MY135674A - Cytotoxic bicyclo [7.3.1] tridec-4-ene-2, 6-diyne compounds and process for the preparation thereof. - Google Patents
Cytotoxic bicyclo [7.3.1] tridec-4-ene-2, 6-diyne compounds and process for the preparation thereof.Info
- Publication number
- MY135674A MY135674A MYPI91000659A MYPI9100659A MY135674A MY 135674 A MY135674 A MY 135674A MY PI91000659 A MYPI91000659 A MY PI91000659A MY PI9100659 A MYPI9100659 A MY PI9100659A MY 135674 A MY135674 A MY 135674A
- Authority
- MY
- Malaysia
- Prior art keywords
- tridec
- bicyclo
- ene
- preparation
- cytotoxic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- ZLSOMGXGWUIINP-UHFFFAOYSA-N bicyclo[7.3.1]tridec-5-en-3,7-diyne Chemical class C1C2CCCC1CC#CC=CC#C2 ZLSOMGXGWUIINP-UHFFFAOYSA-N 0.000 title 1
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- ITXLXISGXCELRQ-UHFFFAOYSA-N bicyclo[7.3.1]tridec-4-en-2,6-diyn-8-ol Chemical group OC1C#CC=CC#CC2CCCC1C2 ITXLXISGXCELRQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C325/00—Thioaldehydes; Thioketones; Thioquinones; Oxides thereof
- C07C325/02—Thioketones; Oxides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/06—Cobalt compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
- C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
- C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/48—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing ten carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51538790A | 1990-04-27 | 1990-04-27 | |
| US62150390A | 1990-11-30 | 1990-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY135674A true MY135674A (en) | 2008-06-30 |
Family
ID=27058485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI91000659A MY135674A (en) | 1990-04-27 | 1991-04-22 | Cytotoxic bicyclo [7.3.1] tridec-4-ene-2, 6-diyne compounds and process for the preparation thereof. |
Country Status (14)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198560A (en) * | 1990-04-27 | 1993-03-30 | Bristol-Myers Squibb Company | Cytotoxic bicyclo[7.3.1]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof |
-
1991
- 1991-04-19 CA CA002040855A patent/CA2040855A1/en not_active Abandoned
- 1991-04-22 MY MYPI91000659A patent/MY135674A/en unknown
- 1991-04-23 YU YU73391A patent/YU73391A/sh unknown
- 1991-04-24 FI FI911982A patent/FI911982A7/fi not_active Application Discontinuation
- 1991-04-24 TW TW080103230A patent/TW217414B/zh active
- 1991-04-25 JP JP3121949A patent/JPH04225934A/ja active Pending
- 1991-04-25 IL IL97965A patent/IL97965A0/xx unknown
- 1991-04-26 PT PT97483A patent/PT97483A/pt not_active Application Discontinuation
- 1991-04-26 AU AU76282/91A patent/AU648073B2/en not_active Ceased
- 1991-04-26 EP EP91106789A patent/EP0454146A1/en not_active Ceased
- 1991-04-26 NZ NZ237944A patent/NZ237944A/xx unknown
- 1991-04-26 IE IE142491A patent/IE911424A1/en unknown
- 1991-04-26 HU HU911399A patent/HU210786B/hu not_active IP Right Cessation
- 1991-04-26 KR KR1019910006728A patent/KR910018349A/ko not_active Withdrawn
-
1994
- 1994-05-06 HU HU9401362A patent/HU9401362D0/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT57781A (en) | 1991-12-30 |
| AU648073B2 (en) | 1994-04-14 |
| IE911424A1 (en) | 1991-11-06 |
| FI911982A0 (fi) | 1991-04-24 |
| NZ237944A (en) | 1992-08-26 |
| HU210786B (en) | 1995-07-28 |
| JPH04225934A (ja) | 1992-08-14 |
| FI911982L (fi) | 1991-10-28 |
| EP0454146A1 (en) | 1991-10-30 |
| TW217414B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-12-11 |
| HU911399D0 (en) | 1991-10-28 |
| YU73391A (sh) | 1994-01-20 |
| KR910018349A (ko) | 1991-11-30 |
| FI911982A7 (fi) | 1991-10-28 |
| HU9401362D0 (en) | 1994-08-29 |
| IL97965A0 (en) | 1992-06-21 |
| CA2040855A1 (en) | 1991-10-28 |
| PT97483A (pt) | 1992-01-31 |
| AU7628291A (en) | 1991-11-07 |
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