NL300198I1 - Toepassing van 2-(2-nitro-4-trifluormethylbenzoyl)cyclohexaandion-1,3 voor het behandelen van tyrosinemie, alsmede farmaceutische preparaten. - Google Patents
Toepassing van 2-(2-nitro-4-trifluormethylbenzoyl)cyclohexaandion-1,3 voor het behandelen van tyrosinemie, alsmede farmaceutische preparaten.Info
- Publication number
- NL300198I1 NL300198I1 NL300198C NL300198C NL300198I1 NL 300198 I1 NL300198 I1 NL 300198I1 NL 300198 C NL300198 C NL 300198C NL 300198 C NL300198 C NL 300198C NL 300198 I1 NL300198 I1 NL 300198I1
- Authority
- NL
- Netherlands
- Prior art keywords
- cyclohexanedione
- tyrosinaemia
- trifluoromethylbenzoyl
- nitro
- treatment
- Prior art date
Links
- 201000011296 tyrosinemia Diseases 0.000 title abstract 2
- -1 2-nitro-4-trifluoromethylbenzoyl Chemical group 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 abstract 3
- 102100028626 4-hydroxyphenylpyruvate dioxygenase Human genes 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- QMNFICMPAXFAPC-UHFFFAOYSA-N 2-benzoylcyclohexane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C1C(=O)CCCC1=O QMNFICMPAXFAPC-UHFFFAOYSA-N 0.000 abstract 1
- 208000032001 Tyrosinemia type 1 Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000007972 tyrosinemia type I Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919113622A GB9113622D0 (en) | 1991-06-24 | 1991-06-24 | Medicinal agents |
GB929206412A GB9206412D0 (en) | 1992-03-24 | 1992-03-24 | Pharmaceutical compositions |
PCT/GB1992/001094 WO1993000080A1 (en) | 1991-06-24 | 1992-06-18 | Use of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione in the treatment of tyrosinaemia and pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
NL300198I1 true NL300198I1 (nl) | 2005-08-01 |
NL300198I2 NL300198I2 (nl) | 2005-09-01 |
Family
ID=26299120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL300198C NL300198I2 (nl) | 1991-06-24 | 2005-06-09 | Toepassing van 2-(2-nitro-4-trifluormethylbenzoyl)cyclohexaandion-1,3 voor het behandelen van tyrosinemie, alsmede farmaceutische preparaten. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5550165A (nl) |
EP (1) | EP0591275B1 (nl) |
JP (1) | JP3130935B2 (nl) |
AT (1) | ATE178207T1 (nl) |
AU (1) | AU672361B2 (nl) |
CA (1) | CA2072047C (nl) |
DE (2) | DE69228813T2 (nl) |
DK (1) | DK0591275T3 (nl) |
ES (1) | ES2129448T3 (nl) |
GR (1) | GR3029841T3 (nl) |
HK (1) | HK1008662A1 (nl) |
IE (1) | IE922024A1 (nl) |
LU (1) | LU91180I2 (nl) |
NL (1) | NL300198I2 (nl) |
NO (3) | NO304923B1 (nl) |
PT (1) | PT100619B (nl) |
WO (1) | WO1993000080A1 (nl) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4305696A1 (de) * | 1993-02-25 | 1994-09-01 | Hoechst Ag | Nachweisverfahren zur Identifizierung von Inhibitoren |
AU5116099A (en) * | 1998-07-21 | 2000-02-14 | Sui Xiong Cai | Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof |
WO2008020150A1 (en) * | 2006-08-18 | 2008-02-21 | Syngenta Limited | Use of hppd inhibitors in the treatment of depression and/or withdrawal symptoms associated with addictive drugs |
US10131672B2 (en) * | 2010-01-29 | 2018-11-20 | Toray Industries, Inc. | Therapeutic or prophylactic agent for biliary diseases |
PL2723320T3 (pl) * | 2011-06-23 | 2016-06-30 | Swedish Orphan Biovitrum Int Ab | Ciekła kompozycja farmaceutyczna zawierająca nityzynon |
WO2013181292A1 (en) * | 2012-05-29 | 2013-12-05 | Biotie Therapies, Inc. | Nitisinone formulations |
CN102976948B (zh) * | 2012-11-28 | 2014-07-09 | 郑州大明药物科技有限公司 | 尼替西农的制备方法 |
GB201400117D0 (en) | 2014-01-03 | 2014-02-19 | Cycle Pharmaceuticals Ltd | Pharmaceutical composition |
ITUB20160650A1 (it) * | 2016-02-11 | 2017-08-11 | Dipharma S A | Formulazioni farmaceutiche solide stabili contenenti 2-(2-nitro-4-trifluorometilbenzoil)-1,3-cicloesandione |
US9783485B1 (en) | 2016-11-30 | 2017-10-10 | Dipharma S.A. | Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and a process of synthesis and crystallization thereof |
WO2024047657A1 (en) * | 2022-08-28 | 2024-03-07 | Brawn Laboratories Ltd | Process for the preparation of nitisinone |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4780127A (en) * | 1982-03-25 | 1988-10-25 | Stauffer Chemical Company | Certain 2-(substituted benzoyl)-1,3-cyclohexanediones and their use as herbicides |
IL77349A (en) * | 1984-12-20 | 1990-07-12 | Stauffer Chemical Co | 2-(2'-nitrobenzoyl)-1,3-cyclohexanediones,their preparation and their use as herbicides |
US4774360A (en) * | 1987-06-29 | 1988-09-27 | Stauffer Chemical Company | Converting enol ester precursor of a benzoyl-1,3-cycloalkyldione to a benzoyl-1,3-cycloalkyldione |
-
1992
- 1992-06-18 JP JP05501383A patent/JP3130935B2/ja not_active Expired - Lifetime
- 1992-06-18 DK DK92912215T patent/DK0591275T3/da active
- 1992-06-18 DE DE69228813T patent/DE69228813T2/de not_active Expired - Lifetime
- 1992-06-18 AT AT92912215T patent/ATE178207T1/de active
- 1992-06-18 AU AU19860/92A patent/AU672361B2/en not_active Expired
- 1992-06-18 WO PCT/GB1992/001094 patent/WO1993000080A1/en active IP Right Grant
- 1992-06-18 DE DE1992628813 patent/DE122005000032I2/de active Active
- 1992-06-18 EP EP92912215A patent/EP0591275B1/en not_active Expired - Lifetime
- 1992-06-18 ES ES92912215T patent/ES2129448T3/es not_active Expired - Lifetime
- 1992-06-23 CA CA002072047A patent/CA2072047C/en not_active Expired - Lifetime
- 1992-06-24 PT PT100619A patent/PT100619B/pt not_active IP Right Cessation
- 1992-07-01 IE IE202492A patent/IE922024A1/en not_active IP Right Cessation
-
1993
- 1993-12-23 NO NO934798A patent/NO304923B1/no active Protection Beyond IP Right Term
-
1994
- 1994-12-19 US US08/359,361 patent/US5550165A/en not_active Expired - Lifetime
-
1998
- 1998-07-27 HK HK98109412A patent/HK1008662A1/xx not_active IP Right Cessation
-
1999
- 1999-04-01 GR GR990400803T patent/GR3029841T3/el unknown
-
2005
- 2005-06-09 NL NL300198C patent/NL300198I2/nl unknown
- 2005-07-06 LU LU91180C patent/LU91180I2/fr unknown
- 2005-08-31 NO NO2005018C patent/NO2005018I2/no unknown
-
2017
- 2017-08-23 NO NO2017045C patent/NO2017045I1/no unknown
Also Published As
Publication number | Publication date |
---|---|
NL300198I2 (nl) | 2005-09-01 |
PT100619B (pt) | 1999-07-30 |
DK0591275T3 (da) | 1999-10-11 |
EP0591275A1 (en) | 1994-04-13 |
PT100619A (pt) | 1994-01-31 |
NO934798D0 (no) | 1993-12-23 |
GR3029841T3 (en) | 1999-07-30 |
DE122005000032I1 (de) | 2005-09-29 |
AU672361B2 (en) | 1996-10-03 |
DE122005000032I2 (de) | 2006-06-08 |
NO304923B1 (no) | 1999-03-08 |
AU1986092A (en) | 1993-01-25 |
CA2072047A1 (en) | 1992-12-25 |
NO2005018I2 (no) | 2008-02-11 |
NO2017045I1 (no) | 2017-08-23 |
ATE178207T1 (de) | 1999-04-15 |
HK1008662A1 (en) | 1999-05-14 |
DE69228813T2 (de) | 1999-08-05 |
LU91180I2 (fr) | 2005-09-06 |
JP3130935B2 (ja) | 2001-01-31 |
DE69228813D1 (de) | 1999-05-06 |
ES2129448T3 (es) | 1999-06-16 |
WO1993000080A1 (en) | 1993-01-07 |
NO2005018I1 (no) | 2005-09-26 |
IE922024A1 (en) | 1992-12-30 |
JPH06508628A (ja) | 1994-09-29 |
US5550165A (en) | 1996-08-27 |
NO934798L (no) | 1993-12-23 |
EP0591275B1 (en) | 1999-03-31 |
CA2072047C (en) | 2003-06-10 |
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