NL192290C - Gestabiliseerde oplossing van stremsel. - Google Patents
Gestabiliseerde oplossing van stremsel. Download PDFInfo
- Publication number
- NL192290C NL192290C NL8203631A NL8203631A NL192290C NL 192290 C NL192290 C NL 192290C NL 8203631 A NL8203631 A NL 8203631A NL 8203631 A NL8203631 A NL 8203631A NL 192290 C NL192290 C NL 192290C
- Authority
- NL
- Netherlands
- Prior art keywords
- methionine
- rennet
- solution
- weeks
- added
- Prior art date
Links
- 229940108461 rennet Drugs 0.000 title claims description 44
- 108010058314 rennet Proteins 0.000 title claims description 44
- 229960004452 methionine Drugs 0.000 claims description 37
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 36
- 239000000243 solution Substances 0.000 claims description 32
- 229930182817 methionine Natural products 0.000 claims description 28
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims description 26
- 230000000694 effects Effects 0.000 claims description 19
- 229930195722 L-methionine Natural products 0.000 claims description 10
- 238000012360 testing method Methods 0.000 claims description 10
- 239000012047 saturated solution Substances 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 claims 1
- 235000006109 methionine Nutrition 0.000 description 25
- 229940024606 amino acid Drugs 0.000 description 15
- 235000001014 amino acid Nutrition 0.000 description 15
- 150000001413 amino acids Chemical class 0.000 description 15
- 239000003381 stabilizer Substances 0.000 description 15
- 108010056587 rennilase Proteins 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000011534 incubation Methods 0.000 description 6
- 230000000813 microbial effect Effects 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000000600 sorbitol Substances 0.000 description 6
- 230000000087 stabilizing effect Effects 0.000 description 6
- 235000013351 cheese Nutrition 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 4
- 241000235403 Rhizomucor miehei Species 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 230000006641 stabilisation Effects 0.000 description 4
- 238000011105 stabilization Methods 0.000 description 4
- 241000235525 Rhizomucor pusillus Species 0.000 description 3
- QEFRNWWLZKMPFJ-UHFFFAOYSA-N methionine S-oxide Chemical compound CS(=O)CCC(N)C(O)=O QEFRNWWLZKMPFJ-UHFFFAOYSA-N 0.000 description 3
- 239000007800 oxidant agent Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 2
- 235000013878 L-cysteine Nutrition 0.000 description 2
- 239000004201 L-cysteine Substances 0.000 description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
- 241000235395 Mucor Species 0.000 description 2
- 230000006229 amino acid addition Effects 0.000 description 2
- 230000001687 destabilization Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000013074 reference sample Substances 0.000 description 2
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 241000221756 Cryphonectria parasitica Species 0.000 description 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
- 239000004470 DL Methionine Substances 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 229960003767 alanine Drugs 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002366 halogen compounds Chemical class 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229960002885 histidine Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002741 methionine derivatives Chemical class 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Dairy Products (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK416881A DK147376C (da) | 1981-09-21 | 1981-09-21 | Stabiliseret oploesning af osteloebe |
| DK416881 | 1981-09-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8203631A NL8203631A (nl) | 1983-04-18 |
| NL192290B NL192290B (nl) | 1997-01-06 |
| NL192290C true NL192290C (nl) | 1997-05-07 |
Family
ID=8130917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8203631A NL192290C (nl) | 1981-09-21 | 1982-09-20 | Gestabiliseerde oplossing van stremsel. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4455375A (cs) |
| BE (1) | BE894447A (cs) |
| DE (1) | DE3234761A1 (cs) |
| DK (1) | DK147376C (cs) |
| FR (1) | FR2522681B1 (cs) |
| GB (1) | GB2106521B (cs) |
| NL (1) | NL192290C (cs) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW306932B (cs) * | 1993-08-27 | 1997-06-01 | Holland Sweetener Co | |
| DE69533986D1 (de) * | 1994-05-03 | 2005-03-10 | Chr Hansen As Horsholm | Verfahren zur trennung milchgerinnender enzyme |
| AU701254B2 (en) * | 1994-05-03 | 1999-01-21 | Chr. Hansen A/S | A process for separating milk clotting enzymes, and stable rennet compositions |
| ATE216724T1 (de) * | 1995-05-12 | 2002-05-15 | Dsm Nv | Enzymatische produktion von glukonsäure und ihrer salzen |
| EP0745677B1 (en) * | 1995-05-12 | 2002-04-24 | Dsm N.V. | Enzymatic production of gluconic acid or its salts |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB900115A (en) * | 1960-06-15 | 1962-07-04 | Armour & Co | Improvements in or relating to trypsin solutions |
| US3051627A (en) * | 1960-08-18 | 1962-08-28 | Armour Pharma | Stabilized chymotrypsin solution |
| US3950513A (en) * | 1965-12-03 | 1976-04-13 | Novo Terapeutisk Laboratorium A/S | Process of stabilizing therapeutically useful plasmin solutions |
| US4348482A (en) * | 1978-05-22 | 1982-09-07 | Miles Laboratories, Inc. | Process for decreasing the thermal stability of microbial rennet |
| US4255454A (en) * | 1978-12-28 | 1981-03-10 | Sven Branner-Jorgensen | Thermal destabilization of microbial rennet |
| BE885584A (fr) * | 1980-10-08 | 1981-02-02 | Hansens Lab | Procede de destabilisation de l'activite proteolytique d'enzymes microbiens de caillage du lait |
-
1981
- 1981-09-21 DK DK416881A patent/DK147376C/da active
-
1982
- 1982-09-14 US US06/417,856 patent/US4455375A/en not_active Expired - Lifetime
- 1982-09-20 NL NL8203631A patent/NL192290C/nl not_active IP Right Cessation
- 1982-09-20 GB GB08226730A patent/GB2106521B/en not_active Expired
- 1982-09-20 BE BE6/47718A patent/BE894447A/fr not_active IP Right Cessation
- 1982-09-20 FR FR8215805A patent/FR2522681B1/fr not_active Expired
- 1982-09-20 DE DE19823234761 patent/DE3234761A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3234761C2 (cs) | 1991-07-25 |
| NL192290B (nl) | 1997-01-06 |
| DK147376C (da) | 1985-01-28 |
| DK147376B (da) | 1984-07-09 |
| GB2106521B (en) | 1985-01-30 |
| DE3234761A1 (de) | 1983-05-05 |
| NL8203631A (nl) | 1983-04-18 |
| FR2522681B1 (fr) | 1985-06-21 |
| DK416881A (da) | 1983-03-22 |
| GB2106521A (en) | 1983-04-13 |
| US4455375A (en) | 1984-06-19 |
| BE894447A (fr) | 1983-03-21 |
| FR2522681A1 (fr) | 1983-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| V4 | Discontinued because of reaching the maximum lifetime of a patent |
Free format text: 20020920 |