MXPA03000394A - Metodo para determinar la estructura tridimensional de proteina a partir de una secuencia de proteina primaria. - Google Patents

Metodo para determinar la estructura tridimensional de proteina a partir de una secuencia de proteina primaria.

Info

Publication number
MXPA03000394A
MXPA03000394A MXPA03000394A MXPA03000394A MXPA03000394A MX PA03000394 A MXPA03000394 A MX PA03000394A MX PA03000394 A MXPA03000394 A MX PA03000394A MX PA03000394 A MXPA03000394 A MX PA03000394A MX PA03000394 A MXPA03000394 A MX PA03000394A
Authority
MX
Mexico
Prior art keywords
sequence
determining
alignment
template
primary
Prior art date
Application number
MXPA03000394A
Other languages
English (en)
Inventor
Derek A Debe
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of MXPA03000394A publication Critical patent/MXPA03000394A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Evolutionary Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Complex Calculations (AREA)

Abstract

Una modalidad preferida de la invencion, es un metodo para determinar una alineacion de secuencias preferida entre una secuencia en cuestion y una o mas secuencias molde, el cual comprende los pasos de: 1) alinear por lo menos dos secuencias de referencia para determinar uno o mas espacios de PUENTES/SALIENTES; 2) determinar una puntuacion de alineacion entre cada alineacion potencial de la secuencia en cuestion y cada secuencia molde con base en si una alineacion de secuencias determinada entre la secuencia en cuestion y cada secuencia molde crea o no un espacio de PUENTE/SALIENTE; y 3) determinar una alineacion de secuencias preferida con base en las puntuaciones de alineacion de la secuencia en cuestion con cada secuencia molde.
MXPA03000394A 2000-07-12 2001-07-12 Metodo para determinar la estructura tridimensional de proteina a partir de una secuencia de proteina primaria. MXPA03000394A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21801600P 2000-07-12 2000-07-12
PCT/US2001/022095 WO2002004685A1 (en) 2000-07-12 2001-07-12 Method for determining three-dimensional protein structure from primary protein sequence

Publications (1)

Publication Number Publication Date
MXPA03000394A true MXPA03000394A (es) 2004-09-13

Family

ID=22813417

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03000394A MXPA03000394A (es) 2000-07-12 2001-07-12 Metodo para determinar la estructura tridimensional de proteina a partir de una secuencia de proteina primaria.

Country Status (12)

Country Link
US (1) US20020150906A1 (es)
EP (1) EP1301636A4 (es)
JP (1) JP2004503038A (es)
KR (1) KR20030043908A (es)
CN (1) CN1447862A (es)
AU (1) AU2002218775A1 (es)
BR (1) BR0112448A (es)
CA (1) CA2415787A1 (es)
IL (1) IL153760A0 (es)
MX (1) MXPA03000394A (es)
WO (1) WO2002004685A1 (es)
ZA (1) ZA200300291B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270969B2 (en) * 1999-05-05 2007-09-18 Phylogica Limited Methods of constructing and screening diverse expression libraries
US7803765B2 (en) * 1999-05-05 2010-09-28 Phylogica Limited Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom
DK2230303T3 (da) * 1999-05-05 2013-04-15 Phylogica Ltd Isolering af biologiske modulatorer fra biodiverse genfragment-biblioteker
US20060036374A1 (en) * 2000-07-12 2006-02-16 Debe Derek A Method for determining three-dimensional protein structure from primary protein sequence
US6988039B2 (en) * 2003-02-14 2006-01-17 Eidogen, Inc. Method for determining sequence alignment significance
US8024127B2 (en) 2003-02-27 2011-09-20 Lawrence Livermore National Security, Llc Local-global alignment for finding 3D similarities in protein structures
DK1754052T3 (en) * 2004-06-03 2015-09-28 Phylogica Ltd Modulators with biochemical properties
KR100598606B1 (ko) * 2004-12-06 2006-07-07 한국전자통신연구원 단백질 구조 검색 시스템 및 단백질 구조 검색 방법
CA2638912A1 (en) * 2006-02-20 2007-08-30 Phylogica Limited Method of constructing and screening libraries of peptide structures
US20070244652A1 (en) * 2006-04-14 2007-10-18 Zhou Carol L Ecale Structure Based Analysis For Identification Of Protein Signatures: PSCORE
US20070244651A1 (en) * 2006-04-14 2007-10-18 Zhou Carol E Structure-Based Analysis For Identification Of Protein Signatures: CUSCORE
US20080059077A1 (en) * 2006-06-12 2008-03-06 The Regents Of The University Of California Methods and systems of common motif and countermeasure discovery
US8467971B2 (en) * 2006-08-07 2013-06-18 Lawrence Livermore National Security, Llc Structure based alignment and clustering of proteins (STRALCP)
CA2663545A1 (en) * 2006-09-19 2008-03-27 Phylogica Limited Neuroprotective peptide inhibitors of ap-1 signaling and uses thereof
US7983887B2 (en) 2007-04-27 2011-07-19 Ut-Battelle, Llc Fast computational methods for predicting protein structure from primary amino acid sequence
US8822409B2 (en) * 2007-06-20 2014-09-02 Phylogica Limited Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith
US8452542B2 (en) * 2007-08-07 2013-05-28 Lawrence Livermore National Security, Llc. Structure-sequence based analysis for identification of conserved regions in proteins
CN101714187B (zh) * 2008-10-07 2011-09-28 中国科学院计算技术研究所 一种规模化蛋白质鉴定中的索引加速方法及相应的系统
EP2448966B1 (en) 2009-07-03 2018-11-14 Avipep Pty Ltd Immuno-conjugates and methods for producing them
WO2011075786A1 (en) 2009-12-23 2011-06-30 Avipep Pty Ltd Immuno-conjugates and methods for producing them 2
CN105224825B (zh) * 2015-10-30 2018-03-06 景德镇陶瓷大学 一种融合局部和全局特征的rna序列描述方法

Also Published As

Publication number Publication date
IL153760A0 (en) 2003-07-06
CN1447862A (zh) 2003-10-08
EP1301636A1 (en) 2003-04-16
CA2415787A1 (en) 2002-01-17
EP1301636A4 (en) 2006-05-24
AU2002218775A1 (en) 2002-01-21
WO2002004685A1 (en) 2002-01-17
ZA200300291B (en) 2004-01-22
JP2004503038A (ja) 2004-01-29
BR0112448A (pt) 2003-09-23
US20020150906A1 (en) 2002-10-17
KR20030043908A (ko) 2003-06-02

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