MX9709301A - Proceso para la produccion de los isomeros (r) y (s) alfa-metil-3(trifluorometil)bencenetanamina. - Google Patents
Proceso para la produccion de los isomeros (r) y (s) alfa-metil-3(trifluorometil)bencenetanamina.Info
- Publication number
- MX9709301A MX9709301A MX9709301A MX9709301A MX9709301A MX 9709301 A MX9709301 A MX 9709301A MX 9709301 A MX9709301 A MX 9709301A MX 9709301 A MX9709301 A MX 9709301A MX 9709301 A MX9709301 A MX 9709301A
- Authority
- MX
- Mexico
- Prior art keywords
- trifluoromethyl
- alpha
- methyl
- isomers
- production
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- MLBHFBKZUPLWBD-ZETCQYMHSA-N (2S)-1-[3-(trifluoromethyl)phenyl]-2-propanamine Chemical compound C[C@H](N)CC1=CC=CC(C(F)(F)F)=C1 MLBHFBKZUPLWBD-ZETCQYMHSA-N 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- QCCDLTOVEPVEJK-UHFFFAOYSA-N phenylacetone Chemical compound CC(=O)CC1=CC=CC=C1 QCCDLTOVEPVEJK-UHFFFAOYSA-N 0.000 abstract 2
- 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 230000000578 anorexic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
- C07C209/26—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with hydrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invencion se refiere a un proceso para la produccion de los isomeros (R) y (S)-alfa-metil-3-(triflurometil)bencenetamina, de los cuales el segundo se puede usar como un compuesto intermedio en la síntesis del fármaco anoréxico dexfenfluramina (INN), proceso que comprende llevar a cabo una animacion reductora, estereoespecífica, de la 1-(3-trifluorometil)fenil-2-propanona con (R) o (S)-alfa-metilbencilamina, bajo atmosfera de hidrogeno, en la presencia de un catalizador, y desbencilar el diasteroisomero resultante (R),(R) o (s), (S)-N-(1-feniletil)-alfa-metil-3-(trifluorometil)b enceno-etamina, mediante el tratamiento con hidrogeno y catalizador.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97BO000252A IT1292885B1 (it) | 1997-04-28 | 1997-04-28 | Processo per la produzione degli isomeri (r) ed (s)- alfa -metil-3- (trifluorometil)benzene-etanamina. |
| BOBO97A000252 | 1997-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9709301A true MX9709301A (es) | 1998-10-31 |
| MXPA97009301A MXPA97009301A (es) | 1999-01-11 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| HU9701364D0 (en) | 1997-09-29 |
| ZA978203B (en) | 1998-04-29 |
| ITBO970252A1 (it) | 1998-10-29 |
| JPH10330330A (ja) | 1998-12-15 |
| IT1292885B1 (it) | 1999-02-11 |
| HUP9701364A3 (en) | 1999-07-28 |
| CA2212203A1 (en) | 1998-10-29 |
| KR19980079310A (ko) | 1998-11-25 |
| AU3322097A (en) | 1998-11-05 |
| ITBO970252A0 (it) | 1997-04-28 |
| AR008700A1 (es) | 2000-02-09 |
| TW389748B (en) | 2000-05-11 |
| US5808156A (en) | 1998-09-15 |
| EP0875498A3 (en) | 2000-07-26 |
| EP0875498A2 (en) | 1998-11-04 |
| HUP9701364A2 (hu) | 1999-04-28 |
| PL322542A1 (en) | 1998-11-09 |
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