HU204438B - Process for producing pharmaceutical composition - Google Patents

Abstract

An analgesic drug composition contains sage oil, mint oil and rosemary oil as active ingredients, in the following proportion: (0.1-1):(0.1-1):(0.1-1). A process for preparing this drug composition is also disclosed.

Description

The present invention relates to a novel pharmaceutical composition having synergistic analgesic activity, in particular ointment, aerosol, milk or solution, by using mint, sage, rosemary essential oil (0.11) :( 0.1-1) :( 0,1- 1), preferably 1: 1: 1, and admixed with pharmaceutical carriers customary in pharmaceutical technology. For similar preparations, including tea containing sage broth, brewing rheumatic diseases, Dovin Kft. Kossuth Publisher 1987,702 also reports on the use of sage extract in the treatment of rheumatic diseases.

The use of essential oils in medicine dates back to the great ancient cultures. The bactericidal action of some essential oils was already known in the Middle Ages, and in the case of epidemics, it was believed to prevent infection by inhaling essential oils. At the beginning of our century Gattefosse called it medicine. Róbert Tisserand is a well-known expert in the field. The Art of Aromatherapy c. her book is used by aromatherapy healers. However, the healing effects of the fragrance itself are mainly reported here.

"Natural cosmetics for everyone" (Medicina 1990. 72-77) for cosmetic purposes, among others, refers to deodorant and sage containing rosemary extract, and there are numerous references in the literature to rosemary and sage as hair care products, hand creams, nail strengthening agents, anti-emulsifying preparations for the feet, lotions.

Mint oil, sage extract, rosemary oil are described separately in pharmacies and standards, these essential oils per se do not satisfy the effect we have found to cause ointment, aerosol, aerosol, are surprisingly more advantageous in their form.

The novelty of our invention is that it has been found that mint oil, which is a vasodilator and synergistic composition, contains, along with sage and rosemary extract, a new, unexpected effect on the above-mentioned partially inflammatory analgesia.

Recently published by us (published in the UK in 1985). Aromatherapy for Women. book by Maggíe Tisserand. It mentions several uses of essential oils of both mint, sage and rosemary. Recommended for inhalation and massage oils, alone or in combination with other essential oils. However, it is not disclosed in the composition described herein.

Essential oils as an abrasive obviously not only act locally through the skin, but also the scent itself affects the human nervous system. Modern medicine is becoming more and more a sick person and is turning to cure the symptom. Avoiding chemicals is also increasingly desirable, with the emphasis on topically applied drugs rather than the flooding of the body with chemicals. The most potent non-steroidal anti-inflammatory and anti-rheumatoid arthritis drugs (salicylic acid derivatives, indomethacin) are known to cause damage to the gastric mucosa. Modem therapies are increasingly being combined with eating habits and lifestyle changes to improve health throughout the body.

The process of the present invention is also directed to the preparation of such a multipoint "modem" modem composition.

Example 7

Ointment preparation

the. , mixture:

5.0 g sage essential oil

5.0 g of peppermint essential oil

5.0 g of rosemary essential oil

15.0 g of Speen 80 emulgens

0.50 g of Xantan gum C stabilizer

b. ,mix:

50.0 g hydrophilic base ointment

30.0 g deionized water

Blends a) and b) are homogenized by vigorous stirring and after standing for several hours, make up to the desired weight with water and fill into a tube.

Example 2

Emulsion preparation

the. , 8.0 g of sage essential oil, 8.0 g of peppermint essential oil,

8.0 g of rosemary essential oil, 25.0 g of Cremaphor ELemulgents are added and 0.30 g of xanthan gum C stabilizer is added.

b. 30.0 g of hydrophilic base ointment and 21.0 g of distilled water were emulsified at 40-60 ° C.

Mixtures (a) and (b) are homogenized by vigorous stirring and removed after standing for several hours.

Example 3

Aerosol

10.0 g of sage essential oil

10.0 g of peppermint essential oil

10,0 Casketmaring Essential Oil

After mixing with 30.0 g of chremaphor EL emulsifier, 40.0 g of glycerol is added.

The resulting mixture is filled into an aerosol can and pressurized with propellant.

Claims (1)

A method for producing a synergistic pharmaceutical composition, in particular ointment, aerosol, emulsion, milk or solution, characterized in that it is essential oil, sage, rosemary oil (0.1-1) :( 0.1-1) :( 0.1-1 ) in a ratio of 1: 1 to 8, preferably in a ratio of 1: 4 to 8: 1, in a proportion of 1: 1 to 1, and to convert the mixture into a pharmaceutical composition having analgesic properties.