MXPA03005954A - Metodo para tratar enfermedades fibroticas u otras indicaciones iiic. - Google Patents

Metodo para tratar enfermedades fibroticas u otras indicaciones iiic.

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Publication number
MXPA03005954A
MXPA03005954A MXPA03005954A MXPA03005954A MXPA03005954A MX PA03005954 A MXPA03005954 A MX PA03005954A MX PA03005954 A MXPA03005954 A MX PA03005954A MX PA03005954 A MXPA03005954 A MX PA03005954A MX PA03005954 A MXPA03005954 A MX PA03005954A
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Mexico
Prior art keywords
ylalkyl
alkyl
group
hydrogen
nitrogen
Prior art date
Application number
MXPA03005954A
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English (en)
Inventor
J Lavoie Edmond
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Alteon Inc
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Application filed by Alteon Inc filed Critical Alteon Inc
Publication of MXPA03005954A publication Critical patent/MXPA03005954A/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Diabetes (AREA)
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  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Gynecology & Obstetrics (AREA)
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Abstract

Se proporciona un metodo para tratar o mejorar ciertas enfermedades fibroticas u otras indicaciones en un animal, incluyendo un humano, que comprende administrar una cantidad eficaz de un compuesto de la farmulg I: Y-Ar+ .X en donde: a) Ar es una cadena de heteroarilo de cinco o seis miembros que tiene un primer nitrogeno en cadena y opcionalmente nitrogenos en cadena, segunda o tercero, con los atomos en cadena restantes siendo carbono, oxigeno o azufre, siempre que el primer nitrogeno de Ar sea un nitrogeno cuaternario y Ar no sea tiazolio, oxazolio imidazolio; b) Y se substituye en el primer nitrogeno en cadena, con la condicion de que si Ar es pirazola, indazola, (1,2,3)-triazola, benzotriazola, o (1,2,4)-triazola, el segundo nitrogeno en cadena se substituye, c) Y es un grupo de la formula -CH(R5)-R6 (como se prefiere en una modalidad), (a) en donde R5 es hidrogeno, alquil-, cicloalquil-, alquenil-, alquinil-, aminoalquil-, hidroxi [C1 a C6] alquilo, dialquilaminoalquil-, (N-[C6 o C10] aril)(N-alquil)aminoalquil-, piperidiri-1- ilalquil-, pirrolidin-1-ilalquilo, azetidinilalquilo, 4-alquilipiperazin-1-ilalquilo, 4-alquilpiperidin-1-ilalquilo, 4-[C6 o C10]arilpiperazin-1-ilalquilo, 4-[C6 o C10]arilpiperidin-1-ilalquilo, azetidin-1-ilalquilo, morfolin-4-ilalquilo, tiomorfolin-4-ilalquilo, piperazin-1-ilalquilo, piperidin-1-ilalquilo, [C6 o C10]arilo o independientemente el mismo que R6; (b) en donde R6 es (1) hidrogeno, alquilo (que puede substituirse por alcoxicarbonil)-, alquenilo, alquinilo, ciano-, cianoalquil-, o Rs, en donde Rs es un [C6 o C10]arilo o un heterociclo que contiene 4-10 atomos en cadena de las cuales 1-3 son heteroatomos seleccionados del grupo que consiste de un oxigeno, nitrogeno y azufre; o (2) un grupo de la formula -W-R7 (como se prefiere en una modalidad), en donde R7 es alquilo, alcoxi, hidroxi, o Rs (como se prefiere en una modalidad), en donde W es -C(=O)- o -S(O)2-; (3) un grupo de la formula -W-OR8 en donde R8 es hidrogeno o alquilo, (4) un grupo de la formula -CH(OH)R5; o (5) un grupo de la formula -W-N(R9)R10, en donde (a) R9 es hidrogeno y R10 es un alquilo o cicloalquilo, opcionalmente substituido; o (b) R9 es hidrogeno o alquilo y R10 es Ar*; o (c) R9 es hidrogeno a alquilo, R10 es un heterociclo que contiene 4-10 atomos en cadena de los cuales 1-3 son heteroatomos seleccionados del grupo que consista de oxigeno, nitrogeno y azufre; o (d) R9 y R10 son ambos grupas alquilo; o (e) R9y R10 junto con N forman un heterociclo que contiene 4-10 atomos en cadena que pueden incorporarse hasta un heteroatomo adicional seleccionado del grupo de N, O o S en la cadena, en donde el heterociclo se substituye opcionalmente; o (f) R9 y R10 son ambos hidrogeno 2 -NH2, y d) X es un anion farmaceuticamente aceptable que puede estar ausente si el compuesto proporciona una sal neutralizante, o una sal farmaceuticamente aceptable del compuesto.
MXPA03005954A 2000-12-29 2001-12-28 Metodo para tratar enfermedades fibroticas u otras indicaciones iiic. MXPA03005954A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25929400P 2000-12-29 2000-12-29
US25923801P 2001-01-02 2001-01-02
US29624601P 2001-06-06 2001-06-06
PCT/US2001/049833 WO2002067851A2 (en) 2000-12-29 2001-12-28 Method for treating fibrotic diseases or other indications iiic

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MXPA03005954A true MXPA03005954A (es) 2004-05-24

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MXPA03005954A MXPA03005954A (es) 2000-12-29 2001-12-28 Metodo para tratar enfermedades fibroticas u otras indicaciones iiic.

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US (2) US20020183365A1 (es)
EP (1) EP1355645A4 (es)
JP (1) JP2004525904A (es)
CA (1) CA2433425A1 (es)
MX (1) MXPA03005954A (es)
WO (1) WO2002067851A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276050B2 (en) * 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
US7838552B2 (en) 2004-06-04 2010-11-23 Forest Laboratories Holdings Limited Compositions comprising nebivolol
EP1750862B1 (en) 2004-06-04 2011-01-05 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
US7803838B2 (en) 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
ME02207B (me) * 2010-05-26 2016-02-20 Adverio Pharma Gmbh UPOTREBA sGC STIMULATORA, sGC AKTIVATORA, POJEDINAČNO I U KOMBINACIJI SA PDE5 INHIBITORIMA ZA TRETMAN SISTEMSKE SKLEROZE (SSc)
EP3024455A1 (en) 2013-07-25 2016-06-01 Bayer Pharma Aktiengesellschaft Sgc stimulators or sgc activators and pde5 inhibitors in combination with additional treatment for the therapy of cystic fibrosis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH335521A (de) * 1955-06-02 1959-01-15 Cilag Ag Verfahren zur Herstellung neuer quaternärer Salze
GB870633A (en) * 1958-05-14 1961-06-14 Ilford Ltd Pentamethincyanines
JPS55138742A (en) * 1979-04-17 1980-10-29 Fuji Photo Film Co Ltd Silver halide emulsion developing method
CA2210684C (en) * 1995-01-18 2008-01-15 Alteon Inc. Use of thiazolium compounds for preventing and reversing the formation of advanced glycosylation endproducts
US5656261A (en) * 1995-01-18 1997-08-12 The Picower Institute For Medical Research Preventing and reversing advanced glycosylation endproducts
NO315930B1 (no) * 1995-01-18 2003-11-17 Picower Inst For Medical Res T Anvendelse av tiazoliumforbindelser ved fremstilling av farmasöytiske preparater, preparater som inneholder forbindelsene, samt nyetiazoliumforbindelser
JP2001519813A (ja) * 1997-04-04 2001-10-23 スミスクライン・ビーチャム・コーポレイション カルシウム溶解性化合物
US6121300A (en) * 1998-11-10 2000-09-19 Wagle; Dilip R. Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts
DK1222171T3 (da) * 1999-10-06 2004-07-05 Torrent Pharmaceuticals Ltd Pyridiniumderivater, til regulering af aldersrelaterede og diabetesvaskulære komplikationer, fremgangsmåde til fremstilling af disse samt terapeutiske anvendelser deraf
WO2001025209A1 (en) * 1999-10-06 2001-04-12 Torrent Pharmaceuticals Ltd Pyridinium derivatives for the treatment of diabetic and aging-related vascular complications
AU2002253432B2 (en) * 2001-04-05 2005-03-24 Torrent Pharmaceuticals Ltd. Heterocyclic compounds for aging-related and diabetic vascular complications
US20030008817A1 (en) * 2001-07-03 2003-01-09 Tom Sander Cross-link reversing agent

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EP1355645A2 (en) 2003-10-29
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