MX9708319A - Vacuna de uresa recombinante, multimerica. - Google Patents

Vacuna de uresa recombinante, multimerica.

Info

Publication number
MX9708319A
MX9708319A MX9708319A MX9708319A MX9708319A MX 9708319 A MX9708319 A MX 9708319A MX 9708319 A MX9708319 A MX 9708319A MX 9708319 A MX9708319 A MX 9708319A MX 9708319 A MX9708319 A MX 9708319A
Authority
MX
Mexico
Prior art keywords
compositions
multimeric
helicobacter
methods
recombinant urease
Prior art date
Application number
MX9708319A
Other languages
English (en)
Inventor
Cynthia K Lee
Thomas P Monath
Samuel K Ackerman
William D Thomas Jr
Gopalan Soman
Harold Kleanthous
Richard A Weltzin
Jacques Pappo
Thomas Ermak
Original Assignee
Oravax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oravax Inc filed Critical Oravax Inc
Publication of MX9708319A publication Critical patent/MX9708319A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se proporcionan métodos y composiciones para prevenir y/o tratar infecciones por helicobacter (por ejemplo H, pylori). las composiciones de la invencion, que son usadas en los métodos de la invencion (los cuáles incluyen administracion mucosal de las composiciones) incluyen composiciones que contienen complejos multiméricos de una ureasa helicobacter enzimáticamente inactiva, recombinante en un portador o diluyente farmacéuticamente aceptable; composiciones que contienen (a) un antígeno helicobacter, y (b) un antibiotico, un agente anti-secretante, una sal de bismuto, o una combinacion de éstos.
MX9708319A 1995-04-28 1997-10-28 Vacuna de uresa recombinante, multimerica. MX9708319A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43104195A 1995-04-28 1995-04-28
US56812295A 1995-12-06 1995-12-06

Publications (1)

Publication Number Publication Date
MX9708319A true MX9708319A (es) 1998-08-30

Family

ID=27028868

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708319A MX9708319A (es) 1995-04-28 1997-10-28 Vacuna de uresa recombinante, multimerica.

Country Status (15)

Country Link
EP (1) EP0831892B1 (es)
JP (1) JPH11504633A (es)
KR (1) KR19990008155A (es)
AT (1) ATE433325T1 (es)
AU (1) AU723063B2 (es)
BR (1) BR9609871A (es)
CA (1) CA2219201A1 (es)
CZ (1) CZ342697A3 (es)
DE (1) DE69637947D1 (es)
HU (1) HUP9801266A3 (es)
MX (1) MX9708319A (es)
NO (1) NO974969L (es)
NZ (1) NZ307017A (es)
PL (1) PL185013B1 (es)
WO (1) WO1996033732A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2637612B1 (fr) * 1988-10-06 1993-09-10 Pasteur Institut Sequences de nucleotides codant pour une proteine a activite ureasique
FR2682122B1 (fr) * 1991-10-03 1995-06-09 Pasteur Institut Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
DE19521314A1 (de) * 1995-06-12 1996-12-19 Max Planck Gesellschaft Adhärenzgen aus Helicobacter pylori und davon codiertes Polypeptid
EP0835928A1 (en) * 1996-10-11 1998-04-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Helicobacter pylori live vaccine
WO1998021225A1 (en) * 1996-11-14 1998-05-22 Merieux Oravax Helicobacter polypeptides and corresponding polynucleotide molecules
US6248551B1 (en) 1997-03-28 2001-06-19 Institut Pasteur Helicobacter aliphatic amidase AmiE polypeptides, and DNA sequences encoding those polypeptides
GB9718616D0 (en) * 1997-09-02 1997-11-05 Queen Mary & Westfield College Oral vaccine
US6599509B2 (en) 1997-09-02 2003-07-29 Massachusetts Institute Of Technology Compositions and methods comprising helicobacter antigens for treatment and prevention of inflammatory bowel disease
US5985631A (en) 1997-09-12 1999-11-16 Oravax-Merieux Co. Method for preventing the activation of inactive, recombinant Helicobacter pylori apourease
CA2335487A1 (en) 1998-06-19 1999-12-23 Merieux Oravax Lt and ct in parenteral immunization methods against helicobacter infection
US6190667B1 (en) 1998-06-30 2001-02-20 Institut Pasteur Methods of inhibiting Helicobacter pylori
WO2000003730A1 (en) * 1998-07-16 2000-01-27 Cheil Jedang Corporation Urease based vaccine against helicobacter infection
EP1327450B1 (de) * 2002-01-15 2007-08-15 Bio Life Science Forschungs- und Entwicklungsges.m.b.H. Orale Vakzinierung mit nackten Tumor-Antigen-Mimotopen
ATE361097T1 (de) * 2002-01-15 2007-05-15 Bio Life Science Forschungs & Entwicklungsgesellschaft Mbh Orale vakzinierung mit dem tumor-antigen-mimotop gln-met-trp-ala-pro-gln-trp-gly-pro-asp
WO2005113603A1 (en) * 2004-05-18 2005-12-01 Universite De Lausanne Eradication of helicobacter infection by activation of stomach mast cells
CN100460013C (zh) * 2006-09-05 2009-02-11 重庆康卫生物科技有限公司 口服重组幽门螺杆菌疫苗及其制备方法
CN100535119C (zh) * 2006-11-07 2009-09-02 上海交通大学医学院附属第九人民医院 一种制备唾液链球菌尿素酶基因的方法
CN101955545B (zh) * 2010-09-07 2012-07-04 四川万可泰生物技术有限责任公司 一种多靶点重组基因及其蛋白在防治幽门螺旋杆菌感染中的应用
CN113433087A (zh) * 2021-06-22 2021-09-24 中南大学 一种尿素浓度快速检测方法及检测传感器和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
US6290962B1 (en) * 1992-11-03 2001-09-18 Oravax, Inc. Urease-based vaccine and treatment for helicobacter infection
JPH08509873A (ja) * 1993-05-19 1996-10-22 アンスティテュ・パストゥール ヘリコバクター感染に対する免疫組成物、該組成物に用いられるポリペプチドおよび該ポリペプチドをコードする核酸配列
FR2732605B1 (fr) * 1995-04-07 1997-05-16 Pasteur Merieux Serums Vacc Composition destinee a l'induction d'une reponse immunitaire mucosale

Also Published As

Publication number Publication date
DE69637947D1 (de) 2009-07-23
AU723063B2 (en) 2000-08-17
CZ342697A3 (cs) 1998-06-17
CA2219201A1 (en) 1996-10-31
EP0831892B1 (en) 2009-06-10
JPH11504633A (ja) 1999-04-27
WO1996033732A1 (en) 1996-10-31
ATE433325T1 (de) 2009-06-15
EP0831892A1 (en) 1998-04-01
EP0831892A4 (en) 2002-06-26
HUP9801266A2 (hu) 1998-08-28
NO974969L (no) 1997-12-23
BR9609871A (pt) 2000-03-28
KR19990008155A (ko) 1999-01-25
HUP9801266A3 (en) 1999-07-28
PL185013B1 (pl) 2003-01-31
NZ307017A (en) 1999-07-29
PL323048A1 (en) 1998-03-02
NO974969D0 (no) 1997-10-27
AU5576496A (en) 1996-11-18

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees