NO120204B - - Google Patents
Download PDFInfo
- Publication number
- NO120204B NO120204B NO169427A NO16942767A NO120204B NO 120204 B NO120204 B NO 120204B NO 169427 A NO169427 A NO 169427A NO 16942767 A NO16942767 A NO 16942767A NO 120204 B NO120204 B NO 120204B
- Authority
- NO
- Norway
- Prior art keywords
- virus
- live
- irradiation
- poliomyelitis virus
- poliomyelitis
- Prior art date
Links
- 241000700605 Viruses Species 0.000 claims description 106
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 86
- 208000000474 Poliomyelitis Diseases 0.000 claims description 68
- 238000000034 method Methods 0.000 claims description 46
- 239000012736 aqueous medium Substances 0.000 claims description 37
- 239000002609 medium Substances 0.000 claims description 30
- 208000015181 infectious disease Diseases 0.000 claims description 26
- 238000011282 treatment Methods 0.000 claims description 24
- 238000010438 heat treatment Methods 0.000 claims description 12
- 238000011534 incubation Methods 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229960001539 poliomyelitis vaccine Drugs 0.000 claims description 6
- 239000007858 starting material Substances 0.000 claims description 5
- 241000991587 Enterovirus C Species 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 description 46
- 239000000047 product Substances 0.000 description 21
- 230000000890 antigenic effect Effects 0.000 description 18
- 230000002458 infectious effect Effects 0.000 description 13
- 239000007788 liquid Substances 0.000 description 13
- 241000282693 Cercopithecidae Species 0.000 description 12
- 239000000203 mixture Substances 0.000 description 10
- 238000011076 safety test Methods 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000000725 suspension Substances 0.000 description 8
- 239000000706 filtrate Substances 0.000 description 7
- 238000001914 filtration Methods 0.000 description 7
- 239000012528 membrane Substances 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 6
- 239000010408 film Substances 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 230000002147 killing effect Effects 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 241000124008 Mammalia Species 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 239000012981 Hank's balanced salt solution Substances 0.000 description 3
- 241000282560 Macaca mulatta Species 0.000 description 3
- 102000004142 Trypsin Human genes 0.000 description 3
- 108090000631 Trypsin Proteins 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 210000005084 renal tissue Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- 241000700198 Cavia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012531 culture fluid Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000008098 formaldehyde solution Substances 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 239000003104 tissue culture media Substances 0.000 description 2
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 101100388690 Plasmodium falciparum (isolate K1 / Thailand) MEF-1 gene Proteins 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000003330 sporicidal effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 238000010972 statistical evaluation Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 239000013026 undiluted sample Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D11/00—Continuous casting of metals, i.e. casting in indefinite lengths
- B22D11/04—Continuous casting of metals, i.e. casting in indefinite lengths into open-ended moulds
- B22D11/049—Continuous casting of metals, i.e. casting in indefinite lengths into open-ended moulds for direct chill casting, e.g. electromagnetic casting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D11/00—Continuous casting of metals, i.e. casting in indefinite lengths
- B22D11/10—Supplying or treating molten metal
- B22D11/11—Treating the molten metal
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D11/00—Continuous casting of metals, i.e. casting in indefinite lengths
- B22D11/10—Supplying or treating molten metal
- B22D11/11—Treating the molten metal
- B22D11/112—Treating the molten metal by accelerated cooling
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Continuous Casting (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57676866A | 1966-09-01 | 1966-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO120204B true NO120204B (enExample) | 1970-09-14 |
Family
ID=24305918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO169427A NO120204B (enExample) | 1966-09-01 | 1967-08-18 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3477494A (enExample) |
| DE (1) | DE1583565A1 (enExample) |
| GB (1) | GB1190059A (enExample) |
| NL (1) | NL6712076A (enExample) |
| NO (1) | NO120204B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3612151A (en) * | 1969-02-14 | 1971-10-12 | Kaiser Aluminium Chem Corp | Control of continuous casting |
| US4244420A (en) * | 1978-05-17 | 1981-01-13 | Davy-Loewy Limited | Apparatus for feeding a horizontal continuous casting mold |
| US4709747A (en) * | 1985-09-11 | 1987-12-01 | Aluminum Company Of America | Process and apparatus for reducing macrosegregation adjacent to a longitudinal centerline of a solidified body |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE702638C (de) * | 1936-08-19 | 1941-08-06 | Wieland Werke Akt Ges | Vorrichtung zum ununterbrochenen Giessen von Metallrohren |
| DE898668C (de) * | 1942-06-09 | 1953-12-03 | Wieland Werke Ag | Rohrzufuehrung fuer das schmelzfluessige Giessgut, insbesondere beim stetigen Giessen von Metallen |
| NL245816A (enExample) * | 1958-11-27 | |||
| NO115409B (enExample) * | 1963-06-07 | 1968-09-30 | Aluminum Co Of America | |
| FR1385585A (fr) * | 1963-12-04 | 1965-01-15 | Pechiney Prod Chimiques Sa | Nouvel appareillage pour la coulée continue verticale |
-
1966
- 1966-09-01 US US576768A patent/US3477494A/en not_active Expired - Lifetime
-
1967
- 1967-08-18 NO NO169427A patent/NO120204B/no unknown
- 1967-08-24 GB GB39086/67A patent/GB1190059A/en not_active Expired
- 1967-08-31 DE DE19671583565 patent/DE1583565A1/de active Pending
- 1967-09-01 NL NL6712076A patent/NL6712076A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL6712076A (enExample) | 1968-03-04 |
| DE1583565A1 (de) | 1970-09-17 |
| GB1190059A (en) | 1970-04-29 |
| US3477494A (en) | 1969-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3019168A (en) | Heat and ultra-violet light attenuation of polio virus | |
| KR950006931B1 (ko) | 생물학적 유체를 멸균하기 위한 자외선 조사장치 | |
| Oliphant et al. | Homologous serum jaundice: experimental inactivation of etiologic agent in serum by ultraviolet irradiation | |
| US8986607B2 (en) | Method for the validatable inactivation of pathogens in a biological fluid by irradiation | |
| JP2012143249A (ja) | ホルマリンおよびｕｖ光での処理によるサンプル中の病原体の不活化 | |
| DE60017243T2 (de) | Verfahren zur inaktivierung von pathogenen mittels breitspektrum-pulslicht | |
| Kallenbach et al. | Inactivation of Viruses by Ultraviolet Light¹ | |
| Collier et al. | The antigenicity of ultra-violet irradiated vaccinia virus | |
| Gugerell et al. | Viral safety of APOSECTM: a novel peripheral blood mononuclear cell derived-biological for regenerative medicine | |
| NO120204B (enExample) | ||
| US20060270017A1 (en) | Inactivation of a pathogen in a sample by a treatment with formalin and UV light | |
| Bovie | The action of Schumann rays on living organisms | |
| NO124265B (enExample) | ||
| Oppenheimer et al. | The ultraviolet irradiation of biological fluids in thin-flowing films | |
| Galasso et al. | Homologous inhibition with heated and ultraviolet-treated vaccinia virus in cultures of L cells | |
| US3076748A (en) | Poliomyelitis virus attenuation with ultraviolet light and beta propiolactone | |
| CN106310247A (zh) | 小鹅瘟灭活疫苗的制备方法及其制备的灭活疫苗 | |
| Taylor et al. | Influence of ultraviolet light on equine encephalomyelitis virus protein (Eastern strain) | |
| US2720485A (en) | Preparation of concentrated, purified ultraviolet inactivated hog cholera vaccine | |
| Hanafusa et al. | Transformation phenomena in the pox group viruses. I | |
| RU2098134C1 (ru) | Способ инактивации инфекционной активности возбудителей кишечных инфекций и вакцина для иммунизации животных | |
| RU2822827C1 (ru) | Способ получения препарата вакцины из цельных вирусов или бактерий | |
| Nelson et al. | Potencies of phenolized rabies vaccine improved by addition of merthiolate during inactivation | |
| SE204939C1 (enExample) | ||
| Polley | Preparation of stable noninfective influenza virus antigens for typing by hemagglutination–inhibition |