NL2032645B1 - Bone-level targeted-ultrasonic triggered drug delivery system, preparation method and application thereof - Google Patents

Bone-level targeted-ultrasonic triggered drug delivery system, preparation method and application thereof Download PDF

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Publication number
NL2032645B1
NL2032645B1 NL2032645A NL2032645A NL2032645B1 NL 2032645 B1 NL2032645 B1 NL 2032645B1 NL 2032645 A NL2032645 A NL 2032645A NL 2032645 A NL2032645 A NL 2032645A NL 2032645 B1 NL2032645 B1 NL 2032645B1
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NL
Netherlands
Prior art keywords
targeted
bone
liposome
delivery system
ultrasound
Prior art date
Application number
NL2032645A
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English (en)
Dutch (nl)
Inventor
Liu Fuwei
Lv Qianxin
Hou Yan
Chen Yicheng
Dai Taiqiang
Jin Dan
Cai Bulei
Wang Le
Xin He
Shi Qianwen
Gao Ye
Cao Feng
Kong Liang
Li Yunpeng
Zhang Kai
Original Assignee
Air Force Medical Univ
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Publication date
Application filed by Air Force Medical Univ filed Critical Air Force Medical Univ
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Publication of NL2032645B1 publication Critical patent/NL2032645B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL2032645A 2021-10-21 2022-07-30 Bone-level targeted-ultrasonic triggered drug delivery system, preparation method and application thereof NL2032645B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111226889.1A CN113967262B (zh) 2021-10-21 2021-10-21 一种骨层级靶向-超声触发式药物递送系统、制备方法及应用

Publications (1)

Publication Number Publication Date
NL2032645B1 true NL2032645B1 (en) 2023-02-24

Family

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Family Applications (1)

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NL2032645A NL2032645B1 (en) 2021-10-21 2022-07-30 Bone-level targeted-ultrasonic triggered drug delivery system, preparation method and application thereof

Country Status (2)

Country Link
CN (1) CN113967262B (zh)
NL (1) NL2032645B1 (zh)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150150801A1 (en) * 2013-11-29 2015-06-04 Samsung Electronics Co., Ltd. Double-layered liposome comprising inner liposome comprising hydrophobic active ingredient and use of the double-layered liposome

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013044734A1 (zh) * 2011-09-28 2013-04-04 中国科学院深圳先进技术研究院 骨靶向脂质体及其制备方法
CN105832670A (zh) * 2015-12-28 2016-08-10 四川大学 一种利用诱导脂质体融合来制备双载或多载脂质体的技术
US10864161B2 (en) * 2017-10-13 2020-12-15 American University Of Sharjah Systems and methods for targeted breast cancer therapies
CN108888782A (zh) * 2018-07-20 2018-11-27 广东省第二人民医院 一种基于低频超声响应的靶向荧光脂质体及其制备方法和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150150801A1 (en) * 2013-11-29 2015-06-04 Samsung Electronics Co., Ltd. Double-layered liposome comprising inner liposome comprising hydrophobic active ingredient and use of the double-layered liposome

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LIANG CHAO ET AL: "Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy", NATURE MEDICINE, vol. 21, no. 3, 9 February 2015 (2015-02-09), New York, pages 288 - 294, XP093013803, ISSN: 1078-8956, Retrieved from the Internet <URL:http://www.nature.com/articles/nm.3791> DOI: 10.1038/nm.3791 *
LIANG CHAO ET AL: "Supporting Information - Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy", NATURE MEDICINE, vol. 21, no. 3, 9 February 2015 (2015-02-09), New York, pages 288 - 294, XP093013830, ISSN: 1078-8956, Retrieved from the Internet <URL:http://www.nature.com/articles/nm.3791> DOI: 10.1038/nm.3791 *
ZHANG GE ET AL: "A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy", NATURE MEDICINE, vol. 18, no. 2, 29 January 2012 (2012-01-29), New York, pages 307 - 314, XP093013805, ISSN: 1078-8956, Retrieved from the Internet <URL:http://www.nature.com/articles/nm.2617> DOI: 10.1038/nm.2617 *
ZHANG GE ET AL: "Supporting information - A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy", NATURE MEDICINE, vol. 18, no. 2, 29 January 2012 (2012-01-29), New York, pages 307 - 314, XP093013847, ISSN: 1078-8956, Retrieved from the Internet <URL:http://www.nature.com/articles/nm.2617> DOI: 10.1038/nm.2617 *

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CN113967262B (zh) 2022-12-23
CN113967262A (zh) 2022-01-25

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