NL8300726A - THE SACCHARINE CALCIUM SALT AND ITS PREPARATION. - Google Patents
THE SACCHARINE CALCIUM SALT AND ITS PREPARATION. Download PDFInfo
- Publication number
- NL8300726A NL8300726A NL8300726A NL8300726A NL8300726A NL 8300726 A NL8300726 A NL 8300726A NL 8300726 A NL8300726 A NL 8300726A NL 8300726 A NL8300726 A NL 8300726A NL 8300726 A NL8300726 A NL 8300726A
- Authority
- NL
- Netherlands
- Prior art keywords
- saccharin
- calcium salt
- calcium
- salt
- preparation
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 5
- -1 SACCHARINE CALCIUM SALT Chemical class 0.000 title 1
- 229940081974 saccharin Drugs 0.000 claims description 16
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 16
- 235000019204 saccharin Nutrition 0.000 claims description 16
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 16
- 159000000007 calcium salts Chemical class 0.000 claims description 11
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 239000012050 conventional carrier Substances 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000008188 pellet Substances 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims 1
- 239000000920 calcium hydroxide Substances 0.000 claims 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 description 5
- 239000002253 acid Substances 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical class OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- MQRKKLAGBPVXCD-UHFFFAOYSA-L calcium;1,1-dioxo-1,2-benzothiazol-2-id-3-one;hydrate Chemical class O.[Ca+2].C1=CC=C2C([O-])=NS(=O)(=O)C2=C1.C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 MQRKKLAGBPVXCD-UHFFFAOYSA-L 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Description
VO 4541VO 4541
Het calciumzout van saccharine en de bereiding daarvan.The calcium salt of saccharin and its preparation.
Saccharine is een algemeen bekend en toegepast zoetmiddel, dat circa 350 maal zo zoet is als rietsuiker, maar niet giftig is, zodat het ook in geval van diabetes kan worden gebruikt.Saccharin is a well-known and widely used sweetener, which is approximately 350 times sweeter than cane sugar, but is non-toxic, so that it can also be used in the case of diabetes.
In verband met zijn goede zoetmiddel eigenschappen wordt het in 5 kleine doses als pilletjes verstrekt, die geheel of gedeeltelijk uit saccharine en voor de rest uit therapeutica en/of dragerstoffen bestaan.Due to its good sweetening properties, it is supplied in 5 small doses as pellets, which consist entirely or partly of saccharin and for the rest consist of therapeutics and / or carriers.
Saccharine zelf is niet erg goed oplosbaar in water. Het wordt derhalve ook wel in de vorm van zijn natriumzout toegepast. Daarbij zijn twee uitvoeringsvormen mogelijk: tabletten met daarin het echte 10 natriumzout van saccharine en tabletten met daarin een combinatie van saccharine (vrij zuur).met natriumwaterstofcarbonaat. Deze laatste combinatie vormt bij contact met water het gewenste natriumzout van saccharine.Saccharin itself is not very soluble in water. It is therefore also used in the form of its sodium salt. Two embodiments are possible here: tablets containing the real sodium salt of saccharin and tablets containing a combination of saccharin (free acid) with sodium hydrogen carbonate. The latter combination forms the desired saccharin sodium salt on contact with water.
De uitvinding betreft nu het calciumzout van saccharine, liefst 15 in kristallijne vorm, desgewenst in de vorm van doseringseenheden of dosishouders. Het voordeel van het calciumzout van saccharine boven het natriumzout is, dat het weinig gunstige natriumion, dat verhoogde bloeddruk kan veroorzaken, is vervangen door het gunstiger calciumion, dat de ionenbalans van het bloed minder stoort en in bijvoorbeeld de botten 20 kan worden opgenomen. Om deze redenen zijn preparaten met calciumzouten veelal beter dein preparaten met overeenkomstige natriumzouten. Verras-senderwijze bleek bovendien het onderhavige calciumzout niet minder zoet dan het natriumzout of het vrije zuur. De uitvinding betreft tevens doseringseenheden en dosishouders met het calciumzout van saccharine, 25 al of niet gecombineerd met therapeurica en/of gebruikelijke drager-stoffen.The invention now relates to the calcium salt of saccharin, most preferably in crystalline form, optionally in the form of dosage units or dose containers. The advantage of the calcium salt of saccharin over the sodium salt is that the less favorable sodium ion, which can cause elevated blood pressure, has been replaced by the more favorable calcium ion, which disturbs the ion balance of the blood less and can be absorbed in, for example, the bones. For these reasons, preparations with calcium salts are often better than preparations with corresponding sodium salts. In addition, surprisingly, the present calcium salt was found to be no less sweet than the sodium salt or the free acid. The invention also relates to dosage units and dose containers with the calcium salt of saccharin, whether or not in combination with therapeutics and / or conventional carriers.
Het volgende voorbeeld geeft een bereidingsmethode weer.The following example shows a cooking method.
Voorbeeld.Example.
In een tank werd een hoeveelheid saccharine (vrij zuur) bij 50 -30 55°C in zo weinig mogelijk water gesuspendeerd en door schudden daarin opgelost. Vervolgens werd de berekende hoeveelheid calciumcarbonaat portiesgewijze toegevoegd, waarbij voorzichtig te werk moet worden gegaan, om een al te snel vrijkomen van koolzuur tegen te gaan. Wanneer de berekende hoeveelheid CaCO^ is toegevoegd moet bij controle de pH 35 van de verkregen oplossing tussen 4,50 en 5,75 zijn gelegen. Vervolgens _ 830 0 72 6 wordt bij dezelfde temperatuur gefiltreerd en het filtraat drooggedampt.In a tank, an amount of saccharin (free acid) was suspended at 50-30 ° C in as little water as possible and dissolved therein by shaking. Then, the calculated amount of calcium carbonate was added portionwise, with care to be taken to avoid too rapid carbonation. When the calculated amount of CaCO2 has been added, the pH of the resulting solution must be between 4.50 and 5.75 on inspection. Then 830 0 72 6 is filtered at the same temperature and the filtrate evaporated to dryness.
Aldus wint men kristallijn calcium-saccharinezout.Crystalline calcium saccharin salt is thus obtained.
-2- 83 0 0 7 2 6 .................................................................................--2- 83 0 0 7 2 6 ......................................... ........................................-
Claims (5)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES509932 | 1982-02-26 | ||
| ES509932A ES509932A0 (en) | 1982-02-26 | 1982-02-26 | "PROCEDURE FOR PREPARING COMPOSITIONS OF CALCICA AND CRYSTALLIZED SACARINE". |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8300726A true NL8300726A (en) | 1983-09-16 |
Family
ID=8483724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8300726A NL8300726A (en) | 1982-02-26 | 1983-02-25 | THE SACCHARINE CALCIUM SALT AND ITS PREPARATION. |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS58157776A (en) |
| BE (1) | BE895741A (en) |
| CH (1) | CH657128A5 (en) |
| ES (1) | ES509932A0 (en) |
| GB (1) | GB2118933B (en) |
| IT (1) | IT1171002B (en) |
| NL (1) | NL8300726A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108586381A (en) * | 2018-04-16 | 2018-09-28 | 天津北方食品有限公司 | A kind of preparation method of saccharin sodium |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1274288A (en) * | 1969-10-20 | 1972-05-17 | Lionel Leslie Frederic Deadman | The use of glutamic acid and glutamates for modifying the taste of artificial sweeteners |
| GB1275505A (en) * | 1970-03-02 | 1972-05-24 | Pfizer | Artificially sweetened non-dairy, water-based food compositions |
-
1982
- 1982-02-26 ES ES509932A patent/ES509932A0/en active Granted
-
1983
- 1983-01-28 BE BE0/209999A patent/BE895741A/en not_active IP Right Cessation
- 1983-02-08 CH CH695/83A patent/CH657128A5/en not_active IP Right Cessation
- 1983-02-08 GB GB08303376A patent/GB2118933B/en not_active Expired
- 1983-02-18 JP JP58026120A patent/JPS58157776A/en active Pending
- 1983-02-25 NL NL8300726A patent/NL8300726A/en not_active Application Discontinuation
- 1983-02-25 IT IT67215/83A patent/IT1171002B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ES8304104A1 (en) | 1983-03-01 |
| GB8303376D0 (en) | 1983-03-16 |
| JPS58157776A (en) | 1983-09-19 |
| IT1171002B (en) | 1987-06-10 |
| BE895741A (en) | 1983-05-16 |
| ES509932A0 (en) | 1983-03-01 |
| GB2118933A (en) | 1983-11-09 |
| GB2118933B (en) | 1987-05-20 |
| CH657128A5 (en) | 1986-08-15 |
| IT8367215A0 (en) | 1983-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |