US2886771A - Fluid-testing device - Google Patents

Fluid-testing device Download PDF

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Publication number
US2886771A
US2886771A US51538155A US2886771A US 2886771 A US2886771 A US 2886771A US 51538155 A US51538155 A US 51538155A US 2886771 A US2886771 A US 2886771A
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Prior art keywords
electrode
fluid
chamber
housing
means
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Vincent Louis Claude
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GEORGE A RUBISSOW
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George A Rubissow
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/4166Systems measuring a particular property of an electrolyte
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4915Blood using flow cells

Description

AGENT May 12, 1959 1 c; VINCENT FLUID-TESTING DEVICE Filed June 14. 1955 May 12, 1959 L. c. VINCENT FLUID-TESTING DEVICE 5 Sheets-Sheet 2 Filed June 14, 1955 INVENTORI LO UIS-CLAUDE VINCENT W WASI-:NT

May 12, 1959 L. c. VINCENT FLUID-TESTING DEVICE 5 Sheets-Sheet 3 Filed June 14. 1955A INVENTom LOUIS-CLAUDE VINCENT M AGENT United 513168 Patent" of fifty percent to George A. Rnbissow, New York,

Application June 14, 1955, Serial No. 515,381 7 Claims. (Cl. 324-30) My invention relates to a device for the testing of uids, notably (but .not exclusively) of body uids such as blood, urine, spinal fluid and the like.

A11 object of the invention is to provide a device adapted for quickly and `dependably determining, with the aid of apparatus known per se, the acidity (pI-1), the oxidation-reduction potential (rH2 or rO2) and the electronic resistance of any liquid, semi-liquid, solution or gel.

Another object of this invention is to provide a device for determining, on the basis of the various measurements set forth above, the state of health of the donor of the tested uid.

An important feature of my invention resides in the provision of a syringe-like receptacle comprising a plurality of electrodes adapted to contact the uid to be tested under conditions excluding the atmospheric air, in combination with means for maintaining a uniform temperature in the receptacle.

The invention will he described in detail with reference to the accompanying drawing in which:

Fig. 1 is a somewhat diagrammatic axial section of a device embodying the invention;

Fig. 2 is a section on the line 2-2 of Fig. 1;

Fig. 3 is a view similar to Fig. l, showing a partial modification;

Fig. 4 is a section on the line 4 4 of Fig. 3;

Fig. 5 is a perspective view of a further modification; and

Fig. 6 is an exploded view of the device shown in Fig. 5.

In Figs. 1 and 2 there has been shown a syringe, generally designated 1, comprising a female part or cylinder 2 and a male part or piston 8 telescoped together. The lower extremity of part 2 is traversed by a central channel 4 which serves to aspirate the duid to be tested when a partial vacuum is created in the cylinder by the upward displacement of piston 8. An electrolyte permeable plug 3, e.g. of cork, wood or other semi-permeable material, is used to close the channel 4 after the uid has been introduced into the central chamber 30 of syringe 1.

Removably inserted in the lower part of piston 8 is a glass electrode 9 making contact with the fluid in chamber 30. imbedded in the walls of cylinder 2, flush with its inner surface, are three electrodes 5, 6 and 7. Each of these electrodes is connected to an external terminal engaged by a respective contact member 23, 24, 25 when the syringe is operatively positioned in a housing 16, the latter being provided with an elastic gasket 17 affording a frictional and air-tight fit between the housing and the cylinder 2. Gasket 17 is provided with an indentation (not shown) receiving an outward projection on cylinder 2, a similar inward projection thereon mating with a recess 14 on piston 8 to insure invariable relative angular alignment between the elements 2, 8 and 16. A flange 18 on cylinder 2 serves as an abutment for gasket 17.

Glass electrode 9 is filled with a suitable electrolytic solution into which dips a terminal member 10 removably 2,886,771` Patented May 12, 1959 ice inserted into the electrode from above; a lead 12 extends from terminal 10 through a plug 11 toward a contact 13 which is engaged by a stationary spring member 26 upon correct insertion of syringe 1 into housing 16. The housing as well as the projecting part of the syringe are enclosed in a thermally insulating envelope 27.

A calomel electrode 22 is immersed in a solution 21 of potassium chloride which is ionically connected with the fluid in chamber 30 through the semi-permeable plug 3. A pH-meter 31 is connected between electrode 22 and contact member 26. A resistance meter 32 is connected between contact members 23, 24 of electrodes 5 and 6. Electrode 7, which is of a type whose potential is substantially insensitive to the concentration of hydrogen ions (e.g` a platinum electrode) and which may be described as ionically inert, serves to indicate the gidation-reduction potential by means of an rHz-meter Means for maintaining a constant temperature within housing 16, preferably of 37 C., have been provided t. in the form of a resistance heater, a thermostatically controlled governor and a Ventilating system schematically indicated at 19, 20 and 34, respectively.

In Figs. 3 and 4 the female part 2a of the syringe has been modied to permit the direct flow of blood or other fluids through the chamber 30a. This chamber has now been provided with an inlet 35 and an outlet 36 to which rubber tubes 28, 29 are shown attached; these tubes may form couplings between the syringe and a pair of hypodermic needles 37, 38 serving for the circulation of blood in an auto-transfusion circuit. Electrodes 5 and 6 have been shifted toward the junction of chamber 30a with outlet 36. The remaining elements are substantially identical with those of Figs. 1 and 2.

In Figs. 5 and 6 I have shown a syringe 101 comprising a cylinder 107, a head 102 provided with a nozzle adapted to receive a hypodermic needle 111, a neck 112 and an intermediate block 113; members 102, 112, 113 and 107 are assembled together by screws 109 and are traversed by a central channel 114 communicating with the interior of cylinder 107 within which a plunger 108 is displaceable by means of a knob 100 to draw in the fluid passing through needle 111.

A platinum electrode 103 is secured to head 102 and is detachable therefrom for the removal of hydrogen bubbles; this electrode serves for measuring the rHz in a circuit extending to a glass electrode 115. The electronic resistivity of the uid in channel 114 is measured by two electrodes 10401, 104b projecting from neck 112. The pH of the iluid is measured by glass electrode 115 and by a calomel electrode 116 connected via microcapillary passage 106 with channel 114.

It will be understood that the invention is not limited to the specific embodiments described and illustrated but that modifications and adaptations thereof are possible without departing from the spirit and scope of the appended claims.

l claim:

1. A device for testing body iluids, comprising a housing forming a chamber, feed means for introducing a fluid to be tested into said chamber, a glass electrode and an ionically inert electrode in contact with said lluid in said chamber, a reference electrode, ionically permeable means forming a microcapillary passage between said reference electrode and said chamber, a pH-rneter, an rH2- meter, and circuit means connecting said pH-meter between said glass electrode and said reference electrode and further connecting said rHZ-meter between said glass electrode and said inert electrode in a circuit including both of said meters and said microcapillary passage in series.

2. A device according to claim 1, further comprising a reservoir containing an electrolytic solution, said housing being provided with an extremity immersed in said solution and with a channel extending from said chamber to thc tip of said extremity, said ionically permeable means comprising plug means at said tip closing said channel, said reference electrode being immersed in said solution.

3. A device according to claim 1, further comprising a substantially air-tight envelope surroundingsaid housing and temperature-stabilizing means in said envelope.

4. A device according to claim 3, wherein said housing is removably inserted in said envelope, further comprising connector means including at least two contacts in said envelope and cooperating connector means including at least two terminals on said housing mounted for conductive engagement with said contacts, respectively, ina predetermined relative position of said housing and said envelope, said terminals being respectively connected 'to saidv glass electrode and to said inert electrode, said meters being connected to said glass electrode and tosaid inert electrode by way of said terminals and said contacts.

5. A device according to claim 4, wherein` the iirstmentioned connector means includestwo additional contacts and said co-operating connector means includes two additional terminals mounted for respective conductive engagement, said chamber being also provided with a pair of spaced-apart electrodes in contact with said uid, further comprising resistance-measuring means con nected across said additional contacts.

6. A device according to claim 5, wherein said housing is provided with an inlet channel and an outlet channel for said chamber, said spaced-apart electrodes facing each other across one of said channels.

7. A device according to claim 6, further comprising coupling meansfor connecting a hypodermic needle to each of said channels.

References Cited in the ile of this patent UNITED STATES PATENTS 1,518,211 Maue Dec. 9, 1924 2,260,840 Rowe Oct. 28, 1941 2,540,425 Byrurn Feb. 6, 1951 2,674,719 Williams Apr. 6, 1954;

FOREIGN PATENTS 1,070,566 France Feb. 24, 1954I 725,586` Great Britain Mar. 9, 1955

US2886771A 1955-06-14 1955-06-14 Fluid-testing device Expired - Lifetime US2886771A (en)

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Application Number Priority Date Filing Date Title
US2886771A US2886771A (en) 1955-06-14 1955-06-14 Fluid-testing device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR656841A FR1381201A (en) 1953-10-23 1953-10-23 Combined apparatus for the simultaneous measurement in the absence of air and temperature self-stabilized pH, rh and electronic resistivity of any liquid, semi-liquid solution or gel, and in particular blood, liquid cerebrospinal rachidie
US2886771A US2886771A (en) 1955-06-14 1955-06-14 Fluid-testing device

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Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049118A (en) * 1961-02-03 1962-08-14 Beckman Instruments Inc Ion electrode assembly
US3151052A (en) * 1962-05-17 1964-09-29 Beckman Instruments Inc Electrochemical flow cell
US3224436A (en) * 1961-04-10 1965-12-21 Honeywell Regulator Co Hypodermic apparatus for measuring hydrogen ion concentration of blood within a living body
US3224433A (en) * 1961-04-10 1965-12-21 Honeywell Inc ph electrodes
US3250987A (en) * 1959-12-24 1966-05-10 Robert H Okada Hematocrit meter
US3265962A (en) * 1965-06-04 1966-08-09 Jr Carl L Otto Method of and apparatus for microsample conductivity measurement
US3298944A (en) * 1962-08-22 1967-01-17 Honeywell Inc Electrochemical sensors
US3324013A (en) * 1963-04-22 1967-06-06 Aluminium Lab Ltd Method and apparatus for determining composition of molten salt mixtures
US3327204A (en) * 1963-04-15 1967-06-20 Beckman Instruments Inc Fluid sample examining apparatus
US3418231A (en) * 1965-11-09 1968-12-24 Instrumentation Labor Inc Cuvette for supporting a sensing cell
US3440525A (en) * 1966-04-13 1969-04-22 Universal Interloc Inc Ph meter and control system
US3471394A (en) * 1966-12-23 1969-10-07 Pennwalt Corp Salt bridge reference electrode
US3497442A (en) * 1967-02-08 1970-02-24 Louis Claude Vincent Fluid testing device
US3505195A (en) * 1965-12-29 1970-04-07 Radiometer As Electrode system for electro-chemical measurements in solutions
US3513079A (en) * 1965-01-06 1970-05-19 Nat Res Dev Method and apparatus for measuring the concentration of dissolved gas in a liquid
US3648159A (en) * 1970-03-11 1972-03-07 Us Air Force Portable, self-contained system for analyzing biological fluids or the like
US3669864A (en) * 1969-09-02 1972-06-13 Robert R Fike Polarographic electrode apparatus and method
FR2163963A5 (en) * 1971-12-08 1973-07-27 Lafarge Ciments Sa
US3795239A (en) * 1970-10-01 1974-03-05 Hoffmann La Roche Electrochemical electrode with heating means
US3844275A (en) * 1971-06-01 1974-10-29 Angelica Elliott Needle and sterilizing apparatus therefor
FR2230328A1 (en) * 1971-10-26 1974-12-20 Derr Lloyd
US3915810A (en) * 1971-09-21 1975-10-28 Harald Dahms Apparatus for analysis of liquids
US4105522A (en) * 1973-06-15 1978-08-08 Friedenberg Robert M Glucose level test apparatus
US4133732A (en) * 1976-06-10 1979-01-09 Jan Boeke Combination electrode system
FR2430605A1 (en) * 1978-07-05 1980-02-01 Sclavo Inst Sieroterapeut Apparatus for carrying out measurements on the fluids directly into the container containing the sample
US4206027A (en) * 1977-06-14 1980-06-03 Dr. Eduard Fresenius Chemisch-pharmazeutische Industrie KG, Apparatatebau KG Multi-probe measuring units and isolation members therefor
US4950225A (en) * 1988-09-22 1990-08-21 American Immuno Tech, Inc. Method for extracorporeal blood shear treatment
US5104373A (en) * 1988-09-22 1992-04-14 American Immuno Tech, Inc. Method and apparatus for extracorporeal blood treatment
US5354277A (en) * 1992-09-04 1994-10-11 Biocontrol Technology, Inc. Specialized perfusion protocol for whole-body hyperthermia
US5476444A (en) * 1992-09-04 1995-12-19 Idt, Inc. Specialized perfusion protocol for whole-body hyperthermia
EP0924512A2 (en) * 1997-12-17 1999-06-23 Eastman Kodak Company Determination of silver in a photographic solution
US6096275A (en) * 1998-05-01 2000-08-01 Biological Technologies International, Inc. Biological fluid testing device
US6579496B1 (en) 1999-05-25 2003-06-17 Viacirq, Inc. Apparatus for implementing hyperthermia
US6579440B2 (en) * 2001-06-19 2003-06-17 Invensys Systems, Inc. Replaceable reference junction including an ion-barrier for an electrochemical sensor
US20030130631A1 (en) * 1997-10-14 2003-07-10 Springer John S. Method and apparatus for indicating the conditions in an absorbent article
US6827898B1 (en) 1999-05-25 2004-12-07 Viacirq, Inc. Hyperthermia method and apparatus
US20070190050A1 (en) * 2003-03-17 2007-08-16 Hema Vation, Llc Apparatus and method for down-regulating immune system mediators in blood
WO2012153048A1 (en) 2011-05-10 2012-11-15 Biofield Device for analyzing a liquid sample
US9737672B2 (en) 2007-08-07 2017-08-22 Belmont Instrument Corporation Hyperthermia, system, method, and components

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1518211A (en) * 1923-02-23 1924-12-09 Maue Henry Peter Electrical device for measuring the conductivity of the stomach contents
US2260840A (en) * 1939-08-19 1941-10-28 Gen Electric Temperature control system
US2540425A (en) * 1948-02-20 1951-02-06 Paul F Byrum Antifreeze indicator
US2674719A (en) * 1950-10-18 1954-04-06 Leeds & Northrup Co Temperature-compensating measuring system
FR1070566A (en) * 1952-11-06 1954-07-29 An apparatus for the determination of liquid properties, such as pH indicators, rh, conductivity or other similar applications
GB725586A (en) * 1953-03-18 1955-03-09 Ralph Christopher Noyes Appliance for measuring the ph value of biological fluids

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1518211A (en) * 1923-02-23 1924-12-09 Maue Henry Peter Electrical device for measuring the conductivity of the stomach contents
US2260840A (en) * 1939-08-19 1941-10-28 Gen Electric Temperature control system
US2540425A (en) * 1948-02-20 1951-02-06 Paul F Byrum Antifreeze indicator
US2674719A (en) * 1950-10-18 1954-04-06 Leeds & Northrup Co Temperature-compensating measuring system
FR1070566A (en) * 1952-11-06 1954-07-29 An apparatus for the determination of liquid properties, such as pH indicators, rh, conductivity or other similar applications
GB725586A (en) * 1953-03-18 1955-03-09 Ralph Christopher Noyes Appliance for measuring the ph value of biological fluids

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1229760B (en) * 1959-12-24 1966-12-01 Yellow Springs Instr Geraet to indicate the hematocrit value of blood
US3250987A (en) * 1959-12-24 1966-05-10 Robert H Okada Hematocrit meter
US3049118A (en) * 1961-02-03 1962-08-14 Beckman Instruments Inc Ion electrode assembly
US3224436A (en) * 1961-04-10 1965-12-21 Honeywell Regulator Co Hypodermic apparatus for measuring hydrogen ion concentration of blood within a living body
US3224433A (en) * 1961-04-10 1965-12-21 Honeywell Inc ph electrodes
US3151052A (en) * 1962-05-17 1964-09-29 Beckman Instruments Inc Electrochemical flow cell
US3298944A (en) * 1962-08-22 1967-01-17 Honeywell Inc Electrochemical sensors
DE1498603B1 (en) * 1963-04-15 1970-11-26 Beckman Instruments Inc Measurement cell set for simultaneously performing a plurality of tests in substantially at least one Fluessigkeitsprobe
US3327204A (en) * 1963-04-15 1967-06-20 Beckman Instruments Inc Fluid sample examining apparatus
US3324013A (en) * 1963-04-22 1967-06-06 Aluminium Lab Ltd Method and apparatus for determining composition of molten salt mixtures
US3513079A (en) * 1965-01-06 1970-05-19 Nat Res Dev Method and apparatus for measuring the concentration of dissolved gas in a liquid
US3265962A (en) * 1965-06-04 1966-08-09 Jr Carl L Otto Method of and apparatus for microsample conductivity measurement
US3418231A (en) * 1965-11-09 1968-12-24 Instrumentation Labor Inc Cuvette for supporting a sensing cell
US3505195A (en) * 1965-12-29 1970-04-07 Radiometer As Electrode system for electro-chemical measurements in solutions
US3440525A (en) * 1966-04-13 1969-04-22 Universal Interloc Inc Ph meter and control system
US3471394A (en) * 1966-12-23 1969-10-07 Pennwalt Corp Salt bridge reference electrode
US3497442A (en) * 1967-02-08 1970-02-24 Louis Claude Vincent Fluid testing device
US3669864A (en) * 1969-09-02 1972-06-13 Robert R Fike Polarographic electrode apparatus and method
US3648159A (en) * 1970-03-11 1972-03-07 Us Air Force Portable, self-contained system for analyzing biological fluids or the like
US3795239A (en) * 1970-10-01 1974-03-05 Hoffmann La Roche Electrochemical electrode with heating means
USRE31440E (en) * 1970-10-01 1983-11-15 Hoffmann-La Roche Inc. Electrochemical electrode with heating means
US3844275A (en) * 1971-06-01 1974-10-29 Angelica Elliott Needle and sterilizing apparatus therefor
US3915810A (en) * 1971-09-21 1975-10-28 Harald Dahms Apparatus for analysis of liquids
FR2230328A1 (en) * 1971-10-26 1974-12-20 Derr Lloyd
FR2163963A5 (en) * 1971-12-08 1973-07-27 Lafarge Ciments Sa
US4105522A (en) * 1973-06-15 1978-08-08 Friedenberg Robert M Glucose level test apparatus
US4133732A (en) * 1976-06-10 1979-01-09 Jan Boeke Combination electrode system
US4206027A (en) * 1977-06-14 1980-06-03 Dr. Eduard Fresenius Chemisch-pharmazeutische Industrie KG, Apparatatebau KG Multi-probe measuring units and isolation members therefor
US4339317A (en) * 1978-07-05 1982-07-13 Instituto Sieroterapico E Vaccinogeno Toscano "Sclavo" S.P.A. Device for performing measurements on fluids, directly in the sample container
FR2430605A1 (en) * 1978-07-05 1980-02-01 Sclavo Inst Sieroterapeut Apparatus for carrying out measurements on the fluids directly into the container containing the sample
US4950225A (en) * 1988-09-22 1990-08-21 American Immuno Tech, Inc. Method for extracorporeal blood shear treatment
US5104373A (en) * 1988-09-22 1992-04-14 American Immuno Tech, Inc. Method and apparatus for extracorporeal blood treatment
US5354277A (en) * 1992-09-04 1994-10-11 Biocontrol Technology, Inc. Specialized perfusion protocol for whole-body hyperthermia
US5476444A (en) * 1992-09-04 1995-12-19 Idt, Inc. Specialized perfusion protocol for whole-body hyperthermia
US20030130631A1 (en) * 1997-10-14 2003-07-10 Springer John S. Method and apparatus for indicating the conditions in an absorbent article
US6617488B1 (en) * 1997-10-14 2003-09-09 Indicator Technologies, Inc. Method and apparatus for indicating the conditions in an absorbent article
EP0924512A2 (en) * 1997-12-17 1999-06-23 Eastman Kodak Company Determination of silver in a photographic solution
EP0924512A3 (en) * 1997-12-17 2000-11-22 Eastman Kodak Company Determination of silver in a photographic solution
US6405138B1 (en) 1997-12-17 2002-06-11 Eastman Kodak Company Determination of silver in a photographic solution
US6096275A (en) * 1998-05-01 2000-08-01 Biological Technologies International, Inc. Biological fluid testing device
US6579496B1 (en) 1999-05-25 2003-06-17 Viacirq, Inc. Apparatus for implementing hyperthermia
US6827898B1 (en) 1999-05-25 2004-12-07 Viacirq, Inc. Hyperthermia method and apparatus
US6579440B2 (en) * 2001-06-19 2003-06-17 Invensys Systems, Inc. Replaceable reference junction including an ion-barrier for an electrochemical sensor
US20070190050A1 (en) * 2003-03-17 2007-08-16 Hema Vation, Llc Apparatus and method for down-regulating immune system mediators in blood
US7753869B2 (en) 2003-03-17 2010-07-13 Hemavation, Llc Removal and deactivation of viruses from blood
US20110006004A1 (en) * 2003-03-17 2011-01-13 Hemavation, Llc Apparatus and method for down-regulating immune system mediators in blood
US9737672B2 (en) 2007-08-07 2017-08-22 Belmont Instrument Corporation Hyperthermia, system, method, and components
WO2012153048A1 (en) 2011-05-10 2012-11-15 Biofield Device for analyzing a liquid sample

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