MXPA01010368A - Transparent composition. - Google Patents

Transparent composition.

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Publication number
MXPA01010368A
MXPA01010368A MXPA01010368A MXPA01010368A MXPA01010368A MX PA01010368 A MXPA01010368 A MX PA01010368A MX PA01010368 A MXPA01010368 A MX PA01010368A MX PA01010368 A MXPA01010368 A MX PA01010368A MX PA01010368 A MXPA01010368 A MX PA01010368A
Authority
MX
Mexico
Prior art keywords
present
composition
transparent composition
water
skin
Prior art date
Application number
MXPA01010368A
Other languages
Spanish (es)
Inventor
Shuichi Tsunetsugu
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MXPA01010368A publication Critical patent/MXPA01010368A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/737Galactomannans, e.g. guar; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8129Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26Optical properties
    • A61K2800/262Transparent; Translucent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54Polymers characterized by specific structures/properties
    • A61K2800/542Polymers characterized by specific structures/properties characterized by the charge
    • A61K2800/5422Polymers characterized by specific structures/properties characterized by the charge nonionic

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

A transparent composition comprising a phospholipid, a water-soluble nonionic polymer, an oily component, and a cosmetic acceptable carrier. The concentration of the water-soluble nonionic polymer in the composition is less than 2.0 wt% by weight of the composition.

Description

TRANSPARENT COMPOSITION FIELD OF THE INVENTION The present invention relates to a transparent composition.
In particular, it deals with a transparent composition for moisturizing the skin.
BACKGROUND OF THE INVENTION Many personal care products currently available to consumers have as their primary goal to improve the health and / or the physical appearance of the skin. Among such skin care products, many seek to delay, minimize or even eliminate the histological changes of the skin that are usually associated with aging of the skin or environmental damage to human skin. In order to maintain or return to the skin a healthy and / or young state, usually, a treatment is given to the skin with a moisturizing agent. Wetting agents include various oily and wetting components, for example, glycol or glycerin. In general, the higher the concentration of these agents, the greater the effect of moisturizing the skin. However, increasing the level of said agents, in particular increasing the concentration of oily components used in emulsions, tends to cause a greasy feeling of the skin and may feel sticky. However, the reduction of such components can result in maldistribution of the wetting agent. In addition, surfactants in formulations can sometimes cause the skin to feel sticky. Phospholipids are known in the cosmetic and pharmaceutical industries as ingredients that offer moisture retention in the skin. Such phospholipids include ingredients that are derived from natural resources and synthetic ingredients. Recently, phospholipids have been used in various formulations, especially in emulsions (aqueous composition), due to the structural properties thereof as emulsifying and / or solubilizing agents. But it is possible that compositions that contain phospholipids and feel less greasy on the skin of the client are not accepted by consumers because they are less easy to spread and do not feel so "rich" when applied to the skin. In addition, due to their property of emulsifying agents, phospholipids are often used in compositions that are not transparent. Based on the foregoing, there is a need for a transparent composition to improve the condition of one's skin, maximizing the amount of the moisturizing agent, increasing the ease of spreading the composition on the skin, but without leaving a greasy feeling in whom he uses it.
BRIEF DESCRIPTION OF THE INVENTION The present invention is directed to a transparent composition that includes a phospholipid, a water-soluble non-ionic polymer, an oily component, and a cosmetically acceptable vehicle, in which the concentration of the water-soluble non-ionic polymer is less than 2.0% by weight of the composition. The transparent compositions containing the specified ingredients are useful for topical application and to give greater transparency and ease to spread the products and a pleasant sensation of the skin such as wetting without leaving a greasy feeling on the skin. In addition, the composition of the present invention is stable for storage even at high temperatures (around 40 ° C). The foregoing and other features, aspects and advantages of the present invention will be better understood upon reading the following description and the appended claims.
DETAILED DESCRIPTION OF THE INVENTION Although the specification concludes with claims that stand out in particular and clearly confer to the invention, it is considered that the present invention will be better understood with the following description.
All percentages, proportions and levels of the ingredients referred to in the present invention are based on the actual total amount of the composition, unless otherwise indicated. All measurements referred to in the present invention are made at 25 ° C unless otherwise indicated. All publications, patent applications and issued patents mentioned in the present invention are incorporated by reference in their entirety. The citation of any reference is not an admission as to any determination as its availability as a prior art to the invention that receives conformance. In the present invention, "comprising" means that other steps and other ingredients may be added that do not affect the final result. This term encompasses the terms "consisting of" and "consisting essentially of". In the present invention, "topical application" means applying or smearing a material on the surface of the skin. In the present invention, "cosmetically acceptable vehicle" means one or more compatible liquid or solid filler diluents, or encapsulating substances, dermatologically acceptable. In the present invention, "dermatologically acceptable" means that the compositions or components as described are suitable for use in contact with human skin without too much toxicity, incompatibility, instability, allergic irritation response among others, according to a reasonable ratio of risk-benefit. In the present invention "safe and effective amount" means an amount of a compound or composition sufficient to induce a positive benefit significantly, preferably a positive benefit in the appearance or sensation of the skin, including independently the benefits described in the present invention; but small enough to avoid serious side effects, that is, to offer a reasonable risk-benefit relationship, within the field of good judgment of an expert in the field. In the present invention, "blends" includes a simple combination of materials and any compound resulting from their combination. All ingredients such as active ingredients and other ingredients useful in the present invention can be categorized or described for their cosmetic and / or therapeutic benefit or by their postulated mode of action. Thus, the classifications in the present invention are made for convenience and are not intended to limit an ingredient to the particular use or uses that are raised or listed.
A. Transparent composition The present invention relates to a transparent composition that includes a phospholipid, a water-soluble non-ionic polymer, an oily component, and a cosmetically acceptable vehicle. In the present invention, "transparent composition" means that the composition has sufficient transparency to see from the other side when the composition is in a transparent glass or plastic bottle of approximately 1cm in diameter. The clear composition of the present invention has an apparent viscosity of from about 2 to about 10,000 centipoise (cps), preferably from about 3 to about 500 cps of viscosity, more preferably from about 4 to about 200 cps. Such viscosity can be determined using a CJV 5000 viscometer (AND, Tokyo, Japan). The viscosity is determined in the composition after the composition has been allowed to stabilize according to its preparation, it is usually a minimum of 24 hours under conditions of 25 ° C +/- 1 ° C and ambient pressure after the preparation of the composition. The viscosity is measured with the composition at a temperature of 25 ° C +/- 1 ° C.
B. Phospholipids The transparent composition of the present invention contains a phospholipid component. Without the limitations of the theory, it is believed that the phospholipid, generally known as an amphiphilic surfactant derived from natural sources, tends to sify and / or solubilize a composition with water and / or oils, because it is an amphiphilic component. .
Among the non-limiting examples of the phospholipids useful in the present invention are synthetic phospholipids such as dialloylphosphatidylcholine and dipalmitoyl phosphatidylcholine, phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine and sphingomyelin; Among the natural phospholipids are egg yolk lecithin and soy lecithin extracted from egg yolk and soy. Preferably, the phospholipid which is used in the present invention is lecithin. To be more specific, "lecithin" is 1, 2-diacyl-sn-glycero-3-phosphocolone and its derivatives, which does not mean a "lecithin" as a group of phospholipids that is commercially and industrially available. The phospholipid component is present in the composition from about 0.05% to about 5.0%, preferably from about 0.1% to about 1.0%.
C. Water-soluble non-ionic polymer The clear composition of the present invention contains a water-soluble non-ionic polymer. The water-soluble non-ionic polymer in the present invention is primarily a thickening agent. Without intending to be limited by theory, it is believed that water-soluble anionic or cationic polymers tend to interact with the phospholipids of the present invention, resulting in an sion. As a consequence, the sified composition is no longer transparent.
In one embodiment, the water soluble polymer described above can be used in both solid and liquid form. The liquid form of the polymer can be used in water solution. The water solution is also transparent. The concentration of the water-soluble non-ionic polymer is less than 2.0% by weight of the composition, preferably from about 0.01% to about 2.0%. Water-soluble non-ionic polymers useful in the present invention include polysaccharides, gums, polyacrylamide and mixtures thereof. Extract materials that are derived from natural sources (eg, locust bean gum) can be included as polymeric water soluble thickening agents. Locust bean gum can be obtained with Pentapharm Ltd, (Basel, Switzerland). (i) Polysaccharides: A large variety of polysaccharides can be used in the present composition. In the present invention, "polysaccharides" refers to water-soluble non-ionic polymers containing an axis of mono-saccharide units repeated, ie, carbohydrate). Examples of the polysaccharides include those selected from the group consisting of cellulose, hydroxyethylcellulose, hydroxyethylethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methylhydroxyethylcellulose, and mixtures thereof. Alkyl substituted celluloses are also useful in the present invention. In such polymers, the hydroxyl groups of the cellulose polymer are hydroxyalkylated (preferably hydroxyethylated or hydroxypropylated) to form a hydroxyalkylated cellulose which is then further modified with a C? 0-3 o chain or branched chain of the alkyl group through a ether link. Typically, these polymers are ethers of alcohols with single or branched C10-30 chains with hydroxyalkylocelluloses. Examples of alkyl groups useful in the present invention include those selected from the group consisting of stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl (i.e., alkyl groups derived from coconut oil alcohols), palmityl, oleyl , linoleyl, linolenyl, ricinoleyl, behenyl and mixtures thereof. The preferred water-soluble non-ionic polymers are hydroxyethylcellulose and cetylhydroxyethylcellulose. (ii) Gums: The gums that are useful in the present invention include materials that are mainly derived from natural sources. Examples of such gums are those selected from the group consisting of amylopectin, amylose, dextrin, guano gum, guano hydroxypropyl, (iii) Polyacrylamide polymers: Polyacrylamide polymers are also useful. Such non-ionic polyacrylamide polymers include polymers with substituted or unbranched branches. These polymers can be formed from a wide variety of monomers, including acrylamide and methacrylamide, which can or can not be substituted with one or two alkyl groups (preferably C1-5). Preferred are acrylate amide and methacrylate amide monomers, wherein the nitrogen of the measure is not substituted, or is substituted with one or two C1-5 alkyl groups (preferably methyl, ethyl or proyl), for example , acrylamide, methacrylamide, N-methacrylamide, N-methylmethacrylamide, N, N-dimethylmethacrylamide, N-isopropylacrylamide, N-isopropylmethacrylamide and N, N-dimethylacrylamide.
Poly (N-vinylpyrrolidones) with crosslinked bonds: Poly (N-vinylpyrrolidones) with crosslinked bonds which are useful in the present invention include those described in US Pat. No. 5,139,770, Shih et al. issued on August 18, 1992, and in the patent E.U.A. No. 5,073,614, Shih et al. issued on December 17, 1991; of which both are incorporated in the present invention by reference in their entirety. Such poly (N-vinylpyrrolidones) with crosslinked bonds usually contain from about 0.25% to about 1% by weight of the crosslinking agent selected from the group consisting of divinyl ethers and diallyl ethers of terminal diols containing about 2%. to about 12 carbon atoms, divinyl ethers and diallyl ethers of polyethylene glycols containing from about 2 to about 600 units, dienes containing from about 6 to about 20 carbon atoms, benzene divinyl, vinyl ethers and allyl pentaerythritol, among others. In general, these gelling agents have a viscosity of about 25,000 cps at about 40,000 cps when measured as a 5% aqueous solution at 25 ° C and using a Brookfield RVT viscometer with # 6 shaft at 10 rpm. Some examples of these commercially available polymers include ACP-1120, ACP-1179 and ACP-1180, from International Specialty Products (Wayne, NJ). (v) Other polymers: Other non-ionic water-soluble polymers which are useful in the present invention include polyvinyl alcohol, polyvinyl pyrrolidones, polyvinyl caprolactam and polyvinyl formamide.
D. Oil component The transparent composition of the present invention contains an oil component. The oily component is used as an emollient. The oily compound is present in the composition from about 0.05% to about 15.0%, preferably from about 0.1% to about 8.0%. The level of the oil component depends in particular on the desired form of the composition, such as lotion or gel. For example, if a composition with high viscosity is desired, the concentration of the oil component may be higher than in a low viscosity composition. Preferably, low viscosity compositions (eg, lotions) contain from about 0.1% to about 2.0% by weight of the oil component. High viscosity compositions (eg, gels) contain from about 1.0% to about 8.0% by weight of the oil component. A wide variety of suitable oily compounds are known and can be used in the present invention; You can find numerous examples in Saqarin, Cosmetics. Science and Technology. 2nd edition. Vol.1. pp. 32-43 (1972). Preferably, the oily component is a mixture of two or more of the oily components described below. Among the endless examples of suitable oily components are: (J) Mineral oil: Mining oil, also known as liquid petrolatum, is a mixture of liquid hydrocarbons obtained from petroleum. See The Merck Index. Tenth edition. Section 7048. p. 1033 (1983) and the International Cosmetic Ingredient Dictionarv, Fifth Edition, vol. 1 p. 415-417 (1993). which have been incorporated in their entirety by reference in the present invention. (ii) Petrolatum: Petrolatum is a colloidal system of non-single chain solid hydrocarbons and high boiling liquid hydrocarbons, in which most liquid hydrocarbons are kept within the micelles. See The Merck Index, Tenth edition, Paragraph 7047, p. 1033 (1983); Schindler, Drug. Cosmet. Ind., 89, 36-37, 76, 78-80, 82 (1961); and the International Cosmetic Ingredient Dictionary, Fifth Edition, vol. 1 p. 537 (1993), which have been incorporated in their entirety by reference in the present invention. (iii) Hydrocarbons with single branched branch containing from about 7 to about 40 carbon atoms: These materials include dodecane, isododecane, squalane, cholesterol, hydrogenated polyisobutylene, docosane (ie, C22 hydrocarbon), hexadecane , isohexadecane (a hydrocarbon commercially available as Permethyl® 101 A by Presperse, South Painfield, NJ). Also useful are C7-0 isoparaffins, which are branched hydrocarbons in C7- or (iv) C? -, 3o dicarboxylic acids: Include single chain and branched materials, as well as, aromatic derivatives (as used in the present invention with reference to the hydrophobic component, mono and polycarboxylic acids include unique chains , and branched chains and aryl carboxylic acids). Among the numerous examples are sebacate, diisopropyl adipate, isopropyl misristate, isopropyl palmitate, methyl palmitate, myristyl propionate, 2-ethylhexyl pamitate, isodecyl neopentanoate, di-2-ethylhexyl maleate, cetyl palmitate, myristyl myristate, stearyl stearate, isopropyl stearate. , methyl stearate, cetyl stearate, behenate behenyl, dioctyl maleate, dioctyl sebacate, diisopropyl adipate, cetyl octanate, diisopropyl dilinoleate. (v) Mono-, di- and tri-glycerides of carboxylic acids of C? -3n: For example, caprylic / capric triglyceride, caprylic / capric triglyceride PEG-6, caprylic / capric triglyceride PEG-8. (vi) Alkylene glycol esters of Ci-Cgo carboxylic acids: For example, mono and di esters of ethylene glycol, and mono and di esters of propylene glycol of C? -3o carboxylic acids, for example, ethylene glycol distearate. Mono and poly sugar esters and related materials: These esters are derived from a sugar or portion of polyol and one or more portions of carboxylic acid. Depending on the acid and component sugar, these esters may be in the form of liquids or solids at room temperature. Ester materials are described in more detail in the patent E.U.A. No. 2,831, 854; 4,005,196 and 4,005,195, Jandacek, issued on January 25, 1977; in the patent E.U.A. Nos. 5,306,516 and 5,306,515, Letton et al., Issued April 26, 1994; in the patent E.U.A. No. 5,305,514, Letton et al., Issued April 26, 1994; in the patent E.U.A. No. 4,797,300, Jandacek et al., Issued January 10, 1989; in the patent E.U.A. No. 3963,699, Rizzi et al, issued June 15, 1976; in the patent E.U.A. No. 4,518,772, Volpenhein, issued May 21, 1985; in the patent E.U.A. No. 4,517,360, Volpenhein, issued January 21, 1985. (viii) Vegetable oils and hydrogenated vegetable oils: Examples of vegetable oils and hydrogenated vegetable oils are safflower oil, castor oil, coconut oil, cottonseed oil, shad oil, palm kernel oil, palm oil. , peanut oil, soy bean oil, colaza oil, flaxseed oil, rice bran oil, pine oil, sesame oil, sunflower seed oil, hydrogenated safflower oil, hydrogenated castor oil, hydrogenated coconut oil, hydrogenated cottonseed oil, hydrogenated shad oil, hydrogenated palm kernel oil, oil hydrogenated palm oil, hydrogenated peanut oil, soybean hydrogenated oil, hydrogenated colaza oil, hydrogenated flaxseed oil, rice bran oil, hydrogenated sesame oil, hydrogenated sunflower seed oil, and mixtures thereof. (ix) Animal oils and fats: These oils include lanolin and its derivatives, and cod liver oil. Other materials: C-20 alkyl ethers of polypropylene glycols, carboxylic acid esters of polypropylene glycols, and di-C8-3 alkyl ethers are also useful.
E. Cosmetically acceptable vehicle The transparent compositions of the present invention contain a cosmetically acceptable vehicle. The vehicle may include a polyhydric alcohol and / or water solvent; preferably water. The composition contains from about 60% to about 99.8% of the vehicle, preferably from about 80% to about 99.5%. In one embodiment, the vehicle includes water and low alkyl alcohols. The lower alkyl alcohols which are useful in the present invention are the C-6 monohydric alkyl alcohols; preferably C2-3 alkyl alcohols. Among the preferred lower alkyl alcohols are ethyl alcohol, isopropyl alcohol and mixtures thereof. Preferred polyhydric alcohols that are useful in the present invention include, but are not limited to, polyalkylene glycols, more preferably alkylene polyols and their derivatives including glycerin, propylene glycol, dipropylene glycol, tripropylene glycol, polyethylene glycol and its derivatives, sorbitol, sorbitol hydroxypropyl, erythritol, treitol, pentaerythritol, xylitol, glucitol, mannitol, hexylene glycol, 1,3-butylene glycol, 1, 2,6-hexantriol, glycerol, ethoxylated glycerol, propoxylated glycerol, soluble collagen, gelatin, and mixtures derived. Preferred wetting agents are glycerin, 1,3-butylene glycol, glucose, trimethylglycine, urea or mixtures thereof; More preferably, glycerin or 1,3-butylene glycol.
F. Optional components The transparent composition of the present invention may include more optional components. In the present invention, "optional components" means one or more fillers, diluents, extenders and the like that are compatible and solid or liquid, whose use is common in cosmetics as defined in the present invention. The term "compatible" in the present invention means that the components of the compositions of this invention are capable of mixing with each other, such that there is no interaction that could significantly reduce the effectiveness of the composition under normal conditions. Optional components useful in the present invention include active and inactive components. The type of optional components used in the present invention depends on the type of product desired and may include various types of vehicles including, but not limited to, oil-in-water or water-in-oil emulsions. 1. - Active Optional components useful in the present invention may include active components. Some examples of such active ingredients include, but are not limited to, a vitamin B3 compound, antioxidants and radical scavengers, anti-inflammatory agents, antimicrobial agents, filters and sunscreens, and chelators. Other active ingredients useful in the present invention include vitamin K and vitamin A, for example the retinoid which is commercially available from many sources, such as Sigma Chemical Company (St. Louis, MO), and Goerhinger Mannheim (Indianapolis, IN) and which are described in U.S. Patent No. 4,677,120, Parish et al., issued June 30, 1987; in the patent E.U.A. No. 4,885,311, Parish et al., Issued December 5, 1989; in the patent E.U.A. No. 5,049,584, Purcell et al., Issued September 17, 1991; in the patent E.U.A. No. 5,124,356, Purcell et al., Issued June 23, 1992; and the redispatch of patent No. 34,075, Purcell et al., issued September 22, 1992. (i) Compounds of vitamin B3: Compounds of vitamin B3 favor the appearance of the skin by improving their condition, including the treatment of signs of skin aging, more specifically wrinkles, fine lines and pores. The compounds of vitamin B3 are preferably present from about 0.01% to about 50%, more preferably from about 0.1% to about 10%, and most preferably from about 1% to about 5%. In the present invention, "vitamin B3 compound" means a compound having the formula: wherein R is -CONH2 (for example, niacinamide), -CH2OH (for example, nicotinyl alcohol); and its derivatives. Examples of derivatives of vitamin B3 compounds include nicotinic acid esters, including non-vasodilating esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide and N- niacinamide oxide. Among the appropriate nicotinic acid esters are the nicotinic acid esters of from about 1 to about 22 carbons, preferably from about 1 to about 16 carbons, more preferably alcohols from about 1 to about 6 carbons. The alcohols may be appropriate with single or branched chain, cyclic or acyclic, saturated or unsaturated (including aromatic), and substituted or unsubstituted. The esters of preference are non-vasodilators. As used in the present invention, "non-vasodilator" means that the ester does not usually provide a visible response of redness after application to the skin (most of the general population would not show visible redness in response, although such compounds they can cause vasodilation not visible to the naked eye, that is, the ester is not rubifiaciente). Non-vasodilating esters of nicotinic acid include tocopherol nicotinate and inositol hexanicotinate; the tocopherol nicotinate is preferred. Other derivatives of the vitamin B3 compound are derivatives of niacinamide resulting from the substitution of one or more hydrogens of the amide groups. Among the variety of examples of niacinamide derivatives useful in the present invention are nicotinyl amino acids, which are derived, for example, from the reaction of an activated nicotinic acid compound (for example, nicotinic acid or nicotinyl chloride) with an amino acid. , and nicotinyl alcohol esters of organic baroxyl acids (eg, C? -? 8). Specific examples of such derivatives include nicotinuric acid (C8H8N2O3) and nicotinyl hydroxamic acid acid (C6H6N2O2), which have the following chemical structures: nicotinuric acid: Nicotinyl hydroxamic acid: Examples of nicotinyl alcohol esters include the nicotinyl alcohol esters of carboxylic acids, salicylic acid, acetic acid, glycolic acid, palmitic acid, and the like. Other examples of vitamin B3 compounds useful in the present invention are 2-chloronicotinamide, 6-aminonicotinamide, 6-methylnicotinamide, n-methyl-nicotinamide, n-n-diethylnicotinamide, n (hydroxymethyl) -nicotinamide, quinolinic acid measure , nicotinanilide, n-benzylnicotinamide, n-ethylnicotinamide, nifenaxone, nicotinaldehyde, isonicotinic acid, isonicotinic acid methyl, thionicotinamide, nialamide, urea 1- (3-pyridylmethyl), 2-mercaptonicotinic acid, nicomol and niaprazine. A number of examples of the aforementioned vitamin B3 compounds are known and can be obtained commercially from a large number of sources, for example, the Sigma Chemical Company (St. Louis, Mo); ICN Biomedicals, Inc. (Irvin, CA) and Aldrich Chemical Company (Milwaukee, Wl). In the present invention, one or more compounds of vitamin B3 can be used. The compounds of vitamin B3 are niacinamide and tocopherol nicotinate. More preferably niacinamide. When salts, derivatives and derivatives of niacinamide salts are used, those with the same efficacy as niacinamide are preferred in the methods for regulating the skin condition described in the present invention. The salts of the vitamin B3 compound are also useful in the present invention. Among the endless examples of salts of the vitamin B3 compound useful in the present invention are organic or inorganic salts, such as inorganic salts with anionic inorganic species (e.g., chloride, bromide, iodide, carbonate, preferably chlorurin), and organic salts of carboxylic acid (include the mono-, di- and tri- C 1-6 carboxylic acid salts, for example, acetate, salicylate, glycolate, lactate, malate, citrate, preferably salts of monocarboxylic acid such as acetate). These and other salts of the vitamin B3 compound can be prepared by experts, for example, as described by W.Wenner, "The Reaction of L-Ascorbic and D -asascorbic Acid with Nicotinic Acid and Its Amide", J. Organic Chemistrv . Vol. 14, 22-26 (1949). Wenner describes the synthesis of the ascorbic acid salt of niacinamide. Preferably, the nitrogen ring of the vitamin B3 compound is substantially chemically free (for example, unbound and / or unencumbered), or after it reaches the skin it remains chemically free ("chemically free") "hereinafter in the present invention is also referred to as" without complex "). More preferably, the vitamin B3 compound is essentially complex. It is for this reason that if the composition contains the vitamin B3 compound in a salt or in another complex form, such complex is preferably significantly reversible, with a greater preference essentially reversible, upon contact of the composition with the skin. For example, such a complex must be significantly reversible at a pH of about 5.0 to about 6.0. Such reversal capacity can be determined with normal skin. More preferably, the vitamin B3 compound is not substantially complex in the composition prior to contact with the skin. Example approaches to minimize or prevent the formation of unwanted complexes include the omission of materials that form irreversible complexes or other complexes with the compound of vitamin B3, pH adjustment, adjustment of ionic strength, the use of surfactants , and the formulation of the vitamin B3 compound and materials whose complexes are in different phases. Such approaches are adequate at the ordinary level of preparation in subject matter. Thus, it is preferred that the vitamin B3 compound contain a limited amount of the salt form and more preferably that it be free of salts of the vitamin B3 compound. Preferably the vitamin B3 compound contains less than about 50% of said salt, and more preferably is essentially free of the salt form. The vitamin B3 compound in the compositions presented in this invention having a pH of about 4 to about 7 generally contains less than about 50% of the salt.
The vitamin B3 compound can be included as a substantially pure material, or as an extract that is obtained by appropriate isolation, either physical and / or chemical from natural sources (eg, plants). The vitamin B3 compound is preferred if it is substantially pure, more preferably if it is essentially pure. (ii) Antioxidants and radical scavengers: Antioxidants and free radical scavengers are especially useful to provide protection against UV radiation that can cause an increase in texture changes in the stratum corneum of the epidermis, and against other environmental agents that can damage the skin. Antioxidants and radical scavengers such as tocopherol (vitamin E), tocopherol sorbate, tocopherol acetate and other tocopherol esters, propyl gallate, uric acid alkyl esters, amines (ie , N, N-diethylhydroxylamine, aminoguanidine), the sulfhydryl compounds (ie glutathione), the lichenoid pidolate, the arginine pilolate, the bioflavonoids, the lysine, the methionine, the proline, the superoxide dismutase, the silymarin, tea extracts, extracts of the skin and grape seeds, melanin, and rosemary extracts. Preferably, antioxidants and radical scavengers are selected from tocopherol sorbate and other tocopherol esters, more preferably tocopherol sorbate. For example, the use of tocopherol sorbate in topical compositions and applicable to the present invention is described in the patent E.U.A. No. 4,847,071, Bissett et al, issued July 11, 1989. (iii) Anti-inflammatory agents: The anti-inflammatory agents favor the benefits to the appearance of the skin, for example, to contribute to the uniformity and to an acceptable tone and / or skin color. Preferably, the anti-inflammatory agent includes a spheroidal anti-inflammatory agent and a non-spheroidal anti-inflammatory agent. The preferred spheroidal anti-inflammatory is hydrocortisone. The variety of compounds included in this group is well known to those skilled in the art. For a detailed description of the chemical structure, synthesis, side effects, etc. of non-spheroidal anti-inflammatory agents, refer to standard texts, including Anti-inflammatorv and Anti-Rheumatic Drugs. K.D. Rainsford, Vol. L-lll, CRC Press, Boca Raton, (1985), and Anti-inflammatorv Agents. Chemistry and Pharmacology. 1, R. A. Scherrer, et al., Academic Press, New York (1974), which are included in the present invention by reference. Those known as "natural" anti-inflammatory agents are also useful. Such agents can be obtained as an extract by appropriate isolation, either physical and / or chemical from natural sources (i.e., plants, fungi, products derived from microorganisms). For example, the alpha bisabolol, the aloe, the manjista (extracted from plants of the genus Commiphora, especially Commiphora Mukul), kola extract, chamomile and seaweed extract, and can also be used.
Antimicrobial agent: As used, "antimicrobial agents" means a compound capable of destroying microbes, preventing the development of microbes or preventing the pathogenic action of microbes. Antimicrobial agents are useful, for example, to control acne. Preferred antimicrobial agents useful in the present invention are benzoyl peroxide, erythromycin, tetracycline, clindamycin, azelaic acid, phenoxyethanol resorcinol sulfur, and Irgasan ™ DP 300 (Ciba Geigy Corp., E.U.A.). A safe and effective amount of the antimicrobial agent can be added to the compositions of the present invention, preferably from about 0.001% to about 10%, more preferably from about 0.01% to about 5%, and most preferably about from 0.05% to approximately 2%. (v) Solar filters and blogidoresres: Filters and sun blockers usually prevent excessive cell death and texture changes of the stratum corneum of the epidermis by exposure to ultraviolet light and can be added to the composition of the present invention. The appropriate filters and sun blockers can be organic.
A wide variety of filters and sunscreens are suitable for use in the present invention. Consult the patent E.U.A. No. 5,087,445, Haffey et al, issued February 11, 1992; the patent E.U.A. No. 5,073,372 and 5,073,371, Turner et al, issued December 17, 1991; and chapter VIII of Segarin, et al, pages 189 et seq., of Cosmetics Science and Technology (1972), which describes a large number of appropriate sunscreen filters. Preferred among the filters and sunscreens which are useful in the compositions are those selected from methoxycinnamate-p-2-ethylhexyl (commercially available as PARSOL MCX), butylmethoxydibenzoyl-methane, 2-hydroxy-4-methoxybenzo-phenone, octocrilene, oxybenzone, salicylate homomethyl, octyl salicylate, 4,4'-methoxy-t-butidibenzoylmethane, dibenzoilmentane 4-isopropyl, camphor 3-benzylidene, camphor 3- (4-methylbenzylidene), Eusolex ™ 6300, Octocrylene, Parsol 1789, and mixtures thereof. Filters and sunblocks are also particularly useful in the compositions as described in the US patent. No. 4,937,370, Sabatelli, issued June 26, 1990; and in the patent E.U.A. 4,999,186, Sabatelli, issued March 12, 1991. The filters and sunblocks described in said patents contain in a single molecular unit, two portions of different chromophores that exhibit different spectra of ultraviolet radiation absorption. One portion of the chromophore absorbs predominantly the UVB radiation margin and the other absorbs the UVA radiation margin to a large extent. These filters and sun blockers offer greater efficiency, a wider UV absorption, less penetration of the skin and a more lasting efficiency compared to conventional filters and sunblocks. The exact amounts vary according to the filter chosen and the desired Sun Protection Factor (SPF). The SPF is a common measure of sun protection against erythema. Consult the Federal Register, Vol. 43, No. 166, pp. 38206-38269, of August 25, 1978.
Chelators: As used in the present invention, "chelator" refers to a compound that reacts to remove a metal ion from a system by forming a complex so that the metal ion can not participate or catalyze chemical reactions. The inclusion of a chelator is especially useful to provide protection against UV radiation that can contribute to excessive cell death or changes in the texture of the skin and other environmental agents that can damage the skin. In the patent E.U.A. No. 5,487,884, Bissett et al, issued January 30, 1996; PCT section 91/16035 and 91/16034, Bush et al, published on October 31, 1995, describe examples of chelator useful in the present invention. Preferred chelators are furildioxin and its derivatives. 2. - Inactive ingredients In addition to the components described above, the composition of the present invention may include more preservatives and preservative enhancers such as water-soluble or solubilizable preservatives, including Germall 115, methyl, ethyl, propyl and butyl esters of hydroxybenzoic acid, benzyl alcohol, EDTA, Bronopol (2-bromo-2-nitropropane-1,3-diol), phenoxyethanol and phenoxypropanol; antifoam agents; binders; biological additives, multiplying agents, coloring agents; perfumes, essence oils, and derived solubilizers; natural extracts; compounds that stimulate the production of collagen.
G. METHOD FOR MAKING THE COMPOSITION The compositions of the present invention are generally prepared by any conventional method for producing skin care compositions, in particular for skin lotions, which are known in the art. Such methods include mixing the ingredients in one or more steps until a relatively uniform state is obtained, with or without heating, cooling and the like. Typical methods are described in, for example, Harry's Cosmeticology. 7th edition, Harry &; Wiikinson (Hill Publishers, London 1982).
EXAMPLES The following examples describe more fully and demonstrate the scope of the present invention. The examples are given only for the purpose of illustration and are not intended to be limitations of the present invention, since many variations are possible without breaking the spirit and scope of the invention. When possible, the ingredients are identified by the chemical name or INCI nomenclature, unless otherwise defined.
EXAMPLES 1 TO 3 Examples 1-3 of the clear composition are prepared from the following ingredients according to the formulated techniques shown below. % of that or unit The compositions described above are prepared in a suitable manner as follows: 1. Mix the ingredients of phase A with an appropriate blade stirrer in size and heat at about 70-75 ° C. 2.- Add the ingredients of phase B to the mixture of phase A and stir at approximately 70-75 ° C. 3.- Add phase C to the mixture of phase A-B at approximately 70-75 ° C. 4.- After cooling the mixture of the phase A-C, add the phase D. The descriptions represented with the previous examples have many advantages. For example, the transparent oil-in-water composition includes lecithin, a water-soluble non-ionic polymer, an oily component, the present invention offers greater transparency and ease to spread the products and a pleasant skin feel such as wetting of the skin without a greasy sensation. It is understood that the above detailed description of examples and principles of the present invention are presented for the sole purpose of illustrating, and that a large number of modifications and variations are apparent to those skilled in the art without departing from the spirit and scope of the invention. the invention; such modifications and apparent variations are included in the claims.

Claims (8)

NOVELTY OF THE INVENTION CLAIMS
1. - A transparent composition comprising a phospholipid, a water-soluble non-ionic polymer, an oily component and a cosmetically acceptable vehicle, characterized in that the concentration of the water-soluble non-ionic polymer is less than 2.0% by weight by weight of the composition.
2. The transparent composition according to claim 1, further characterized in that the concentration of the water-soluble non-ionic polymer is from about 0.02% to about 1.0% by weight.
3. The transparent composition according to claim 2, further characterized in that the viscosity of the transparent composition is from about 2 to about 10,000 cps.
4. The transparent composition according to claim 3, further characterized in that the viscosity of the transparent composition is from about 2 to about 500 cps.
5. The transparent composition according to claim 4, further characterized in that the viscosity of the transparent composition is around at about 200 cps.
6. - The transparent composition for skin care according to claim 1, further characterized in that it contains two or more oily components.
7. The transparent composition for skin care according to claim 6, further characterized in that the non-ionic water-soluble polymer is selected from a group consisting of hydroxyethylcellulose, cetyl hydroxyethylcellulose, locust bean gum, pullulan, gum of sclerot, termarindo seed gum, polyvinyl alcohol and polyvinylpyrorridridone.
8. A transparent composition for skin care characterized in that it comprises: a) from about 0.05 to about 5.0% by weight of a phospholipid; b) from about 0.01 to about 2.0% by weight of a non-ionic polymer soluble in water; and c) from about 0.05 to about 15.0% by weight of an oil component; wherein the viscosity of the composition is from about 2 to about 10,000 cps.
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DE10213956A1 (en) * 2002-03-28 2003-10-09 Beiersdorf Ag Cosmetic or pharmaceutical emulsions based on cross-linked oil droplets
DE10213957A1 (en) * 2002-03-28 2003-10-09 Beiersdorf Ag Crosslinked cosmetic or pharmaceutical phospholipid-containing gels and emulsions based on ethylene oxide-containing or propylene oxide-containing emulsifiers
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