DE10213956A1 - Cosmetic or pharmaceutical emulsions based on cross-linked oil droplets - Google Patents

Abstract

The invention relates to a process for the preparation of emulsions of the oil-in-water type, comprising a water phase and an oil phase, which are composed essentially of non-volatile constituents, containing at least one oil-in-water emulsifier and optionally a W / O Emulsifier and at least one crosslinking agent and, if appropriate, auxiliaries, additives and / or active ingredients, DOLLAR A d) obtainable in such a way that the water phase with its components to the oil phase with its components, the O / W emulsifier and optionally the W / O emulsifier, and where one or more crosslinkers are added to the water phase or the oil phase or to both phases, resulting in an increase in viscosity and crosslinked O / W emulsions are obtained, DOLLAR A e) available on the By bringing the mixture to a temperature inside or outside the phase inversion temperature range and then cooling it to room temperature, whereby there is an increase in viscosity and crosslinked O / W emulsions are obtained, DOLLAR A f) or obtainable by adding the crosslinker subsequently to a low-viscosity O / W emulsion and obtaining a crosslinked O / W emulsion.

Description

The present invention relates to oil-in-water emulsions, processes for their Manufacture and its use for cosmetic or pharmaceutical purposes. she are used especially topically, used as impregnation medium for wipes or foamed.

Cosmetic skin care means primarily that the natural Function of the skin as a barrier against environmental influences (e.g. dirt, chemicals, Microorganisms) and against the loss of the body's own substances (e.g. water, natural fats, Electrolytes) is strengthened or restored.

If this function is disturbed, the absorption of toxic or allergenic substances may increase Substances or for infestation of microorganisms and as a result too toxic or allergic skin reactions are coming.

The aim of skin care is also to reduce the fat and fat caused by daily washing Compensate for skin water loss. This is especially important when the natural Regeneration capacity is not sufficient. In addition, skin care products are said to exist Protect environmental influences, especially from the sun and wind, and skin aging delay.

Medical topical compositions typically contain one or more Medications in effective concentration. For the sake of simplicity, it becomes clean Differentiation between cosmetic and medical application and corresponding Products on the legal provisions of the Federal Republic of Germany referenced (e.g. cosmetics regulation, food and drug law).

Usual, and more and more widespread cosmetic and dermatological forms of preparation are gels.

In simple emulsions, one phase is finely dispersed, one phase Emulsifier shell enclosed droplets of the second phase (water droplets in W / O or Lipid vesicles in O / W emulsions). The droplet diameter of the ordinary Emulsions are in the range from approx. 200 µm to approx. 50 µm. Such "macro emulsions" are without further coloring additives, milky white colored and opaque.

In itself, the use of the usual cosmetic emulsifiers is harmless. Nevertheless, emulsifiers, like ultimately every chemical substance, can in individual cases allergic or hypersensitivity reactions cause.

So it is known that certain light dermatoses by certain emulsifiers, but also triggered by various fats and simultaneous exposure to sunlight become. Such light dermatoses are also called "Mallorca acne". A task the present invention was therefore to develop sun protection products.

The present invention thus relates to cosmetic and special embodiments dermatological light protection preparations, in particular cosmetic cosmetics and dermatological sunscreen preparations.

The harmful effect of the ultraviolet part of solar radiation on the skin is well known. During rays with a wavelength that is less than 290 nm (the so-called UVC range), absorbed by the ozone layer in the earth's atmosphere cause rays in the range between 290 nm and 320 nm, the so-called UVB area, an erythema, a simple sunburn or even more or less severe burns.

In general, as a maximum of the erythema effectiveness of sunlight considered narrower range around 308 nm.

To protect against UVB radiation, numerous compounds are known in which it mostly derivatives of 3-benzylidene camphor, 4-aminobenzoic acid, the Cinnamic acid, salicylic acid, benzophenone and also 2-phenylbenzimidazole is.

Also for the range between about 320 nm and about 400 nm, the so-called UVA Area, it is important to have filter substances available because of that too Rays can cause damage. So it is proven that UVA radiation to a Damage to the elastic and collagen fibers of the connective tissue leads to what the Skin ages prematurely, and that it is the cause of numerous phototoxic and photo-allergic reactions can be seen. The harmful influence of UVB radiation can be intensified by UVA radiation.

However, UV radiation can also lead to photochemical reactions, in which case the photochemical reaction products interfere with skin metabolism.

To prevent these reactions, the cosmetic or dermatological Formulations additional antioxidants and / or radical scavengers are incorporated.

UV absorbers or UV reflectors are the most inorganic pigments are known to be used in cosmetics to protect the skin from UV rays. These are oxides of titanium, zinc, iron, zirconium, silicon, Manganese, aluminum, cerium and mixtures thereof, as well as modifications.

Crosslinked creams are also suitable for other cosmetic dermatological Applications, for example deodorants, so that the present invention in one Special embodiment of these creams as the basis for cosmetic deodorants concerns.

Cosmetic deodorants are used to eliminate body odor that arises when the odorless fresh sweat is decomposed by microorganisms. The Common cosmetic deodorants are based on different principles of action.

In so-called antiperspirants, astringents can - predominantly Aluminum salts such as aluminum hydroxychloride (aluminum chlorohydrate) - the formation of sweat be reduced.

By using antimicrobial substances in cosmetic deodorants, the Bacterial flora on the skin can be reduced. Ideally, only the smell causing microorganisms can be effectively reduced. The sweat flow itself is not affected by this, ideally only the microbial decomposition of the Sweat temporarily stopped.

Also the combination of astringents with antimicrobial substances in one and the same composition is common.

• 1. Sie sollen eine zuverlässige Desodorierung bewirken.
• 2. Die natürlichen biologischen Vorgänge der Haut dürfen nicht durch die Desodorantien beeinträchtigt werden.
• 3. Die Desodorantien müssen bei Überdosierung oder sonstiger nicht bestimmungsgemäßer Anwendung unschädlich sein.
• 4. Sie sollen sich nach wiederholter Anwendung nicht auf der Haut anreichern.
• 5. Sie sollen sich gut in übliche kosmetische Formulierungen einarbeiten lassen.

Deodorants should meet the following conditions:

• 1. They should cause reliable deodorization.
• 2. The natural biological processes of the skin must not be impaired by the deodorants.
• 3. The deodorants must be harmless in the event of an overdose or other improper use.
• 4. They should not accumulate on the skin after repeated use.
• 5. They should be easy to incorporate into common cosmetic formulations.

Both liquid deodorants, for example, are known and customary Aerosol sprays, roll-ons and the like as well as solid preparations, for example deodorant sticks ("Sticks"), powder, powder sprays, intimate cleansers, etc.

Also the use of creams as the basis for deodorant or antiperspirant active preparations are known. Their relatively high content of emulsifiers, with The disadvantages described have so far been a problem that has to be remedied.

Another object of the present invention was therefore to prepare preparations develop which as a basis for cosmetic deodorants or antiperspirants are suitable and do not have the disadvantages of the prior art.

Furthermore, it was an object of the invention to provide cosmetic bases for cosmetic To develop deodorants that are well tolerated by the skin.

It was also an object of the present invention to produce products based on cross-linked emulsions with the widest possible range of applications put. For example, the basics for preparation forms such as Cleaning products, face and body care preparations, but also pronounced medical-pharmaceutical dosage forms are created, for example Preparations against acne and other skin symptoms.

In a particular embodiment, the invention therefore relates Facial cleansing products, preferably make-up removers, for example eye make-up up remover or face care and body care creams / lotions, Make-up removing emulsions, cleansing creams / lotions, sun protection creams / lotions, Anti-wrinkle creams, hair creams, repellent creams, after-sun emulsions, shower creams, Aftershave emulsions, shaving creams, deodorant / AT emulsions, anti-acne creams / lotions.

Waterproof eye make-up, such as mascara, is on with make-up removers can only be removed satisfactorily with special surfactants. This However, surfactants often have only limited physiological tolerance. With a contact such substances with the mucous membrane, in particular the mucous membrane of the eyes, cause this Substances for irritation, which manifest themselves, for example, in reddening of the eyes. Reactions of this type are typical for products containing surfactants.

An object of the present invention was therefore to remedy such problems create.

In a further embodiment, the present invention relates to hair cosmetics Preparations. In particular, the present invention relates to hair cosmetics Preparations for the care of the hair and scalp. In a preferred embodiment The present invention relates to preparations which serve to remove the individual hair strong and / or to give the hair style overall hold and fullness.

Roughly generalized, human hair can be divided into living hair Part, the hair root, and the dead part, the hair shaft. The hair shaft in turn consists of the medulla, which, however, is due to the development history of the modern people has become insignificant and regressed and with thin Hair is often completely missing, as well as the cortex surrounding the medulla and the Entire of medulla and cortex enveloping cuticle.

In particular the cuticle, but also the keratinous area between the cuticle and Cortex as the outer shell of the hair are particularly exposed to environmental influences, by combing and brushing, but also by hair treatment, in particular Hair coloring and hair shaping, e.g. B. permanent wave method, exposed.

With particularly aggressive stress, for example bleaching with oxidants like hydrogen peroxide, in which the pigments distributed in the cortex are oxidatively destroyed the inside of the hair can also be affected. Should human hair is permanently colored, only come in practice oxidizing hair dyeing processes into consideration. Training takes place in oxidative hair dyeing of the dye chromophore through reaction of precursors (phenols, aminophenols, less often diamines) and bases (mostly p-phenylenediamine) with the Oxidizing agents, mostly hydrogen peroxide. Hydrogen peroxide concentrations will be around 6% usually used.

Usually it is assumed that in addition to the coloring effect also Bleaching effect takes place through the hydrogen peroxide. In oxidatively dyed human hair are, similar to bleached hair, microscopic holes in the places where Melanin granules, detectable. The fact is that the oxidizer Hydrogen peroxide not only with the color precursors, but also with the hair substance react and may cause damage to the hair.

Even washing your hair with aggressive tensides can stress the hair, at least its appearance or the appearance of the hairstyle as a whole decrease. For example, certain water-soluble hair components (e.g. Urea, uric acid, xanthine, keratin, glycogen, citric acid, lactic acid) by the Be washed out.

For these reasons, hair care cosmetics have been used for some time, which are intended to be rinsed out of the hair after exposure, partly those that should remain on the hair. The latter can be formulated in this way that they serve not only the care of the individual hair, but also that Improve the overall appearance of the hairstyle, for example by giving it Give hair more volume, fix the hairstyle over a longer period of time or improve his manageability.

The combability of the quaternary ammonium compounds, for example Improve hair decisively. Such connections pull on the hair and are often detectable on the hair after several washes.

However, the prior art lacked active ingredients and preparations which gave the damaged hair satisfactory care. Also Preparations that should give the hairstyle fullness often proved to be inadequate, at least they were unsuitable for use as hair care preparations. The Preparations of the prior art fixing hairstyle contain, for example, in Usually viscous ingredients that run the risk of feeling sticky awaken, which often has to be compensated by clever wording.

The task was therefore to remedy these disadvantages of the prior art create.

A particular object of the present invention was to make preparations based finely dispersed, cross-linked emulsions of the oil-in-water type with a possible to provide low emulsifier content, which does not have the disadvantages of Have state of the art and which for various cosmetic and / or dermatological applications, for example the uses described above can. Another object of the invention was the limited supply Preparations based on finely dispersed, crosslinked oil-in-water emulsions To enrich the state of the art.

Process for the preparation of O / W microemulsion gels by crosslinking Hydrophobically modified water-soluble polymers are described in WO 9628132 Service.

Microemulsions containing lecithin for cosmetic, pharmaceutical, parenteral Applications are from the literature and the patent system (see WO 9815255) known. It explains how microemulsions containing lecithin are based on ethylene oxide-free emulsifiers can be crosslinked to form the corresponding gels.

WO 0037042 describes gels which in addition to lecithin, an O / W and a W / O emulsifier included as well as water. Networking with hydrophobically modified water-soluble polymers to lecithin-containing emulsions is not described.

Another disadvantage of viscous O / W emulsions of the prior art is that they without thickeners (low-viscosity O / W emulsions) are advantageously fine-particle (for example PIT emulsions) and often only by adding the thickeners (polymers) as a result Interaction of the finely divided droplets with the thickener polymer backbone in pass over coarser O / W droplets. Appropriately dispersed active ingredients are therefore often less well distributed than before the thickener was added, since the droplets partially coalesce and form larger droplets or agglomerates. Furthermore, this can be done on the Skin lead to a difficult delivery of active ingredient or the emulsion forms disadvantageous Lipid films after evaporation of the water, which leads to a reduced absorption of the Emulsion residue leads. The addition of a crosslinker (which is the droplet size not / little influenced) or the combination of a crosslinking agent with one not crosslinking polymer (classic thickener, hydrocolloid) is not considered in this sense have been described advantageously.

These tasks are solved according to the invention.

• a) erhältlich auf die Weise, daß die Wasserphase mit ihren Bestandteilen zu der Ölphase mit ihren Bestandteilen, dem O/W-Emulgator und gegebenfalls dem W/O- Emulgator gegeben wird, und wobei ein Vernetzer oder mehrere Vernetzer in die Wasserphase oder die Ölphase oder in beide Phasen gegeben werden, wobei sich ein Viskositätsanstieg ergibt und vernetzte O/W- Emulsionen erhalten werden,
• b) erhältlich auf die Weise, daß man das Gemisch auf eine Temperatur innerhalb oder außerhalb des Phaseninversionstemperaturbereichs bringt und danach auf Raumtemperatur abkühlt, wobei sich ein Viskositätsanstieg ergibt und vernetzte O/W- Emulsionen erhalten werden,
• c) oder dadurch erhältlich, daß der Vernetzer nachträglich einer niedrigviskosen O/W- Emulsion zugesetzt wird und vernetzte O/W-Emulsionen erhalten werden.

The invention relates to a process for the preparation of emulsions of the oil-in-water type, comprising a water phase and an oil phase which is composed essentially of non-volatile constituents, comprising at least one oil-in-water emulsifier and, if appropriate, a W / O Emulsifier and at least one crosslinker, and optionally auxiliaries, additives and / or active ingredients,

• a) obtainable in such a way that the water phase with its constituents is added to the oil phase with its constituents, the O / W emulsifier and optionally the W / O emulsifier, and one or more crosslinkers are added to the water phase or the oil phase or be given in both phases, resulting in an increase in viscosity and crosslinked O / W emulsions,
• b) obtainable in such a way that the mixture is brought to a temperature within or outside the phase inversion temperature range and then cooled to room temperature, resulting in an increase in viscosity and crosslinked O / W emulsions being obtained,
• c) or obtainable by adding the crosslinker subsequently to a low-viscosity O / W emulsion and obtaining crosslinked O / W emulsions.

The droplets of the discontinuous oil phase are separated by one or more Crosslinking substances linked together. The network structure is characterized by at least one hydrophilic region, which has an extent that is suitable to bridge the distance between the emulsion droplets, and through at least one hydrophobic region, in particular at least two hydrophobic areas, which with the emulsion droplets in hydrophobic Able to interact. If only one hydrophobic area is present, Emulsions are formed in which entanglements of the hydrophilic domains are several Polymers occur. A cross-linked O / W emulsion is also obtained in this way. It is equally advantageous if the crosslinking substance is an independent one Gel network forms in which the emulsion droplets then through hydrophobic Interaction are recorded (then there are so-called associative thickeners before), or whether the cohesion of the network through networking with the Emulsion droplets in the nodes of the network is caused.

The droplet diameters of the preparations according to the invention are preferably in the areas mentioned at the beginning.

The droplet size distribution curve of the low viscosity emulsion changes Surprisingly not or only slightly compared to the crosslinked emulsion, in Contrary to the increase in viscosity of low-viscosity emulsions with classic Thicken where an increase in the original droplets is observed.

The invention therefore also relates to the use of crosslinkers Stabilization of the droplet size of low-viscosity O / W emulsions in the Increase in viscosity.

The crosslinking substances (one or more) advantageously used according to the invention generally follow structural schemes as follows:


where B symbolizes a hydrophilic region of the respective crosslinker molecule and A each represents hydrophobic regions, which may also be of a different chemical nature within a molecule.

But also structure schemes like


and analogously formed, even more complex structures definitely fall within the scope of the invention presented here.

Structural diagrams also fall within the scope of the invention presented as follows:




where Z represents a central unit, which can be hydrophilic or hydrophobic and generally consists of an oligo- or polyfunctional molecular residue.

Of course, crosslinkers with a higher degree of branching also fall within the scope of the present invention.

For example, Z in scheme (10) may consist of a glyceryl residue, the three OH- Functions pass into areas B, which in turn, for example Polyoxyethylene chains of the same or different lengths can represent, and their terminals OH group are esterified with a longer-chain fatty acid. Also partial substitution Glycerin is conceivable, whereby structures can arise, which scheme (9) correspond.

The hydrophilic groups B can advantageously be chosen so that the crosslinker is overall water-soluble or at least dispersible in water, in which case the hydrophobic portion of groups A should be overcompensated.

For the structure scheme (1), for example, the following more specific structure schemes can be followed:





where R ₁ , R ₂ , R ₃ , R ₄ , R ₅ and R _{6 can} independently represent branched or unbranched, saturated or unsaturated, cyclic or chain-shaped aliphatic, aromatic or heteroaromatic radicals, for example branched or unbranched or cyclic alkyl or alkanoyl radicals , Aryl or aroyl radicals substituted or unsubstituted by alkyl or aryl substituents or also alkylated or arylated organylsilyl radicals. x means numbers which allow the entire molecule to be soluble or at least dispersible in water, typically selected from the range greater than 10, advantageously from the range 20-300. a and b are numbers which are chosen as a function of x in such a way that the total molecule has at least sufficient water solubility or water dispersibility. In individual cases, for example if the crosslinking agent is selected from the group of the derivatized polysaccharides, x can also assume values which are significantly higher than 300, even several million. This is known per se to the person skilled in the art and requires no further explanation.

For the structure scheme (2), for example, the following more specific structure schemes can be followed:


where R ₁ , R ₂ and R _{3 can} independently represent branched or unbranched, saturated or unsaturated, cyclic or chain-like aliphatic, aromatic or heteroaromatic radicals, for example branched or unbranched or cyclic alkyl or alkanoyl radicals, substituted or unsubstituted by alkyl or aryl substituents Aryl or aroyl residues or also alkylated or arylated organylsilyl residues. x, y and z mean, independently of one another, numbers which allow the entire molecule to be soluble or at least dispersible in water, typically selected from the range greater than 10, advantageously from the range 20-300.

Partial substitution is also conceivable, where one or more of the indices x, y or z can assume the value zero and one or more of the radicals R ₁ , R ₂ or R ₃ can represent hydrogen atoms.

For the structure scheme (3), for example, the following more specific structure schemes can be followed:


where R ₁ , R ₂ , R ₃ and R _{4 can} independently represent branched or unbranched, saturated or unsaturated, cyclic or chain-shaped aliphatic, aromatic or heteroaromatic radicals, for example branched or unbranched or cyclic alkyl or alkanoyl radicals, with alkyl or aryl substituents Substituted or unsubstituted aryl or aroyl residues or also alkylated or arylated organylsilyl residues. u, v, w and x mean, independently of one another, numbers which allow the entire molecule to be soluble or at least dispersible in water, typically selected from the range greater than 10, advantageously from the range 20-300.

Of course, partial substitution is also conceivable here, where one or more of the indices u, v, w, x can assume the value zero and one or more of the radicals R ₁ , R ₂ , R ₃ or R ₄ can represent hydrogen atoms. The substances naturally change into other structural schemes.

For the structure scheme (9), for example, the following more specific structure schemes can be followed:


where R ₁ , R ₂ , R ₃ and R _{4 can} independently represent branched or unbranched, saturated or unsaturated, cyclic or chain-shaped aliphatic, aromatic or heteroaromatic radicals, for example branched or unbranched or cyclic alkyl or alkanoyl radicals, with alkyl or aryl substituents Substituted or unsubstituted aryl or aroyl residues or also alkylated or arylated organylsilyl residues. x and y mean, independently of one another, numbers which allow the entire molecule to be soluble or at least dispersible in water, typically selected from the range greater than 10, advantageously from the range 20-300.

For the structure scheme (10), for example, the following more specific structure schemes can be followed:




where R ₁ , R ₂ and R _{3 can} independently represent branched or unbranched, saturated or unsaturated, cyclic or chain-shaped aliphatic, aromatic or heteroaromatic radicals, for example branched or unbranched or cyclic alkyl or alkanoyl radicals, substituted by alkyl or aryl substituents or unsubstituted aryl or aroyl residues or also alkylated or arylated organylsilyl residues. x, y and z mean, independently of one another, numbers which allow the entire molecule to be soluble or at least dispersible in water, typically selected from the range greater than 10, advantageously from the range 20-300.

For the structure scheme (11), for example, the following more specific structure scheme can be followed:


where R ₁ , R ₂ , R ₃ and R _{4 can} independently represent branched or unbranched, saturated or unsaturated, cyclic or chain-shaped aliphatic, aromatic or heteroaromatic radicals, for example branched or unbranched or cyclic alkyl or alkanoyl radicals, with alkyl or aryl substituents Substituted or unsubstituted aryl or aroyl residues or also alkylated or arylated organylsilyl residues. u, v, w and x mean, independently of one another, numbers which allow the entire molecule to be soluble or at least dispersible in water, typically selected from the range greater than 10, advantageously from the range 20-300. k, l, m and n can independently represent numbers from 0 to 50.

For the structure scheme (12), for example, the following more specific structure scheme can be followed:


where R ₁ , R ₂ , R ₃ , R ₄ and R _{5 can} independently represent branched or unbranched, saturated or unsaturated, cyclic or chain-like aliphatic, aromatic or heteroaromatic radicals, for example branched or unbranched or cyclic alkyl or alkanoyl radicals, with alkyl - or aryl substituents substituted or unsubstituted aryl or aroyl radicals or also alkylated or arylated organylsilyl radicals. u, v, w, x and y mean, independently of one another, numbers which allow the entire molecule to be soluble or at least dispersible in water, typically selected from the range greater than 10, advantageously from the range 20-100.

For the structure scheme (13), for example, the following more specific structure scheme can be followed:


where R ₁ , R ₂ , R ₃ , R ₄ , R ₅ and R _{6 can} independently represent branched or unbranched, saturated or unsaturated, cyclic or chain-shaped aliphatic, aromatic or heteroaromatic radicals, for example branched or unbranched or cyclic alkyl or alkanoyl radicals , Aryl or aroyl radicals substituted or unsubstituted by alkyl or aryl substituents or also alkylated or arylated organylsilyl radicals. u, v, w, x, y and z mean, independently of one another, numbers which allow the entire molecule to be soluble or at least dispersible in water, typically selected from the range greater than 10, advantageously from the range 20-1000.

It may also be advantageous to use the structure schemes described above to modify that branching occurs again at the end of the crosslinker molecule, for example as it is realized in the group of so-called dendrimers.

• - der Polyethylenglycolether der allgemeinen Formel R-O-(-CH₂-CH₂-O-)_n-R', wobei R und R' unabhängig voneinander verzweigte oder unverzweigte Alkyl-, Aryl- oder Alkenylreste und n eine Zahl größer als 100 darstellen;
• - der veretherten Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂-CH₂-O-)_n-R', wobei R und R' unabhängig voneinander verzweigte oder unverzweigte Alkyl-, Aryl- oder Alkenylreste und n eine Zahl größer als 100 darstellen;
• - der veresterten Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂-CH₂-O-)_n-C(O)-R', wobei R und R' unabhängig voneinander verzweigte oder unverzweigte Alkyl-, Aryl- oder Alkenylreste und n eine Zahl größer als 100 darstellen, der Polypropylenglycolether der allgemeinen Formel R-O-(-CH₂-CH(CH₃)-O-)_n-R', wobei R und R' unabhängig voneinander verzweigte oder unverzweigte Alkyl-, Aryl- oder Alkenylreste und n eine Zahl größer als 100 darstellen, der veresterten Fettsäurepropoxylate der allgemeinen Formel R-COO-(-CH₂-CH(CH₃)-O-)_n-C(O)-R', wobei R und R' unabhängig voneinander verzweigte oder unverzweigte Alkyl-, Aryl- oder Alkenylreste und n eine Zahl größer als 100 darstellen, der Polypropylenglycolether der allgemeinen Formel R-O-X_n-Y_m-R', wobei R und R' unabhängig voneinander verzweigte oder unverzweigte Alkyl-, Aryl- oder Alkenylreste darstellen, wobei X und Y nicht identisch sind und jeweils entweder eine Oxyethylengruppe oder eine Oxypropylengruppe und n und m unabhängig voneinander Zahlen darstellen, deren Summe größer als 100 ist;
• - der veretherten Fettsäurepropoxylate der allgemeinen Formel R-COO-X_n-Y_m-R', wobei R und R' unabhängig voneinander verzweigte oder unverzweigte Alkyl-, Aryl- oder Alkenylreste darstellen, wobei X und Y nicht identisch sind und jeweils entweder eine Oxyethylengruppe oder eine Oxypropylengruppe und n und m unabhängig voneinander Zahlen darstellen, deren Summe größer als 100 ist.

Those selected from the group have proven to be particularly suitable crosslinkers

• - The polyethylene glycol ether of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl, aryl or alkenyl radicals and n is a number greater than 100;
• - The etherified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl, aryl or alkenyl radicals and n is a number greater than Represent 100;
• - The esterified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -C (O) -R ', where R and R' independently of one another are branched or unbranched alkyl, aryl or alkenyl radicals and n represents a number greater than 100, the polypropylene glycol ether of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl, aryl or Alkenyl radicals and n represent a number greater than 100, the esterified fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -C (O) -R ', where R and R' independently branched or unbranched alkyl, aryl or alkenyl radicals and n represent a number greater than 100, the polypropylene glycol ether of the general formula ROX _n -Y _m -R ', where R and R' independently of one another branched or unbranched alkyl, aryl or Represent alkenyl radicals, where X and Y are not identical and each have either an oxyethylene group or an oxypropylene group e and n and m independently represent numbers whose sum is greater than 100;
• - The etherified fatty acid propoxylates of the general formula R-COO-X _n -Y _m -R ', where R and R' independently of one another are branched or unbranched alkyl, aryl or alkenyl radicals, where X and Y are not identical and in each case either Oxyethylene group or an oxypropylene group and n and m independently represent numbers, the sum of which is greater than 100.

The PEG-150 distearate, PEG 800 distearate, PEG-800 Chol ₂ and the PEG-150 dioleate are particularly advantageous. The PEG-300 pentaerythrityl tetraisostearate, the PEG-120 methyl glucose dioleate, the PEG-160 sorbitan triisostearate, the PEG-450 sorbitol hexaisostearate and the PEG-230 glyceryl triisostearate can also be used advantageously as crosslinkers. PEG-200 glyceryl palmitate is also suitable. Furthermore, the crosslinker from Südchemie with the name Purethix 1442 (polyether-1) is also advantageous. Furthermore, polyurethane crosslinkers can also be used, such as Rheolate 204, 205, 208 (Rheox company) or modified cosmetic variants or DW 1206B from Rhom & Haas or Serad Fx 1010, 1035 from Hüls.

It is also advantageous to use mixtures of the polymers described above, for example from PEG 800 distearate and PEG-800 Chol ₂ .

A slightly modified way of forming emulsions according to the invention consists of making the oil droplets more synthetic by using hydrophobically modified or immobilize natural polymers. Such polymers are also used occasionally also known as associative thickener.

In Figs. 1 and 2, the spine is shown a water-soluble or water-dispersible cross-linking agent by lines, wherein the branch points represent covalently to the polymer Specific kinds of hydrophobic groups, here symbolized by rectangles. The hydrophobic residues can adhere to one another through hydrophobic interaction. Emulsion droplets can also attach to the crosslinking sites through hydrophobic interactions. It is fundamentally irrelevant whether the hydrophobic residues "immerse" or whether the hydrophobic residues only come into contact with the emulsion droplets on the surface and adhere more or less strongly to them.

Accordingly, it is also advantageous, in particular if the crosslinker (s) is selected should be from the group of associative thickeners, hydrophobically substituted To choose polysaccharide derivatives, for example hydrophobically substituted cellulose ethers, Hydrophobically substituted starches, alginates, glucans, chitins, dextrans, caseinates, Pectins, proteins and gums, also polyurethanes, polyacrylamides, polyvinyl alcohols, Polyacrylates, water-soluble silicone polymers and the like.

For example, cetylhydroxyethyl cellulose can advantageously be used.

It may also be advantageous if the one or more according to the invention Crosslinkers used on physiological effectiveness in the sense of a cosmetic or has or have pharmaceutical effect. For example, those in the German Offenlegungsschrift 43 44 661 disclosed biosurfactant esters advantageously in Find meaning of the present invention.

Combinations of the crosslinkers described above are also included classical polymers, which cannot crosslink due to their structure, possible hereinafter referred to as thickeners. Even inorganic Thickeners can be used.

The inorganic thickener (s) can be advantageous, for example be chosen from the group of modified or unmodified, of course occurring or synthetic layered silicates. Very beneficial inorganic Gelling agents in the sense of the present invention are aluminum silicates like that Montmorillonites (bentonites, hectorites and their derivatives such as Quaternium-18 Bentonite, Quaternium-18 hectorite, stearalkonium Bentonite or stearalkonium Hectorite) or magnesium aluminum silicates (Veegum® types) as well Sodium magnesium silicates (Laponite® types). Bentone® is one Trade name for various neutral and chemically inert gelling agents made from long-chain, organic ammonium salts and special types of montmorillonite are set up.

• - organische, natürliche Verbindungen, wie beispielsweise Agar-Agar, Carrageen, Tragant, Gummi arabicum, Alginate, Pektine, Polyosen, Guar-Mehl, Johannisbrotbaumkernmehl, Stärke, Dextrine, Gelatine, Casein;
• - organische, abgewandelte Naturstoffe, wie z. B. Carboxymethylcellulose und andere Celluloseether, Hydroxyethyl- und -propylcellulose und mikrokristalline Cellulose dergleichen;
• - organische, vollsynthetische Verbindungen, wie z. B. Polyacryl- und Polymethacryl- Verbindungen, Vinylpolymere, Polycarbonsäuren, Polyether, Polyimine, Polyamide, Polyurethane;
• - anorganische Verbindungen, wie z. B. Polykieselsäuren, Tonmineralien wie Montmorillonite, Zeolithe, Kieselsäuren.

The group of cosmetically and dermatologically relevant hydrocolloids can be, for example:

• - organic, natural compounds such as agar-agar, carrageenan, tragacanth, acacia, alginates, pectins, polyoses, guar flour, locust bean gum, starch, dextrins, gelatin, casein;
• - Organic, modified natural substances, such as. B. carboxymethyl cellulose and other cellulose ethers, hydroxyethyl and propyl cellulose and microcrystalline cellulose the like;
• - Organic, fully synthetic compounds, such as. B. polyacrylic and polymethacrylic compounds, vinyl polymers, polycarboxylic acids, polyethers, polyimines, polyamides, polyurethanes;
• - inorganic compounds, such as. B. polysilicic acids, clay minerals such as montmorillonites, zeolites, silicas.

Further hydrocolloids which are advantageous according to the invention are, for example, methyl celluloses, as the methyl ethers of cellulose are referred to. They are characterized by the following structural formula


in which R can represent a hydrogen or a methyl group.

Those in general are particularly advantageous for the purposes of the present invention also referred to as methyl cellulosic mixed cellulose ether, which in addition to a dominant content of methyl additionally 2-hydroxyethyl, 2-hydroxypropyl or 2- Contain hydroxybutyl groups. Are particularly preferred (Hydroxypropyl) methyl celluloses, for example those under the trade name Methocel® E4M from Dow Chemical Comp. available.

Also advantageous according to the invention is sodium carboxymethyl cellulose, the sodium salt of the glycolic acid ether of cellulose, for which R in structural formula I can be a hydrogen and / or CH ₂ COONa. Particularly preferred are the sodium carboxymethyl cellulose available under the trade name Natrosol Plus 330 CS from Aqualon, also referred to as cellulose gum.

For the purposes of the present invention, preference is also given to xanthan (CAS No. 11138-66-2), also called xanthan gum, which is an anionic heteropolysaccharide which is generally formed from corn sugar by fermentation and is isolated as the potassium salt. It is produced by Xanthomonas campestris and some other species under aerobic conditions with a molecular weight of 2 × 10 ⁶ to 24 × 10 ⁶ . Xanthan is formed from a chain with β-1,4-bound glucose (cellulose) with side chains. The structure of the subgroups consists of glucose, mannose, glucuronic acid, acetate and pyruvate. Xanthan is the name for the first microbial anionic heteropolysaccharide. It is produced by Xanthomonas campestris and some other species under aerobic conditions with a molecular weight of 2-15 10 ⁶ . Xanthan is formed from a chain with β-1,4-bound glucose (cellulose) with side chains. The structure of the subgroups consists of glucose, mannose, glucuronic acid, acetate and pyruvate. The number of pyruvate units determines the viscosity of the xanthane. Xanthan is produced in two-day batch cultures with a yield of 70-90%, based on the carbohydrate used. Yields of 25-30 g / l are achieved. The work-up takes place after killing the culture by precipitation with z. B. 2-propanol. Xanthan is then dried and ground.

An advantageous gel former in the sense of the present invention is carrageenan, a gel-forming and similar to agar extract from North Atlantic, to the Red algae counting florids (Chondrus crispus and Gigartina stellata).

The term carrageen is often used for the dried algae product and carrageenan for the extract from it. The carrageenan precipitated from the hot water extract of the algae is a colorless to sand-colored powder with a molecular weight range of 100,000-800,000 and a sulfate content of approx. 25%. Carrageenan, which is very easily soluble in warm water; a thixotropic gel forms on cooling, even if the water content is 95-98%. The firmness of the gel is brought about by the double helix structure of the carrageenan. There are three main components in carrageenan: The gel-forming κ fraction consists of D-galactose-4-sulfate and 3,6-anhydro-α-D-galactose, which are alternately glycosidically linked in the 1,3- and 1,4-positions (In contrast, agar contains 3,6-anhydro-α-L-galactose). The non-gelling λ fraction is composed of 1,3-glycosidically linked D-galactose-2-sulfate and 1,4-linked D-galactose-2,6-disulfate residues u. Easily soluble in cold water. The ι-carrageenan composed of D-galactose-4-sulfate in 1,3-bond and 3,6-anhydro-α-D-galactose-2-sulfate in 1,4-bond is both water-soluble and gel-forming. The type of cations present (K ⁺ , NH ₄ ⁺ , Na ⁺ , Mg ²⁺ , Ca ²⁺ ) also influences the solubility of the carrageenans.

The use of chitosan in cosmetic preparations is known per se. Chitosan is a partially deacylated chitin. This biopolymer has u. a. film-forming Properties and is characterized by a silky skin feeling. The disadvantage is however, its strong stickiness on the skin, which in particular - temporarily - occurs during application. Appropriate preparations can then Individual cases may not be marketable because they are not accepted by the consumer or be judged negatively. Chitosan is known for example in the Hair care used. It works better than the chitin on which it is based Thickener or stabilizer and improves the adhesion and water resistance of polymeric films. Representing a variety of sites of the state of the Technology: H. P. Fiedler, "Lexicon of auxiliary substances for pharmacy, cosmetics and related Territories ", third edition 1989, Editio Cantor, Aulendorf, p. 293, keyword" Chitosan ". It is advantageous to use chitosans with molecular weights between 10,000 and 1,000,000 to choose, especially those with molecular weights between 100,000 and 1,000,000 [determined by gel permeation chromatography].

Polyacrylates are also advantageous gelators to be used in the sense of the present invention. Polyacrylates which are advantageous according to the invention are acrylate-alkyl acrylate copolymers, in particular those which are selected from the group of the so-called carbomers or carbopols (Carbopol® is actually a registered trademark of the BF Goodrich Company). In particular, the acrylate-alkyl acrylate copolymers which are advantageous according to the invention are distinguished by the following structure:

R 'represents a long-chain alkyl radical and x and y numbers which represent the symbolize the respective stoichiometric proportion of the respective comonomers.

Acrylate copolymers and / or acrylate copolymers are particularly preferred according to the invention. Alkyl acrylate copolymers sold under the trade names Carbopol® 1382, Carbopol® 981 and Carbopol® 5984 are available from B.F. Goodrich Company, preferably polyacrylates from the group of carbopoles of types 980, 981, 1382, 2984, 5984 and particularly preferably Carbomer 2001.

Copolymers of C _10-30 alkyl acrylates and one or more monomers of acrylic acid, methacrylic acid or their esters, which are crosslinked with an allyl ether of sucrose or an allyl ether of pentaerythritol, are also advantageous.

Compounds which have the INCI name "Acrylates / C _10-30 Alkyl Acrylate Crosspolymer" are advantageous. Particularly advantageous are those available under the trade names Pemulen TR1 and Pemulen TR2 from the BF Goodrich Company.

Connections that have the INCI name are advantageous Wear ammonium acryloyldimethyl taurate / vinyl pyrrolidone copolymers.

Advantageously according to the invention, the ammonium acryloyldimethyltaurate / vinylpyrrolidone copolymers have the empirical formula [C ₇ H ₁₆ N ₂ SO ₄ ] _n [C ₆ H ₉ NO] _m , corresponding to a statistical structure as follows

Preferred species for the purposes of the present invention are in the chemicals Abstracts under registration numbers 58374-69-9, 13162-05-5 and 88-12-0 filed and available under the trade name Aristoflex® AVC der Company Clariant GmbH.

Copolymers / crosspolymers comprising acryloyldimethyl are also advantageous Taurate, such as Simugel ® EG or Simugel ® EG from society Seppic S.A.

• 1. in Wasser lösliche oder dispergierbare anionische Polyurethane, welche vorteilhaft erhältlich sind aus
  • a) mindestens einer Verbindung, die zwei oder mehrere aktive Wasserstoffatome pro Moleküle enthält,
  • b) mindestens einem Säure- oder Salzgruppen enthaltenden Diol
  und
  • a) mindestens einem Diisocyanat.

Other hydrocolloids to be used advantageously according to the invention are also

• 1. Water-soluble or dispersible anionic polyurethanes, which are advantageously obtainable from
  • a) at least one compound which contains two or more active hydrogen atoms per molecule,
  • b) at least one diol containing acid or salt groups
  and
  • a) at least one diisocyanate.

Component i) is, in particular, diols, amino alcohols, diamines, polyesterols, polyetherols with a number-average molecular weight of up to 3000 in each case or mixtures thereof, it being possible for up to 3 mol% of the compounds mentioned to be replaced by triols or triamines. Diols and polyester diols are preferred. In particular, component (a) comprises at least 50% by weight, based on the total weight of component (a), of a polyester diol. Suitable polyester diols are all those which are customarily used for the production of polyurethanes, in particular reaction products of phthalic acid and diethylene glycol, isophthalic acid and 1,4-butanediol, isophthalic acid / adipic acid and 1,6-hexanediol, and adipic acid and ethylene glycol or 5-NaSO ₃ -Isophthalic acid, phthalic acid, adipic acid and 1,6-hexanediol.

Useful diols are e.g. B. ethylene glycol, propylene glycol, butylene glycol, Neopentyl glycol, polyetherols, such as polyethylene glycols with molecular weights up to 3000, Block copolymers of ethylene oxide and propylene oxide with number-average Molecular weights of up to 3000 or block copolymers of ethylene oxide, propylene oxide and Butylene oxide, which distributes the alkylene oxide units statistically or in the form of blocks polymerized included. Ethylene glycol, neopentyl glycol, di-, tri-, Tetra, penta or hexaethylene glycol. Useful diols are also Poly (hydroxycarboxylic acid □) diols.

Suitable amino alcohols are e.g. B. 2-aminoethanol, 2- (N-methylamino) ethanol, 3- Aminopropanol or 4-aminobutanol.

Suitable diamines are e.g. B. ethylenediamine, propylenediamine, 1,4-diaminobutane and 1,6-diaminohexane and α, ω-diamines, which are obtained by amination of polyalkylene oxides can be produced with ammonia.

Component ii) is in particular dimethylolpropanoic acid or compounds of the formulas




where RR stands for a C ₂ -C ₁₈ alkylene group and Me stands for Na or K.

• 1. In Wasser lösliche oder dispergierbare, kationische Polyurethane und Polyharnstoffe aus
  • a) mindestens einem Diisocyanat, welches bereits vorher mit einer oder mehreren Verbindungen, die zwei oder mehrere aktive Wasserstoffatome pro Moleküle enthalten, umgesetzt worden sein kann, und
  • b) mindestens einem Diol, primären oder sekundären Aminoalkohol, primären oder sekundärem Diamin oder primären oder sekundären Triamin mit einem oder mehreren tertiären, -quaternären oder protonierten tertiären Aminostickstoffatomen.

Component iii) is in particular hexamethylene diisocyanate, isophorone diisocyanate, methyldiphenyl isocyanate (MDI) and / or tolylene diisocyanate. calculated, in which mean: η _r = relative viscosity (dynamic viscosity of the solution / dynamic viscosity of the solvent) and c = mass concentration of polymer in the solution (in g / cm ³ ).

• 1. Water-soluble or dispersible, cationic polyurethanes and polyureas
  • a) at least one diisocyanate which may already have been reacted beforehand with one or more compounds which contain two or more active hydrogen atoms per molecule, and
  • b) at least one diol, primary or secondary amino alcohol, primary or secondary diamine or primary or secondary triamine with one or more tertiary, quaternary or protonated tertiary amino nitrogen atoms.

Preferred diisocyanates are indicated as under 1) above. Connections with two or more active hydrogen atoms are diols, amino alcohols, diamines, Polyesterols. Polyamide diamines and polyetherols. Suitable compounds of this type are as indicated under 1) above.

The polyurethanes are produced as described under 1) above. Charged cationic groups can be obtained from the tertiary amino nitrogen atoms present either by protonation, e.g. B. with carboxylic acids such as lactic acid, or by quaternization, e.g. B. with alkylating agents such as C ₁ - to C ₄ alkyl halides or sulfates in the polyureas. Examples of such alkylating agents are ethyl chloride, ethyl bromide, methyl chloride, methyl bromide, dimethyl sulfate and diethyl sulfate.

• 1. Lineare Polyurethane mit Carboxylatgruppen aus
  • a) einer 2,2-Hydroxymethyl-substituierten Carbonsäure der Formel
    
    
    worin RR' für ein Wasserstoffatom oder eine C₁-C₂₀-Alkylgruppe steht, die in einer Menge verwendet wird, welche ausreicht, daß in dem Polyurethan 0,35 bis 2,25 Milliäquivalente Carboxylgruppen pro g Polyurethan vorhanden sind,
  • b) 10 bis 90 Gew.-%, bezogen auf das Gewicht des Polyurethans, einer oder mehrerer organischer Verbindungen mit nicht mehr als zwei aktiven Wasserstoffatomen und
  • c) einem oder mehreren organischen Diisocyanaten.

These polymers and their preparation are described in more detail in DE-A-42 41 118, to which reference is hereby made in full.

• 1. Linear polyurethanes with carboxylate groups
  • a) a 2,2-hydroxymethyl-substituted carboxylic acid of the formula
    
    
    wherein RR 'represents a hydrogen atom or a C ₁ -C ₂₀ alkyl group which is used in an amount sufficient to have 0.35 to 2.25 milliequivalents of carboxyl groups per g of polyurethane in the polyurethane,
  • b) 10 to 90 wt .-%, based on the weight of the polyurethane, one or more organic compounds with no more than two active hydrogen atoms and
  • c) one or more organic diisocyanates.

• 1. Carboxylhaltige Polykondensationsprodukte aus Anhydriden von Tri- oder Tetracarbonsäuren und Diolen, Diaminen oder Aminoalkoholen (Polyester, Polyamide oder Polyesteramide). Diese Polymere und ihre Herstellung sind in der DE-A-42 24 761 näher beschrieben, auf die hiermit in vollem Umfang Bezug genommen wird.
• 2. Polyacrylate und Polymethacrylate, wie sie in den DE-A-43 14 305, 36 27 970 und 29 17 504 näher beschrieben sind. Auf diese Publikationen wird hiermit in vollem Umfang Bezug genommen.

Finally, the carboxyl groups contained in the polyurethane are at least partially neutralized with a suitable base. These polymers and their preparation are described in EP-A-619 111, which is hereby incorporated by reference in its entirety.

• 1. Carboxyl-containing polycondensation products from anhydrides of tri- or tetracarboxylic acids and diols, diamines or amino alcohols (polyesters, polyamides or polyester amides). These polymers and their preparation are described in more detail in DE-A-42 24 761, to which reference is hereby made in full.
• 2. Polyacrylates and polymethacrylates as described in more detail in DE-A-43 14 305, 36 27 970 and 29 17 504. Reference is hereby made in full to these publications.

The total amount of one or more hydrocolloids is in the finished cosmetic or dermatological preparations advantageously less than 5% by weight, preferably between 0.01 and 1.0% by weight, based on the total weight of the Preparations, chosen.

The preparations according to the invention can advantageously each 0.001-20% by weight one or more crosslinking agents used according to the invention and non-crosslinking ones Thickeners included. It is preferred that the content of thickeners and crosslinkers in each case To choose 0.01 to 10 wt .-%, in particular 0.1 to 5 wt .-%, each based on the Total weight of the preparations.

The oils and fats customary in cosmetics can be used as the oil phase.

The method according to the invention enables the production of finely divided emulsions a variety of typical oil phases: ether (dicaprylyl ether), carbonates (Dicaprylyl carbonate), butylene glycol ester (butylene glycol caprylate, caprate), Tartaric acid esters, (Di-C12-13 alkyl tartrate), succinates (Caprylic / Capric Diglyceryl Succinates), triglycerides (caprylic / capric triglycerides), alcohols (octyldodecanol), Ester oils (cetearyl isonoanoate), glycerides (cocoglyceride), hydrocarbons (Mineral oil, hydrogenated polydecene, isoeicosane, dioctylcyclohexane, squalane, squalene), Silicone oils (cyclomethicone) or mixtures of these oil phases.

Furthermore, waxes can also be part of the oil phase, such as, for example, methyl palmitate, cetyl palmitate, C _20-40 alkyl stearate, C _18-36 acid triglyceride.

The following weight percentages, each based on the total weight of the preparations, are preferred for the preparations according to the invention:
O / W emulsifier: 0.01-60%, especially 0.1-10%
W / O emulsifier: 0.1-60%, especially 0.1-10%
Oil phase: 0.01-50%, especially 0.1-30%
Additives for the oil phase: 0.01-20%, especially 0.1-15%
Additives for the water phase: 0.01-80%, especially 0.1-60%
Crosslinker: 0.01-20%, especially 0.1-10%
Thickener (non-crosslinking): 0.01-20%, especially 0.1-10%
Water ad 100%

Cross-linked systems based on oil-in-water emulsions, which comprise, are particularly advantageous for the purposes of the present invention
a discontinuous oil phase and a continuous water phase
optionally containing at least one W / O emulsifier,
containing at least one O / W emulsifier,
wherein the O / W emulsifier or the O / W emulsifiers are advantageously selected or are selected from the group
the fatty alcohol ethoxylates of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -H, where R is a branched or unbranched alkyl, aryl or alkenyl radical and n is a number from 10 to 50,
the ethoxylated / propoxylated wool wax alcohols,
the polyethylene glycol ether of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 10 to 80,
the fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical and n is a number from 10 to 40,
the etherified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 10 to 80,
the esterified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -C (O) -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number of Represent 10 to 80,
the polyethylene glycol glycerol fatty acid esters of saturated and / or unsaturated, branched and / or unbranched fatty acids and a degree of ethoxylation between 3 and 50,
the ethoxylated sorbitan esters with a degree of ethoxylation of 3 to 100
cholesterol ethoxylates with a degree of ethoxylation between 3 and 50,
the ethoxylated triglycerides with a degree of ethoxylation between 3 and 150,
the alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -CH ₂ -COOH or their cosmetically or pharmaceutically acceptable salts, where R is a branched or unbranched alkyl or alkenyl radical having 5-30 carbon atoms and n represents a number from 5 to 30,
the polyoxyethylene sorbitol fatty acid ester based on branched or unbranched alkanoic or alkenoic acids and having a degree of ethoxylation of 5 to 100, for example of the sorbeth type,
the alkyl ether sulfates or the acids on which these sulfates are based, of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -SO ₃ -H with cosmetically or pharmaceutically acceptable cations, where R is a branched or unbranched alkyl or alkenyl radical with 5 -30 carbon atoms and n represent a number from 1 to 50,
the fatty alcohol propoxylates of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical and n is a number from 10 to 80,
the polypropylene glycol ether of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 10 to 80,
the etherified fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 10 to 80 represent
the esterified fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -C (O) -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n represent a number from 10 to 80,
the fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical and n is a number from 10 to 80,
the polypropylene glycol glycerol fatty acid ester of saturated and / or unsaturated, branched and / or unbranched fatty acids and a degree of propoxylation between 3 and 80
the propoxylated sorbitan esters with a degree of propoxylation of 3 to 100
the cholesterol propoxylates with a degree of propoxylation of 3 to 100
the propoxylated triglycerides with a degree of propoxylation of 3 to 100
the alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH (CH ₃ ) O-) _n -CH ₂ -COOH or their cosmetically or pharmaceutically acceptable salts, where R is a branched or unbranched alkyl or alkenyl radical and n is a number of 3 to 50,
the alkyl ether sulfates or the acids on which these sulfates are based, of the general formula RO - (- CH ₂ -CH (CH ₃ -O-) _n -SO ₃ -H with cosmetically or pharmaceutically acceptable cations, where R is a branched or unbranched alkyl or alkenyl radical with 5-30 carbon atoms and n represent a number from 1 to 50,
the fatty alcohol ethoxylates / propoxylates of the general formula ROX _n -Y _m -H, where R represents a branched or unbranched alkyl or alkenyl radical, where X and Y are not identical and each have either an oxyethylene group or an oxypropylene group and n and m independently of one another are numbers from 5 to 50,
the polypropylene glycol ether of the general formula ROX _n -Y _m -R ', where R and R' independently of one another represent branched or unbranched alkyl or alkenyl radicals, where X and Y are not identical and in each case either an oxyethylene group or an oxypropylene group and n and m independently represent numbers from 5 to 100 from each other,
the etherified fatty acid propoxylates of the general formula R-COO-X _n -Y _m -R ', where R and R' independently of one another represent branched or unbranched alkyl or alkenyl radicals, where X and Y are not identical and in each case either an oxyethylene group or an oxypropylene group and n and m independently represent numbers from 5 to 100,
the fatty acid ethoxylates / propoxylates of the general formula R-COO-X _n -Y _m -H, where R is a branched or unbranched alkyl or alkenyl radical, where X and Y are not identical and in each case either an oxyethylene group or an oxypropylene group and n and m independently represent numbers from 5 to 50 from each other.
the polyglycerol methyl glucose ester of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids or hydroxy carboxylic acids with a chain length of 8-24, in particular 12-18, carbon atoms
the glycerin fatty acid citrate
of water-dispersible silicone emulsifiers
the polyglycerol ester (saturated and unsaturated) with a chain length of 8-24, in particular 12-18, carbon atoms

The W / O emulsifiers (one or more) optionally contained can preferably be selected from the group
the fatty alcohol ethoxylates of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -H, where R is a branched or unbranched alkyl, aryl or alkenyl radical and n is a number from 1 to 10
the polyethylene glycol ether of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 1 to 30
the fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical and n is a number from 1 to 20,
the esterified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -C (O) -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number of Represent 1 to 20,
the esterified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -C (O) -R ', where R and R' independently of one another are branched or unbranched alkyl, hydroxyalkyl or alkenyl radicals and n one Represent a number from 1 to 40,
the etherified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 1 to 40
the fatty alcohol propoxylates of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical and n is a number from 1 to 30,
the polyoxyethylene sorbitan fatty acid ester based on branched or unbranched alkanoic or alkenoic acids and having a degree of ethoxylation of 1 to 10
cholesterol ethoxylates with a degree of ethoxylation between 1 and 10,
the ethoxylated glycerides with a degree of ethoxylation of 1 to 30
the ethoxylated triglycerides with a degree of ethoxylation between 1 and 30,
the monoglycerol ether of the type RO-CH ₂ -C (H) OH-CH ₂ OH where R represents a branched or unbranched alkyl, aryl or alkenyl radical and
the monoglycerol ester of the type RC (O) OCH ₂ -C (H) OH-CH ₂ OH where R represents a branched or unbranched alkyl, hydroxyalkyl, aryl or alkenyl radical
the diglycerol ester of the type RC (O) OCH ₂ -C (H) OH-CH ₂ OC (O) R ', where R and R' independently of one another are branched or unbranched alkyl, hydroxyalkyl or alkenyl radicals and n is a number from 1 to 30 or represent
the polyglycerol mono- or di- or polyester, where the fatty acids independently of one another represent branched or unbranched alkyl, hydroxyalkyl or alkenyl radicals,
the pentaerythritol ester, the fatty acids independently representing branched or unbranched alkyl, hydroxyalkyl or alkenyl radicals,
the propylene glycol ester, the fatty acids independently of one another being branched or unbranched alkyl, hydroxyalkyl or alkenyl residues,
the sorbitan ester, the fatty acids independently of one another being branched or unbranched alkyl, hydroxyalkyl or alkenyl radicals,
the fatty alcohols R-OH and fatty acids RCOOH, where R is a branched or unbranched alkyl or alkenyl radical,
the silicone emulsifiers such as, for example, Dimethicone Copolyol, Alkyl Dimethicone Copolyol (Cetyl Dimethicone Copolyol), Alkyl Methicone Copolyol (Lauryl Methicon Copolyol), Octyl Dimethicone Ethoxy Glucoside
the methyl glucose ester, the fatty acids independently of one another being branched or unbranched alkyl, hydroxyalkyl or alkenyl radicals.
The total emulsifier content is preferably 0.01 to 20% by weight, based on the total weight of the preparation.

It is particularly advantageous if the O / W emulsifier or the O / W emulsifiers is selected or are selected from the group
the fatty alcohol ethoxylates of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical having 5-30 C atoms and n is a number from 10 to 25
of the ethoxylated / propoxylated wool wax alcohols with HLB values of 11-16
the polyethylene glycol ether of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals having 5-30 carbon atoms and n is a number of 10 represent to 25,
the fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical having 5-30 carbon atoms and n is a number from 10 to 25 .
the etherified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals having 5-30 carbon atoms and n a Represent a number from 10 to 50,
the esterified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -C (O) -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals with 5-30 C. Atoms and n represent a number from 10 to 50,
the polyethylene glycol glycerol fatty acid esters of saturated and / or unsaturated, branched and / or unbranched fatty acids with 6 to 26 carbon atoms and a degree of ethoxylation between 3 and 40
the ethoxylated sorbitan esters with a degree of ethoxylation of 3 to 30
the cholesterol ethoxylates with HLB values of 11-16
the ethoxylated triglycerides with HLB values of 11-16
the alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -CH ₂ -COOH or their cosmetically or pharmaceutically acceptable salts, where R is a branched or unbranched alkyl or alkenyl radical having 5-30 carbon atoms and n represents a number from 10 to 20,
the polyoxyethylene sorbitol fatty acid ester based on branched or unbranched alkanoic or alkenoic acids and having a degree of ethoxylation of 10 to 80, for example of the sorbeth type,
the alkyl ether sulfates or the acids on which these sulfates are based, of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -SO ₃ -H with cosmetically or pharmaceutically acceptable cations, where R is a branched or unbranched alkyl or alkenyl radical with 5 -30 carbon atoms and n represent a number from 3 to 30,
the fatty alcohol propoxylates of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical having 5-30 carbon atoms and n is a number from 10 to 30 represent
the polypropylene glycol ether of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals having 5-30 carbon atoms and n a Represent a number from 10 to 40,
the fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical having 5-30 carbon atoms and n is a number of 10 up to 40,
the etherified fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals having 5-30 carbon atoms and n represents a number from 10 to 30,
the esterified fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -C (O) -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals with 5 -30 carbon atoms and n represent a number from 10 to 50,
the polypropylene glycol glycerol fatty acid ester of saturated and / or unsaturated, branched and / or unbranched fatty acids with 6 to 26 carbon atoms and a degree of propoxylation between 3 and 50
the propoxylated sorbitan esters with a degree of propoxylation of 3 to 80
the cholesterol propoxylates with HLB values of 11-16,
of the propoxylated triglycerides with HLB values of 11-16
the alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH (CH ₃ ) O-) _n -CH ₂ -COOH or their cosmetically or pharmaceutically acceptable salts, where R is a branched or unbranched alkyl or alkenyl radical with 5-30 C. Atoms and n represent a number from 10 to 30,
the alkyl ether sulfates or the acids on which these sulfates are based, of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -SO ₃ -H with cosmetically or pharmaceutically acceptable cations, where R is a branched or unbranched alkyl or Alkenylrest with 5-30 carbon atoms and n represent a number from 1 to 30.
the polyglycerol methyl glucose ester of the type polyglyceryl-3 methyl glucose distearate
the glycerol fatty acid citrate of the glyceryl stearate citrate type
Bis PEG / PPG-16/16 PEG / PPG16 / 16 dimethicone + caprylic acid / capric acid triglyceride (Abil Care 85).

According to the invention, the ethoxylated O / W Emulsifiers selected from the group of substances with HLB values of 11-16, if the O / W emulsifiers have saturated radicals R and R '. Assign the O / W Emulsifiers unsaturated radicals R and / or R ', or are isoalkyl derivatives, so the preferred HLB value of such emulsifiers can also be lower or higher.

It is advantageous to choose the fatty alcohol ethoxylates from the group of the ethoxylated stearyl alcohols, cetyl alcohols, cetylstearyl alcohols (cetearyl alcohols). The following are particularly preferred:
Polyethylene glycol (13) stearyl ether (steareth-13), polyethylene glycol (14) stearyl ether (steareth-14), polyethylene glycol (15) stearyl ether (steareth-15), polyethylene glycol (16) stearyl ether (steareth-16), polyethylene glycol (17) stearyl ether ( Steareth-17), polyethylene glycol (18) stearyl ether (steareth-18), polyethylene glycol (19) stearyl ether (steareth-19), polyethylene glycol (20) stearyl ether (steareth-20), steareth-21;
Polyethylene glycol (12) isostearyl ether (isosteareth-12), polyethylene glycol (13) isostearyl ether (isosteareth-13), polyethylene glycol (14) isostearyl ether (isosteareth-14), polyethylene glycol (15) isostearyl ether (isosteareth-15), polyethylene glycol (16) isostearyl ether ( Isosteareth-16), polyethylene glycol (17) isostearyl ether (isosteareth-17), polyethylene glycol (18) isostearyl ether (isosteareth-18), polyethylene glycol (19) isostearyl ether (isosteareth-19-), polyethylene glycol (20) isostearyl ether (isosteareth-20) ;
Polyethylene glycol (13) cetyl ether (ceteth-13), polyethylene glycol (14) cetyl ether (ceteth-14), polyethylene glycol (15) cetyl ether (ceteth-15), polyethylene glycol (16) cetyl ether (ceteth-16), polyethylene glycol (17) cetyl ether ( Ceteth-17), polyethylene glycol (18) cetyl ether (ceteth-18), polyethylene glycol (19) cetyl ether (ceteth-19), polyethylene glycol (20) cetyl ether (ceteth-20);
Polyethylene glycol (13) isocetyl ether (isoceteth-13), polyethylene glycol (14) isocetyl ether (isoceteth-14), polyethylene glycol (15) isocetyl ether (isoceteth-15), polyethylene glycol (16) - isocetyl ether (isoceteth-16), polyethylene glycol (17) isocetyl ether (Isoceteth-17), polyethylene glycol (18) isocetyl ether (isoceteth-18), polyethylene glycol (19) isocetyl ether (isoceteth-19), polyethylene glycol (20) isocetyl ether (isoceteth-20);
Polyethylene glycol (12) oleyl ether (Oleth-12), polyethylene glycol (13) oleyl ether (Oleth-13), polyethylene glycol (14) oleyl ether (Oleth-14), polyethylene glycol (15) oleyl ether (Oleth-15);
Polyethylene glycol (12) lauryl ether (Laureth-12), polyethylene glycol (12) isolauryl ether (Isolaureth-12);
Polyethylene glycol (13) cetyl stearyl ether (ceteareth-13), polyethylene glycol (14) cetyl stearyl ether (ceteareth-14), polyethylene glycol (15) cetyl stearyl ether (ceteareth-15), polyethylene glycol (16) cetyl stearyl ether (ceteareth-16), polyethylene glycol (17) Ceteareth-17), polyethylene glycol (18) cetylstearyl ether (Ceteareth-18), polyethylene glycol (19) cetylstearyl ether (Ceteareth-19), polyethylene glycol (20) cetylstearyl ether (Ceteareth-20).

It is also advantageous to choose the fatty acid ethoxylates from the following group:
Polyethylene glycol (20) stearate, polyethylene glycol (21) stearate, polyethylene glycol (22) stearate, polyethylene glycol (23) stearate, polyethylene glycol (24) stearate, polyethylene glycol (25) stearate;
Polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate, polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate, polyethylene glycol (16) isostearate, polyethylene glycol (17) isostearate, polyethylene glycol (18) isostearate, polyethylene glycol (19) isostearate (20) isostearate, polyethylene glycol (21) isostearate, polyethylene glycol (22) isostearate, polyethylene glycol (23) isostearate, polyethylene glycol (24) isostearate, polyethylene glycol (25) isostearate;
Polyethylene glycol (12) oleate, Polyethylene glycol (13) oleate, Polyethylene glycol (14) oleate, Polyethylene glycol (15) oleate, Polyethylene glycol (16) oleate, Polyethylene glycol (17) oleate, Polyethylene glycol (18) oleate, Polyethylene glycol (19) oleate, Polyethylene glycol ( 20) oleate.

As an ethoxylated alkyl ether carboxylic acid or its salt, this can be advantageous Sodium laureth-11 carboxylate can be used.

Sodium laureth 1-4 sulfate can advantageously be used as alkyl ether sulfate.

As an ethoxylated cholesterol derivative can be advantageous Polyethylene glycol (30) cholesteryl ether can be used. Polyethylene glycol (25) soyasterol has also proven itself.

Polyethylene glycol (60) evening can advantageously be used as ethoxylated triglycerides Primrose Glycerides can be used (Evening Primrose = evening primrose).

Another advantage is the polyethylene glycol glycerol fatty acid ester from the group Polyethylene glycol (20) glyceryl laurate, polyethylene glycol (21) glyceryl laurate, Polyethylene glycol (22) glyceryl laurate, polyethylene glycol (23) glyceryl laurate, Polyethylene glycol (6) glyceryl caprate / caprinate, polyethylene glycol (20) glyceryl oleate, Polyethylene glycol (20) glyceryl isostearate, polyethylene glycol (18) glyceryl oleate / cocoat to choose.

It is also cheap to use the sorbitan esters from the group Polyethylene glycol (20) sorbitan monolaurate, polyethylene glycol (20) sorbitan monostearate, Polyethylene glycol (20) sorbitan monoisostearate, polyethylene glycol (20) sorbitan monopalmitate, polyethylene glycol (20) - to choose sorbitan monooleate.

Abil Care 85 can be selected as the silicone emulsifier.

As optional, yet advantageous W / O emulsifiers according to the invention are used: fatty alcohols with 8 to 30 carbon atoms, saturated monoglycerol esters and / or unsaturated, branched and / or unbranched alkane carboxylic acids or Hydroxyalkanecarboxylic acids with a chain length of 8 to 24, in particular 12-18 C atoms, diglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids or hydroxyalkane carboxylic acids with a chain length of 8 to 24, in particular 12-18 C atoms, monoglycerol ethers saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 8 to 24, in particular 12-18 C atoms, diglycerol ethers of saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 8 to 24, in particular 12-18 carbon atoms, propylene glycol ester saturated and / or unsaturated, branched and / or unbranched alkane arbonic acids or hydroxyalkane carboxylic acids Chain length from 8 to 24, in particular 12-18 C atoms and sorbitan esters saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids or hydroxyalkanecarboxylic acids with a chain length of 8 to 24, in particular 12-18 C- Atoms.

Particularly advantageous W / O emulsifiers are glyceryl monostearate, Glyceryl monoisostearate, glyceryl linoleate, triglycerol diisostearate, glyceryl monomyristate, Glyceryl monooleate, diglyceryl monostearate, diglyceryl monoisostearate, propylene glycol monostearate, Propylene glycol monoisostearate, propylene glycol monocaprylate, propylene glycol monolaurate, Sorbitan monoisostearate, sorbitan monostearate, sorbitan monolaurate, Sorbitan monocaprylate, sucrose distearate, cetyl alcohol, stearyl alcohol, Arachidyl alcohol, behenyl alcohol, isobehenyl alcohol, selachyl alcohol, chimyl alcohol, Polyethylene glycol (2) stearyl ether (steareth-2), glyceryl monolaurate, glyceryl monocaprinate, Glyceryl monocaprylate, polyglyceryl-3 methylglucose distearate, PEG-45 / Dodecyl glycol copolymer, methoxy-PEG-22-dodecyl glycol copolymer, Methyl glucose sesquistearate, polyglyceryl-2 dipolyhydroxystearate, cetyl dimethicone Copolyol, alkyl methicon copolyol, alkyl dimethicone ethoxy glucoside, PEG-40- Sorbitan perisostearate, PEG-30 dipolyhydroxystearate.

According to the invention, the total content of emulsifiers is less than 15% by weight, to keep based on the total weight of the preparations according to the invention. It is preferred that the total content of emulsifiers is less than 10% by weight, in particular less than 8% by weight, based on the total weight of the preparations, to keep.

Glycerol, chitosan, fucogel, lactic acid, Polyethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, 2-methyl-1,3- Propanediol, mannitol, acids such as sodium pyrolidone carboxylic acid, hyaluronic acid and their salts, amino acids and their salts such as glycine, urea, sodium, Use potassium, magnesium and calcium salts. Glycerin is particularly advantageous alone and in combination with one of the humidifiers mentioned above.

It can be shown that preparations containing skin-moistening ingredients excellent properties for moisturizing, smoothing and reducing flaking of the skin.

The oil phase of the preparations according to the invention is advantageously chosen from the Group of esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols Chain length of 3 to 30 carbon atoms, from the group of esters from aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols a chain length of 3 to 30 carbon atoms. Such ester oils can then be advantageous are selected from the group of isopropyl myristate, isopropyl palmitate, isopropyl stearate, Isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, Isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2- Hexyldecyl stearate, 2-octyldodecyl palmitate, oleyl oleate, olerlerucate, erucyl oleate, Erucylerucat and synthetic, semi-synthetic and natural mixtures of such Esters, e.g. B. Jojoba oil.

Furthermore, the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the Group of saturated or unsaturated, branched or unbranched alcohols, as well as the fatty acid triglycerides, especially the saturated and / or triglycerol esters unsaturated, branched and / or unbranched alkane carboxylic acids of a chain length from 8 to 24, especially 12-18 C atoms. The fatty acid triglycerides can for example advantageously selected from the group of synthetic, semi-synthetic and natural oils, e.g. B. olive oil, sunflower oil, soybean oil, peanut oil, Rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.

Examples include dicaprylyl carbonate, butylene glycol caprylate / caprate, di-C12-13 alkyl tartrate, caprylic / capric diglyceryl succinate, caprylic / capric triglyceride, octyldodecanol, cetearyl isonoanoate, cocoglyceride, mineral oil, hydrogenated polydecanaleno, isoeylylanocene, iso C _12-15 alkyl benzoate or mixtures of these oil phases.

Mixtures of C _12-15 alkylbenzoate and 2-ethylhexyl isostearate, mixtures of C _12-15 alkylbenzoate and isotridecyl isononanoate and mixtures of C _12-15 alkylbenzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate are particularly advantageous.

Furthermore, waxes can also be part of the oil phase, such as, for example, methyl palmitate, cetyl palmitate, C _20-40 alkyl stearate, C _18-36 acid triglyceride. In such cases, the preparations according to the invention can also be obtained as microdispersions of solid wax particles.

Any mixtures of such oil and wax components are also advantageous in To use the sense of the present invention.

The oil phase can also advantageously contain cyclic or linear silicone oils have or consist entirely of such oils, although it is preferred besides the silicone oil or oils an additional content of others To use oil phase components. Cyclomethicone is advantageous (Octamethylcyclotetrasiloxane) as silicone oil to be used according to the invention used. However, other silicone oils are also advantageous in the sense of the present To use the invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, Poly (methylphenylsiloxane).

Mixtures of cyclomethicone and are also particularly advantageous Isotridecyl isononanoate, from cyclomethicone and 2-ethylhexyl isostearate.

The preparations according to the invention advantageously contain electrolytes, in particular one or more salts with the following anions: chlorides, also inorganic Oxo element anions, of these in particular sulfates, carbonates, phosphates, borates and Aluminates. Electrolytes based on organic anions can also be advantageous are used, for example lactates, acetates, benzoates, propionates, tartrates, citrates and others. Comparable effects are also due to ethylenediaminetetraacetic acid and to achieve their salts.

Preferred cations of the salts are ammonium, alkylammonium, alkali metal, Alkaline earth metal, magnesium, iron or zinc ions used. In itself, no one is needed Mention that only physiologically acceptable electrolytes are used in cosmetics should be. Special medical applications of the invention Microemulsions, on the other hand, can, at least in principle, use Electrolytes require, which should not be used without medical supervision.

Sodium and potassium chloride, sodium and potassium bromide are particularly preferred, Magnesium and calcium chloride, magnesium and calcium bromide, zinc sulfate and Mixtures of these. Salt mixtures such as those found in natural salt are also advantageous occur from the Dead Sea. All of these salts are beneficial because they are endogenous Stimulate lipid synthesis.

The concentration of the electrolyte or electrolytes should, for example, be about 0.1-10.0% by weight, are particularly advantageously about 0.3-8.0% by weight, based on the total weight the preparation.

The preparations according to the invention also contribute excellently Skin smoothing, especially if they are provided with one or more substances that promote skin smoothing.

The preparations according to the invention form the basis for cosmetic Deodorants / antiperspirants, so all common active ingredients can be used advantageously, for example odor maskers like the common perfume ingredients, Odor absorbers, for example those described in the patent application DE-P 40 09 347 Layered silicates, of which in particular montmorillonite, kaolinite, ilite, beidellite, nontronite, Saponite, hectorite, bentonite, smectite, and furthermore, for example, zinc salts of ricinoleic acid. Germ inhibitors are also suitable in the invention Microemulsions to be incorporated. Examples of advantageous substances are 2,4,4'-trichloro-2'-hydroxydiphenyl ether (irgasane), 1,6-di- (4-chlorophenylbiguanido) hexane (Chlorhexidine), 3,4,4'-trichlorocarbonilide, quaternary ammonium compounds, clove oil, Mint oil, thyme oil, triethyl citrate, farnesol (3,7,11.trimethyl-2,6,10-dodecatrien-1-ol) as well as those in the patent publication DE-37 40 186, DE-39 38 140, DE-42 04 321, DE-42 29 707, DE-42 29 737, DE-42 37 081, DE-43 09 372, DE-43 24 219 described effective agents.

The usual antiperspirant active ingredients can also be advantageous in the Preparations according to the invention are used, in particular astringents, for example basic aluminum chlorides.

The cosmetic deodorants according to the invention can be in the form of aerosols, So from aerosol containers, squeeze bottles or by a pump device sprayable preparations are present or in the form of those which can be applied by means of roll-on devices liquid compositions, but also in the form of from normal bottles and Preparations according to the invention which can be applied to containers.

As a propellant for cosmetic sprayable according to the invention from aerosol containers Deodorants are the usual known volatile, liquefied propellants, For example, hydrocarbons (propane, butane, isobutane) suitable alone or in Mixture can be used together. Compressed air is also advantageous use.

Of course, the person skilled in the art knows that there are non-toxic propellant gases per se that would in principle be suitable for the present invention, but nevertheless because of harmful effects on the environment or other accompanying circumstances should, especially chlorofluorocarbons (CFCs).

It has also surprisingly been found that the Use of blowing agents that are soluble in the oil phase, e.g. conventional propane Butane mixtures, the preparations according to the invention not simply as Aerosol droplets are sprayed, but become fine-bubble, rich Develop foams as soon as such systems loaded with such blowing agents Experience pressure relief.

Such post-foaming preparations are therefore also considered to be advantageous Embodiments of the present invention with independent inventive step considered.

When using blowing agents which are insoluble in the oil phase, the O / W emulsions according to the invention sprayed as aerosol droplets.

Those cosmetic and dermatological preparations which are in the Form of a sunscreen. In addition to the active substance combinations according to the invention additionally at least one UVA Filter substance and / or at least one UVB filter substance and / or at least one inorganic pigment.

However, it is also advantageous in the sense of the present invention to use such cosmetic and to create dermatological preparations, the main purpose of which is not the Protection against sunlight is, but which nevertheless contains UV protection substances contain. So z. B. in day creams usually UV-A or UV-B Filter substances incorporated.

Preparations according to the invention can advantageously contain substances which have UV Absorb radiation in the UVB range, taking the total amount of filter substances z. B. 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in particular 1 to 6% by weight is based on the total weight of the preparations.

• - 3-Benzylidencampher und dessen Derivate, z. B. 3-(4-Methylbenzyliden)campher,
• - 4-Aminobenzoesäure-Derivate, vorzugsweise 4-(Dimethylamino)-benzoesäure(2- ethylhexyl)ester, 4-(Dimethylamino)benzoesäureamylester;
• - Ester der Zimtsäure, vorzugsweise 4-Methoxyzimtsäure(2-ethylhexyl)ester, 4-Methoxyzimtsäureisopentylester;
• - Ester der Salicylsäure, vorzugsweise Salicylsäure(2-ethylhexyl)ester, Salicylsäure- (4-isopropylbenzyl)ester, Salicylsäurehomomenthylester;
• - Derivate des Benzophenons, vorzugsweise 2-Hydroxy-4-methoxybenzophenon, 2- Hydroxy-4-methoxy-4'-methylbenzophenon, 2,2'-Dihydroxy-4-methoxybenzophenon;
• - Ester der Benzalmalonsäure, vorzugsweise 4-Methoxybenzalmalonsäuredi(2-ethylhexyl)ester;
• - Triazine wie 2,4,6-Trianilino-(p-carbo-2'-ethyl-1'-hexyloxy)-1,3,5-triazin, Dioctylbutamidotriazon (Uvasorb HEB, Sigma 3V), Triazine (Triazole) unter der Handelsbezeichnung Tinosorb M und S (Ciba), Uvinul T 150
• - Dibenzoylmethanderivate [beispielsweise das 4-(tert.-Butyl)-4'-methoxydibenzoylmethan],
• - das 1,4-di(2-oxo-10-Sulfo-3-bornylidenmethyl)-Benzol und/oder dessen Salze und/oder das 2,4-Bis-{[4-(2-Ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin, jeweils einzeln oder in beliebigen Kombinationen miteinander.

The UVB filters can be oil-soluble or water-soluble. As oil-soluble substances such. B. To name:

• - 3-Benzylidene camphor and its derivatives, e.g. B. 3- (4-methylbenzylidene) camphor,
• - 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
• - Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
• - Esters of salicylic acid, preferably salicylic acid (2-ethylhexyl) ester, salicylic acid (4-isopropylbenzyl) ester, salicylic acid homomethyl ester;
• - Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;
• - Esters of benzalmalonic acid, preferably 4-methoxybenzalmalonic acid di (2-ethylhexyl) ester;
• - Triazines such as 2,4,6-trianilino- (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine, dioctylbutamidotriazon (Uvasorb HEB, Sigma 3V), triazines (triazoles) under the Trade name Tinosorb M and S (Ciba), Uvinul T 150
• Dibenzoylmethane derivatives [for example the 4- (tert-butyl) -4'-methoxydibenzoylmethane],
• - the 1,4-di (2-oxo-10-sulfo-3-bornylidenemethyl) benzene and / or its salts and / or the 2,4-bis - {[4- (2-ethylhexyloxy) -2 -hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine, in each case individually or in any combination with one another.

• - 2-Phenylbenzimidazol-5-sulfonsäure, Phenylen-1,4-bis-(2-benzimidazyl)-3,3'-5,5'- tetrasulfonsäure und/oder deren Salze, z. B. Natrium-, Kalium- oder Triethanolammonium-Salze, sowie die Sulfonsäure selbst
• - Sulfonsäure-Derivate von Benzophenonen, vorzugsweise 2-Hydroxy-4-methoxybenzophenon-5-sulfonsäure und ihre Salze;
• - Sulfonsäure-Derivate des 3-Benzylidencamphers, wie z. B. 4-(2-Oxo-3-bornylidenmethyl)benzolsulfonsäure, 2-Methyl-5-(2-oxo-3-bornylidenmethyl)sulfonsäure und ihre Salze.
• - Eine weiterere erfindungsgemäß vorteilhaft zu verwendende Lichtschutzfiltersubstanz ist das Ethylhexyl-2-cyano-3,3-diphenylacrylat (Octocrylen), welches von BASF unter der Bezeichnung Uvinul® N 539 erhältlich ist.

The following are advantageous as water-soluble substances:

• - 2-Phenylbenzimidazole-5-sulfonic acid, phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and / or salts thereof, e.g. B. sodium, potassium or triethanolammonium salts, and the sulfonic acid itself
• - Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts;
• - Sulfonic acid derivatives of 3-benzylidene camphor, such as. B. 4- (2-oxo-3-bornylidene methyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidene methyl) sulfonic acid and their salts.
• A further light protection filter substance to be used advantageously according to the invention is ethylhexyl-2-cyano-3,3-diphenylacrylate (octocrylene), which is available from BASF under the name Uvinul® N 539.

It can also be of considerable advantage to be polymer-bound or polymeric Use UV filter substances in preparations according to the present invention, in particular those as described in WO-A-92/20690.

Furthermore, it may be advantageous to use further UV-A and / or incorporate UV-B filters in cosmetic or dermatological preparations, for example certain salicylic acid derivatives such as 4-isopropylbenzyl salicylate, 2-ethylhexyl salicylate (= octyl salicylate), homomenthyl salicylate.

The list of the UVB filters mentioned, which can be used according to the invention, should of course not be limiting.

The invention also relates to the combination of an inventive UVA filter with a UVB filter or an inventive cosmetic or dermatological preparation, which also contains a UVB filter.

It can also be advantageous to use UVA filters in preparations according to the invention to be used, usually in cosmetic and / or dermatological preparations are included. Such substances are preferably derivatives of Dibenzoylmethane, especially 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane 1,3-dione and 1-phenyl-3- (4'-isopropylphenyl) propane-1,3-dione. Also preparations, which contain these combinations are the subject of the invention. They can equal amounts of UVA filter substances are used, which for UVB Filter substances were called.

Cosmetic and / or dermatological preparations according to the invention can also be granular contain inorganic pigments that are commonly used in cosmetics to protect the Skin against UV rays. These are oxides of titanium, Zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof, as well as variations in which the oxides are the active agents. Especially it is preferably pigments based on titanium dioxide. It can be used for the amounts mentioned above combinations are used.

An astonishing property of the present invention is that according to the invention Preparations very good vehicles for cosmetic or dermatological active ingredients in the Skin are, with beneficial agents being antioxidants that protect the skin can protect against oxidative stress.

According to the invention, the preparations advantageously contain one or more Antioxidants. As inexpensive, yet optional antioxidants all for cosmetic and / or dermatological applications suitable or customary Antioxidants are used. It is advantageous to have antioxidants as the only ones Active ingredient class to use, for example, if a cosmetic or dermatological The main focus is on combating oxidative stress of the skin. However, it is also favorable to use the microemulsions according to the invention with a Provide content of one or more antioxidants when the preparations serve another purpose, e.g. B. as deodorants or sunscreens.

The antioxidants are advantageously selected from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D- Carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, β-carotene, lycopene) and their derivatives, lipoic acid and their derivatives (e.g. dihydroliponic acid), Aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, , Oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g. buthioninsulfoximines Homocysteine sulfoximine, buthionine sulfones, penta-, hexa-, heptathioninsul foximin) in very low tolerable doses (e.g. B. pmol to µmol / kg), also (metal) chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, Bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. B. Ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and konyferyl benzoate of benzoin, rutinic acid and its derivatives, ferulic acid and its derivatives , Butylhydroxytoluene, Butylhydroxyanisol, Nordihydroguajakharzäure, Nordihydroguajaretsäure, Trihydroxybutyrophenon, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (e.g. ZnO, ZnSO ₄ ) selenium and its derivatives (e.g. Selenomethionine), stilbene and their derivatives (e.g. B. stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active substances.

For the purposes of the present invention, water-soluble ones can be particularly advantageous Antioxidants are used.

An amazing property of the preparations according to the invention is that they are very are good vehicles for cosmetic or dermatological agents in the skin, whereby preferred active ingredients are antioxidants, which protect the skin from oxidative stress can protect. Preferred antioxidants are vitamin E and its derivatives and vitamin A and its derivatives.

The amount of antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05 to 20% by weight, in particular 0.1 to 10 wt .-%, based on the total weight of the preparation.

If vitamin E and / or its derivatives are the antioxidant (s) advantageous, the respective concentrations of which range from 0.001 to 10% by weight, based on the total weight of the formulation.

If vitamin A or vitamin A derivatives, or carotenes or their derivatives, the or the antioxidants are advantageous, their respective concentrations from the Range from 0.001 to 10 wt .-%, based on the total weight of the formulation choose.

According to the invention, the active ingredients (one or more compounds) can also be selected very advantageously from the group of lipophilic active ingredients, in particular from the following group:
Acetylsalicylic acid, atropine, azulene, hydrocortisone and its derivatives, e.g. B. hydrocortisone 17-valerate, vitamins, e.g. B. ascorbic acid and its derivatives, vitamins of the B and D series, very cheap vitamin B ₁ , vitamin B _12, vitamin D ₁ , but also bisabolol, unsaturated fatty acids, especially the essential fatty acids (often called vitamin F) , in particular gamma-linolenic acid, oleic acid, eicosapentaenoic acid, docosahexaenoic acid and their derivatives, chloramphenicol, caffeine, prostaglandins, thymol, camphor, extracts or other products of plant and animal origin, e.g. B. evening primrose oil, borage oil or currant seed oil, fish oils, cod liver oil but also ceramides and ceramide-like compounds and so on.

It is also advantageous to add the active ingredients from the group of refatting substances choose, for example Purcellinöl, Eucerit® and Neocerit®.

The active ingredient (s) are particularly advantageously selected from the group of NO synthase inhibitors, especially when the preparations according to the invention are used for Treatment and prophylaxis of the symptoms of intrinsic and / or extrinsic Skin aging as well as for the treatment and prophylaxis of the harmful effects ultraviolet radiation to serve the skin.

The preferred NO synthase inhibitor is nitroarginine.

The active ingredient (s) are also advantageously selected from the group consisting of Catechins and bile esters from catechins and aqueous or organic extracts Plants or parts of plants which contain catechins or Bile acid esters of catechins, such as the leaves of Plant family Theaceae, especially the species Camellia sinensis (green tea). Their typical ingredients (such as polyphenols or catechins, Caffeine, vitamins, sugar, minerals, amino acids, lipids).

Catechins are a group of compounds known as hydrogenated flavones or Anthocyanidins are to be understood and derivatives of "catechins" (catechol, 3,3 ', 4', 5,7-flavanpentaol, 2- (3,4-dihydroxyphenyl) -chroman-3,5,7-triol). Epicatechin too ((2R, 3R) -3,3 ', 4', 5,7-flavanpentaol) is an advantageous active substance in the sense of present invention.

Plant extracts containing catechins are also advantageous, in particular extracts of green tea, such as. B. Extracts from leaves of the plants of the species Camellia spec., Especially the types of tea Camellia sinenis, C. assamica, C. taliensis or C. irrawadiensis and crossings of these with, for example, Camellia japonica.

Preferred active ingredients are also polyphenols or catechins from the group (-) - Catechin, (+) - catechin, (-) - catechin gallate, (-) - gallocatechin gallate, (+) - epicatechin, (-) - Epicatechin, (-) - epicatechin gallate, (-) - epigallocatechin, (-) - epigallocatechin gallate.

Flavon and its derivatives (often also collectively called "flavones") are also advantageous active substances in the sense of the present invention. They are characterized by the following basic structure (substitution positions specified):

Some of the more important flavones, which can also preferably be used in preparations according to the invention, are listed in the table below:

In nature, flavones usually occur in glycosidated form.

According to the invention, the flavonoids are preferably selected from the group of substances of the generic structural formula


where Z ₁ to Z ₇ are selected independently of one another from the group H, OH, alkoxy and hydroxyalkoxy, where the alkoxy or hydroxyalkoxy groups can be branched and unbranched and can have 1 to 18 carbon atoms, and wherein Gly is selected from the group of mono- and oligoglycoside residues.

According to the invention, the flavonoids can also be advantageously selected from the group of substances of the generic structural formula


where Z ₁ to Z _{6 are} independently selected from the group H, OH, alkoxy and hydroxyalkoxy, where the alkoxy or hydroxyalkoxy groups can be branched and unbranched and can have 1 to 18 carbon atoms, and wherein Gly is selected from the group of mono- and oligoglycoside residues.

Such structures can preferably be selected from the group of substances of the generic structural formula


where Gly ₁ , Gly ₂ and Gly ₃ independently of one another represent monoglycoside residues or. Gly ₂ or Gly ₃ can also individually or together represent saturations by hydrogen atoms.

Gly ₁ , Gly ₂ and Gly ₃ are preferably selected independently of one another from the group of the hexosyl radicals, in particular the rhamnosyl radicals and glucosyl radicals. However, other hexosyl radicals, for example allosyl, altrosyl, galactosyl, gulosyl, idosyl, mannosyl and talosyl, may also be used advantageously. It can also be advantageous according to the invention to use pentosyl residues.

Z ₁ to Z ₅ are advantageously selected independently of one another from the group H, OH, methoxy, ethoxy and 2-hydroxyethoxy, and the flavone glycosides have the structure

The flavone glycosides according to the invention from the group which are represented by the following structure are particularly advantageous:


where Gly ₁ , Gly ₂ and Gly ₃ independently of one another represent monoglycoside residues or. Gly ₂ or Gly ₃ can also individually or together represent saturations by hydrogen atoms.

Gly ₁ , Gly ₂ and Gly ₃ are preferably selected independently of one another from the group of the hexosyl radicals, in particular the rhamnosyl radicals and glucosyl radicals. However, other hexosyl radicals, for example allosyl, altrosyl, galactosyl, gulosyl, idosyl, mannosyl and talosyl, may also be used advantageously. It can also be advantageous according to the invention to use pentosyl residues.

For the purposes of the present invention, this or that is particularly advantageous Flavone glycosides to be selected from the group α-glucosylrutin, α-glucosylmyricetin, α-glucosylisoquercitrin, α-glucosylisoquercetin and α-glucosylquercitrin.

According to the invention, α-glucosylrutin is particularly preferred.

Naringin (aurantiin, Naringenin-7-rhamnoglucoside), hesperidin (3 ', 5,7-trihydroxy-4'-methoxyflavanon-7-rutinoside, hesperidoside, Hesperetin-7-O-rutinoside). Rutin (3,3 ', 4', 5,7-pentahydroxyflyvon-3-rutinosid, Quercetin-3-rutinoside, sophorin, birutan, rutabion, taurutin, phytomelin, melin), troxerutin (3,5-dihydroxy-3 ', 4', 7-tris (2-hydroxyethoxy) flavone-3- (6-O- (6-deoxy-α-L-mannopyranosyl) -β-D- glucopyranoside)), monoxerutin (3,3 ', 4', 5-tetrahydroxy-7- (2-hydroxyethoxy) -flavon-3- (6-O- (6-deoxy-α-L-mannopyranosyl) -β-dglucopyranoside)), dihydrorobinetin (3,3 ', 4', 5 ', 7- Pentahydroxyflavanon), Taxifolin (3,3 ', 4', 5,7-Pentahydroxyflavanon), Eriodictyol-7-glucoside (3,4 ', 5,7-tetrahydroxyflavanone-7-glucoside), Flavanomareïn (3 ', 4', 7,8-tetrahydroxyflavanone-7-glucoside) and isoquercetin (3,3 ', 4', 5,7-pentahydroxyflavanone-3- (β-D- Glucopyranoside).

It is also advantageous to use the active ingredient (s) from the group of ubiquinones and To choose plastoquinones.

Ubiquinones are characterized by the structural formula


and represent the most widespread and thus the best studied bioquinones. Ubiquinones are classified as Q-1, Q-2, Q-3 etc. depending on the number of isoprene units linked in the side chain or as the number of C atoms U-5, U-10, U-15, etc. designated. They preferably occur with certain chain lengths, e.g. B. in some microorganisms and yeasts with n = 6. In most mammals, including humans, Q10 predominates.

Coenzyme Q10, which is characterized by the following structural formula, is particularly advantageous:

Plastoquinones have the general structural formula


on. Plastoquinones differ in the number n of isoprene residues and are designated accordingly, e.g. B. PQ-9 (n = 9). There are also other plastoquinones with different substituents on the quinone ring.

Creatine and / or creatine derivatives, phsophocreatine are also preferred active substances in the sense of the present invention. Creatine is characterized by the following structure:

Preferred derivatives are creatine phosphate and creatine sulfate, creatine acetate, Creatine ascorbate and that on the carboxyl group with mono- or polyfunctional alcohols esterified derivatives.

Another advantageous active ingredient is L-carnitine [3-hydroxy-4- (trimethylammonio) butyric acid betaine]. Also acyl-carnitine, which is selected from the group of substances of the following general structural formula


where R is selected from the group of branched and unbranched alkyl radicals having up to 10 carbon atoms are advantageous active ingredients in the sense of the present invention. Propionylcarnitine and in particular acetylcarnitine are preferred. Both entantiomers (D- and L-form) can be used advantageously for the purposes of the present invention. It may also be advantageous to use any mixture of enantiomers, for example a racemate of D and L form.

Other advantageous active ingredients are sericoside, pyridoxol, aminoguadin, phytochelatin, Isoflavones (genistein, daidzein, daidzin, glycitin), niacin, tyrosine sulfate, dioic acid, Adenosine, pyridoxine, arginine, vitamin K, biotin and flavorings.

The list of active substances or combinations of active substances mentioned in the Preparations according to the invention can of course not be limiting his. The active substances can be used individually or in any combination with one another be used.

Active ingredients can be in the preparations in the amounts of 0.0001-25 wt .-%, preferably 0.001-20% by weight, in particular 0.01-10% by weight, each based on the total weight of the preparations.

Although of course the use of hydrophilic active ingredients Another advantage of the preparations according to the invention is that the high number of finely divided droplets, especially oil-soluble or lipophilic active ingredients makes bioavailability particularly great effectiveness.

It is also advantageous to add the active ingredients from the group of refatting substances choose, for example Purcellinöl, Eucerit® and Neocerit®.

It is also possible and possibly advantageous to use the invention Add detergent surfactants to preparations. Aqueous cosmetic according to the invention Detergent or water-free or water-free intended for aqueous cleaning Detergent concentrates can be cationic, anionic, nonionic and / or Amphoteric surfactants contain, for example, conventional soaps, e.g. B. fatty acid salts of Sodium, alkyl sulfates, alkyl ether sulfates, alkane and alkylbenzenesulfonates, sulfoacetates, Sulfobetaines, sarcosinates, amidosulfobetaines, sulfosuccinates, Sulfosuccinic acid semiesters, alkyl ether carboxylates, protein fatty acid condensates, alkyl betaine and Amidobetaïne, fatty acid alkanolamides, polyglycol ether derivatives.

Cosmetic preparations, the cosmetic cleaning preparations for the skin represent can be in liquid or semi-solid form, for example as gels. she preferably contain at least one anionic, cationic, non-ionic or amphoteric surface-active substance or mixtures thereof, if appropriate Electrolytes and auxiliaries, as are usually used for this. The surface-active substance can preferably in a concentration between 1 and 30 wt .-% are present in the cleaning preparations, based on the total weight of the Preparations.

Cosmetic preparations containing a shampoo containing preferably at least one anionic, non-ionic or amphoteric surface-active Substance or mixtures thereof, optionally electrolytes and auxiliaries, such as those usually used for this. The surface-active substance can preferably be in a concentration between 1 and 50% by weight in the cleaning preparations are present, based on the total weight of the preparations. Are advantageous for example, to use cetyltrimethylammonium salts.

Intended for cleaning the hair or skin In addition to the aforementioned surfactants, preparations contain water and, if appropriate the additives customary in cosmetics, for example perfume, thickeners, dyes, Deodorants, antimicrobials, moisturizing agents, complexing and Sequestering agents, pearlescent agents, plant extracts, vitamins, active ingredients and like.

The preparations according to the invention, despite their oil content, are astonishing Very good foam development, high cleaning power and act to a high degree regenerating in relation to the general skin condition. In particular, they work Preparations according to the invention smoothing the skin, reduce the feeling of dryness of the Skin and make the skin supple.

If the preparations according to the invention are to be used for hair care, they can contain the usual constituents, usually for example film-forming polymers. Such polymers with at least partially quaternized nitrogen groups (hereinafter referred to as "film formers") are preferably those which are selected from the group of substances which, according to the INCI nomenclature (International Nomenclature Cosmetic Ingredient), bear the name "Polyquaternium", for example:
Polyquaternium-2: (Chemical Abstracts No. 63451-27-4, e.g. Mirapol® A-15)
Polyquaternium-5: (copolymer of acrylamide and β-methacryloxyethyltrimethylammonium methosulfate, CAS No. 26006-22-4)
Polyquaternium-6: (Homopolymer of N, N-dimethyl-N-2-propenyl-2-propen-1-aminium chloride, CAS No. 26062-79-3, e.g. Merquat® 100
Polyquaternium-7: N, N-dimethyl-N-2-propenyl-2-propen-1-aminium chloride, polymer with 2-propenamide, CAS no. 26590-05-6, e.g. B. Merquat® S
Polyquaternium-10: Quaternary ammonium salt of hydroxyethyl cellulose, CAS no. 53568-66-4, 55353-19-0, 54351-50-7, 68610-92-4, 81859-24-7, e.g. B. Celquat® SC-230M,
Polyquaternium-11: vinyl pyrrolidone / dimethylaminoethyl methacrylate copolymer / diethyl sulfate reaction product, CAS no. 53633-54-8, e.g. B. Gafquat® 755N
Polyquaternium-16: vinyl pyrrolidone / vinyl imidazolinium methochloride copolymer, CAS No. 29297-55-0, e.g. B. Luviquat® HM 552
Polyquaternium-17: CAS No. 90624-75-2, e.g. B. Mirapol® AD-1
Polyquaternium-19: Quaternized water-soluble polyvinyl alcohol
Polyquaternium-20: water-dispersible quaternized polyvinyl octadecyl ether
Polyquaternium-21: polysiloxane-polydimethyl-dimethylammonium acetate copolymer, e.g. B. Abil® B 9905
Polyquaternium-22: dimethyldiallylammonium chloride / acrylic acid copolymer, CAS no. 53694-7-0, e.g. B. Merquat® 280
Polyquaternium-24: Polymeric quaternary ammonium salt of hydroxyethyl cellulose, reaction product with an epoxy substituted with lauryldimethylammonium, CAS no. 107987-23-5, e.g. B. Quatrisoft® LM-200
Polyquaternium-28: vinyl pyrrolidone / methacrylamidopropyl trimethyl ammonium chloride copolymer, e.g. B. Gafquat® HS-100
Polyquaternium-29: e.g. B. Lexquat® CH
Polyquaternium-31: CAS no. 136505-02-7, e.g. B. Hypan® QT 100
Polyquaternium-32: N, N, N-trimethyl-2 - [(2-methyl-1-oxo-2-propenyl) oxy] -ethanaminium chloride, polymer with 2-propenamide, CAS no. 35429-19-7
Polyquaternium-37: CAS No. 26161-33-1
Cetyl trimethyl ammonium salts such as CTAB, CTAC.

Preparations for hair care according to the invention advantageously contain 0.01-5% by weight one or more film formers, preferably 0.1-3% by weight, in particular 0.2-2% by weight, each based on the total weight of the preparations. such Embodiments of the preparations according to the invention maintain due to environmental influences damaged or damaged hair or prevent such environmental influences. Further give the preparations according to the invention to the hairstyle loose fullness and Firmness without being sticky.

Accordingly, the preparations according to the invention, depending on their structure, used for example as a skin protection emulsion, cleansing milk, Sunscreen lotion, nutrient lotion, day or night emulsion, etc.

The preparations according to the invention also contribute excellently Skin smoothing, especially if they are provided with one or more substances that promote skin smoothing.

It is optionally possible and advantageous to prepare the preparations according to the invention as Use base for pharmaceutical formulations. Mutatis mutandis apply corresponding requirements for the formulation of medical preparations. The Transitions between pure cosmetics and pure pharmaceuticals are fluid. As According to the invention, pharmaceutical active substances are basically all classes of active substances geeginet, with lipophilic active substances being preferred. Examples are: antihistamines, Anti-inflammatory drugs, antibiotics, antifungals, active substances that promote blood circulation, Keratolytics, hormones, steroids, vitamins, etc.

The cosmetic and dermatological preparations according to the invention can Contain cosmetic auxiliaries, as they are usually used in such preparations be, e.g. B. preservatives, bactericides, virucides, perfumes, substances for Prevent foaming, dyes, pigments that have a coloring effect Thickeners, surface-active substances, emulsifiers, plasticizers, moisturizing and / or moisturizing substances, anti-inflammatory Substances, drugs, fats, oils, waxes or other common components of one cosmetic or dermatological formulation such as alcohols, polyols, polymers, Foam stabilizers, electrolytes, organic solvents.

Mixtures of the abovementioned solvents are particularly advantageous used.

Fats, waxes and other natural substances can be used as further components and synthetic fat bodies, preferably esters of fatty acids with lower alcohols C number, e.g. B. with isopropanol, propylene glycol or glycerin, or esters of fatty alcohols with low C number alkanoic acids or with fatty acids, alcohols, diols or polyols low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, Glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, Propylene glycol monomethyl, monoethyl or monobutyl ether, Diethylene glycol monomethyl or monoethyl ether and analog products.

All quantities, percentages or parts refer, unless otherwise indicated, on the weight of the preparations or the respective mixture.

The following examples are intended to illustrate the present invention. example 1 Wt .-% Isoceteth-20 1,700 Glyceryl stearate 5,300 Coco-caprylate caprate 5,000 dicaprylyl 5,000 PEG-150 distearate 0,800 glycerin 3,000 water ad 100,000 Wt .-% Isoceteth-20 4,600 Glyceryl stearate 2,400 Dicapryl ether 5,000 Cyclomethicone 5,000 PEG-150 distearate 1,000 glycerin 3,000 water ad 100,000 Wt .-% Isoceteth-20 4,600 Sorbitan isostearate 2,400 Dicapryl ether 5,000 Cyclomethicone 5,000 Coco-caprylate caprate 5,000 PEG-150 distearate 1,000 glycerin 3,000 water ad 100,000 Wt .-% PEG-20 sorbitan isostearate 4,600 Sorbitan isostearate 2,400 Diethylhexylcyclohexane 5,000 PEG-150 distearate 1,000 glycerin 2,000 water ad 100,000 Wt .-% PEG-25 stearate 4,600 Glyceryl stearate 2,400 Dicapryl ether 5,000 octyldodecanol 5,000 PEG-150 distearate 0,800 glycerin 3,000 water ad 100,000 Wt .-% PEG-25 stearate 4,600 Glyceryl stearate 2,400 Dicapryl ether 5,000 Paraffinum Liquidum 5,000 PEG-150 distearate 0,800 glycerin 3,000 water ad 100,000 Wt .-% Ceteareth-20 1,000 Caprylic / Capric triglycerides 1,000 Cetearyl isononanoate 3,000 C12-15 alkyl benzoates 3,000 PEG-150 distearate 2,000 Dimethicone 3,000 glycerin 3,000 water ad 100,000 Wt .-% Sorbitan stearate 1,000 Polyglyceryl-3 methyl glucose distearate 3,000 C12-15 alkyl benzoates 4,000 Cetearyl alcohol 1,500 PEG-150 distearate 1,000 Cyclomethicone 3,000 glycerin 5,000 water ad 100,000 Wt .-% Glyceryl stearate 1,500 Ceteareth-20 2,000 Myristyl myristate 4,000 Isostearyl isostearate 5,000 C12-15 alkyl benzoates 5,000 Squalane 1,000 Behenyl alcohol 2,500 Dimethicone 2,000 PEG-150 distearate 1,000 Butylene glycol 5,000 water ad 100,000 Wt .-% Polyglyceryl-3 methyl glucose distearate 5,000 Cetyl alcohol 1,500 Paraffinum Liquidum 3,000 Dimethicone 2,000 Isostearyl isostearate 4,000 Cyclomethicone 4,000 Butylene glycol 5,000 water ad 100,000 Wt .-% Sorbitan stearate 1,000 Polyglyceryl-3 methyl glucose distearate 3,000 C12-15 alkyl benzoates 4,000 Cetearyl alcohol 0,500 PEG-150 distearate 1,500 Cyclomethicone 3,000 glycerin 5,000 water ad 100,000 Wt .-% Sorbitan stearate 1,000 Polyglyceryl-3 methyl glucose distearate 3,000 C12-15 alkyl benzoates 4,000 PEG-150 distearate 2,000 Cyclomethicone 3,000 glycerin 5,000 water ad 100,000 Wt .-% Ceteareth-20 1,000 Caprylic / Capric triglycerides 1,000 Cetearyl isononanoate 3,000 C12-15 alkyl benzoates 3,000 PEG-150 distearate 2,000 Dimethicone 3,000 glycerin 3,000 water ad 100,000

Claims (12)

1. A process for the preparation of emulsions of the oil-in-water type, comprising a water phase and an oil phase which is composed essentially of non-volatile constituents, containing at least one oil-in-water emulsifier and optionally a W / O emulsifier and at least one a crosslinker, and optionally auxiliary substances, additives and / or active substances, a) obtainable in such a way that the water phase with its constituents is added to the oil phase with its constituents, the O / W emulsifier and optionally the W / O emulsifier, and one or more crosslinkers are added to the water phase or the oil phase or be given in both phases, resulting in an increase in viscosity and crosslinked O / W emulsions, b) obtainable in such a way that the mixture is brought to a temperature within or outside the phase inversion temperature range and then cooled to room temperature, resulting in an increase in viscosity and crosslinked O / W emulsions being obtained, c) or obtainable in that the crosslinking agent is subsequently added to a low-viscosity O / W emulsion and a crosslinked O / W emulsion is obtained. 2. The method according to claim 1, characterized in that as an O / W emulsifier at least one polyethoxylated and / or polypropoxylated O / W emulsifier selected becomes. 3. The method according to claim 1, characterized in that as an O / W emulsifier Ceteth-15, ceteth-16, ceteareth-15, ceteareth-16, ceteareth-20, isoceteth-20, Isosteareth-20, Steareth-20, Oleth-15, Laureth-15, PEG-20 stearate, PEG-25 stearate, PEG-20 oleate, PEG-20 sorbitan stearate, PEG-20 sorbitan isostearate, PEG-20 Sorbitan oleate, sodium laureth-11 carboxylate, sodium lauryl ether sulfate, PEG-30 Cholesteryl ether, PEG-60 Evening Primrose Glyceride, Up to PEG / PPG-16/16 PEG / PPG16 / 16 dimethicone + caprylic acid / capric acid triglyceride (Abil Care 85), PEG-45 palm kernel oil glyceride, PEG-20 glyceryl laurate, PEG-20 glyceryl stearate, PEG-20 Glycerol isostearate selected or combinations of the aforementioned can be selected. 4. The method according to claim 1, characterized in that as an O / W emulsifier at least one non-ethoxylated or non-propoxylated O / W emulsifier is used becomes. 5. The method according to claim 1, characterized in that as a non-ethoxylated O / W emulsifier polyglyceryl-3 methylglucose distearate, glyceryl stearate citrate, Polyglycerin-10 stearate, polyglycerin-10 laurate selected or combinations of the be selected above. 6. The method according to claim 1, characterized in that a combination of at least one polyethoxylated and / or polypropoxylated O / W emulsifier and a W / O emulsifier is selected. 7. The method according to claim 1, characterized in that a combination of at least one non-polyethoxylated or non-polypropoxylated O / W Emulsifier and a W / O emulsifier is selected. 8. The method according to claim 1, characterized in that as a W / O emulsifier Glyceryl stearate, glycerol isostearate, glyceryl linoleate, diglycerin isostearate, Triglycerol diisostearate, sorbitan isostearate, propylene glycol isostearate, Propylene glycol stearate, cetyl alcohol, stearyl alcohol, steareth-2, glyceryl laurate, Glyceryl caprinate, glyceryl caprylate, selachyl alcohol, chimyl alcohol, PEG-5 cholesteryl ether PEG-30 dipolyhydroxystearate, polyglyceryl-3 methylglucose distearate, PEG- 45 / dodecyl glycol copolymer, methoxy-PEG-22-dodecyl glycol copolymer, Methyl glucose sesquistearate, polyglyceryl-2 dipolyhydroxystearate, cetyl dimethicone Copolyole, Alkyl Methicon Copolyole, Alkyl Dimethicone Ethoxy Glucoside used become. 9. The method according to claim 1, characterized in that individually as a crosslinker or in combination in each case hydrophobically substituted cellulose ethers, starches, acrylates, Alginates, glucans, chitins, dextrans, caseinates, pectins, proteins and gums, Polyurethanes, polyacrylamides, polyvinyl alcohols, polyacrylates, water-soluble Silicone polymers are used. 10. The method according to claim 1, characterized in that as the crosslinking agent PEG-150 distearate, PEG 800 distearate, PEG-800 Chol ₂ , PEG-150 dioleate, PEG-300 pentaerythrityl tetraisostearate, PEG-120 methylglucose dioleate, PEG-160- Sorbitan triisostearate, PEG-450 sorbitol hexaisostearate, PEG-230 glyceryl triisostearate PEG-200 glyceryl palmitate, polyether-1, polyurethane crosslinker Rheolate 204, 205, 208, cetylhydroxyethyl cellulose can be used. 11. The method according to claim 1, characterized in that combinations of Crosslinkers and non-crosslinking thickeners can be used. 12. The method according to claim 1, characterized in that one or more Skin moisturizers such as glycerin, chitosan, fucogel, 2 methyl propanediol, Polyethylene glycol, lactic acid, propylene glycol, dipropylene glycol, butylene glycol, Mannitol, acids and their salts such as sodium pyrolidone carboxylic acid, hyaluronic acid, Amino acids, urea, electrolytes, preferably salts of inorganic and / or organic acids, especially sodium, potassium, magnesium and calcium salts be used.