MXPA02000721A - Soluciones y metodos para la inhibicion del dolor, la inflamacion y la degradacion de cartilago. - Google Patents

Soluciones y metodos para la inhibicion del dolor, la inflamacion y la degradacion de cartilago.

Info

Publication number
MXPA02000721A
MXPA02000721A MXPA02000721A MXPA02000721A MXPA02000721A MX PA02000721 A MXPA02000721 A MX PA02000721A MX PA02000721 A MXPA02000721 A MX PA02000721A MX PA02000721 A MXPA02000721 A MX PA02000721A MX PA02000721 A MXPA02000721 A MX PA02000721A
Authority
MX
Mexico
Prior art keywords
pain
solutions
cartilage degradation
inflammation
methods
Prior art date
Application number
MXPA02000721A
Other languages
English (en)
Inventor
P Palmer Pamela
Original Assignee
Omeros Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corp filed Critical Omeros Corp
Publication of MXPA02000721A publication Critical patent/MXPA02000721A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se presentan metodos y soluciones para inhibir una variedad de procesos de dolor e inflamacion en heridas de procedimientos quirurgicos generales que incluyen a los procesos artroscopicos y para inhibir la degradacion de cartilago. Las soluciones incluyen preferentemente multiples inhibidores del dolor y la inflamacion a concentracion diluida en un portador fisiologico, como por ejemplo solucion salina o solucion de Ringer lactato. La solucion puede aplicarse mediante la irrigacion continua de una herida durante un procedimiento quirurgico para la inhibicion preventiva del dolor y al tiempo que se evitan los efectos secundarios indeseables asociados con la aplicacion oral, intramuscular, subcutanea o intravenosa de mayores dosis de los agentes. Alternativamente, para combinaciones de inhibidores de la degradacion de cartilago, las soluciones pueden inyectarse directamente a la articulacion.
MXPA02000721A 1999-07-21 2000-07-21 Soluciones y metodos para la inhibicion del dolor, la inflamacion y la degradacion de cartilago. MXPA02000721A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14490499P 1999-07-21 1999-07-21
PCT/US2000/019864 WO2001007067A2 (en) 1999-07-21 2000-07-21 Solutions and methods for inhibition of pain, inflammation and cartilage degradation

Publications (1)

Publication Number Publication Date
MXPA02000721A true MXPA02000721A (es) 2004-03-10

Family

ID=22510670

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02000721A MXPA02000721A (es) 1999-07-21 2000-07-21 Soluciones y metodos para la inhibicion del dolor, la inflamacion y la degradacion de cartilago.

Country Status (13)

Country Link
EP (3) EP2322226A3 (es)
JP (2) JP2003505427A (es)
KR (2) KR20080099355A (es)
CN (2) CN101850120A (es)
AT (1) ATE399025T1 (es)
AU (1) AU779532B2 (es)
CA (2) CA2378880C (es)
DE (1) DE60039301D1 (es)
ES (1) ES2308985T3 (es)
HK (1) HK1046096B (es)
MX (1) MXPA02000721A (es)
RU (1) RU2271825C2 (es)
WO (1) WO2001007067A2 (es)

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Also Published As

Publication number Publication date
AU6116100A (en) 2001-02-13
EP2322226A2 (en) 2011-05-18
CN1402642A (zh) 2003-03-12
EP1200127B1 (en) 2008-06-25
HK1046096B (zh) 2008-08-29
JP2007077165A (ja) 2007-03-29
JP2003505427A (ja) 2003-02-12
WO2001007067A3 (en) 2001-03-29
EP1797869A2 (en) 2007-06-20
AU779532B2 (en) 2005-01-27
EP1797869A3 (en) 2008-07-23
EP2322226A3 (en) 2011-08-17
DE60039301D1 (de) 2008-08-07
KR20080099355A (ko) 2008-11-12
ATE399025T1 (de) 2008-07-15
CA2378880C (en) 2010-02-23
CA2689694A1 (en) 2001-02-01
KR20020012320A (ko) 2002-02-15
RU2271825C2 (ru) 2006-03-20
HK1046096A1 (en) 2002-12-27
ES2308985T3 (es) 2008-12-16
CA2378880A1 (en) 2001-02-01
WO2001007067A2 (en) 2001-02-01
RU2002104495A (ru) 2004-03-10
CN101850120A (zh) 2010-10-06
EP1200127A2 (en) 2002-05-02

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