MXPA06015003A - Formas cristalinas de 1,2,2-trimetilhidrazida de acido (3r)-1-(2-metilalanil-d-triptofil)-3-(fenilmetil)-3- piperidincarboxilico. - Google Patents
Formas cristalinas de 1,2,2-trimetilhidrazida de acido (3r)-1-(2-metilalanil-d-triptofil)-3-(fenilmetil)-3- piperidincarboxilico.Info
- Publication number
- MXPA06015003A MXPA06015003A MXPA06015003A MXPA06015003A MXPA06015003A MX PA06015003 A MXPA06015003 A MX PA06015003A MX PA06015003 A MXPA06015003 A MX PA06015003A MX PA06015003 A MXPA06015003 A MX PA06015003A MX PA06015003 A MXPA06015003 A MX PA06015003A
- Authority
- MX
- Mexico
- Prior art keywords
- crystalline
- methylalanyl
- trimethylhydrazide
- phenylmethyl
- radiation
- Prior art date
Links
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- 229960004666 glucagon Drugs 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
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- 230000035790 physiological processes and functions Effects 0.000 description 1
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- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58375704P | 2004-06-29 | 2004-06-29 | |
| PCT/US2005/022408 WO2006016995A1 (en) | 2004-06-29 | 2005-06-22 | Crystal forms of (3r)-1-(2-methylalanyl-d-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06015003A true MXPA06015003A (es) | 2007-08-07 |
Family
ID=35064648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA06015003A MXPA06015003A (es) | 2004-06-29 | 2005-06-22 | Formas cristalinas de 1,2,2-trimetilhidrazida de acido (3r)-1-(2-metilalanil-d-triptofil)-3-(fenilmetil)-3- piperidincarboxilico. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7825138B2 (enExample) |
| EP (2) | EP1768976B1 (enExample) |
| JP (2) | JP5122950B2 (enExample) |
| KR (1) | KR101324340B1 (enExample) |
| CN (3) | CN1976921B (enExample) |
| CA (1) | CA2572325C (enExample) |
| IL (1) | IL180336A0 (enExample) |
| MX (1) | MXPA06015003A (enExample) |
| WO (1) | WO2006016995A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130281701A1 (en) | 2004-06-29 | 2013-10-24 | Helsinn Therapeutics (U.S.), Inc. | Crystal forms of anamorelin |
| CN1976921B (zh) * | 2004-06-29 | 2013-08-21 | 蓝宝石治疗公司 | (3r)-1-(2-甲基丙氨酰-d-色氨酰)-3-(苯甲基)-3-哌啶羧酸1,2,2-三甲基酰肼的晶形 |
| JO3353B1 (ar) | 2012-04-20 | 2019-03-13 | Ono Pharmaceutical Co | شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي |
| CA2900322C (en) * | 2013-02-21 | 2019-03-26 | Pfizer Inc. | Solid forms of the selective cdk4/6 inhibitor compound acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8h-pyrido[2,3-d]pyrimidin-7-one |
| HUE046894T2 (hu) | 2014-09-04 | 2020-04-28 | Helsinn Healthcare Sa | Anamorelinen alapuló gyógyászati kezelések |
| CN107001323A (zh) * | 2015-10-20 | 2017-08-01 | 江苏恒瑞医药股份有限公司 | 一种阿拉莫林的结晶形式及其制备方法 |
| US9837965B1 (en) | 2016-09-16 | 2017-12-05 | Peregrine Semiconductor Corporation | Standby voltage condition for fast RF amplifier bias recovery |
| US20220323430A1 (en) | 2019-08-30 | 2022-10-13 | Helsinn Healthcare Sa | Methods of manufacturing anamorelin tablets having improved stability |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR960705808A (ko) * | 1993-11-09 | 1996-11-08 | 조셉 에프. 디프리마 | 성장 호르몬의 방출을 촉진시키는 피페리딘, 피롤리딘 및 헥사하이드로-1H-아제핀(Piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone) |
| JP4425992B2 (ja) * | 1996-07-22 | 2010-03-03 | サファイア セラピューティクス，インコーポレイティド | 成長ホルモン放出特性を有する化合物 |
| WO1999036431A1 (en) * | 1998-01-16 | 1999-07-22 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6303620B1 (en) * | 1998-05-11 | 2001-10-16 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| CA2329881C (en) * | 1998-05-11 | 2010-03-16 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
| UA73530C2 (uk) * | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
| JP2007531769A (ja) * | 2004-03-30 | 2007-11-08 | サファイア セラピューティクス インコーポレイテッド | 成長ホルモン分泌促進薬を使用したｃ−反応性蛋白質の低減方法 |
| CN1976921B (zh) | 2004-06-29 | 2013-08-21 | 蓝宝石治疗公司 | (3r)-1-(2-甲基丙氨酰-d-色氨酰)-3-(苯甲基)-3-哌啶羧酸1,2,2-三甲基酰肼的晶形 |
-
2005
- 2005-06-22 CN CN2005800215163A patent/CN1976921B/zh not_active Expired - Lifetime
- 2005-06-22 EP EP05766869.1A patent/EP1768976B1/en not_active Expired - Lifetime
- 2005-06-22 CN CN201310308801.XA patent/CN103772483A/zh active Pending
- 2005-06-22 EP EP10185517.9A patent/EP2298760B1/en not_active Expired - Lifetime
- 2005-06-22 KR KR1020067026722A patent/KR101324340B1/ko not_active Expired - Lifetime
- 2005-06-22 WO PCT/US2005/022408 patent/WO2006016995A1/en not_active Ceased
- 2005-06-22 CA CA2572325A patent/CA2572325C/en not_active Expired - Lifetime
- 2005-06-22 CN CN201110251236.9A patent/CN102584937B/zh not_active Expired - Lifetime
- 2005-06-22 JP JP2007519301A patent/JP5122950B2/ja not_active Expired - Lifetime
- 2005-06-22 MX MXPA06015003A patent/MXPA06015003A/es active IP Right Grant
- 2005-06-22 US US11/165,598 patent/US7825138B2/en active Active
-
2006
- 2006-12-26 IL IL180336A patent/IL180336A0/en unknown
-
2010
- 2010-07-06 US US12/831,009 patent/US8466173B2/en active Active
-
2012
- 2012-06-14 JP JP2012134975A patent/JP5718286B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008505078A (ja) | 2008-02-21 |
| CN102584937A (zh) | 2012-07-18 |
| US7825138B2 (en) | 2010-11-02 |
| CA2572325A1 (en) | 2006-02-16 |
| US20110003996A1 (en) | 2011-01-06 |
| CN103772483A (zh) | 2014-05-07 |
| EP1768976B1 (en) | 2017-04-26 |
| EP2298760B1 (en) | 2015-08-05 |
| JP5718286B2 (ja) | 2015-05-13 |
| US8466173B2 (en) | 2013-06-18 |
| IL180336A0 (en) | 2007-07-04 |
| EP2298760A1 (en) | 2011-03-23 |
| CN1976921B (zh) | 2013-08-21 |
| JP2012188452A (ja) | 2012-10-04 |
| EP1768976A1 (en) | 2007-04-04 |
| WO2006016995A1 (en) | 2006-02-16 |
| CA2572325C (en) | 2013-08-27 |
| CN102584937B (zh) | 2017-03-01 |
| JP5122950B2 (ja) | 2013-01-16 |
| CN1976921A (zh) | 2007-06-06 |
| HK1105000A1 (en) | 2008-02-01 |
| US20070004638A1 (en) | 2007-01-04 |
| KR20070030222A (ko) | 2007-03-15 |
| KR101324340B1 (ko) | 2013-10-31 |
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| GB | Transfer or rights | ||
| FG | Grant or registration |