MX9802238A - Derivados de acriloilguanidina substituidos con heteroarilos y composicion medicinal de los mismos. - Google Patents
Derivados de acriloilguanidina substituidos con heteroarilos y composicion medicinal de los mismos.Info
- Publication number
- MX9802238A MX9802238A MX9802238A MX9802238A MX9802238A MX 9802238 A MX9802238 A MX 9802238A MX 9802238 A MX9802238 A MX 9802238A MX 9802238 A MX9802238 A MX 9802238A MX 9802238 A MX9802238 A MX 9802238A
- Authority
- MX
- Mexico
- Prior art keywords
- heteroaryl
- medicinal composition
- ring
- substituted
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Derivados de acriloilguanidina substituidos con heteroarilos representados por la formula general (I): o sus sales que sirven como medicamentos, en particular, un inhibidor del intercambiador de Na+/H+ y que son utiles como un medicamento preventivo, de remedio o diagnostico para varias enfermedades en las cuales participa el intercambiador de Na+/H+, por ejemplo, hipertension, arritmia, angina de pecho, arterioesclerosis y complicaciones de diabetes, en donde el anillo A representa un heteroarilo de 5 o 6 miembros opcionalmente substituidos, el cual puede ser fusionado con uno o dos anillos de benceno; el anillo B representa un arilo opcionalmente substituido; y R1 representa hidrogeno, halogeno alquilo inferior opcionalmente halogenado.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7-241716 | 1995-09-20 | ||
HEHEI-7-241716 | 1995-09-20 | ||
JP24171695 | 1995-09-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX9802238A true MX9802238A (es) | 1998-08-30 |
MXPA98002238A MXPA98002238A (es) | 1998-11-12 |
Family
ID=
Also Published As
Publication number | Publication date |
---|---|
AU702092B2 (en) | 1999-02-11 |
NO981241D0 (no) | 1998-03-19 |
SK35198A3 (en) | 1999-06-11 |
EP0861831A4 (en) | 1998-11-11 |
BR9610530A (pt) | 1999-07-06 |
AU7000796A (en) | 1997-04-09 |
CZ84098A3 (cs) | 1998-09-16 |
WO1997011055A1 (fr) | 1997-03-27 |
EP0861831A1 (en) | 1998-09-02 |
PL326033A1 (en) | 1998-08-17 |
NO981241L (no) | 1998-05-20 |
ZA967800B (en) | 1997-04-03 |
CA2232497A1 (en) | 1997-03-27 |
KR19990063589A (ko) | 1999-07-26 |
CN1196721A (zh) | 1998-10-21 |
HUP9901336A2 (hu) | 1999-08-30 |
HUP9901336A3 (en) | 2000-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0861831A4 (en) | HETEROARYL-SUBSTITUTED ACRYLOYLGUANIDINE DERIVATIVES AND THEIR MEDICINAL COMPOSITIONS | |
EA199800477A1 (ru) | Производные хинолина | |
GB0206860D0 (en) | Compounds | |
KR927003052A (ko) | 2-아릴티아졸 유도체 및 그의 약제학적 조성물 | |
ES8202334A1 (es) | Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina | |
ES2108371T3 (es) | Nuevos derivados de estradieno de 11-benzaldoxima, procedimientos para su produccion y farmacos conteniendo estos compuestos. | |
ES8801787A1 (es) | Procedimiento para la obtencion de amidas de acidos benzoheterociclilalcanoicos | |
DK0648779T3 (da) | 11-benzaldoxim-17beta-methoxy-17alfa-methoxymethyl-estradien-derivater, fremgangsmåder til deres fremstilling og lægemidler indeholdende disse forbindelser | |
DE69009195T2 (de) | Isoxazol-Derivate mit Anti-Serotonin-Aktivität, deren Herstellungsverfahren und diese enthaltende Zusammensetzungen. | |
HUP0100184A2 (hu) | Szubsztituált 2-(benzil-amino)-2-fenil-acetamid-vegyületek és ezeket tartalmazó gyógyszerkészítmények | |
ATE97901T1 (de) | Cephalosporinderivate, verfahren zu ihrer herstellung sowie entsprechende pharmazeutische praeparate. | |
ATE106868T1 (de) | N-((2-oxopyrrolidin-1-yl)acetyl>piperazin- derivate und arzneimittel gegen senile dementia. | |
DE69103630T2 (de) | Oxazolederivate, ihre herstellung und diese enthaltende pharmazeutischen zubereitungen. | |
FI941963A (fi) | Pyridiinijohdannaiset, niiden valmistus ja käyttö | |
DE69031331D1 (de) | Thiophenverbindungen und ihre pharmazeutischen Verwendungen | |
ATE101139T1 (de) | (alkylthio-3-propyl)-3-benzothiazolinderivate, ihre herstellung und diese enthaltende arzneimittel. | |
HUP0004386A2 (hu) | Metilén-biszfoszfonsav-származékok, eljárás előállításukra és azokat hatóanyagként tartalmazó gyógyszerkészítmények | |
DE69412794T2 (de) | 2'-desoxy-5-fluoruridin, pharmazeutisch anwendbare salze davon, verfahren zu ihrer herstellung und antitumormedikament | |
IE45889L (en) | 4-AMINO-BENZO (b) BICYCLO [3.3.1] NONENE DERIVATIVES,¹ANTI-DEPRESSANTS | |
NO165593C (no) | Analogifremgangsmaate ved fremstilling av nye tetracykliske indolderivater. | |
ES8103079A1 (es) | Un procedimiento para preparar derivados de fenotiazina | |
AU6675794A (en) | Benzo(F)quinoxalindione derivatives, their preparation and their use in drugs | |
WO2000050017A3 (en) | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases | |
HUP0103302A2 (hu) | (Polihidroxi-alkil)-pirazin-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények | |
MX9802816A (es) | Derivados de pirimidina. |