NL2023169B1 - Biotin prototrophy - Google Patents

Biotin prototrophy Download PDF

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Publication number
NL2023169B1
NL2023169B1 NL2023169A NL2023169A NL2023169B1 NL 2023169 B1 NL2023169 B1 NL 2023169B1 NL 2023169 A NL2023169 A NL 2023169A NL 2023169 A NL2023169 A NL 2023169A NL 2023169 B1 NL2023169 B1 NL 2023169B1
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Netherlands
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ala
leu
gly
val
glu
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NL2023169A
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English (en)
Dutch (nl)
Inventor
Georges Daran Jean-Marc
Kristina Wronska Anna
Thomas Pronk Jacobus
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Univ Delft Tech
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Priority to NL2023169A priority Critical patent/NL2023169B1/en
Priority to PCT/EP2020/063762 priority patent/WO2020234215A1/fr
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Publication of NL2023169B1 publication Critical patent/NL2023169B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01062—Adenosylmethionine--8-amino-7-oxononanoate transaminase (2.6.1.62)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
    • C12Y208/01—Sulfurtransferases (2.8.1)
    • C12Y208/01006—Biotin synthase (2.8.1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/03—Cyclo-ligases (6.3.3)
    • C12Y603/03003—Dethiobiotin synthase (6.3.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C12P17/186—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing a 2-oxo-thieno[3,4-d]imidazol nucleus, e.g. Biotin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NL2023169A 2019-05-21 2019-05-21 Biotin prototrophy NL2023169B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NL2023169A NL2023169B1 (en) 2019-05-21 2019-05-21 Biotin prototrophy
PCT/EP2020/063762 WO2020234215A1 (fr) 2019-05-21 2020-05-18 Prototrophy de biotine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL2023169A NL2023169B1 (en) 2019-05-21 2019-05-21 Biotin prototrophy

Publications (1)

Publication Number Publication Date
NL2023169B1 true NL2023169B1 (en) 2020-12-01

Family

ID=67106114

Family Applications (1)

Application Number Title Priority Date Filing Date
NL2023169A NL2023169B1 (en) 2019-05-21 2019-05-21 Biotin prototrophy

Country Status (2)

Country Link
NL (1) NL2023169B1 (fr)
WO (1) WO2020234215A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
WO1995006722A1 (fr) 1993-09-03 1995-03-09 Japan Tobacco Inc. Procede permettant de transformer une monocotyledone avec un scutellum d'embryon immature
US5591616A (en) 1992-07-07 1997-01-07 Japan Tobacco, Inc. Method for transforming monocotyledons
US20020138879A1 (en) 1997-04-30 2002-09-26 Tishu Cai Agrobacterium mediated transformed sorghum

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2221358A1 (fr) * 2009-02-24 2010-08-25 Universität für Bodenkultur Wien Levures prototrophiques de biotine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5591616A (en) 1992-07-07 1997-01-07 Japan Tobacco, Inc. Method for transforming monocotyledons
WO1995006722A1 (fr) 1993-09-03 1995-03-09 Japan Tobacco Inc. Procede permettant de transformer une monocotyledone avec un scutellum d'embryon immature
US20020138879A1 (en) 1997-04-30 2002-09-26 Tishu Cai Agrobacterium mediated transformed sorghum

Non-Patent Citations (30)

* Cited by examiner, † Cited by third party
Title
BRACHER JMDE HULSTER E, KOSTER CC ET AL.: "Laboratory evolution of a biotin-requiring Saccharomyces cerevisiae strain for full biotin prototrophy and identification of causal mutations", APPL ENVIRON MICROBIO, vol. 83, 2017, pages 1 - 16
BRACHER JMDE HULSTER EKOSTER CC ET AL., LABORATORY EVOLUTION OF A BIOTIN-REQUIRING SACCHAROMYCES CEREVISIAE STRAIN FOR FULL BIOTIN 1 PROTOTROPHY AND IDENTIFICATION OF CAUSAL MUTATIONS 2 3 4, 2017
BRACHER JMDE HULSTER EKOSTER CC ET AL.: "Laboratory Evolution of a Biotin-Requiring Saccharomyces cerevisiae Strain for Full Biotin Prototrophy and Identification of Causal Mutations", APPL ENVIRON MICROBIO, vol. 83, 2017, pages e00892 - 17
BRIGITTE GASSER ET AL: "Engineering of biotin-prototrophy in Pichia pastoris for robust production processes", METABOLIC ENGINEERING, vol. 12, no. 6, 3 August 2010 (2010-08-03), US, pages 573 - 580, XP055616745, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2010.07.002 *
CREIGHTON, T.E.: "Proteins: Structure and Molecular Principles", 1984, W.H. FREEMAN & CO.
DANIEL GIETZ RWOODS RA: "Transformation of Yeast by Lithium AcetatelSingle-Stranded Carrier DNA", POLYETHYLENE GLYCOL METHOD, 2002
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JUERGENS HVARELA JAGORTER DE VRIES AR ET AL.: "Genome editing in Kluyveromyces and Ogataea yeasts using a broad-host-range Cas9/gRNA co-expression plasmid", FEMS YEAST RES, 2018, pages 18
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LINDNER P.: "Schizosaccharomyces pombe n. sp., ein neuer Gahrungserreger", WOCHENSCHRIFT FURBRAUEREI, vol. 10, 1893, pages 1298 - 300
LOOKE MKRISTJUHAN KKRISTJUHAN A, EXTRACTION OF GENOMIC DNA FROM YEASTS FOR PCR-BASED APPLICATIONS
MANS RVAN ROSSUM # HMWIJSMAN M ET AL.: "CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae", FEMS YEAST RES, vol. 15, 2015, XP002762726
PAPAPETRIDIS IGOUDRIAAN MVAZQUEZ VITALI M ET AL.: "Optimizing anaerobic growth rate and fermentation kinetics in Saccharomyces cerevisiae strains expressing Calvin-cycle enzymes for improved ethanol yield Biotechnology for Biofuels", BIOTECHNOL BIOFUELS, vol. 11, 2018, pages 17
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SAMBROOKRUSSELL: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
SCHULZ, G. E. ET AL.: "Principles of Protein Structure", 1979, SPRINGER- VERLAG
SUH S-OZHOU JJ: "Methylotrophic yeasts near Ogataea (Hansenula) polymorpha: a proposal of Ogataea angusta comb. nov. and Candida parapolymorpha sp. nov", FEMS YEAST RES, vol. 10, 2010
THOMPSON JRREGISTER ECUROTTO J ET AL., AN IMPROVED PROTOCOL FOR THE PREPARATION OF YEAST CELLS FOR TRANSFORMATION BY ELECTROPORATION, 1998
VAN DER WALT JP: "New combinations in the genera Brettanomyces, Kluyveromyces, Lodderomyces and Wingea", BOTHALIA, 1971
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