NL7610040A - Antiphlogistic, analgesic benzyloxy alkanes - prepd. e.g. by reacting ethoxy-phenyl-ethanol deriv. with (para)-chloro-benzyl chloride - Google Patents

Antiphlogistic, analgesic benzyloxy alkanes - prepd. e.g. by reacting ethoxy-phenyl-ethanol deriv. with (para)-chloro-benzyl chloride

Info

Publication number
NL7610040A
NL7610040A NL7610040A NL7610040A NL7610040A NL 7610040 A NL7610040 A NL 7610040A NL 7610040 A NL7610040 A NL 7610040A NL 7610040 A NL7610040 A NL 7610040A NL 7610040 A NL7610040 A NL 7610040A
Authority
NL
Netherlands
Prior art keywords
alkanes
ethoxy
phenyl
deriv
antiphlogistic
Prior art date
Application number
NL7610040A
Other languages
Dutch (nl)
Other versions
NL186238C (en
NL186238B (en
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NL7610040A publication Critical patent/NL7610040A/en
Publication of NL186238B publication Critical patent/NL186238B/en
Application granted granted Critical
Publication of NL186238C publication Critical patent/NL186238C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The new alkanes are of formula (I) (where X is H or halogen; R1 is 1-4C alkyl; R2 and R3 are 1-4C alkyl, or NR2R3 forms a heterocycle; n is 2 or 3). (I) and their salts are useful in steroid-free therapy of inflammatory and degenerative conditions of the osteomuscular system for relief of pain and inflammation. They have low toxicity, dosage being 100-300 mg/day, enterally or parenterally. A typical cpd. is 1-(p-chlorobenzyloxy)-1-(o-(beta(diethylamino)ethoxy)phenyl)-etha- ne.
NLAANVRAGE7610040,A 1975-09-09 1976-09-09 PROCESS FOR PREPARING A MEDICINAL PRODUCT WITH ANTI-ANTI-ANTI-INFLAMMATORY EFFECTS, BASED ON 2-AMINOALKOXYDIBENZYL ETHER DERIVATIVES, AND PROCESS FOR THE PREPARATION OF 2-AMINEREDYL-ZINO-ZYL-KEROYL-ZYL-KEROYL-ZYL-KEROYL-KYL-KYL-OYL-DEROZYL KILLER KYL-KYL-OYL-KYL-IDERANE-KYL-KYL-KEROYL-KYL-IDERYL-KYL-KYL-ATHYL-KIN-PRODUCT-PREPARATION METHOD. NL186238C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2539941A DE2539941C2 (en) 1975-09-09 1975-09-09 Basic benzyloxyalkyl derivatives, their preparation and pharmaceuticals containing these compounds

Publications (3)

Publication Number Publication Date
NL7610040A true NL7610040A (en) 1977-03-11
NL186238B NL186238B (en) 1990-05-16
NL186238C NL186238C (en) 1990-10-16

Family

ID=5955902

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7610040,A NL186238C (en) 1975-09-09 1976-09-09 PROCESS FOR PREPARING A MEDICINAL PRODUCT WITH ANTI-ANTI-ANTI-INFLAMMATORY EFFECTS, BASED ON 2-AMINOALKOXYDIBENZYL ETHER DERIVATIVES, AND PROCESS FOR THE PREPARATION OF 2-AMINEREDYL-ZINO-ZYL-KEROYL-ZYL-KEROYL-ZYL-KEROYL-KYL-KYL-OYL-DEROZYL KILLER KYL-KYL-OYL-KYL-IDERANE-KYL-KYL-KEROYL-KYL-IDERYL-KYL-KYL-ATHYL-KIN-PRODUCT-PREPARATION METHOD.

Country Status (14)

Country Link
JP (1) JPS5233639A (en)
AT (1) AT346306B (en)
AU (1) AU502573B2 (en)
BE (1) BE845964A (en)
CH (1) CH628613A5 (en)
DE (1) DE2539941C2 (en)
DK (1) DK153142C (en)
ES (1) ES451158A1 (en)
FR (1) FR2323377A1 (en)
GB (1) GB1488646A (en)
IE (1) IE43284B1 (en)
LU (1) LU75735A1 (en)
NL (1) NL186238C (en)
SE (1) SE430056B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK368687A (en) * 1986-11-21 1988-05-22 Cheminova As AMINOALCYLED HYDROXY COMPOUNDS AND THEIR USE AS FUNGICIDES
JPH032229U (en) * 1989-05-26 1991-01-10

Also Published As

Publication number Publication date
AU1736176A (en) 1978-03-09
BE845964A (en) 1977-03-08
DK403576A (en) 1977-03-10
IE43284B1 (en) 1981-01-28
NL186238C (en) 1990-10-16
AU502573B2 (en) 1979-08-02
GB1488646A (en) 1977-10-12
NL186238B (en) 1990-05-16
JPS5233639A (en) 1977-03-14
DE2539941A1 (en) 1977-03-17
LU75735A1 (en) 1977-06-15
CH628613A5 (en) 1982-03-15
AT346306B (en) 1978-11-10
IE43284L (en) 1977-03-09
ES451158A1 (en) 1977-12-01
ATA668876A (en) 1978-03-15
SE430056B (en) 1983-10-17
JPS6121940B2 (en) 1986-05-29
FR2323377A1 (en) 1977-04-08
DE2539941C2 (en) 1984-04-26
FR2323377B1 (en) 1978-11-17
DK153142B (en) 1988-06-20
SE7609746L (en) 1977-03-10
DK153142C (en) 1988-11-07

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Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01