ATE435218T1 - Benzo 1,2,5 oxadiazole und benzo 1,2,5 thiadiazole als histopathologische anfärbungsmittel, abbildungsmittel und biomarker - Google Patents
Benzo 1,2,5 oxadiazole und benzo 1,2,5 thiadiazole als histopathologische anfärbungsmittel, abbildungsmittel und biomarkerInfo
- Publication number
- ATE435218T1 ATE435218T1 AT04725341T AT04725341T ATE435218T1 AT E435218 T1 ATE435218 T1 AT E435218T1 AT 04725341 T AT04725341 T AT 04725341T AT 04725341 T AT04725341 T AT 04725341T AT E435218 T1 ATE435218 T1 AT E435218T1
- Authority
- AT
- Austria
- Prior art keywords
- benzo
- oxadiazoles
- thiadiazoles
- biomarkers
- imaging agents
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title 1
- 150000002244 furazanes Chemical class 0.000 title 1
- WNSDZBQLMGKPQS-UHFFFAOYSA-N hydron;piperazine-2-carboxylic acid;dichloride Chemical compound Cl.Cl.OC(=O)C1CNCCN1 WNSDZBQLMGKPQS-UHFFFAOYSA-N 0.000 title 1
- 239000012216 imaging agent Substances 0.000 title 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- PDQRQJVPEFGVRK-UHFFFAOYSA-N 2,1,3-benzothiadiazole Chemical class C1=CC=CC2=NSN=C21 PDQRQJVPEFGVRK-UHFFFAOYSA-N 0.000 abstract 1
- AWBOSXFRPFZLOP-UHFFFAOYSA-N 2,1,3-benzoxadiazole Chemical class C1=CC=CC2=NON=C21 AWBOSXFRPFZLOP-UHFFFAOYSA-N 0.000 abstract 1
- -1 5-(2-fluoro-ethylamino)-thiazol-2-yl Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials For Medical Uses (AREA)
- Stringed Musical Instruments (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0307855.7A GB0307855D0 (en) | 2003-04-04 | 2003-04-04 | Organic compounds |
| PCT/EP2004/003517 WO2004087684A1 (en) | 2003-04-04 | 2004-04-02 | Benzo[1,2,5]oxadiazoles and benzo [1,2,5]thiadiazoles useful as histopathological staining agents, imaging agents and biomarkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435218T1 true ATE435218T1 (de) | 2009-07-15 |
Family
ID=9956218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04725341T ATE435218T1 (de) | 2003-04-04 | 2004-04-02 | Benzo 1,2,5 oxadiazole und benzo 1,2,5 thiadiazole als histopathologische anfärbungsmittel, abbildungsmittel und biomarker |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7632851B2 (de) |
| EP (1) | EP1613610B8 (de) |
| JP (1) | JP4486930B2 (de) |
| CN (1) | CN100402512C (de) |
| AT (1) | ATE435218T1 (de) |
| AU (1) | AU2004226216A1 (de) |
| BR (1) | BRPI0409174A (de) |
| CA (1) | CA2520278A1 (de) |
| DE (1) | DE602004021791D1 (de) |
| ES (1) | ES2329368T3 (de) |
| GB (1) | GB0307855D0 (de) |
| MX (1) | MXPA05010710A (de) |
| WO (1) | WO2004087684A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005270026A1 (en) | 2004-07-02 | 2006-02-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of thioflavin radiolabeled derivatives in amyloid imaging for assessing anti-amyloid therapies |
| JP2006241111A (ja) * | 2005-03-04 | 2006-09-14 | Univ Nihon | 新規ベンゾフロキサン及びその合成法 |
| EP2727965B1 (de) | 2006-10-27 | 2019-03-06 | Life Technologies Corporation | FLUOROGENE pH-SENSITIVE FARBSTOFFE UND IHRE VERWENDUNG |
| FR2919287B1 (fr) * | 2007-07-26 | 2012-10-12 | Pf Medicament | Nouveaux derives fluorescents de polyamines, leur procede de preparation et leurs applications en tant qu'outils de diagnostic dans le traitement des tumeurs cancereuses. |
| JP7193071B2 (ja) * | 2017-02-08 | 2022-12-20 | 国立大学法人東海国立大学機構 | 蛍光発光材料および紫外線吸収剤 |
| JP7045752B2 (ja) * | 2017-08-07 | 2022-04-01 | 信一郎 礒部 | 蛍光色素 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6168776B1 (en) * | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| JPH11505526A (ja) * | 1995-05-01 | 1999-05-21 | ユニヴァーシティ・オヴ・ピッツバーグ | アルツハイマー病の死前診断ならびにアミロイド沈着のイン・ビボのイメージ化及び予防のためのアゾ化合物 |
| JPH11228550A (ja) * | 1998-02-19 | 1999-08-24 | Doujin Kagaku Kenkyusho:Kk | イソチオシアネート化合物 |
| CA2340394A1 (en) * | 1998-08-20 | 2000-03-02 | Jorge R. Barrio | Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles |
| JP5022554B2 (ja) * | 2000-08-24 | 2012-09-12 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体 |
| TWI245764B (en) * | 2001-04-23 | 2005-12-21 | Hank F Kung | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
-
2003
- 2003-04-04 GB GBGB0307855.7A patent/GB0307855D0/en not_active Ceased
-
2004
- 2004-04-02 AU AU2004226216A patent/AU2004226216A1/en not_active Abandoned
- 2004-04-02 WO PCT/EP2004/003517 patent/WO2004087684A1/en active Application Filing
- 2004-04-02 MX MXPA05010710A patent/MXPA05010710A/es not_active Application Discontinuation
- 2004-04-02 ES ES04725341T patent/ES2329368T3/es not_active Expired - Lifetime
- 2004-04-02 CN CNB2004800087067A patent/CN100402512C/zh not_active Expired - Fee Related
- 2004-04-02 JP JP2005518689A patent/JP4486930B2/ja not_active Expired - Fee Related
- 2004-04-02 CA CA002520278A patent/CA2520278A1/en not_active Abandoned
- 2004-04-02 AT AT04725341T patent/ATE435218T1/de not_active IP Right Cessation
- 2004-04-02 DE DE602004021791T patent/DE602004021791D1/de not_active Expired - Fee Related
- 2004-04-02 BR BRPI0409174-4A patent/BRPI0409174A/pt not_active IP Right Cessation
- 2004-04-02 EP EP04725341A patent/EP1613610B8/de not_active Expired - Lifetime
- 2004-04-02 US US10/549,248 patent/US7632851B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1613610A1 (de) | 2006-01-11 |
| JP4486930B2 (ja) | 2010-06-23 |
| CN100402512C (zh) | 2008-07-16 |
| MXPA05010710A (es) | 2005-12-12 |
| DE602004021791D1 (de) | 2009-08-13 |
| EP1613610B8 (de) | 2009-12-16 |
| JP2006521290A (ja) | 2006-09-21 |
| CA2520278A1 (en) | 2004-10-14 |
| GB0307855D0 (en) | 2003-05-14 |
| AU2004226216A1 (en) | 2004-10-14 |
| WO2004087684A1 (en) | 2004-10-14 |
| US20060093551A1 (en) | 2006-05-04 |
| EP1613610B1 (de) | 2009-07-01 |
| US7632851B2 (en) | 2009-12-15 |
| BRPI0409174A (pt) | 2006-04-11 |
| ES2329368T3 (es) | 2009-11-25 |
| CN1768047A (zh) | 2006-05-03 |
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