NL7505253A - 2(3,4,5-Trimethoxybenzyl)-3,4-dimethyl-pyridines - with analgesic activity - Google Patents

2(3,4,5-Trimethoxybenzyl)-3,4-dimethyl-pyridines - with analgesic activity

Info

Publication number
NL7505253A
NL7505253A NL7505253A NL7505253A NL7505253A NL 7505253 A NL7505253 A NL 7505253A NL 7505253 A NL7505253 A NL 7505253A NL 7505253 A NL7505253 A NL 7505253A NL 7505253 A NL7505253 A NL 7505253A
Authority
NL
Netherlands
Prior art keywords
trimethoxybenzyl
pyridines
dimethyl
analgesic activity
dextropropoxypene
Prior art date
Application number
NL7505253A
Other languages
Dutch (nl)
Other versions
NL159966B (en
NL159966C (en
Original Assignee
Made Labor Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES425972A external-priority patent/ES425972A1/en
Priority claimed from ES434904A external-priority patent/ES434904A1/en
Application filed by Made Labor Sa filed Critical Made Labor Sa
Publication of NL7505253A publication Critical patent/NL7505253A/en
Publication of NL159966B publication Critical patent/NL159966B/en
Application granted granted Critical
Publication of NL159966C publication Critical patent/NL159966C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel 3,4-dimethylpyridine derivs of formula (I) (where R is H, OEt or O.CO.Me). are analgesics with a higher activity than dextropropoxypene (II) but with a lower acute toxicity, e.g. the LD50 of (I; R=H) is 250 mg/kg (i.p. mouse) compared with 140 mg/kg for (II).
NL7505253.A 1974-05-04 1975-05-02 PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION WITH ANALGETIC ACTION, FORMED PREPARATION AND PROCEDURE FOR PREPARING A 2- (METHOXYBENZYL) PYRIDINE COMPOUND. NL159966C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES425972A ES425972A1 (en) 1974-05-04 1974-05-04 Compound 3,4,5-trimethoxyphenyl-(3,4-dimethyl-2-pyridyl)-carbonyl
ES434904A ES434904A1 (en) 1975-02-20 1975-02-20 Certain analgesically active substituted benzyl pyridine compounds

Publications (3)

Publication Number Publication Date
NL7505253A true NL7505253A (en) 1975-11-06
NL159966B NL159966B (en) 1979-04-17
NL159966C NL159966C (en) 1979-09-17

Family

ID=26155880

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7505253.A NL159966C (en) 1974-05-04 1975-05-02 PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION WITH ANALGETIC ACTION, FORMED PREPARATION AND PROCEDURE FOR PREPARING A 2- (METHOXYBENZYL) PYRIDINE COMPOUND.

Country Status (1)

Country Link
NL (1) NL159966C (en)

Also Published As

Publication number Publication date
NL159966B (en) 1979-04-17
NL159966C (en) 1979-09-17

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Legal Events

Date Code Title Description
V1 Lapsed because of non-payment of the annual fee
NL80 Abbreviated name of patent owner mentioned of already nullified patent

Owner name: LABORATORIOS