MXPA06010505A - Composiciones y conjugados, basados en polimeros, de inhibidores de ingreso de vih. - Google Patents

Info

Publication number

MXPA06010505A

MXPA06010505A MXPA06010505A MXPA06010505A MXPA06010505A MX PA06010505 A MXPA06010505 A MX PA06010505A MX PA06010505 A MXPA06010505 A MX PA06010505A MX PA06010505 A MXPA06010505 A MX PA06010505A MX PA06010505 A MXPA06010505 A MX PA06010505A

Authority

MX

Mexico

Prior art keywords

polymer

conjugate according

conjugate

group

poly

Prior art date

2004-03-15

Links

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• 239000000203 mixture Substances 0.000 title claims abstract description 103
• 239000002835 hiv fusion inhibitor Substances 0.000 title abstract description 3
• 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 69
• 238000000034 method Methods 0.000 claims abstract description 49
• 229920001223 polyethylene glycol Polymers 0.000 claims description 163
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 92
• 239000003112 inhibitor Substances 0.000 claims description 81
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• 239000003153 chemical reaction reagent Substances 0.000 claims description 58
• PEASPLKKXBYDKL-FXEVSJAOSA-N enfuvirtide Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(C)=O)[C@@H](C)O)[C@@H](C)CC)C1=CN=CN1 PEASPLKKXBYDKL-FXEVSJAOSA-N 0.000 claims description 54
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• 208000031886 HIV Infections Diseases 0.000 claims description 4
• 150000008064 anhydrides Chemical class 0.000 claims description 4
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• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 3
• WSNMPAVSZJSIMT-UHFFFAOYSA-N COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 Chemical compound COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 WSNMPAVSZJSIMT-UHFFFAOYSA-N 0.000 claims description 2
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical class C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 2
• 125000002947 alkylene group Chemical group 0.000 claims description 2
• 229920000765 poly(2-oxazolines) Polymers 0.000 claims description 2
• 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
• 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 2
• 125000004104 aryloxy group Chemical group 0.000 claims 2
• 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
• 229920001584 poly(acrylomorpholines) Polymers 0.000 claims 1
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• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 98
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