var klekket. Etter slaktingen ble b) The agent III prepared according to example 1 was fed to a group of fertilizing roosters over a period of 82 days. Feeding was started immediately after the animals had hatched. After the slaughter was

1 kortere anvendelsestid er det å anbefale et for som er rikere på Csoesteren. 1 shorter application time, we recommend a lining that is richer in Csoester.

De Caoestere som virker pigmenterende er nye kjemiske forbindelser, som man kan fremstille fra (3-Cio-aldehyd (8-(2,6,6-tri-metyl-cycloheksen- (1) -yl) -2,6-dimetyl-octatrien-(2,4,6)-al-(l)) ved acetylentil-leiring, kondensasjon med benzoyloksy-me-tylpropenal, syrebehandling, acetalisering av de dannede dehydro-C^s-aldehyd, vinyl-eterkondensasjon og syrebehandling, kondensasjon av den oppnådde dehydro-C27-aldehyd med carbalkoksyetylen-trifenyl-fosfin, partialhydrering og isomerisering av den utvunnede C^esteren. The Caoesters that act as pigments are new chemical compounds, which can be prepared from (3-Cio-aldehyde (8-(2,6,6-tri-methyl-cyclohexen-(1)-yl)-2,6-dimethyl- octatriene-(2,4,6)-al-(l)) by acetylene addition, condensation with benzoyloxy-methylpropenal, acid treatment, acetalization of the dehydro-C^s-aldehyde formed, vinyl ether condensation and acid treatment, condensation of the obtained dehydro-C27-aldehyde with carbaloxyethylene-triphenyl-phosphine, partial hydrogenation and isomerization of the recovered C^ester.

Eksempel 1: Som basisfor blir anvendt en blanding Fremstilling av formidlet. med følgende sammensetning: Example 1: A mixture is used as the base material. with the following composition:

dyrene underkastet en kontroll med<1> hensyn til farven på ben, nebb, hud og kjøtt. Det viste seg at en utpreget gul pigmentering forelå, som var betydelig mer intens enn ved dyr hvis for ikke inneholdt C30-esteren the animals submitted to a control with<1> regard to the color of the legs, beak, skin and meat. It turned out that a distinct yellow pigmentation was present, which was significantly more intense than in animals that did not contain the C30 ester

Claims (4)

1. Formiddel med f arvende virkning på ben, nebb, hud, kjøtt og eggeplomme hos fjærkre, karakterisert ved en tilsetning av alkylester av 17-(2,6,6-trimetyl-cyclohéxen-(1) -yl) -2,6,11,15-tetrametyl-heptadecåoc-taen- (2,4,6,8,10,12,14,16) -syre- (1).1. Agent with coloring effect on bones, beak, skin, meat and egg yolk in poultry, characterized by an addition of alkyl ester of 17-(2,6,6-trimethyl-cyclohexen-(1)-yl)-2,6 ,11,15-tetramethyl-heptadecaoc-taene-(2,4,6,8,10,12,14,16)-acid-(1). 2. Formiddel ifølge påstand 1, karakterisert ved at esteren er stabilisert.2. Agent according to claim 1, characterized in that the ester is stabilized. 3. Formiddel ifølge påstand 1 eller 2, karakterisert ved at innholdet av esteren er 0,5—30 mg pr. kg for.3. Agent according to claim 1 or 2, characterized in that the content of the ester is 0.5-30 mg per kg for. 4. Formiddel ifølge påstand 1, 2 eller 3, karakterisert ved en tilsetning av 17-(2,6, 6-trimetyl-cycloheksen-(l)-yl)-2,6,11,15-tetrametyl-heptadecaoctaen-(2,4,6,8,10,12, 14,16-syre- (1) -metylester.4. Agent according to claim 1, 2 or 3, characterized by an addition of 17-(2,6,6-trimethyl-cyclohexen-(1)-yl)-2,6,11,15-tetramethyl-heptadecaoctaene-(2 ,4,6,8,10,12,14,16-acid-(1)-methyl ester.
NO713601A 1970-10-01 1971-09-30 NO130779B (en)

Applications Claiming Priority (1)

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CH1454470A CH530006A (en) 1970-10-01 1970-10-01 Electrode arrangement

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NO130779B true NO130779B (en) 1974-10-28

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US (2) US3795239A (en)
JP (1) JPS5112199B1 (en)
AT (1) AT313480B (en)
AU (1) AU463724B2 (en)
BE (1) BE773307A (en)
CA (1) CA1008931A (en)
CH (1) CH530006A (en)
CS (1) CS158566B2 (en)
DE (1) DE2145400C3 (en)
DK (1) DK156285C (en)
ES (1) ES395581A1 (en)
FR (1) FR2110906A5 (en)
GB (1) GB1312169A (en)
IL (1) IL37643A (en)
NL (1) NL152084B (en)
NO (1) NO130779B (en)
SE (1) SE373952C (en)

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SE373952B (en) 1975-02-17
CS158566B2 (en) 1974-11-25
ES395581A1 (en) 1975-11-01
IL37643A0 (en) 1971-11-29
DE2145400B2 (en) 1980-08-28
DE2145400C3 (en) 1985-06-05
CA1008931A (en) 1977-04-19
USRE31440E (en) 1983-11-15
DE2145400A1 (en) 1972-04-06
AU463724B2 (en) 1975-08-07
SE373952C (en) 1979-08-20
DK156285C (en) 1990-02-26
DK156285B (en) 1989-07-24
US3795239A (en) 1974-03-05
CH530006A (en) 1972-10-31
BE773307A (en) 1972-03-30
GB1312169A (en) 1973-04-04
NL152084B (en) 1977-01-17
JPS5112199B1 (en) 1976-04-16
IL37643A (en) 1974-09-10
NL7113018A (en) 1972-04-05
AU3296571A (en) 1973-03-08
FR2110906A5 (en) 1972-06-02
AT313480B (en) 1974-02-25

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