MXPA05010710A - Benzo[1,2,5]oxadiazoles y benzo[1,2,5]tiadiazoles utiles como agentes de tincion histopatologicos, agentes formadores de imagen y biomarcadores. - Google Patents
Benzo[1,2,5]oxadiazoles y benzo[1,2,5]tiadiazoles utiles como agentes de tincion histopatologicos, agentes formadores de imagen y biomarcadores.Info
- Publication number
- MXPA05010710A MXPA05010710A MXPA05010710A MXPA05010710A MXPA05010710A MX PA05010710 A MXPA05010710 A MX PA05010710A MX PA05010710 A MXPA05010710 A MX PA05010710A MX PA05010710 A MXPA05010710 A MX PA05010710A MX PA05010710 A MXPA05010710 A MX PA05010710A
- Authority
- MX
- Mexico
- Prior art keywords
- benzo
- agents
- oxadiazoles
- biomarkers
- thiadiazoles
- Prior art date
Links
- PDQRQJVPEFGVRK-UHFFFAOYSA-N 2,1,3-benzothiadiazole Chemical class C1=CC=CC2=NSN=C21 PDQRQJVPEFGVRK-UHFFFAOYSA-N 0.000 title abstract 2
- AWBOSXFRPFZLOP-UHFFFAOYSA-N 2,1,3-benzoxadiazole Chemical class C1=CC=CC2=NON=C21 AWBOSXFRPFZLOP-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000090 biomarker Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 239000012216 imaging agent Substances 0.000 title 1
- 238000010186 staining Methods 0.000 title 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- -1 5-(2-fluoro-ethylamino)-thiazol-2-yl Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials For Medical Uses (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Stringed Musical Instruments (AREA)
Abstract
La presente invencion se refiere a benzo[1,2,5]oxadiazoles y benzo[1,2,5]tiadiazoles novedosos de la formula (I), en donde X es O u S, R1 es 5-(2-fluoro-etilamino)-tiazol-2-ilo, 5-(2-18F-etilamino)-tiazol-2-ilo o un grupo de la formula (a) en donde Y es CH o N, R2 es NHCH3, NH11CH3, N(CH3)11CH3, N(CH3)2, N(11CH3)2, NH(CH2)nF, NH(CH2)n18F, N(CH3)-(CH2)nF o CONHC(CH2)n18F, O-(CH2)nF, O-(CH2)n18F, CONH(CH2)nF o CONH(CH2)n18F (n siendo en cada caso de 2 a 4), y R3 es hidroxi, alcoxi (C1-4), hidrogeno o nitro, en forma de base libre o en forma de sal de adicion de acido; su preparacion, su uso como marcadores en el diagnostico y composiciones que los contienen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0307855.7A GB0307855D0 (en) | 2003-04-04 | 2003-04-04 | Organic compounds |
| PCT/EP2004/003517 WO2004087684A1 (en) | 2003-04-04 | 2004-04-02 | Benzo[1,2,5]oxadiazoles and benzo [1,2,5]thiadiazoles useful as histopathological staining agents, imaging agents and biomarkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05010710A true MXPA05010710A (es) | 2005-12-12 |
Family
ID=9956218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05010710A MXPA05010710A (es) | 2003-04-04 | 2004-04-02 | Benzo[1,2,5]oxadiazoles y benzo[1,2,5]tiadiazoles utiles como agentes de tincion histopatologicos, agentes formadores de imagen y biomarcadores. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7632851B2 (es) |
| EP (1) | EP1613610B8 (es) |
| JP (1) | JP4486930B2 (es) |
| CN (1) | CN100402512C (es) |
| AT (1) | ATE435218T1 (es) |
| AU (1) | AU2004226216A1 (es) |
| BR (1) | BRPI0409174A (es) |
| CA (1) | CA2520278A1 (es) |
| DE (1) | DE602004021791D1 (es) |
| ES (1) | ES2329368T3 (es) |
| GB (1) | GB0307855D0 (es) |
| MX (1) | MXPA05010710A (es) |
| WO (1) | WO2004087684A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101137397A (zh) * | 2004-07-02 | 2008-03-05 | 匹兹堡大学高等教育联邦体系 | 淀粉样蛋白成像作为抗淀粉样蛋白疗法的功效的替代标记物 |
| JP2006241111A (ja) * | 2005-03-04 | 2006-09-14 | Univ Nihon | 新規ベンゾフロキサン及びその合成法 |
| EP2727965B1 (en) | 2006-10-27 | 2019-03-06 | Life Technologies Corporation | FLUOROGENIC pH SENSITIVE DYES AND THEIR METHOD OF USE |
| FR2919287B1 (fr) * | 2007-07-26 | 2012-10-12 | Pf Medicament | Nouveaux derives fluorescents de polyamines, leur procede de preparation et leurs applications en tant qu'outils de diagnostic dans le traitement des tumeurs cancereuses. |
| JP7193071B2 (ja) * | 2017-02-08 | 2022-12-20 | 国立大学法人東海国立大学機構 | 蛍光発光材料および紫外線吸収剤 |
| JP7045752B2 (ja) * | 2017-08-07 | 2022-04-01 | 信一郎 礒部 | 蛍光色素 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6168776B1 (en) * | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| KR19990008328A (ko) * | 1995-05-01 | 1999-01-25 | 제롬 코크란 | 알쯔하이머 질환의 생전 진단 및 생체내 영상화 및 아밀로이드침착 예방을 위한 아조 화합물 |
| JPH11228550A (ja) * | 1998-02-19 | 1999-08-24 | Doujin Kagaku Kenkyusho:Kk | イソチオシアネート化合物 |
| US6274119B1 (en) * | 1998-08-20 | 2001-08-14 | The Regents Of The Univ. Of California | Methods for labeling β-amyloid plaques and neurofibrillary tangles |
| AU8670201A (en) * | 2000-08-24 | 2002-03-04 | Univ Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| CN100422180C (zh) * | 2001-04-23 | 2008-10-01 | 宾夕法尼亚州大学理事会 | 淀粉样斑块聚集抑制剂和诊断成像剂 |
-
2003
- 2003-04-04 GB GBGB0307855.7A patent/GB0307855D0/en not_active Ceased
-
2004
- 2004-04-02 MX MXPA05010710A patent/MXPA05010710A/es not_active Application Discontinuation
- 2004-04-02 US US10/549,248 patent/US7632851B2/en not_active Expired - Fee Related
- 2004-04-02 BR BRPI0409174-4A patent/BRPI0409174A/pt not_active IP Right Cessation
- 2004-04-02 JP JP2005518689A patent/JP4486930B2/ja not_active Expired - Fee Related
- 2004-04-02 AU AU2004226216A patent/AU2004226216A1/en not_active Abandoned
- 2004-04-02 AT AT04725341T patent/ATE435218T1/de not_active IP Right Cessation
- 2004-04-02 DE DE602004021791T patent/DE602004021791D1/de not_active Expired - Fee Related
- 2004-04-02 ES ES04725341T patent/ES2329368T3/es not_active Expired - Lifetime
- 2004-04-02 CA CA002520278A patent/CA2520278A1/en not_active Abandoned
- 2004-04-02 WO PCT/EP2004/003517 patent/WO2004087684A1/en active Application Filing
- 2004-04-02 CN CNB2004800087067A patent/CN100402512C/zh not_active Expired - Fee Related
- 2004-04-02 EP EP04725341A patent/EP1613610B8/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7632851B2 (en) | 2009-12-15 |
| CN100402512C (zh) | 2008-07-16 |
| EP1613610B8 (en) | 2009-12-16 |
| JP2006521290A (ja) | 2006-09-21 |
| ES2329368T3 (es) | 2009-11-25 |
| JP4486930B2 (ja) | 2010-06-23 |
| ATE435218T1 (de) | 2009-07-15 |
| EP1613610A1 (en) | 2006-01-11 |
| DE602004021791D1 (de) | 2009-08-13 |
| US20060093551A1 (en) | 2006-05-04 |
| BRPI0409174A (pt) | 2006-04-11 |
| WO2004087684A1 (en) | 2004-10-14 |
| CN1768047A (zh) | 2006-05-03 |
| AU2004226216A1 (en) | 2004-10-14 |
| GB0307855D0 (en) | 2003-05-14 |
| EP1613610B1 (en) | 2009-07-01 |
| CA2520278A1 (en) | 2004-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |