CA2570065A1 - Novel alkyl substituted piperidine derivatives as monoamine neurotransmitter re-uptake inhibitors - Google Patents
Novel alkyl substituted piperidine derivatives as monoamine neurotransmitter re-uptake inhibitors Download PDFInfo
- Publication number
- CA2570065A1 CA2570065A1 CA002570065A CA2570065A CA2570065A1 CA 2570065 A1 CA2570065 A1 CA 2570065A1 CA 002570065 A CA002570065 A CA 002570065A CA 2570065 A CA2570065 A CA 2570065A CA 2570065 A1 CA2570065 A1 CA 2570065A1
- Authority
- CA
- Canada
- Prior art keywords
- piperidin
- tetramethyl
- disorder
- pain
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000000217 alkyl group Chemical group 0.000 title claims abstract description 34
- 230000001561 neurotransmitter reuptake Effects 0.000 title claims abstract description 11
- 150000003053 piperidines Chemical class 0.000 title claims abstract description 7
- 239000003112 inhibitor Substances 0.000 title abstract description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 70
- 238000000034 method Methods 0.000 claims abstract description 48
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 16
- -1 trifluoromethoxy, cyano, hydroxy, amino Chemical group 0.000 claims description 73
- 239000000203 mixture Substances 0.000 claims description 50
- 150000003839 salts Chemical class 0.000 claims description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 29
- 208000002193 Pain Diseases 0.000 claims description 20
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 208000035475 disorder Diseases 0.000 claims description 15
- 125000004076 pyridyl group Chemical group 0.000 claims description 15
- 201000010099 disease Diseases 0.000 claims description 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 10
- 125000001072 heteroaryl group Chemical group 0.000 claims description 9
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 230000002265 prevention Effects 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000003342 alkenyl group Chemical group 0.000 claims description 7
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 7
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- KHNDLOHOJNKSNI-UHFFFAOYSA-N 3-bromo-2-chloro-6-(2,2,6,6-tetramethylpiperidin-4-yl)oxypyridine Chemical compound C1C(C)(C)NC(C)(C)CC1OC1=CC=C(Br)C(Cl)=N1 KHNDLOHOJNKSNI-UHFFFAOYSA-N 0.000 claims description 2
- UDTFENWHLKIODK-UHFFFAOYSA-N 3-bromo-2-methoxy-6-(2,2,6,6-tetramethylpiperidin-4-yl)oxypyridine Chemical compound C1=C(Br)C(OC)=NC(OC2CC(C)(C)NC(C)(C)C2)=C1 UDTFENWHLKIODK-UHFFFAOYSA-N 0.000 claims description 2
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- 229940095064 tartrate Drugs 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000004685 tetrahydrates Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 1
- 125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
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- GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200400960 | 2004-06-18 | ||
| DKPA200400960 | 2004-06-18 | ||
| US58136004P | 2004-06-22 | 2004-06-22 | |
| US60/581,360 | 2004-06-22 | ||
| PCT/EP2005/052733 WO2005123715A1 (en) | 2004-06-18 | 2005-06-14 | Novel alkyl substituted piperidine derivatives as monoamine neurotransmitter re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2570065A1 true CA2570065A1 (en) | 2005-12-29 |
Family
ID=37018704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002570065A Abandoned CA2570065A1 (en) | 2004-06-18 | 2005-06-14 | Novel alkyl substituted piperidine derivatives as monoamine neurotransmitter re-uptake inhibitors |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20070232659A1 (enExample) |
| EP (1) | EP1761518A1 (enExample) |
| JP (1) | JP2008502653A (enExample) |
| CN (2) | CN101812056A (enExample) |
| AR (1) | AR049923A1 (enExample) |
| CA (1) | CA2570065A1 (enExample) |
| MX (1) | MXPA06013918A (enExample) |
| TW (1) | TW200603803A (enExample) |
| WO (1) | WO2005123715A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010527915A (ja) * | 2007-04-26 | 2010-08-19 | アバロン ファーマシューティカルズ，インコーポレイテッド | 多重環化合物及びその用途 |
| EP2313394A1 (en) * | 2008-06-27 | 2011-04-27 | NeuroSearch A/S | Novel tetramethyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2010060852A1 (en) * | 2008-11-26 | 2010-06-03 | Neurosearch A/S | Novel piperidine-butyramide derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA284097A (en) * | 1928-10-16 | Schonhofer Fritz | Pharmaceutical product | |
| US718124A (en) * | 1902-05-19 | 1903-01-13 | John B Heydt | Loaf-forming device. |
| NL21937C (enExample) * | 1926-12-20 | |||
| US1760781A (en) * | 1926-12-20 | 1930-05-27 | Winthrop Chem Co Inc | Manufacture of new pharmaceutical products |
| DE490275C (de) * | 1926-12-20 | 1930-02-05 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung N-substituierter Amine der carbo- und heterocyclischen Reihen |
| GB1393551A (en) * | 1972-04-21 | 1975-05-07 | Ciba Geigy Ag | Piperidine derivatives |
| JP3087763B2 (ja) * | 1990-11-30 | 2000-09-11 | 三井化学株式会社 | 新規な複素環式化合物およびそれを含有する医薬組成物 |
| DE4228792A1 (de) * | 1992-08-29 | 1994-03-03 | Hoechst Ag | Pyridylaminopiperidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und deren Verwendung als Fungizide |
| PL167185B1 (pl) * | 1992-09-09 | 1995-08-31 | Univ Lodzki | Sposób równoczesnego otrzymywania izomerycznych pochodnych 3-pirydynokarbonitrylu |
| US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
| US5852037A (en) * | 1995-11-13 | 1998-12-22 | Eli Lilly And Company | Method for treating anxiety |
| US5804622A (en) * | 1996-03-22 | 1998-09-08 | Ciba Specialty Chemicals Corporation | Monomeric N-piperidinylmelamines as stabilizers for chlorine-containing polymers |
| TW438849B (en) * | 1996-04-01 | 2001-06-07 | Ciba Sc Holding Ag | Polytriazine derivatives containing polyalkyl-piperidinyloxy or polyalkylpiperidinylamino groups |
| CA2306477A1 (en) * | 1997-11-05 | 1999-05-20 | Neurosearch A/S | Azaring-ether derivatives and their use as nicotinic ach receptor modulators |
| JP3589160B2 (ja) * | 2000-07-07 | 2004-11-17 | 日本電気株式会社 | レジスト用材料、化学増幅型レジスト及びそれを用いたパターン形成方法 |
| EP1403255A4 (en) * | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | RHO KINASE INHIBITORS |
| EP1467986A1 (en) * | 2002-01-17 | 2004-10-20 | Eli Lilly And Company | Aza-cyclic compounds as modulators of acetylcholine receptors |
| GB0308466D0 (en) * | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| WO2004094380A1 (en) * | 2003-04-18 | 2004-11-04 | Eli Lilly And Company | (piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-ht1f agonists |
| EP1638939A2 (en) * | 2003-06-24 | 2006-03-29 | Neurosearch A/S | Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CA2530023A1 (en) * | 2003-06-24 | 2004-12-29 | Neurosearch A/S | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| RS53109B (sr) * | 2003-07-30 | 2014-06-30 | Rigel Pharmaceuticals Inc. | Jedinjenja 2,4 pirimidindiamina za upotrebu u tretmanu ili prevenciji autoimunih bolesti |
-
2005
- 2005-06-14 CN CN201010178208A patent/CN101812056A/zh active Pending
- 2005-06-14 CN CNA2005800172613A patent/CN1960985A/zh active Pending
- 2005-06-14 JP JP2007515946A patent/JP2008502653A/ja not_active Abandoned
- 2005-06-14 CA CA002570065A patent/CA2570065A1/en not_active Abandoned
- 2005-06-14 US US11/579,059 patent/US20070232659A1/en not_active Abandoned
- 2005-06-14 MX MXPA06013918A patent/MXPA06013918A/es not_active Application Discontinuation
- 2005-06-14 WO PCT/EP2005/052733 patent/WO2005123715A1/en not_active Ceased
- 2005-06-14 EP EP05752808A patent/EP1761518A1/en not_active Withdrawn
- 2005-06-17 TW TW094120096A patent/TW200603803A/zh unknown
- 2005-06-17 AR ARP050102509A patent/AR049923A1/es unknown
-
2009
- 2009-11-09 US US12/614,857 patent/US20100056567A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1761518A1 (en) | 2007-03-14 |
| AR049923A1 (es) | 2006-09-13 |
| TW200603803A (en) | 2006-02-01 |
| WO2005123715A1 (en) | 2005-12-29 |
| US20070232659A1 (en) | 2007-10-04 |
| CN1960985A (zh) | 2007-05-09 |
| MXPA06013918A (es) | 2007-03-07 |
| CN101812056A (zh) | 2010-08-25 |
| US20100056567A1 (en) | 2010-03-04 |
| JP2008502653A (ja) | 2008-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20120614 |