MXPA04011127A - Oligonucleotidos inmuno estimuladores metilados y metodos para utilizar los mismos. - Google Patents
Oligonucleotidos inmuno estimuladores metilados y metodos para utilizar los mismos.Info
- Publication number
- MXPA04011127A MXPA04011127A MXPA04011127A MXPA04011127A MXPA04011127A MX PA04011127 A MXPA04011127 A MX PA04011127A MX PA04011127 A MXPA04011127 A MX PA04011127A MX PA04011127 A MXPA04011127 A MX PA04011127A MX PA04011127 A MXPA04011127 A MX PA04011127A
- Authority
- MX
- Mexico
- Prior art keywords
- methylated
- lipid
- nucleic acid
- antigen
- formulation
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Oncology (AREA)
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- Mycology (AREA)
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- Zoology (AREA)
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- Biotechnology (AREA)
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- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37934302P | 2002-05-10 | 2002-05-10 | |
| US10/290,545 US20030125292A1 (en) | 2001-11-07 | 2002-11-07 | Mucoscal vaccine and methods for using the same |
| US46064603P | 2003-04-04 | 2003-04-04 | |
| PCT/CA2003/000678 WO2003094963A2 (en) | 2002-05-10 | 2003-05-12 | Methylated immunostimulatory oligonucleotides and methods of using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04011127A true MXPA04011127A (es) | 2005-07-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04011127A MXPA04011127A (es) | 2002-05-10 | 2003-05-12 | Oligonucleotidos inmuno estimuladores metilados y metodos para utilizar los mismos. |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1503793A2 (https=) |
| JP (2) | JP2005532315A (https=) |
| CN (1) | CN1665531A (https=) |
| AT (1) | ATE411815T1 (https=) |
| AU (2) | AU2003229434A1 (https=) |
| CA (2) | CA2485400A1 (https=) |
| DE (1) | DE60324270D1 (https=) |
| IL (1) | IL165107A0 (https=) |
| MX (1) | MXPA04011127A (https=) |
| WO (2) | WO2003094963A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| SI1077722T1 (sl) | 1998-05-22 | 2007-02-28 | Ottawa Health Research Inst | Metode in produkti za induciranje sluznicne imunosti |
| US7807803B2 (en) | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7605138B2 (en) | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7569553B2 (en) | 2002-07-03 | 2009-08-04 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7576066B2 (en) | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| CN1753687A (zh) | 2002-10-29 | 2006-03-29 | 科勒制药集团股份有限公司 | Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用 |
| AU2004275876B2 (en) | 2003-09-25 | 2011-03-31 | Coley Pharmaceutical Gmbh | Nucleic acid-lipophilic conjugates |
| PT2078080E (pt) | 2006-09-27 | 2015-09-18 | Coley Pharm Gmbh | Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada |
| JP2012507565A (ja) | 2008-10-30 | 2012-03-29 | グオ・ペイシュエン | Ｄｎａのシークエンシング及び他の用途のための、膜に組み込まれたウイルスｄｎａパッケージングモータタンパク質コネクタバイオセンサ |
| EP2484698A4 (en) * | 2009-09-28 | 2014-07-02 | Sysmex Corp | HYBRIDOMAS FOR THE PRODUCTION OF ANTIBODIES TO METHYLATED DNA AND USE THEREOF |
| CN109985234A (zh) * | 2019-04-12 | 2019-07-09 | 南华大学 | 一种梅毒螺旋体dna疫苗及其应用 |
| CA3183951A1 (en) * | 2020-07-14 | 2022-01-20 | Birgitte Rono | Apc targeting units for immunotherapy |
| CN116602920B (zh) * | 2023-04-18 | 2024-03-19 | 中国科学技术大学 | 一种透皮肽修饰、含有Ce6和CpG的脂质体及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1167379A3 (en) * | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| FI107974B (fi) * | 1999-07-14 | 2001-10-31 | Nokia Networks Oy | Menetelmä ja järjestelmä tilastointiin puhelinkeskusjärjestelmässä |
| EP1212085B1 (en) * | 1999-08-27 | 2007-10-31 | INEX Pharmaceuticals Corp. | Compositions for stimulating cytokine secretion and inducing an immune response |
| US20030119774A1 (en) * | 2001-09-25 | 2003-06-26 | Marianna Foldvari | Compositions and methods for stimulating an immune response |
| EP1441763A2 (en) * | 2001-11-07 | 2004-08-04 | Inex Pharmaceuticals Corp. | Mucosal adjuvants comprising an oligonucleotide and a cationic lipid |
-
2003
- 2003-05-12 EP EP03722134A patent/EP1503793A2/en not_active Withdrawn
- 2003-05-12 WO PCT/CA2003/000678 patent/WO2003094963A2/en not_active Ceased
- 2003-05-12 EP EP03722133A patent/EP1506010B1/en not_active Expired - Lifetime
- 2003-05-12 JP JP2004503046A patent/JP2005532315A/ja active Pending
- 2003-05-12 AU AU2003229434A patent/AU2003229434A1/en not_active Abandoned
- 2003-05-12 CA CA002485400A patent/CA2485400A1/en not_active Abandoned
- 2003-05-12 JP JP2004502917A patent/JP2005530761A/ja active Pending
- 2003-05-12 AT AT03722133T patent/ATE411815T1/de not_active IP Right Cessation
- 2003-05-12 DE DE60324270T patent/DE60324270D1/de not_active Expired - Fee Related
- 2003-05-12 CN CN038162296A patent/CN1665531A/zh active Pending
- 2003-05-12 CA CA002484266A patent/CA2484266A1/en not_active Abandoned
- 2003-05-12 WO PCT/CA2003/000679 patent/WO2003094828A2/en not_active Ceased
- 2003-05-12 MX MXPA04011127A patent/MXPA04011127A/es active IP Right Grant
- 2003-05-12 AU AU2003229433A patent/AU2003229433B2/en not_active Ceased
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2004
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2485400A1 (en) | 2003-11-20 |
| WO2003094828A3 (en) | 2004-02-05 |
| AU2003229434A1 (en) | 2003-11-11 |
| WO2003094963A2 (en) | 2003-11-20 |
| EP1503793A2 (en) | 2005-02-09 |
| AU2003229434A8 (en) | 2003-11-11 |
| DE60324270D1 (de) | 2008-12-04 |
| JP2005532315A (ja) | 2005-10-27 |
| ATE411815T1 (de) | 2008-11-15 |
| AU2003229433B2 (en) | 2008-04-24 |
| WO2003094828A2 (en) | 2003-11-20 |
| WO2003094963A3 (en) | 2004-02-12 |
| CN1665531A (zh) | 2005-09-07 |
| JP2005530761A (ja) | 2005-10-13 |
| EP1506010A2 (en) | 2005-02-16 |
| IL165107A0 (en) | 2005-12-18 |
| AU2003229433A1 (en) | 2003-11-11 |
| EP1506010B1 (en) | 2008-10-22 |
| CA2484266A1 (en) | 2003-11-20 |
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