MXPA06013918A - Nuevos derivados de piperidina sustituidos con alquilo como inhidibores de la recaptacion del neurotransmisor de monoamina. - Google Patents
Nuevos derivados de piperidina sustituidos con alquilo como inhidibores de la recaptacion del neurotransmisor de monoamina.Info
- Publication number
- MXPA06013918A MXPA06013918A MXPA06013918A MXPA06013918A MXPA06013918A MX PA06013918 A MXPA06013918 A MX PA06013918A MX PA06013918 A MXPA06013918 A MX PA06013918A MX PA06013918 A MXPA06013918 A MX PA06013918A MX PA06013918 A MXPA06013918 A MX PA06013918A
- Authority
- MX
- Mexico
- Prior art keywords
- piperidin
- tetramethyl
- disorder
- pain
- pyridin
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 title claims abstract description 34
- 150000003053 piperidines Chemical class 0.000 title claims abstract description 7
- 239000003112 inhibitor Substances 0.000 title abstract description 5
- 230000001561 neurotransmitter reuptake Effects 0.000 title abstract description 3
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 16
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
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- 125000003545 alkoxy group Chemical group 0.000 claims description 8
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- 231100001274 therapeutic index Toxicity 0.000 description 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 1
- 125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 description 1
- 125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 150000003813 tropane derivatives Chemical class 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200400960 | 2004-06-18 | ||
| US58136004P | 2004-06-22 | 2004-06-22 | |
| PCT/EP2005/052733 WO2005123715A1 (en) | 2004-06-18 | 2005-06-14 | Novel alkyl substituted piperidine derivatives as monoamine neurotransmitter re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06013918A true MXPA06013918A (es) | 2007-03-07 |
Family
ID=37018704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA06013918A MXPA06013918A (es) | 2004-06-18 | 2005-06-14 | Nuevos derivados de piperidina sustituidos con alquilo como inhidibores de la recaptacion del neurotransmisor de monoamina. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20070232659A1 (enExample) |
| EP (1) | EP1761518A1 (enExample) |
| JP (1) | JP2008502653A (enExample) |
| CN (2) | CN101812056A (enExample) |
| AR (1) | AR049923A1 (enExample) |
| CA (1) | CA2570065A1 (enExample) |
| MX (1) | MXPA06013918A (enExample) |
| TW (1) | TW200603803A (enExample) |
| WO (1) | WO2005123715A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2685029A1 (en) * | 2007-04-26 | 2008-11-06 | Avalon Pharmaceuticals | Multi-ring compounds and uses thereof |
| WO2009156396A1 (en) * | 2008-06-27 | 2009-12-30 | Neurosearch A/S | Novel tetramethyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US20110263651A1 (en) * | 2008-11-26 | 2011-10-27 | Neurosearch A/S | Novel piperidine-butyramide derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA284097A (en) * | 1928-10-16 | Schonhofer Fritz | Pharmaceutical product | |
| US718124A (en) * | 1902-05-19 | 1903-01-13 | John B Heydt | Loaf-forming device. |
| US1760781A (en) * | 1926-12-20 | 1930-05-27 | Winthrop Chem Co Inc | Manufacture of new pharmaceutical products |
| DE490275C (de) * | 1926-12-20 | 1930-02-05 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung N-substituierter Amine der carbo- und heterocyclischen Reihen |
| NL21937C (enExample) * | 1926-12-20 | |||
| GB1393551A (en) * | 1972-04-21 | 1975-05-07 | Ciba Geigy Ag | Piperidine derivatives |
| JP3087763B2 (ja) * | 1990-11-30 | 2000-09-11 | 三井化学株式会社 | 新規な複素環式化合物およびそれを含有する医薬組成物 |
| DE4228792A1 (de) * | 1992-08-29 | 1994-03-03 | Hoechst Ag | Pyridylaminopiperidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und deren Verwendung als Fungizide |
| PL167185B1 (pl) * | 1992-09-09 | 1995-08-31 | Univ Lodzki | Sposób równoczesnego otrzymywania izomerycznych pochodnych 3-pirydynokarbonitrylu |
| US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
| US5852037A (en) * | 1995-11-13 | 1998-12-22 | Eli Lilly And Company | Method for treating anxiety |
| US5804622A (en) * | 1996-03-22 | 1998-09-08 | Ciba Specialty Chemicals Corporation | Monomeric N-piperidinylmelamines as stabilizers for chlorine-containing polymers |
| ES2128978B1 (es) * | 1996-04-01 | 2000-03-01 | Ciba Sc Holding Ag | Derivados de politriazina que contienen grupos de polialquilpiperidiniloxilo o polialquilpiperidinilamino. |
| EP1034174B1 (en) * | 1997-11-05 | 2003-08-13 | Neurosearch A/S | Azaring-ether derivatives and their use as nicotinic ach receptor modulators |
| JP3589160B2 (ja) * | 2000-07-07 | 2004-11-17 | 日本電気株式会社 | レジスト用材料、化学増幅型レジスト及びそれを用いたパターン形成方法 |
| EP1403255A4 (en) * | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | RHO KINASE INHIBITORS |
| WO2003062224A1 (en) * | 2002-01-17 | 2003-07-31 | Eli Lilly And Company | Aza-cyclic compounds as modulators of acetylcholine receptors |
| GB0308466D0 (en) * | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| JP2006523692A (ja) * | 2003-04-18 | 2006-10-19 | イーライ リリー アンド カンパニー | ５−ｈｔ１ｆ作用薬としての（ピペリジニルオキシ）フェニル、（ピペリジニルオキシ）ピリジニル、（ピペリジニルスルファニル）フェニル、および（ピペリジニルスルファニル）ピリジニル化合物 |
| EP1638939A2 (en) * | 2003-06-24 | 2006-03-29 | Neurosearch A/S | Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2004113334A1 (en) * | 2003-06-24 | 2004-12-29 | Neurosearch A/S | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| ES2421139T3 (es) * | 2003-07-30 | 2013-08-29 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias |
-
2005
- 2005-06-14 US US11/579,059 patent/US20070232659A1/en not_active Abandoned
- 2005-06-14 JP JP2007515946A patent/JP2008502653A/ja not_active Abandoned
- 2005-06-14 CN CN201010178208A patent/CN101812056A/zh active Pending
- 2005-06-14 EP EP05752808A patent/EP1761518A1/en not_active Withdrawn
- 2005-06-14 CA CA002570065A patent/CA2570065A1/en not_active Abandoned
- 2005-06-14 CN CNA2005800172613A patent/CN1960985A/zh active Pending
- 2005-06-14 MX MXPA06013918A patent/MXPA06013918A/es not_active Application Discontinuation
- 2005-06-14 WO PCT/EP2005/052733 patent/WO2005123715A1/en not_active Ceased
- 2005-06-17 AR ARP050102509A patent/AR049923A1/es unknown
- 2005-06-17 TW TW094120096A patent/TW200603803A/zh unknown
-
2009
- 2009-11-09 US US12/614,857 patent/US20100056567A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AR049923A1 (es) | 2006-09-13 |
| JP2008502653A (ja) | 2008-01-31 |
| CA2570065A1 (en) | 2005-12-29 |
| US20100056567A1 (en) | 2010-03-04 |
| US20070232659A1 (en) | 2007-10-04 |
| TW200603803A (en) | 2006-02-01 |
| EP1761518A1 (en) | 2007-03-14 |
| CN1960985A (zh) | 2007-05-09 |
| CN101812056A (zh) | 2010-08-25 |
| WO2005123715A1 (en) | 2005-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |