NL173398B - PROCESS FOR PREPARING PHARMACEUTICAL PREPARATIONS AND PROCESS FOR PREPARING A BENZENE SUBSTITUTED 1-METHYL-4-(10,11-DIHYDRO-5H-DIBENZOŸA,DŸCYCLOHEPTEN-5-YLIDEN)-PIPERIDINE DERIVATIVE. - Google Patents

PROCESS FOR PREPARING PHARMACEUTICAL PREPARATIONS AND PROCESS FOR PREPARING A BENZENE SUBSTITUTED 1-METHYL-4-(10,11-DIHYDRO-5H-DIBENZOŸA,DŸCYCLOHEPTEN-5-YLIDEN)-PIPERIDINE DERIVATIVE.

Info

Publication number
NL173398B
NL173398B NLAANVRAGE7512384,A NL7512384A NL173398B NL 173398 B NL173398 B NL 173398B NL 7512384 A NL7512384 A NL 7512384A NL 173398 B NL173398 B NL 173398B
Authority
NL
Netherlands
Prior art keywords
preparing
dihydro
dÿcyclohepten
dibenzoÿa
yliden
Prior art date
Application number
NLAANVRAGE7512384,A
Other languages
Dutch (nl)
Other versions
NL7512384A (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NL7512384A publication Critical patent/NL7512384A/en
Publication of NL173398B publication Critical patent/NL173398B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)

Abstract

10,11-Dihydro-3-carboxycyproheptadine and its esters, amides and N-oxide are disclosed to have pharmaceutical utility as appetite stimulants and as antihistaminic agents. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such, compounds; and methods of treatment comprising administering such compounds and compositions.
NLAANVRAGE7512384,A 1974-11-11 1975-10-22 PROCESS FOR PREPARING PHARMACEUTICAL PREPARATIONS AND PROCESS FOR PREPARING A BENZENE SUBSTITUTED 1-METHYL-4-(10,11-DIHYDRO-5H-DIBENZOŸA,DŸCYCLOHEPTEN-5-YLIDEN)-PIPERIDINE DERIVATIVE. NL173398B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52267674A 1974-11-11 1974-11-11
US56328575A 1975-03-28 1975-03-28

Publications (2)

Publication Number Publication Date
NL7512384A NL7512384A (en) 1976-05-13
NL173398B true NL173398B (en) 1983-08-16

Family

ID=27060901

Family Applications (2)

Application Number Title Priority Date Filing Date
NLAANVRAGE7512384,A NL173398C (en) 1974-11-11 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS AND PROCEDURE FOR THE PREPARATION OF A PETROL-SUBSTITUTED 1-METHYL-4- (10,11-DIHYDRO-5H-DIBENZO (A, D) CYCLOHEPTEN-5-YYLIDES) -PIPLIDEEN.
NLAANVRAGE7512384,A NL173398B (en) 1974-11-11 1975-10-22 PROCESS FOR PREPARING PHARMACEUTICAL PREPARATIONS AND PROCESS FOR PREPARING A BENZENE SUBSTITUTED 1-METHYL-4-(10,11-DIHYDRO-5H-DIBENZOŸA,DŸCYCLOHEPTEN-5-YLIDEN)-PIPERIDINE DERIVATIVE.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7512384,A NL173398C (en) 1974-11-11 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS AND PROCEDURE FOR THE PREPARATION OF A PETROL-SUBSTITUTED 1-METHYL-4- (10,11-DIHYDRO-5H-DIBENZO (A, D) CYCLOHEPTEN-5-YYLIDES) -PIPLIDEEN.

Country Status (19)

Country Link
JP (1) JPS6011029B2 (en)
AR (1) AR211108A1 (en)
AT (1) AT352126B (en)
CA (1) CA1082177A (en)
CH (1) CH621114A5 (en)
DE (1) DE2550395C3 (en)
DK (1) DK474575A (en)
ES (1) ES442375A1 (en)
FI (1) FI59583C (en)
FR (1) FR2290203A1 (en)
IE (1) IE42220B1 (en)
IL (1) IL48365A (en)
LU (1) LU73771A1 (en)
NL (2) NL173398B (en)
NO (1) NO144422C (en)
NZ (1) NZ179080A (en)
PH (1) PH13443A (en)
SE (1) SE424990B (en)
YU (1) YU273475A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195091A (en) * 1978-11-15 1980-03-25 Merck & Co., Inc. Appetite stimulating pyrrolo[2,1-b][3]benzazepines
US4412999A (en) * 1982-04-14 1983-11-01 Merck & Co., Inc. Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same

Also Published As

Publication number Publication date
CH621114A5 (en) 1981-01-15
DE2550395B2 (en) 1978-11-30
NO753562L (en) 1976-05-12
YU273475A (en) 1983-04-27
CA1082177A (en) 1980-07-22
ATA843975A (en) 1979-02-15
PH13443A (en) 1980-04-23
NO144422B (en) 1981-05-18
FI752920A (en) 1976-05-12
NZ179080A (en) 1978-07-10
SE424990B (en) 1982-08-23
JPS5170769A (en) 1976-06-18
AU8605775A (en) 1977-05-05
ES442375A1 (en) 1977-08-16
FR2290203B1 (en) 1980-05-30
AR211108A1 (en) 1977-10-31
DE2550395C3 (en) 1979-08-09
NL7512384A (en) 1976-05-13
IL48365A0 (en) 1975-12-31
IE42220B1 (en) 1980-07-02
NL173398C (en)
LU73771A1 (en) 1976-09-06
JPS6011029B2 (en) 1985-03-22
IL48365A (en) 1978-10-31
NO144422C (en) 1981-08-26
SE7511792L (en) 1976-05-12
FR2290203A1 (en) 1976-06-04
DK474575A (en) 1976-05-12
IE42220L (en) 1976-05-11
FI59583C (en) 1981-09-10
DE2550395A1 (en) 1976-05-13
FI59583B (en) 1981-05-29
AT352126B (en) 1979-09-10

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Legal Events

Date Code Title Description
V1 Lapsed because of non-payment of the annual fee