MX9803315A - Queto acidos aromaticos y sus derivados como inhibidores de metaloproteinasas matriz. - Google Patents

Queto acidos aromaticos y sus derivados como inhibidores de metaloproteinasas matriz.

Info

Publication number
MX9803315A
MX9803315A MX9803315A MX9803315A MX9803315A MX 9803315 A MX9803315 A MX 9803315A MX 9803315 A MX9803315 A MX 9803315A MX 9803315 A MX9803315 A MX 9803315A MX 9803315 A MX9803315 A MX 9803315A
Authority
MX
Mexico
Prior art keywords
inhibitors
derivatives
matrix metalloproteinases
acids
aromatic keto
Prior art date
Application number
MX9803315A
Other languages
English (en)
Other versions
MXPA98003315A (es
Inventor
Donald J Hupe
Linda Lea Johnson
Daniel Fred Ortwine
Claude Forsey Purchase Jr
Andrew David White
Qi-Zhuang Ye
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of MX9803315A publication Critical patent/MX9803315A/es
Publication of MXPA98003315A publication Critical patent/MXPA98003315A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se describen compuestos de queto ácidos aromáticos de la formula (I) y derivados así como también métodos para la preparacion y composiciones farmacéuticas de los mismos, que son utiles como inhibidores de metaloproteinasas matriz, particularmente gelatinasa A (72kD gelatinasa) y estromelisín - 1 y para el tratamiento de esclerosis multiple, ruptura de placa aterosclerotica, aneurismo aortico, fallas cardiacas, restenosis, enfermedad periodontal, ulceracion corneal, tratamiento de quemaduras, ulceras decubitales, curacion de heridas, cáncer, artritis u otros desordenes autoinmunologicos o inflamatorios dependientes de la invasion al tejido de luecocitos. Ar, Y, W, R1-R4, n son como se define en la solicitud.
MXPA/A/1998/003315A 1995-12-22 1998-04-27 Queto acidos aromaticos y sus derivados como inhibidores de metaloproteinasas matriz MXPA98003315A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US948995P 1995-12-22 1995-12-22
US009489 1998-01-20

Publications (2)

Publication Number Publication Date
MX9803315A true MX9803315A (es) 1998-09-30
MXPA98003315A MXPA98003315A (es) 1998-11-16

Family

ID=

Also Published As

Publication number Publication date
HUP9902079A3 (en) 2000-06-28
DE69619865D1 (de) 2002-04-18
NZ323329A (en) 1999-02-25
AU1024997A (en) 1997-07-17
EP0876343B1 (en) 2002-03-13
ES2175155T3 (es) 2002-11-16
BG63461B1 (bg) 2002-02-28
HU222986B1 (hu) 2004-01-28
NO982840L (no) 1998-06-19
CZ287868B6 (en) 2001-02-14
US6008220A (en) 1999-12-28
WO1997023459A1 (en) 1997-07-03
CZ195298A3 (cs) 1998-09-16
DK0876343T3 (da) 2002-07-01
HUP9902079A2 (hu) 1999-10-28
AU713174C (en) 2002-05-02
SK87598A3 (en) 1999-04-13
JP2000502343A (ja) 2000-02-29
PT876343E (pt) 2002-08-30
PL327494A1 (en) 1998-12-21
BG102471A (en) 1999-08-31
ZA9610722B (en) 1997-06-27
NO309470B1 (no) 2001-02-05
DE69619865T2 (de) 2002-11-07
EP0876343A1 (en) 1998-11-11
ATE214368T1 (de) 2002-03-15
BR9612188A (pt) 1999-07-13
NO982840D0 (no) 1998-06-19
AU713174B2 (en) 1999-11-25

Similar Documents

Publication Publication Date Title
IL123901A (en) Sulfonamide inhibitors of matrix metalloproteinases and pharmaceutical compositions comprising them
ZA9610722B (en) Aromatic keto-acids and their derivatives as inhibitors of matrix metalloproteinases
NZ509439A (en) Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases
CA2356380A1 (en) Immunosuppressive effects of pteridine derivatives
NO972980D0 (no) Anvendelse av nebivolol som et anti-aterogent middel
CA2106172A1 (en) Use of 2-(3,4-Dimethoxycinnamoyl)Aminobenzoic Acid for the Treatment of Restenosis Associated with Coronary Intervention
HU9301550D0 (en) New hydroxamine acid and n-hydroxy-carbamide derivatives and their applications
HUP9802762A2 (hu) Difenil-metilén-piperidin-származékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk
BR9712794A (pt) Compostos para e um método de inibição de metaloproteinases matriciais
SE9201628D0 (sv) Pharmaceutical composition
ZA964508B (en) Tricyclic inhibitors of matrix metalloproteinases
BR9503572A (pt) Composto composiçao farmaceutica e método de tratamento ou prevençao de uma doença
TR199700694T1 (xx) D vitamini t�revlerinin dermotolojik kullan�m�.
EE9700231A (et) Aminotetraliini derivaat kardiovaskulaarsete haiguste raviks
ATE275953T1 (de) 2,3 diaryl-1-benzopyrame zur behandlung von dermatitis
CA2233560A1 (en) Sulfonamide inhibitors of matrix metalloproteinases
UY24693A1 (es) Ácidos bifenil butíricos y sus derivados como inhibidores de metaloproteinasas de matriz