NL8900252A - PHARMACEUTICAL PREPARATIONS WITH A PLANT EXTRACT IN IT AND METHOD FOR THE PREPARATION THEREOF. - Google Patents

Description

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NL 35701-Kp / vD

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Pharmaceutical preparations containing a plant extract and process for their preparation.

The invention relates to new pharmaceutical preparations containing a transdermally absorbable plant extract. In addition, the invention relates to a process for the preparation of such preparations.

The preparation according to the invention optionally contains the plant extract together with a carrier, preferably polyethylene glycol and / or propylene glycol or silicone oil, included in a bag consisting of a thermoplastic polymer, such as polyolefins, polyvinyl compounds and their copolymers, polyamides and polycarbonates, or in a cellulose bag, which are permeable to the plant extract and which are provided with a skin adhesive plaster.

The method according to the invention comprises optionally mixing a plant extract with a carrier, preferably with polyethylene glycol and / or propylene glycol or silicone oil, followed by transferring it into a bag of a thermoplastic polymer, such as polyolefins, polyvinyl- compounds and their copolymers, polyamides or polycarbonates or in a cellulose bag, which are permeable to the plant extract and which are provided with a skin sticking plaster.

According to the invention, the following therapeutically active plant extracts are introduced into the polymer bag (hereinafter abbreviated as dermatological plaster) (according to the type of their pharmacological action): diuretics, analgesics, antirheumatics, anti-inflammatory agents, preferably anti-phlebitic agents, 30 anti-hyperemic sedatives agents for use in the treatment of reddish skin of the face, slimming agents, antitussive agents 89 00252 "4 - 2 - antispasmodics, skin regenerating agents, agents for the treatment of eczema, ulcers and warts, 5 hyperemic agents and energizers.

The dermatological plaster according to the invention preferably contains as extract of the extract of mint or rosemary, or garden sage or Chinese oil or juniper or la-10 feather oil or maize, (sea maize) or safflower (Carthamus tinctorius) or tree-primrose (Oenothera) biennia) oil in the form of an extract concentrate. The following plant extract concentrates are used as further preferred active ingredients: smoke tree (Cotinus coggyria), valerian, hops, garlic, balm, basil, chamomile, anise, achillea, wormwood (Artemisia absinthium), ginger and eucalyptus oils.

The tree primrose oil-containing preparation according to the invention has also been found to be suitable for the treatment of psoriasis.

The preparation of dermatological preparations containing synthetic active ingredients has been described in a number of patents. Non-adhesive storage layers are published in U.S. Patent Nos.

3,946,106, 3,992,518, and 4,053,580, in published Japan Patent Applications Nos. 82-146,711 and 83-11,136, and in published German Patent Applications (DOS) No. 3,319,468. A general aspect of the preparations prepared by the known methods consists in their long-lasting effect without determining the constant release rate of the active ingredient.

Adhesive storage layers have been proposed in published Japanese Patent Applications Nos. 82-42,619, 82-59,977, 82-75,917, 82-107,155, 82-123,117, 82-125,753 and 82-179,271. The prolonged action of the preparations prepared according to these methods is also ensured, but the uniform release of the active ingredient cannot be achieved. According to the methods 8300 * 52: s - 3 - disclosed in Japanese patent applications Nos. 59-84,811, 59-84,813 and 81-74,733 as well as in Dutch patent application No. 82.01034, the prolonged action of and the uniform release of the active ingredient from the preparation simultaneously guaranteed using a layer that controls the release of the active ingredient. However, the quality of the release control polymer in these compositions should be selected depending on the nature of the active ingredient.

The therapeutic applications of medicinal plant extracts and oils are known from textbooks. In addition, some references regarding the therapeutic use of medicinal plant extracts are listed below.

According to European Patent No. 0.085.579 [C.A. 99, 14612m (1983)] is an ointment containing tree-key flower oil and lithium citrate suitable for the treatment of inflammation, psoriatic pruritis and eczema.

According to European Patent No. 0.087.863 [C.A. 99, 181492Z (1983)], a capsule containing tree primrose oil and biotin is prepared, which can be used for the treatment of inflammatory conditions.

20 According to Berke-Meyenberg [Deut. Perfume-Ztg. 27, 249 (1943); C.A. 37, 4855/8 (1943)], blood circulation of the skin is enhanced by the essential oils contained in the compositions which are suitable for the treatment of liver.

According to the published Dutch patent application No. 82.03249 [C.A. 101, 60123f (1984)], the addition of 4-6% diazepam induces a synergistic effect on the anti-rheumatic activity of a number of medicinal plants. Peppermint, hops, melissa and the like are mentioned among other things as plants.

According to published Japanese Patent Application No. 77-30,579 [C.A. 88, 11738q (1978)], peppermint oil is used in beverages and cosmetics.

According to Hungarian Patent No. 190,763 [C.A. 103, 177287v (1985)], drinks are prepared from plant extracts. Nettle leaf, mint, juniper, marjoram, genti root, thyme, rosehip, lavender and hollyhock are among others mentioned.

No literature has been found on transdermal absorbable plant extracts or concentrates included in an 8900151.

f. - 4 - plaster. The preparation according to the present invention containing a plant extract incorporated in a dermatological form has the following advantages: The consumption of herbal teas with an unpleasant odor, which overloads the organism, is unnecessary.

- The active ingredient content is high and is delayed release. Therefore, a local systemic action can be prepared, which is not possible by any other way.

10 - The application of compresses and ointments that are difficult to handle is unnecessary.

The preparation can be realized without any special research, while due to its properties, its packaging can be realized unlike other preparations and without any difficulty.

The invention is further illustrated by the following non-limitative Examples.

EXAMPLE I

0.85 g of medicinal garden sage oil was mixed with 0.85 g of rosemary oil and 0.9 mint oil, after which 2.0 g of this mixture was stirred with 16.71 g of propylene glycol. Thereafter, 1.25 g of colloidal silicon dioxide was mixed with the slightly opal-reflecting liquid thus obtained to yield a viscous translucent mass, which was then transferred into bags of 10 cm2 of surface in an amount of 0.5 g, one side of which plywood aluminum foil (60 / um polyethylene, 12 / um aluminum and 20 / um poly-propylene), while the other side was ethylene-vinyl-30 acetate copolymer sheet (containing 8-10% vinyl acetate), after which the bag was welded was closed.

The bag was then placed with its ethylene-vinyl acetate foil surface on the body surface to be treated (ie on the center of the rheumatic pain) and then fixed with a medicated plaster.

EXAMPLE II

0.8 g of juniper oil was mixed with 6.7 g of liquid polyoxyethylene (molecular weight = 300) and 0.5 g of 83 00152 colloidal silica was added to the clear solution. The viscous translucent gel-like mass thus obtained was transferred in 0.5 g portions into 10 can2 surface bags prepared from plywood-5 aluminum foil and ethylene-vinyl acetate copolymer sheet (containing 27-30% vinyl acetate). The bags were then melt-sealed and placed with their aluminum foil surface on the center of a medicated plaster such that at least 3-4mm protruded from the foil in all directions; Then, the other surface of the bag and the sticking protruding part of the patch was covered with a paper whose surface was siliconized. Finally, the thus obtained preparation was packed in a bag prepared from the above plywood aluminum foil.

When used, the siliconized paper is subtracted from the preparation, then taken out of the aluminum bag, and the preparation is then adhered to the top of the thigh or hip.

EXAMPLE III

2.0 g of Chinese balsam oil was mixed with 16.6 g of propylene glycol, after which 1.4 g of colloidal silicon dioxide was added to the clear liquid. 0.5 g portions of the translucent gel-like mass were placed on the center of the 6 cm diameter plywood aluminum foil according to Example I, covered with an ethylene-vinyl acetate copolymer sheet of 6 cm in diameter (100 µm in thickness with a vinyl acetate content of 18-20%), after which the two films containing 0.5 g of a gel are fused together along the circumference of a circle with a surface of 10 cm 2 using a round sealing device. The preparation thus obtained was cut circumferentially, pasted on a suitable sized adhesive plaster and covered with a foil.

The preparation can be used to treat rheumatic pain, headache and toothache.

EXAMPLE IV

0.25 g portions of a gel containing Chinese balm oil according to Example III were transferred into a 5 cm2 bag which was prepared from plywood-5500252 fi-6-aluminum foil and ethylene-vinyl acetate sheet. Due to its small size, this preparation can be used advantageously for the treatment of headache and toothache.

EXAMPLE V

After mixing 1.0 g of smoke tree oil with 8.3 g of a 1: 1 mixture of propylene glycol and polyethylene glycol 400, 0.7 g of colloidal silicon dioxide was added to the mixture.

1.0 g portions of the resulting gel-like mass were transferred to a 20 cm2 bag as described in Example III.

The bag was placed with its ethylene-vinyl acetate side on the swollen blood vessels of the foot and attached to the body surface by means of a medicated plaster.

EXAMPLE VI

After mixing 1.0 g of mint oil with 1.0 g of eucalyptus oil, 5 g of glycerol, 10 g of propylene glycol and 5.0 g of polyethylene glycol, 1.3 colloidal silicon dioxide was added to the slightly opaque liquid. 0.5 g portions of the viscous translucent mass thus obtained were transferred into a bag with a surface of 10 cm 2, which bag consisted of polyethylene on one side and plywood aluminum foil on the other side.

By attaching the composition on its polyethylene side to the body surface, an invigorating effect could be obtained.

EXAMPLE VII

1.0 g of nutmeg oil was mixed with 1.0 g of rosemary oil, 1.0 g of lavender oil, 15 g of propylene glycol and 15 g of polyethylene glycol, after which pieces of cloth measuring 10 cm 2 and 1 mm thick were dissolved in the solution baptized. The cloth pieces were dried on a sieve and then melted between ethylene-vinyl acetate copolymer films. After attachment to the body surface, the composition has an invigorating effect.

EXAMPLE VIII

1.2 g of colloidal silicon dioxide was added to a mixture of 2.0 g of honey clover oil and 18 g of propylene glycol. 0.5 g portions of the thus obtained light-transmitting gel were transferred into bags with a surface of 10 cm 2, prepared from polypropylene sheet and plywood aluminum foil, after which the bags were sealed. on the body surface via its polypropylene sheet-5 side, the preparation was found to have a sedative effect.

EXAMPLE IX

1.5 g of juniper oil, 0.5 g of senna leaf extract, 0.5 g of black else extract and 0.5 g of rhubarb root extract were mixed with 15 g of propylene glycol, 5 g of glycerol and 10 g of poly-10 ethylene glycol 300, followed by 1.5 g of colloidal silicon dioxide. was added. 0.25 g portions of the gel thus obtained were transferred into 5 cm2 surface bags prepared from ethylene-vinyl acetate copolymer sheet and tri-plex aluminum foil.

After its attachment to the body surface via its ethylene-vinyl acetate side, the preparation was found to have a slimming effect.

EXAMPLE X

Example IX was followed except that no jene-20 verbes oil was added to the preparation.

The preparation thus obtained had a laxative effect.

EXAMPLE XI

1 g of colloidal silicon dioxide was added to a mixture of 1 g of sweet fennel oil, 1 g of marjoram oil and 1 g of rosemary oil in 25 g of polyethylene glycol 300, after which 0.5 g portions of the gel thus obtained were transferred into 10 cm 2 cellophane bags. . After attaching the bag to the skin surface by means of a medicated plaster, the preparation was found to have an anti-constipation action.

EXAMPLE XII

1.2 g of colloidal silicon dioxide was added to a mixture of 1 g of sweet fennel oil, 1 g of culinary fennel oil, 1 g of anise oil and 1 g of mint oil in 24 g of polyethylene glycol 300. 0.8 g portions of the gel thus obtained were transferred into bags with an area of 20 cm 2, prepared from a polyvinyl chloride sheet with a thickness of 50 µm.

After attaching the bag to the body surface by 8300252.

The preparation was found to have an effect against flatulence by means of a medicated plaster.

EXAMPLE XIII

1.1 g of colloidal silicon dioxide was added to a mixture of 2 g of juniper oil, 1 g of lavender oil and 1 g of rosemary oil in 12 g of propylene glycol, 8 g of glycerol and 8 g of polyethylene glycol 400. Portions of 0.4 g of the gel thus obtained were transferred into bags with an area of 8 cm2, prepared from a high density polyethylene with a thickness of 0.03 mm. After attaching the bag to the body surface by means of a medicated plaster, the preparation was found to have an anti-corpulence effect.

EXAMPLE XIV

1.5 g of colloidal silicon dioxide was added to a mixture of 1 g of eucalyptus oil, 1 g of lavender oil, 1 g of pine oil and 1 g of hyssopoly in 25 g of polyethylene glycol 300. 0.5 g portions of the gel thus obtained were transferred into bags of a surface of 10 cm 2, prepared from polyethylene with a thickness of 0.06 mm. After attaching the bag to the body surface by means of an adhesive plaster, the preparation was found to have a respiratory purifying effect.

EXAMPLE XV

1.0 g of colloidal silicon dioxide was added to a mixture of 1 g of dill oil, 1 g of hyssop oil, 1 g of pine oil and 1 g of eucalyptus oil in 23 g of propylene glycol. 1.0 g portions were transferred into 20 cm2 bags consisting of 60 µm thick polyethylene on one side and a plywood aluminum foil 30 of Example I on the other side. The preparation had an anti-asthmatic effect.

EXAMPLE XVI

2 g of juniper oil, 2 g of rosemary oil, 2 g of lavender oil and 0.1 g of croton oil were mixed with 45 g of poly-ethylene glycol 400 using 2 g of polyoxyethylene sorbitan monooleate (Tween 80) as a surfactant. Then 2 g of colloidal silicon dioxide was mixed, after which the resulting gel was transferred into bags with an area of 10 cm 2, prepared from ethylene-vinyl acetate co-89 00 252-9 polymer with a thickness of 80 µm on one side and tri- plex aluminum foil according to Example I on the other side. The preparation has a slimming effect.

EXAMPLE XVII

1 g of ylang ylang oil, 1 g of orange flower oil, 1 g of jasmine oil and 1 g of sandalwood oil were mixed with 23 g of polyethylene glycol 300. After addition of 1.3 g of colloidal silicon dioxide, 0.3 g portions of the gel thus obtained were transferred into bags with a surface area of 5 10 cm2 of polyethylene with a thickness of 60 µm on one side and plywood aluminum foil on the other side. The preparation exerts a sedative effect.

8300252

Claims (8)

1. Pharmaceutical composition containing a transdermally absorbable plant extract optionally together with a carrier contained in a thermoplastic polymer or cellulose bag, which is permeable to the plant extract and is provided with a skin-sticking plaster. Pharmaceutical preparation according to claim 1, characterized in that the preparation as carrier contains polyethylene glycol, propylene glycol and / or silicone oil. 3. A composition according to claim 1, characterized in that it contains juniper oil, mint oil, honey clover oil, Chinese oil, medicinal sage oil, smoke tree oil or rosemary oil as a plant extract. 4. Preparation according to claim 1, characterized in that it contains as a plant extract a mixture of a mint oil, rosemary oil and medicinal sage oil. 5. Preparation according to claim 1, characterized in that it contains as a plant extract a mixture of mint oil and eucalyptus oil. 6. A composition according to claim 1, characterized in that it contains as a plant extract a mixture of sage oil, rosemary oil and lavender oil. 7. A composition according to claim 1, characterized in that it contains as a plant extract a mixture of juniper oil, senna leaf extract, black oil extract and rhubarb extract. 8. A composition according to claim 1, characterized in that it contains as a plant extract a mixture of senna leaf extract, black else extract and rhubarb root extract. 89 00252.,