MXPA97001807A - Granula compositions - Google Patents

Abstract

A granular composition comprising from 45 to 98% w / w of a water-insoluble particle is described, wherein from 10 to 75% of the water-insoluble particle is made from a water-soluble particulate material, having a size of medium particle by weight less than 20 microns and an oil absorption capacity of 60 to 180g / 100g, and from 10 to 75% of the water-insoluble particle is made of a water-insoluble particulate material, which has a size of medium particle by weight below 20 microns and an oil absorption of 200 to 350g / 100g, the granulated composition having a particle size, by screening analysis, of 95% below 600 microns, and 95% above of 40 micr

Description

GRANULATED COMPOSITIONS FIELD OF THE INVENTION The present invention relates to granular compositions, which provide "useful sensory-perceived benefits in toothpaste compositions.

BACKGROUND OF THE INVENTION The use of water as a binder for silica particles has been described in GB 1,365,516, and water is known to be a common binder for size enlargement (Handbook of Powder Technology - Vol. 1 - Particle Size Enlarge ent - page 41 , Table 2.3 - Elsevier). Formulations of toothpastes containing a granular composition comprising a water-insoluble material and a water-insoluble binder have been described in EP-B-269, 966. Such granulated compositions may contain functional substances such as drugs, enzymes and agents. polishers. The problem addressed in this document is that it is not possible to agglutinate the particles within the granulated composition with water-soluble binders for use in formulations containing large amounts of water, such as toothpastes. The reason is that the water-soluble binder will dissolve in the aqueous component of the formulation and weaken the granulated composition, making it impossible to detect coarse particles in the mouth. The addition of a zinc salt, as an agent against the plate, to the composition of the toothpaste, has already been described in GB 1,373,001. It was found that granular compositions containing only water insoluble particles of a low to medium structure, particularly those with a low oil absorption capacity favored as abrasives and polishing agents in dental formulations, joined with water and dried, are too weak to survive the normal procedures in the manufacture of toothpastes, and, therefore, could not be felt in the subsequent procedure of tooth cleaning. In addition, granular compositions containing highly insoluble water-insoluble particles (ie, with a high oil absorption capacity) for example, silicas, favored as thickening agents in toothpaste formulations, are considered to have much more strength and provide unacceptable levels of sensation to the mouth.

To overcome this problem, it has been discovered that granulated compositions with sufficient strength can be prepared by mixing a highly structured water insoluble particle with low to medium structuring prior to the agglutination process. Surprisingly, the addition of powdered therapeutic agents, for example, zinc citrate, opacifiers, for example, titanium dioxide, and color pigments, have been shown to have no significant harmful effect on the properties of the granulated composition.

Normal Procedures The granular compositions of the invention are defined in terms of the properties and textures of the water-insoluble particles used to produce the agglomerate, its particle size distribution, and strength. i) Oil Absorption The oil absorption is determined by the ASTM spatula friction method (American Society of Test Material Standards D, 281).

The test is based on the principle of mixing flaxseed oil with the water-insoluble particle, rubbing with a spatula on a smooth surface, until a firm, putty type paste is formed, which will not break or separate when Cut with a spatula. The volume of oil used is converted to weight and expressed as grams of oil / 100 g of insoluble particles in water. ii) Average particle size in weight The average particle size by weight of the water-insoluble particle before agglomeration is determined using an X Malvern Mastersizer model, made by Malvern Instruments, Malvern, Worcestershire with the sample presentation unit MS15. This instrument uses the principle of dissemination, using a low energy He / Ne laser. The water-insoluble particles are ultrasonically dispersed in water for 5 minutes to form an aqueous suspension, and then mechanically agitated before they are subjected to the measurement procedure underlined in the instruction manual for the instrument, using a 45 mm lens in the detector system. The Malvern Particle Sizer measures the particle size by weight of the insoluble particle in water. The average particle size by weight (or-50) or 50th percentile, 10th percentile (d10) and 90th percentile (ó-90) are easily obtained from the data generated by the instrument. iii) Resistance of the Granular Composition The average particle size distribution by weight of the granulated composition is measured using the same Malvern instrument and the general method described above, but with the following differences: a) the granules are measured with a 300 mm lens in the detector system . b) an initial particle size distribution of the granules is taken without any ultrasonic dispersion (0-ultrasonic) that is, the sample dispersed only with mechanical agitation. c) the granules are dispersed using ultrasonics for two minutes, setting at 50, and then subjecting them to the usual measurement method (ultrasonic 50). d) the granules are dispersed using ultrasonics for two minutes, setting at 100, and then subjecting them to the usual measurement procedure (100 ultrasonics).

The dlO, d50 and d90 can then be interpolated from the particle size distribution generated by the instrument, and the larger the values obtained after exposure to the ultrasonics, the stronger the granulated composition. iv) Distribution of the particle size by sieve analysis A more accurate measurement of the true particle size distribution of the granulated composition is made using the sieve analysis. 100 g of the sample is placed on the upper sieve of a series of BS sieves, at intervals of about 50 microns between 45 and 600 microns. The sieves are arranged in the order of the thinnest in the background and the thickest at the top of the row. The sieves are placed in a mechanical vibrator, for example, Inclyno Mechanical Sieve Shaker by Pascall Engineering Co Ltd., covered with a lid and shaken for 10 minutes. Each sieve fraction is exactly weighed and the results are calculated: Waste% = weight of the waste * 100 weight of the sample Next, a particle size distribution can be plotted from the data.

General Description of the Invention It is a first object of the present invention to provide a granular composition comprising from 45 to 98% w / w of a water-insoluble particle, whereby from 10 to 75% of the water-insoluble particle is made of a material which is insoluble in water. insoluble particles in water, which has the average particle size by weight less than 20 microns and an absorbency of oil 60 to 180g / l00g, and selected from the group consisting of amorphous silicas, aluminas, calcium carbonates, phosphate dicalcium phosphate tribasic calcium, insoluble sodium metaphosphate, calcium pyrophosphates, hydroxyapatites, perlites, zeolites, magnesium carbonate, pumice, and 10 to 75% of water insoluble particles is made of a material water-insoluble particle which has a mean particle size per weight below 20 microns and an oil absorption of 200 to 350g / 100g, selected from the group consisting of amorphous silicas, low density aluminas and pearls and xpandidas, the granulated composition having a particle size, by sieve analysis, of 95% below 600 microns, and 95% above 40 microns.

This granulated composition is substantially free of organic or inorganic binder. It is preferable that the granulated composition should have a particle size distribution, as measured by the sieve analysis, so that 95% of the granules are less than 400 microns and 95% of the particles are above 100. microns, more preferably 150 microns. Due to the porous nature of the agglomerates, it is possible that these act as delivery vehicles for substances that provide cosmetic benefits, such as coloring pigments, flavors, perfumes or other cosmetics. The agglomerates may also contain other therapeutic and / or oral cosmetic and / or dental actives, and release them in the mouth. Such substances may be contained within the pores of the material. The inclusion of a material that has a therapeutic or cosmetic effect on the gums or teeth, or oral cavity, in these agglomerates, provides an additional benefit since by breaking or crushing these agglomerates, the therapeutic / cosmetic agent is slowly released, thus delivering the therapeutic agent over the entire mouth for a long period. Suitable examples of such therapeutic agents are zinc salts, such as zinc citrate; antimicrobial agents such as Triclosan; anti-caries agents such as sodium fluoride and sodium monofluorophosphate; agents against plaque formation such as stannous pyrophosphate, etc. In this respect, it has surprisingly been found that the inclusion of zinc citrate in the agglomerates (in an amount up to 15%, preferably up to 12% by weight of the agglomerates) significantly reduced the level of astringency, perceived by a group trained after trying a toothpaste with such agglomerates for its sensory properties. The addition of Ti02, as an opacifying agent, at a concentration of 1 to 5% w / w, usually at the expense of the water-insoluble particles, ensures that the granules have a white appearance, and therefore persist in the formulations of toothpaste with color. If colored granules are required, then you can be added color pigment food grade, for example pigment dispersions under the trade name Cosmenyl or pigment powders under the trade name Hostaperm or Cosmetic Pink RC 01 (D &C Red No. 30) supplied by Hoechst, to the composition of the granule, without affecting the strength of the same. If the titanium dioxide and the therapeutic agent are omitted from the granular composition, which contains abrasive and thickener silicas, then the coarse particles are invisible in the transparent gel formulations. In addition, the strength of the agglomerate can be varied over a wide variety of scales by changing the structure of the water-insoluble particle, i.e., the insoluble particles in water of low structure reduce the strength, while the insoluble particles in water of high structure increase the strength of the agglomerate. The use of water insoluble particles, which have proven to play an important role in toothpaste formulations, such as toothpaste abrasive silicas [e.g., Sorbosil AC77 (obtained from Crosfield Limited - England)], as The low / medium structure component is an added advantage, since such silicas are able to provide extra cleaning to the formulation and have good compatibility with the formulation. Actually, the insoluble particles particularly preferred water, which make up the granular composition are mixtures of synthetic thickening silicas, amorphous [for example, Sorbosil TC15 (obtainable from Crosfield Limited - England)] and abrasive silicas. The agglomerates must be insoluble in the medium of the composition of the toothpaste to which they are incorporated. In this context, "insoluble" means that it has an insufficient solubility at room temperature, since the agglomerates remain undissolved or substantially undissolved in the composition, so that its friability under the conditions of use of the composition and thus its ability to perform its cleaning / polishing function are not in a harmful way affected. Preferably, the level of insolubility of the agglomerates extends to their insolubility in the oral environment, where the composition is to be used, which may often contain higher levels of water, than, for example, a toothpaste, caused by the presence of saliva and added water frequently used in the brushing regime. When the granules are incorporated into a toothpaste composition, it is important that they break under the shear stresses generated by the toothbrush in a relatively short period, thereby eliminating the gritty feeling experienced by the user. This means, that the agglomerates must have a particle resistance, so that they will crush within the scale of shear and / or crushing forces, normally produced in the relevant brushing regime, since the considerably variable forces produced in a particular location for a time, they allow at least some of the agglomerates to remain intact enough to perform their cleaning function to a satisfactory degree.

It is still possible to develop the break time of the agglomerates, such as controlling the contact time for a given duration of brushing the composition, controlling the average deformation resistance of the agglomerates, for example, selecting a particular type of source of particulate materials and / or the manner in which they are agglomerated in the manufacturing process. When the agglomerates are broken under the action of shear and / or deformation forces, the resulting average particle size (diameter) will typically be less than about 40 microns. Such reduced particle sizes will generally prevent any gritty feeling in the mouth, and impart a feeling of polished teeth. It is another object of the present invention to provide a process for producing a granular composition wherein, from 10 to 75 parts by weight of a water-insoluble particulate material, having a mean particle size per weight of less than 20 microns and a capacity of of oil absorption from 60 to 180g / 100g and selected from the group consisting of amorphous silicas, aluminas, calcium carbonates, dicalcium phosphate, tribasic calcium phosphates, insoluble sodium metaphosphate, calcium pyrophosphates, hydroxyapatites, pearlites, zeolites, carbonate of magnesium, pumice, are mixed with 10 to 75 parts by weight of a particulate material insoluble in water, having a mean particle size per weight below 20 microns and an oil absorption of 200 to 350g / 100g, selected from the group consisting of amorphous silicas, low density aluminas and expanded perlites, then agglomerated with water, the resulting product being then dried. Preferably, the water-insoluble particulate powders are amorphous silica particles of high structure and low to medium, and a therapeutic agent is mixed therewith prior to agglomeration. If opaque granules are required, then Ti02 is added to the powder mixture. If colored granules are required, a pigment dispersion with a suitable color, food grade, can be added. By drying the product after agglomeration, a granular composition is obtained, which is stable in a toothpaste composition. Agglomeration can be achieved, for example, by tray granulation, extrusion, spray granulation or spinning disk granulation. Preferably, the agglomeration is operated in a tray granulator, when the ratio of water: solids (ie water-insoluble particles with optionally Ti02 / mixed therapeutic agent etc.) is on the scale of 1.1-1.35: 1. This relationship is important to obtain agglomerates of correct resistance, since below this, the material remains as a powder and above it a paste is formed. Afterwards, the agglomerates are dried. This drying can be carried out in various ways, for example, in an oven or in a fluidized bed. During this drying step, the required degree of resistance develops in the agglomerates. It has also been found that agglomeration can be obtained by compacting the powder mixture and in this process a drying step is not required. Therefore, another object of the present invention is to provide a process for producing a granular composition, wherein, from 10 to 75 parts by weight of a particulate water insoluble material, having a mean particle size by weight less than 20 microns and an oil absorption capacity of 60 to 180g / l00g, and is selected from the group consisting of amorphous silicas, aluminas, calcium carbonates, dicalcium phosphate, tribasic calcium phosphates, insoluble sodium metaphosphate, calcium pyrophosphates, hydroxyapatites, pearlites, zeolites, magnesium carbonate, pumice, are mixed with 10 to 75 parts by weight of a particulate material insoluble in water, having a mean particle size per weight below 20 microns and an oil absorption from 200 to 350g / 100g, selected from the group consisting of amorphous silicas, low density aluminas and expanded perlites, the resulting mixture being agglomerated by compaction. To be incorporated into toothpastes, it is important that virtually all particles are below 600 μm, preferably below 400 μm, since gritty particles give unpleasant sensation properties in the mouth. Therefore, a size reduction step using a minimum energy is required to avoid unnecessary breakage of the agglomerate. Then, one or more screening steps are desirable to ensure that no size oversize and also provide a background cut, for example, at 150 microns.

Specific Description of the Invention The present invention will be further illustrated in the following examples.

Comparative Example 1 Two highly structured silicas [Sorbosil TC15 (obtained from Crosfield Limited - England)] and a medium structure (almost low) [Sorbosil AC77 (obtained from Crosfield Limited -England)] were agglomerated individually, at a batch size of dust of 200g, laboratory scale with deionized water (water ratio: 1.33: 1 solids) using a Sirman CV6 mixer, supplied by Metcalfe Catering Equipment Ltd, Blaenau Ffestiniog, Víales. The resulting wet agglomerates were then dried in an oven at 150 ° C for 4 hours, moderately forced through a 420 micron sieve and sieved at 150 microns to adjust the particle size distribution. Silicas have the following properties: (*) - obtained from Crosfield Limited - England Granulated silicas after agglomeration have the following properties: Ultrasonic dlO d50 d90 Sorbosil TC15 0 268 415 549 50 249 410 553 100 70 265 469 Sorbosil AC77 0 16 187 346 50 3.2 10 37.4 100 2.9 8.5 21.2 The highly structured silica TC15 (obtained from Crosfield Limited - England) forms an agglomerate, which is too strong and will not break in the required time with brushing in a toothpaste composition, while the silica with a structure of medium / low AC77 (obtained from Crosfield Limited England), produces an agglomerate, which is too weak to survive the normal procedures in the manufacture of toothpastes.

Example 1 The silicas used in Comparative Example 1 were mixed together with titanium dioxide in the following matrix, which includes the individual silicas with TiO2: (*) - which is obtained from Joseph Crosfield & Sons - England Deionized water was added to the powder mixtures to give a water: solids ratio of 1.33 to 1 and the resulting 200g mixtures were agglomerated using a laboratory-scale Sir an CV6 mixer, supplied by Metcalfe Catering Equipment Ltd, Blaenau Ffestiniog, Wales.

The resulting wet agglomerates were then dried in an oven at 150 ° C for 4 hours, moderately forced through a 420 micron sieve and screened at 150 microns to adjust the particle size distribution. The resulting agglomerates have the following properties: Ultrasonic dlO d50 d90 Composition 1 0 258 404 555 50 254 389 547 100 128 309 500 Composition 2 0 228 370 542 50 201 355 530 100 118 277 474 Composition 3 0 207 351 534 50 167 320 509 100 5.3 73 220 Composition 4 0 176 324 506 50 4 15.6 71 100 3.4 11 29.8 Composition 5 0 8. 8 186 332 50 2. 8 9. 4 31. 6 100 2. 6 8. 3 21. 1 Compositions 1 and 5 show that the addition of Ti02 does not have any harmful effect on the strength of the agglomerate particle. It can be seen that the particle resistance varies according to the relative amounts of high and medium / low structure silicas present in the agglomerate. Compositions 1 and 2 are considered too strong, and compositions 4 and 5 too weak for a granule of optimum strength. Composition 3, since it is not considered optimal within the desired scale of resistance.

Example 2 The following powders were mixed together to give an intimate mixture: parts by weight parts by weight Sorbosil AC77 (*) 43.15 48.5 Sorbosil TC15 (*) 43.15 48.5 Titanium dioxide 3.0 3.0 Zinc trihydrate-citrate 10.7 or (*) - obtained from Crosfield Limited - England Water was added to this mixture to give a water: solids ratio of 1.33 to 1, the resulting mixture being granulated in a 100 liter CMG mixer / granulator manufactured by Eurovent Ltd, Fenton, Stoke-on-Trent, with an intermittent load of 6 kg. The resulting wet agglomerates were then partially dried for 30 minutes in a fluid bed dryer and terminated in a furnace for 2 hours at a temperature of 120 ° C. The particle size distribution was subjected by sieving to 150 and 400 microns. The properties of the granulated composition are presented below.

Ultrasonic dlO d50 d90 Composition 1 0 193 334 502 50 112 289 475 100 3.3 14.3 41.5 Composition 2 0 268 391 539 50 224 365 526 100 3.3 12 39 Clearly, the presence of zinc citrate has a small effect on the strength of the granular compositions, and the granules of this strength have been shown to survive the normal processing conditions used in the manufacture of toothpastes, they are stable and have good sensory properties in a toothpaste composition.

Examples 3-7: The following homogeneous powder mixtures were made: Deionized water was added to the powder mixes (200g) to give a water: solids ratio of 1.33 to 1, for examples 3, 4 and 7, and 0.72 to for examples 5 and 6. The resulting mixtures were agglomerated using a laboratory-scale Sirman CV6 mixer, supplied by Metcalfe Catering Equipment Ltd, Blaenau Ffestiniog, Wales. The resulting wet agglomerates were then dried in an oven at 150 ° C for 12 hours, moderately forced through a 420 micron sieve and screened at 150 microns to adjust the particle size distribution. The resulting agglomerates have the following properties: Ultrasonic dlO d50 d90 Example 3 0 186 306 488 50 14 222 425 100 3.8 23 62 Example 4 0 223 385 530 50 9.4 151 423 100 4 16 41 Example 5 0 32 233 460 50 11 128 376 100 3.9 17 45 Example 6 0 199 386 554 50 8 180 412 100 3 13 41 Example 7 0 190 346 532 50 30 286 510 100 4 16 46 Examples 8-10 The following homogeneous powder mixtures were made: I INNGRADIENT EJ. 8 EJ. 9 EJ. 10 SORBOSIL AC77 26.3 43.1 60.0 SORBOSIL C15 26. 3 43. 1 40 0 PYROPHOSPHATE OF 24. 6 POTASSIUM PIROPHOSPHATE OF 19.8 SODIUM ZINC TRIHYDRATE-CITRATE 10 .8 TITANIUM DIOXIDE 3.0 3.0 The powder mixes were fed through a Fitzpatrick Chilsonator model L83 roller compactor (manufactured by Fitzpatrick Company, Elmhurst, Illinois, USA), which was configured as Figure 1 in the article "Preconditioning process powders with dry granulation" by Calvin E. Johnson (The Fitzpatrick Company), cited in Powder and Bulk Engineering, December 1987. The upper sieve size was 425 microns and the lower sieve was 250 microns. The resulting agglomerate product had the following properties: Ultrasonic dlO d50 d90 Example 8 0 150 326 526 50 17 162 383 00 4 29 69 Example 9 0 176 331 530 50 74 292 516 100 6.9 72 314 Example 10 0 160 300 497 50 120 288 495 100 3 15 69 Examples 11-14 The following homogeneous powder mixtures were made: Deionized water was added to the powder mixtures (200g) to give a water: solids ratio of 1.33 to 1, for Examples 11, 12 and 14 and from 0.72 to 1 for Example 13. The resulting mixtures were agglomerated using a Sirman CV6 laboratory scale mixer, supplied by Metcalfe Catering Equipment Ltd, Blaenau Ffestiniog, Wales. The resulting wet agglomerates were then dried in an oven at 150 ° C for 12 hours, moderately forced through a 420 micron sieve and sieved at 150 microns to adjust the particle size distribution. The resulting agglomerates have the following properties: Ultrasonic dlO d50 d90 Example 11 0 197 354 526 50 10 213 465 100 3.3 15 50 Example 12 0 187 311 498 50 16 250 471 100 5 34 297 Example 13 0 190 333 518 50 14 210 455 00 4 24 69 Example 14 0 196 326 514 50 96 282 476 100 4 29 104 Examples 15-16 The following homogeneous powder mixtures were made: Deionized water was added to the powder mixes (200g) to give a water ratio: solids of 1.33 to 1. The resulting mixtures were agglomerated using a mixer of Sirman CV6 laboratory scale, supplied by Metcalfe Catering Equipment Ltd, Blaenau Ffestiniog, Wales. The resulting wet agglomerates were then dried in an oven at 150 ° C for 12 hours, moderately forced through a 420 micron sieve and screened at 150 microns to adjust the particle size distribution. The resulting agglomerates have the following properties: Ultrasonic dlO d50 d90 Example 15 0 219 379 536 50 194 355 524 100 6.7 43 186 Example 16 0 215 373 534 50 177 339 517 100 3 37 95 Examples 17-19 The following mixtures were made: Deionized water was added to the powder mixes (200g) to give a water: solids ratio of 1.33 to 1. With examples 17 and 19, the Cosmenyl pigment dispersions were added to the deionized mixing water, which was then added to the powder mixture. The resulting mixtures were agglomerated using a laboratory-scale Sirman CV6 mixer, supplied by Metcalfe Catering Equipment Ltd, Blaenau Ffestiniog, Wales. The resulting wet agglomerates were then dried in an oven at 150 ° C for 12 hours, moderately forced through a 420 micron sieve and screened at 150 microns to adjust the particle size distribution. The resulting agglomerates have the following properties: Ultrasonic dlO d50 d90 Example 17 0 182 301 487 50 41 251 447 00 4 22 62 Example 18 0 191 344 532 50 163 347 534 100 5.6 39 210 Example 19 0 192 345 537 50 77 285 511 100 4 19 49 Example 20 A toothpaste having the following composition was produced: INGREDIENT% BY WEIGHT Sorbitol 45 Water 22. .12 Sorbosil AC77 10. .0 Silica of the invention 7. .0 Sorbosil TC15 6. .0 PEG 1500 5. .0 SLS 1. .5 TÍO2 1 .0 Mint flavor DP5017 0 .5 SMPF 0 .8 SCMC 0 .8 Saccharin 0 .2 Sodium Benzoate 0 .08 The above formulations were made under vacuum, using conventional preparative procedures in a Lang mixer. In preparation 1, the flavor component was added on the side of the container, near the end of the formulation.

An identical additional preparation 2 was performed, with the exception that the flavor was added to the silica granule of the invention by means of a pipette, before its introduction to the toothpaste mixer. The granule of the invention, containing the flavor, was mixed dry with the other two silicas and the resulting powder mixture was added in portions for 40 minutes under a closed vacuum. The two pastas were then examined "blindly" by 6 people, who were asked to analyze the flavor properties. The 6 people established that the pasta 2 had a significantly stronger mint flavor, indicating that the granule of the invention can carry and deliver the flavor more effectively than by simply adding it to the dental platte mixture, separately.

Claims (10)

1. A granulated composition, characterized in that it comprises from 45 to 98% w / w of a water-insoluble particle, whereby from 10 to 75% of the water-insoluble particle is made of a water-insoluble particulate material, which has a average particle size per weight less than 20 microns and an oil absorption capacity of 60 to 180g / 100g, and is selected from the group consisting of amorphous silicas, aluminas, calcium carbonates, dicalcium phosphate, tribasic calcium phosphates, metaphosphate of insoluble sodium, calcium pyrophosphates, hydroxyapatites, pearlites, zeolites, magnesium carbonate, pumice, and 10 to 75% water-insoluble particles are made from a water-insoluble particulate material, which has a mean particle size by weight below 20 microns and an oil absorption of 200 to 350g / l00g, selected from the group consisting of amorphous silicas, low density aluminas and expanded perlites, the granulated composition endo a particle size, by screening analysis, 95% below 600 microns, and 95% above 40 microns.

2. The granulated composition according to claim 1, characterized in that it comprises from 1 to 5% w / w of Ti023.

The granulated composition according to claims 1 and 2, characterized in that it comprises up to 15% zinc citrate.

4. The granulated composition according to claims 1-3, characterized in that the agglomerate contains a material that has a therapeutic cosmetic dental benefit.

5. The granulated composition according to claims 1-3, characterized in that the material having a therapeutic cosmetic benefit is a flavoring compound.

6. The granular composition according to claims 1-3, characterized in that it comprises a high structure silica thickener and a low structure silica abrasive.

7. A process for producing a granular composition, according to claim 1, characterized in that from 10 to 75 parts by weight of a water-insoluble particulate material, having a mean particle size per weight of less than 20 microns and a capacity of oil absorption of 60 to 180g / 100g, and is selected from the group consisting of amorphous silicas, aluminas, calcium carbonates, dicalcium phosphate, tribasic calcium phosphates, insoluble sodium metaphosphate, calcium pyrophosphates, hydroxyapatites, pearlites, zeolites, Magnesium carbonate, pumice, are mixed from 10 to 75 parts by weight of a water-insoluble particulate material, which has a mean particle size per weight below 20 microns and an oil absorption of 200 to 350g / l00g , selected from the group consisting of amorphous silicas, low density aluminas and expanded perlites, then agglomerated with water, and the resulting product is then dried.

8. A process for producing a granular composition, characterized in that from 10 to 75 parts by weight of a water-insoluble particulate material, having a mean particle size per weight of less than 20 microns and an oil absorption capacity of 60 to 180g / l00g, and is selected from the group consisting of amorphous silicas, aluminas, calcium carbonates, dicalcium phosphate, tribasic calcium phosphates, insoluble sodium metaphosphate, calcium pyrophosphates, hydroxyapatites, pearlites, zeolites, magnesium carbonate, pumice, 10 to 75 parts by weight of a water-insoluble particulate material having a mean particle size per weight below 20 microns and an oil absorption of 200 to 350g / 100g, selected from the group consisting of Amorphous silicas, low density aluminas and expanded pearls, the resulting mixture agglomerated by compaction.

9. The process according to claim 7 or 8, characterized in that Ti02 and zinc citrate are added to the amorphous silica particles before agglomeration.

10. The process according to claim 7, characterized in that the agglomeration with water is carried out with a water: solids ratio of 1.1: 1 to 1.35: 1.