NO119590B - - Google Patents

Description

Process for the production of new 6,14-hydrogenates

derivatives of thebaine and oripavine.

This invention relates to a process for the production of therapeutically active 6,14-hydrogenated derivatives of thebaine and oripavine.

The compounds produced by the method according to the invention have the formula:

where R means a hydrogen atom, or a methyl group, R is a hydrogen atom, an alkyl, alkenyl or alkynyl group containing up to 3 carbon atoms or a cyclopropylmethyl group,

R 2 is a hydrogen atom or an alkyl group containing up to 3 carbon atoms, R 2 is an alkyl group containing up to 5 carbon atoms.

The compounds are therapeutically useful because of their ability to affect the central nervous system, particularly through their analgesic, sedative and antitussive effects, and in certain cases their ability to counteract the effects of narcotics.

The new compounds of formula I are prepared according to the invention in that a compound of the formula: where Z is a radical selected from the group:

IN

COR2, .

CO, Alk, R, R, and R have the meanings given above and Alk is

an alkyl radical, R is methyl and when Z means HO

can R

also mean hydrogen, is hydrogenated in the presence of a hydrogenation catalyst, and then when Z is OC-R2 the hydrogenated product is reacted with an organometallic compound to give a compound

1

to give a compound of formula I, or when Z is 0=CI-OAlk<,> the hydrogenated product is reduced with lithium aluminum hydride to give

give a compound of the formula I where and R_ are both hydrogen atoms, and optionally, if desired, can: a) a compound of the formula I obtained in this way where R^ is a methyl group, obtained as described above,

is converted into a compound of the same formula, where R^ has a meaning other than a methyl group or a hydrogen atom, by treatment with cyanogen bromide followed by hydrolysis and reaction of the resulting product with a halide of the formula R^Hal where R^ is preceded by given meaning, but is other than a hydrogen atom or a methyl group and Hal is a halogen atom, or by reaction with an acyl halide followed by reduction with lithium aluminum hydride, or

b) a compound of the formula I, where R^ is a methyl group, obtained as described above, is converted by reaction with

dimethyl or diethyl azodicarboxylate followed by treatment of the resulting product with an alkyl, alkenyl or alkynyl halide of the formula R^Hal where Hal is a halogen atom.

The following examples shall serve to illustrate

the invention further.

Example 1

6.14- endoethano- 7- f2- h<y>droxy- 2-pro<py>lHetrahydrothebaine

6,14-endoetheno-7-(2-hydroxy-2-propyl)tetrahydrothebaine (40 g) in ethanol (300 mL) was hydrogenated in the presence of Raney nickel catalyst (10 g) at 161-164°C and 164-182 atm,

for 4 hours. Concentration of the solution after the catalyst was removed by filtration gave a white crystalline solid (26 g). This material was recrystallized from ethanol, m.p. 142°C. (Found: C: 71.7»H: 8t2' f N: 3.5% C24H33N04 requires C: 72.2; H: 8.3; N: 3.5*).

Example 2

6 l14- endoethano- 7-( 2- h. ydrox. y- 2- but. vlHetrah. ydrothebain

6,14-endoetheno-7-(2-hydroxy-2-butyl)tetrahydrothebaine (10 g) in ethanol (300 mL) was hydrogenated in the presence of Raney nickel catalyst (4 g) at 150-155°C and 182-188 atm.

for 4 hours. Concentration of the solution after the catalyst was removed by filtration gave a white crystalline solid (9 g). This material was recrystallized from ethanol, m.p. 145.5°C (Found: C: 72.7; H: 8.3; N: 3.4#,

C25<H>35NO4 requires Ci 72.7; H: 8.5; N: 3.4^).

Example 3

6l14-endoethno-7-(2-hydroxy.Y-2-pent.yl')tetrahydrothephain

6,14-endoetheno-7-(2-hydroxy-2-pentyl)tetrahydrothebaine (20 g) in ethanol (300 mL) was hydrogenated in the presence of Raney nickel catalyst (5 g) at 140-142°C and 160-168 atm.

for 6 hours. Concentration of the solution after the catalyst was removed by filtration gave a white crystalline solid

fabric (8 g). This material was recrystallized from ethanol, m.p. 185-187°C

Example 4

6114- endoethano- 7-( 2- h. ydroxy- 4- methyl 1- 2- pentyl) tetrahydrothebaine

6,14-endo et eno-7-(2-hydroxy-4-methyl-2-pentyl)-tetrahydrothebaine (20 g) in ethanol (300 mL) was hydrogenated in the presence of Raney nickel catalyst (5 g ) at 150°C and 150 atm.

for 6 hours. Concentration of the solution after removal of the catalyst by filtration gave a white crystalline solid (12 g). This material was recrystallized from ethanol, m.p. 170°C.

Example 5

6. 14-e" troftajio- 7-( 2- hydroxy- 5- meth. yl- 2- hex. yl') tetrah. ydrothebain

6,14-endoetheno-7-(2-hydroxy-5-methyl-2-hexyl)-tetrahydrothebaine (20 g) in ethanol (300 ml) was hydrogenated in an excess of Raney nickel catalyst (4 g) at 170-174° C and 193-196 atm» for 3 hours* The product was processed as in example 1, m.p. 125-126°C.

Example 6

6. 14f-endoethano-7-(2-h.hydroxy-2-heptyl')tetrahydrothebain

6,14k-endoetheno-7-(2-hydroxy-2-heptyl)tetrahydrothebaine (16 g) in ethanol (200 mL) was hydrogenated; in the presence of Raney nickel catalyst (5 g) at 170-175°C and 188-192 atm.

for 3 hours. Concentration of the solution after the catalyst had been removed by filtration gave a gummy substance. This glue: was dissolved in petroleum ether (b.p. 30 to 40°C), and on standing gave solution, a white solid which was recrystallized from ethanol, m.p. 110-112°C.

Example 7

6, 14- endoethano- 7- C2- h. ydrok3. y-1-o.cyclohexyl-2-propyl')-tetrahydrothebaine

6,14-endoetheno-7-(2-hydroxy-1-phenyl-2-propyl)-tetrahydrothebaine (18 g) in ethanol (300 ml) was hydrogenated in the presence of Raney nickel catalyst (4 g) at 157°C and 178 atm" for 8 hours" After removal of the catalyst, a solid (2.5 g) separated from the cooled, concentrated solution, m.p. 160-162°C (Found: C: 74.8; H: 8.9; N: 3.0'* C30H43N04 requires C: 74.9; H: 9.0; N: 2.9v).

Example 8

6. 14- endoethano- 7-( 2- hydroxy. γ- 2- hexyl) tetrahydrothebaine

6,14-endoetheno-7-(2-hydroxy-2-hexyl)tetrahydrothebaine (30 g) in ethanol (400 mL) was hydrogenated in the presence of Raney nickel catalyst (8 g) at 160-165°C and 173-182 atm.

for 4 hours'. The product was processed as in example 1, and after recrystallization from ethanol the product (8.0 g) had m.p. 146-147°C. (Found: C: 73.5; H: 8.9; N: 3.0* G27H3gN04 requires C: 73.5; H: 8.9; N: 3.2v0*

Example 9 6 . 14— endoethano- 7- h. ydrox. yum. yltetrahydrothebaine

6,14-endoetheno-7-hydroxymethyltetrahydrothebaine (9.25 g) in ethanol (40 mL) was hydrogenated at atmospheric pressure and temperature in the presence of a palladium-on-charcoal catalyst (10^, 200 mg). The mixture was filtered, the filtrate was evaporated to dryness, and the product was crystallized from diethyl ether to give 5.7 g of m.p. 122-124°C. (Found: C: 71.0; H:8.0<*>* C22H2gH04 requires C: 71.1} H: 7.9*>),

Example 10

7- acetyl- 6, 14- endoethano- tetrahydrothebaine

(a) 7-acetyl-6,14-endoetheno-tetrahydrothebaine (225 g)

in acetic acid (450 mL) was hydrogenated in the presence of palladium-on-charcoal catalyst (10,*, 4.5 g) at 60°C and 45 atm. for 15 hours. After the catalyst was removed, the solvent was evaporated and a gum was recovered which was dissolved in water, treated with charcoal, filtered and the solution made alkaline with ammonia, and the product collected.

This material was recrystallized from methanol (183 g),

sm.p. 136°C. A sample that was further recrystallized had m.p. 136°C. (Found: C: 71.6} H: 7.6; N: 3.7'v C231I29II04 requires C: 72»°» H: 7'6'N: 3>7W

(b) 7-aoety1-6,14-endoetheno-tetrahydrothebaine (5 g)

in ethanol (200 mL) was hydrogenated in the presence of palladium-on-charcoal (10^, 0.5 g) at 4 atm. and 50°C for 10 hours. Filtration, evaporation of the filtrate and recrystallization of the residue from ethanol gave the product (3.5 g) with m.p. 133-136°C.

Example 11

6. 14- endoethano- 7- C2- h, hydroxy- 2- but. yl) tetrahydro thebaine

7-aoety1-6,14-endoethanetetrahydrothebaine (100 g,

0.26 mol) in ether (2.5 L) was added with stirring to a boiling solution of ethyl magnesium iodide prepared from magnesium: (19 g, 0.79 mol) and ethyl iodide (122 g, 0.78 mol) in ether ( 100 ral). The mixture was then stirred and heated under reflux for l/j hour. The mixture was added to a saturated aqueous solution of ammonium chloride (5 L), the ether layer was separated, and the aqueous layer was then extracted two

times with ether* The combined ether extracts were dried and evaporated» The product was crystallized from aqueous methanol and recrystallized from ethanol» The product (40.6 g) had, m.p.» 145.5°C» The product was identical to what was fiddled with example 2"

Example 12

6 , 14- endoethano- 7- C2- h, ydrok3. γ- 2- propyl) tetrahydrothebaine

7-Aoethyl-6,14-endoethanetetrahydrothebaine (126.6 g) in benzene (600 ml) was added with stirring to a solution of methylmagnesium iodide prepared from magnesium (32.2 g) and methyl iodide (187.5 g) in ether ( 300 ml) and benzene (300 ml). After standing overnight, the mixture was added to a saturated aqueous solution of ammonium chloride (5 L). The organic layer was separated, the aqueous layer was extracted with ether,

and the combined organic solutions were dried and evaporated" The residue was crystallized from methanol to give the product (106 g) with mp" 142°C" The product was identical to that obtained in example 1"

Example 13

6 114- endoethano- 7-( 2- hydroc3. y- 3. 3- dimethyl- 2- butyl') tetrahydrothebain

A solution of tert-butyl magnesium chloride was prepared from magnesium, (38.1 g) in ether (300 ml) and 2-chloro-2-methylpropane (tert-butyl chloride) (145 g) in ether (200 ml) and benzene (200ml). The mixture was stirred overnight and titration of a sample showed 67° conversion to the Grignard reagent» 7-Acetyl-6,14-endoethanetetrahydrothebaine (100 g)

in benzene (500 ml) was added over the course of 1 hour to the stirred

mixture» After standing overnight, the mixture was added to a saturated, aqueous solution of ammonium chloride (5 1),

the organic layer was separated, the aqueous layer was extracted with methanol, and 28.4 g of product were obtained. A sample recrystallized from methanol had a melting point of 188°C.

(Found: C: 73.2} H: 9.0} N: 2.9% (^H^NO^ requires- C: 73.4} H: 8.9} N: 3.2^),

Example 14

6, 14- endoethano- 7-( 2- h, hydroxy- 3- met. vl- 2- butyl') tetrahydrothebain

A solution of isopropyl magnesium chloride was prepared from magnesium (48.6 g) in ether (300 ml) and 2-chloro*-propane (157 g) in ether (200 ml) and benzene (200 ml)» The mixture was stirred overnight, and after titration showed that a 73% conversion to the Grignard reagent had taken place, over 1 hour 7-acetyl-6,14-endoethanetetrahydrothebaine (140 g) in benzene (800 ml) was added to the stirred mixture. After stirring for 5 hours, the mixture was allowed to stand overnight. The mixture was added to a saturated aqueous solution of ammonium chloride (5 L), the organic layer was separated, the aqueous layer was extracted with ether and the separated organic layer was evaporated. The resulting gum was crystallized from methanol, and the yield of crystals (phenolic) was discarded. The liquid was evaporated and the residue was repeatedly recrystallized from a mixture of 2N aqueous sodium hydroxide (100 mL) and ethanol (200 mL) to give the product (38 g) with a mp # 157-158°C. (Found: C: 73.4} H: 8.7}

N: 3.1% C26H37N04 requires C: 73.1} H: 8.7} N: 3.3%).

Example 15

6, 14^ ndoethano- 7-( 2- hydroxy- buten- 2- yl) tetrahydrothebaine

A solution of vinyl magnesium bromide was prepared from magnesium (2.54 g) in tetrahydrofurate (50 ml) and vinyl bromide (11.2 g) in tetrahydrofuran (50 ml)» The mixture was stirred for 18 hours, and then 7-aoety 1-6,14r-«ndoethano-tetrahydratebain (10 g) in tetrahydrofuran (100 ml) was added with stirring.* After standing overnight* the mixture was added to a saturated aqueous solution of ammonium chloride (500 ml) with stirring * The organic layer was separated and the aqueous layer was extracted with ether (2 x 200 mL)* The combined organic layers were extracted with water (3 x 300 mL) and the ethereal solution was dried and evaporated* The resulting oil was crystallized from aqueous methanol to give the product (4.8 g) with an mp* 129°C*

Example 16

6. 14r^ ndoetajio- 7-^ 2- Kv6^ oxy*- 3- methyl- 2- pentyl') tetrane. ydrotebain and 6, 14- endoe tano- 7- n.- hy droks. know. yl") tea trahydro thebain

A solution of sec-butyl magnesium chloride was prepared from magnesium (48.6 g) in ether (300 ml) and 2-chlorobutane (185 g) in ether (200 ml) and benzene (200 ml)* After standing overnight above, 7*-aoethyl-6,14^6ndoethanotetrahydro-thebaine (140 g) in benzene (800 ml) was added to the stirred mixture over the course of 1 hour* After stirring for 5 hours, the mixture was allowed to stand overnight* The mixture was added to a saturated aqueous solution of ammonium chloride, and after extraction; and inor evaporation of the organic extracts, the gum was crystallized twice from a mixture of 2N sodium hydroxide solution: (200 mL) and ethanol (200 mL) and then recrystallized from methanol to give 6,14-endoethano-7-(2-hydroxy -3-methyl-2-pentyl)-tetrabydrothebaine (16.2 g), m.p. 162-164°C. (Found: C: 74.1} H: 8.8} N: 3.1% C^E^IK^ requires C: 73.4} H: 8.9} N: 3.2<0»Water was added to the methanolic mother liquor, and

the crystalline product (42 g) was collected, recrystallized from aqueous isopropanol and purified by repeated chromatography on an alumina column in diisopropyl ether» The product

was then recrystallized from aqueous methanol to give 6,14r-endoethano-7-(1-nydroxyethyl)tetrahydrothebaine (2.4 g), m.p. 64-66°C»(Found: C: 71.3} H: 8.0} N: 3.8%

C23H31N04 requires C» 71.6f Hi 8.1} N: 3.6*).

Example 17

N- oyan- 6. 14- endoethano- 7-( 2- hydroxy- 2- prop. yl) tetrahydro-nortebain

6,14-endoethano-7-(2-hydroxy-2-propyl)tetrahydrothebaine (46 g) and cyanobromide (13.5 g) were dissolved in methylene chloride (80 ml) and allowed to stand overnight. The solution was evaporated, and the product was recrystallized from methanol (38.2 g), m.p. 2-5°C (Found: C: 69.6} H: 7.0} II: 6.9% C24H30N2°4 requires C: 70.2} H: 7.4; N: 6.8'/0 .

Example 18

6, 14- endoethano- 7-( l- hydroxy- l- oxyclohexyl- l- ethyl) tetrahydro-nortebain

N-oyan-6,14-endoethano-7-(1-hydroxy-1-oxychlorohexyl-1-ethyl)tetrahydronortebaine (36.2 g) was added to a stirred solution of potassium hydroxide (36.2 g) in diethylene glycol

(440 mL) at 170°C under nitrogen. The mixture was stirred in

1% hour at 170°C»The mixture was poured onto a mixture of ice and water (3 L), the precipitate was collected., crystallized from methanol and recrystallized from ethanol (27.9 g)»A sample recrystallized from ethanol had sm. p» 174°C»(Found: C: 74.3} H: 8.5} Nr 3.2% C28H3gN04 requires C: 74.1} H: 8.7} N: 3.lfr).

Example 19

7- aoethyl- 6. 14- endoethanotetrah. ydronortebainr- h. ydrochloride (a) N-oyan-7-aoethy1-6,14-endoethanetetrahydronortebain was prepared by the method according to example 17 with 89% yield, m.p. 195-199°C (Found: C: 69.9} H: 7.0}

N: 7.0% C23B26N204requires: C: 70.0} H: 6.6} N: 7.1%).

The solution of the N-oyan compound (10 g) in acetic acid (100 ml) was stirred for a few minutes with charcoal and filtered. The filtrate was hydrogenated in the presence of palladium-on-charcoal (10%, 0.5 g) at room temperature and 3.4 atm for 1 hour. Concentration of the solution after removal of the catalyst gave a paste which was dissolved in hot water (150 ml).* The solution was made alkaline with aqueous sodium hydroxide to pH 8.5. Ethanol was added to obtain a clear solution, and the solution was heated on a water bath for 2 hours. The precipitate (8.1 g) was collected. A sample crystallized from isopropanol gave N-formyl-7-aoethyl-6,14-endoethanetetrahydronortebaiL, m.p. 217-218°C. (Found: C: 68.9} H: 7.1# CgjH^NOjkrevear C: 69.5} H: 6.9%).

N-formyl compound xti (4.5 g) in isopropanol (20 ml) was refluxed with stirring, for 17 hours with ethanol saturated with hydrogen chloride (9 ml)» After cooling;

the mixture was filtered to give 7-aoethyl-6,14-endoethanetetra-hydronortebaine (3.6 g). A sample was recrystallized from n-butanol, m.p. > 300°C. (Found: C: 64.9} H: 7.2}

N: 3.3% C22H27N04HC1 requires C: 65.1} H: 7.0} N: 3.5*).

(b) Dimethyl-azodicarboxylate (1.9 g) was added to a solution of 7-aoethyl-6,14-endoethanetetrahydrothebaine (5.0 g)

in the minimal amount of hot aoeton. The solvent was evaporated on a steam bath, and the residue was heated for ½ hour. The gum was dissolved in 2U hydrochloric acid (14 ml) and water (6 ml) and allowed to stand for 4 hours» The solution was made alkaline, and the solid was collected and recrystallized from aqueous methanol» The base was converted to the hydrochloride and recrystallized from n- butanol (1.2 g), identical to the material obtained in (a).

Example 20

N-prop. vl- 6. 14- endoethano- 7- C2- h. vdrok8y- 2- propyl') tetrahydro-nortebain

(a) 6,14f-endoethano-7-(2-hydroxy-2-propyl)tetrahydro-nortebaine (6.0 g), propyl iodide (9.0 g) and anhydrous potassium carbonate (15 g) in acetone were stirred under reflux for 20 hours" The hot mixture was filtered, the filtrate was concentrated and water was added" The solid was collected and recrystallized from aqueous; aoetoa (5.4 g), mp»p» 136-138°C»

(Tunnet: C: 72.6} H: 3.8} N: 3.4% CggEjyNO^requires C: 73.0} Ht 8.7} N: 3.3%).

(b) 7-Aoethyl-6,14-ndoethanotetrahydronortebain hydrochloride (5.5 g) was dissolved in water* the solution was made alkaline

and extracted with benzene, after which the extract was dried and

evaporated. The gum was dissolved in acetone (44 ml) and stirred under reflux for 17 h with propyl iodide (9.25 g)

and anhydrous potassium carbonate (15 g). The hot solution was filtered, the residue washed with acetone and the combined liquids evaporated to dryness. The residue was extracted with chloroform, the extract evaporated, and the gum (5.5 g) crystallized from ethanol to give N-propyl-7-acetyl-6,14-endoethanetetrahydro-nortebaln (3.1 g), m.p. » 94-97°C. The product was further recrystallized and had m.p. 98-100°C. (Found: C: 73.0;

H: 7.7* C25H33N04 requires C: 73.0; H: 8.D.0"

N-propyl-6,14-endoethano-7-(2-hydroxy-2-propyl)-tetrahydronortebaine was obtained from N-propyl-7-aoethyl-6,14-endoethanotetrahydronortebaine (3.0 g) and methyl iodide by the general method indicated in example 12. Crystallization of the crude product from methanol gave (1.73 g) m.p. 136-138°C, identical (IR spectrum, mixed m.p.) to the material prepared in (a). Example 21

I. r- c. cycloprop, ylmethyl- 6, 14- endoethano- 7-( 2- h. hydroxy- 2- but. yl)-tetrahydronorthebain

Cyclopropyl carbonyl chloride (11.3 g) was cautiously added to a solution of 6,14-endoethano-7-(2-hydroxy-2-butyl)-trach<y>dronortebaine (14.5 g) in dichloromethane (75 mL ) and triethylamine (11.0 g). After two days, the mixture was washed with water (3 x 100 mL), and the organic layer was dried and evaporated. The residue in dry tetrahydrofuran. (250 ml) was added to a

stirred suspension of lithium aluminum hydride (3.0 g) in dry tetrahydrofuran (250 mL) and refluxed for 4 hours. A cold, saturated solution of sodium potassium tartrate

was then added» The aqueous layer was extracted with ether (3 x 100 mL) and the ethereal extracts were combined with the original organic layer; and washed three times with water" The solution was dried and evaporated, and the glassy material was crystallized from methanol to give 9.7 g. A sample which was further recrystallized had m.p. 99-100°C.

(Found: C: 74.3, H: 8.7, N: 2.7% C^gH^gNO^ requires

- C: 74.1} H: 8.7} N: 3.1%).

, Example 22

gi- o. kpotr opylme t. yl- 6. 14- endoe tano- 7— hy dr oxime tyl— te trahydro-nortebain

Cyclopropyl carbonyl chloride (2.8 g) was added to 6,14-endoethano-7-ethoxy-carbonyl-tetrahydronortebaine (5.3 g) in triethylamia (2.6 g) and dichloromethane (40 ml)» After standing at room temperature for two days, the mixture was washed with water, and the organic layer was dried and evaporated." The residue was crystallized from methanol to give N-oxycyclopropylcarbonyl-6,14-endoethano-7-ethoxy-carbonyl-tetrahydronortebaine (5.2 g), m.p. 202°C»(Found: C: 69.5} H: 7.2} N: 3.0% C^H^NOg requires C: 69.4} H: 7.1} N: 3.0%) .

the imide in dry tetrahydrofuran (80 ml) was added to a stirred suspension of lithium aluminum hydride (1.25 g) in dry tetrahydrofuran (50 ml) and the mixture was boiled under reflux for 3 hours» The product was worked up by the method of Example 21 , and after recrystallization from litebenein, cyclohexane and aqueous ethanol, the product was obtained as prisms (1.3 g) with a m.p. 107°C. (Found: C: 73.4} H: 8.5}

Nt 3.4% C^B^jJK^ requires C: 73.0} H: 8.1} N: 3.4%).

Example 23

H- cyclopropylmethyl- 6, 14- endoethano- 7- C2- hydroc3. y-2-but. yl')-t e trahydronororipavine

N-Cyclopropylmethyl-6,14-endoethano-7-(2-hydroxy-2-butyl)tetrahydronortebaine (7.9 g) was added to a stirred solution of potassium hydroxide (23.7 g) in diethylene glycol (96 mL) at 210 -220°C under nitrogen. The mixture was stirred at this temperature for 2 hours and then poured into ice-water (500 ml). The solution was saturated with ammonium chloride and the precipitated phenolic base was collected, washed well with water and recrystallized from methanol (4.0 g). A sample recrystallized from methanol had m.p. 195°C. (Found: C: 73.8i H: 8.4} N: 3.2% C27H37N04 requires C: 73.8} H: 8.4; N: 3.2*).

Example 24

6, 14- endoethano- 7-( 2- hydroxy- 2- pentylVtetrahydronororipavine

N-oyan-6,14-endoethano-7-(2-hydroxy-2-pentyl)-tetrahydronortebaine (16 g) was added to potassium hydroxide (50 g) in diethylene glycol (180 ml) at 180-190°C, and the mixture was stirred at 210-220°C for 45 min. and then completely in ice water. Saturated ammonium chloride was added and the precipitated phenolic base was collected and washed well with water. The raw material was dissolved in dilute acetic acid and treated with charcoal, and the base was precipitated with ammonia. The solid was crystallized from aqueous oellosolve to give the crude product (7.2 g). A sample was purified by further dissolution in dilute acetic acid, treatment with charcoal, alkalization and recrystallization, and it had a m.p. at 236-239°C.

(Found: C: 73.1} H: 7.9} N: 3.6% C^H^NC^ requires C: 72.1} H: 8.3} N: 3.5%).

Example 25

N- oxyclopropylmethyl- 6. 14.- endoethano- 7-( 2- hydroxy- 2- pentyiyl tetrahydronororipavine

Cyclopropyl carbonyl chloride (8.8 g) was added to 6,14-endoethano-7-(2-hydroxy-2-pentyl)tetrahydronororipavine: (4.2 g) in tetrahydrofuran (150 mL) and triethylamine (16 mL). After standing overnight, the mixture was evaporated, treated with dilute hydrochloric acid and extracted with ether (3 x 100 mL).

After washing with water (3 x 100 ml), the ethereal extracts were dried and evaporated. The resulting gum was dissolved in dry tetrahydrofuran. (60 mL) and reduced with lithium aluminum hydride (7.5 g) in tetrahydrofuran (200 mL). The cooled, stirred mixture was carefully cleaved by the addition of a cold, saturated solution of sodium potassium tartrate. The aqueous layer was extracted with ether, and the ethereal extracts were combined with the original organic layer, washed with water, dried and evaporated. The crude product was crystallized from methanol. The product was dissolved in 2N sodium hydroxide, the solution was washed with ether and then treated with saturated ammonium chloride solution. The mixture was extracted with ether and the extracts were evaporated. The remaining oil was crystallized from aqueous methanol and further purified, by precipitation, with ammonium chloride solution. from a solution in a mixture of ethanol and 2N sodium hydroxide solution, m.p. 177-179°C (Found: C: 74.1} H: 8.5} N: 3.3% CggH^IK^ requires C: 43.1} H: 8.7} N: 3.lv).

Satisfactory analytical data were obtained for all compounds from Examples 26 to 63.

Footnotes

a The product was identical to the product obtained in example 3"

b The product was identical to the product obtained in example 8W

o The product was identical to the product obtained in example 4#

d The product was identical to the product obtained in example 6"

e The product was identical to the product obtained in example 5"

f S.p. for the hydrochloride.

g Sm.p. for the hydrochloride.

The folding .comparison should serve to illustrate that

The 6, 1 k-endoa tn.no two trahydrothebaine derivatives, purified according to their origin, are more active than the corresponding 6,1^-endoetenotetrahydro thebaine derivatives with regard to analgesic and antagonistic v.i.i" len ing.

Analgesic v i rien im: .

<:>ial pressure- ; letodon.

<; mp po r nv rats fidget either saline as a control or

<5n of a logarithmic series of doses of the agent being tried. The pain threshold for each rat was determined by exposing its tail to gradually increasing pressure until the animal flinched. The animals were considered to exhibit an analgesic effect if they did not scream when exposed to a pressure pfi. more than double the pressure needed to produce an audible response in the control animals. On the basis of the percentage showing analgesic convulsion at each dose level, the effective dose in 50/•> of the examined animals, KD„0> was calculated.

Antagonism.

Efficacy as an antidote for morphine was measured using the assay described above, by determining the dose of compound necessary to reduce the elevation of the pain threshold produced by a co-administered standard dose of morphine back to normal levels. 50<*>;é of the examined animals (ED^Q).

The results shown in the following table show that the endoethano compounds are therapeutically more active; than do the corresponding endophyte»fortaiiv.ie 1 s o. i■ „

This effect is not entirely consistent, but the change from the endoetheno to the endoethano group can produce approximately a tenfold increase in activity.

Claims (1)

Process for the production of new 6,14-hydrogenated derivatives of thebaine and oripavine with the formula: where R means a hydrogen atom or a methyl group, R is a hydrogen atom, an alkyl, alkenyl or alkynyl group, containing up to 3 carbon atoms or a cyclopropylmethyl group, R2 is a hydrogen atom or an alkyl group containing up to 3 carbon atoms, is an alkyl group containing up to 5 carbon atoms, characterized in that a compound of the formula: where Z is a radical selected from the groups: In COR2 IN C 02 Alk, R , R 2 and R 3 have the above meaning and Alk is an alkyl radical, R is methyl and when Z means can R also mean hydrogen, is hydrogenated in the presence of a hydrogenation catalyst, and then when Z is 0=é-R2 the hydrogenated product is reacted with an organometallic compound to give a compound of formula I, or when Z is 0=C -OAlk, the hydrogenated product is reduced with lithium aluminum hydride to give a compound of the formula I where R 2 and R 1 are both hydrogen atoms, and optionally, if desired, can: a) a compound of the formula I obtained in this way where R^ is a methyl group, obtained as described above, is converted into a compound of the same formula, where R^ has a meaning other than a methyl group or a hydrogen atom, by treatment with cyanogen bromide followed by hydrolysis and reaction of the resulting product with a halide of the formula R^ Hal where R^ has the above meaning but is other than a hydrogen atom or a methyl group and Hal is a halogen atom, or by reaction with an acyl halide followed by by reduction with lithium aluminum hydride, or b) a compound of the formula I, where R^ is a methyl group, obtained as described above, is converted by reaction with dimethyl or diethyl azodicarboxylate followed by treatment of the resulting product with an alkyl, alkenyl or alkynyl halide of the formula R^ Hal where Hal means a halogen atom.