NL7307406A - O-substd oximes of formylsalicylic acids - with analgesic activity - Google Patents

O-substd oximes of formylsalicylic acids - with analgesic activity

Info

Publication number
NL7307406A
NL7307406A NL7307406A NL7307406A NL7307406A NL 7307406 A NL7307406 A NL 7307406A NL 7307406 A NL7307406 A NL 7307406A NL 7307406 A NL7307406 A NL 7307406A NL 7307406 A NL7307406 A NL 7307406A
Authority
NL
Netherlands
Prior art keywords
morpholino
substd
formylsalicylic
oximes
acids
Prior art date
Application number
NL7307406A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH789672A external-priority patent/CH572602A5/xx
Priority claimed from US352739A external-priority patent/US3872113A/en
Application filed filed Critical
Publication of NL7307406A publication Critical patent/NL7307406A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B5/00—Melting in furnaces; Furnaces so far as specially adapted for glass manufacture
    • C03B5/14—Melting in furnaces; Furnaces so far as specially adapted for glass manufacture in revolving cylindrical furnaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B5/00—Melting in furnaces; Furnaces so far as specially adapted for glass manufacture
    • C03B5/005—Melting in furnaces; Furnaces so far as specially adapted for glass manufacture of glass-forming waste materials
    • C—CHEMISTRY; METALLURGY
    • C21—METALLURGY OF IRON
    • C21B—MANUFACTURE OF IRON OR STEEL
    • C21B13/00—Making spongy iron or liquid steel, by direct processes
    • C21B13/0006—Making spongy iron or liquid steel, by direct processes obtaining iron or steel in a molten state
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/20—Recycling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Metallurgy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. of formula (I) and their salts are new: where R is H or acetyl; R' is phenyl, morpholino or phenyl mono- or di-substd. by Cl, F, Br, NO2, CF3, MeO and/or EtO; A is 1-3C alkylene, with proviso that A is ethylene or propylene when R' is morpholino. (I) are analgesics, and some also have anti-inflammatory antipyretic or immunosuppressive activity. The analgesic ED50 values range from 11 to 350 (aspirin 94, codeine=19). A soln. of 6.64 g. 6-hydroxyisophthalaldehydic acid and 8.76 g. (III; A= CH2CH2, R' = morpholino).2HCl in 85 ml. of a mixt. of pyridine and anhydrous EtPH (1:1) was refluxed 8 hrs., the solvent evapd. off in vacuo, and the residue triturated with 10% ethanolic HCl. The mixt. was cooled, filtered, and the ppte. recrystd. from 95% EtOH to give the O-(2-morpholinoethyl) oxime of 6-hydroxyisophthalaldehydic acid dihydrochloride, m.p. 204-206 degrees C.
NL7307406A 1972-05-29 1973-05-29 O-substd oximes of formylsalicylic acids - with analgesic activity NL7307406A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH789672A CH572602A5 (en) 1972-05-29 1972-05-29
US352739A US3872113A (en) 1972-05-30 1973-04-19 Hydroxy- and acetoxy-phthalaldehydric acid, O-(substituted) oximes

Publications (1)

Publication Number Publication Date
NL7307406A true NL7307406A (en) 1973-12-04

Family

ID=25702429

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7307406A NL7307406A (en) 1972-05-29 1973-05-29 O-substd oximes of formylsalicylic acids - with analgesic activity

Country Status (1)

Country Link
NL (1) NL7307406A (en)

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Legal Events

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BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BV The patent application has lapsed