MX9703476A - Factor derivado de neuronas sensoriales y motoras (smdf). - Google Patents

Factor derivado de neuronas sensoriales y motoras (smdf).

Info

Publication number
MX9703476A
MX9703476A MX9703476A MX9703476A MX9703476A MX 9703476 A MX9703476 A MX 9703476A MX 9703476 A MX9703476 A MX 9703476A MX 9703476 A MX9703476 A MX 9703476A MX 9703476 A MX9703476 A MX 9703476A
Authority
MX
Mexico
Prior art keywords
smdf
neuregulins
sensory
motor neuron
isolated
Prior art date
Application number
MX9703476A
Other languages
English (en)
Inventor
Wei-Hsien Ho
Phyllis L Osheroff
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX9703476A publication Critical patent/MX9703476A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invencion describe SMDF aislado, ADN aislado que codifica el SMDF, y métodos recombinantes y sintéticos de preparar el SMDF. El SMDF contiene un dominio semejante al EGF de tipo beta, y una secuencia N-terminal que es distinta de todas las neurregulinas reportadas a la fecha. El SMDF, cuando es expresado en un cultivo de células recombinantes, activa la fosforilacion de tirosina del receptor HER2/neu en células de cáncer de seno humano, y exhibe actividad mitogénica sobre células de Schwann. Los análisis de manchado de Northern e hibridacion in situ muestran que el SMDF difiere de otras neurregulinas en queéste es especifico del tejido nervioso, y es muy altamente expresado, en comparacion a otras neurregulinas, en las neuronas motoras y las neuronas sensoriales de la médula espinal humana y de rata.
MX9703476A 1994-11-14 1995-11-08 Factor derivado de neuronas sensoriales y motoras (smdf). MX9703476A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/339,517 US5770567A (en) 1994-11-14 1994-11-14 Sensory and motor neuron derived factor (SMDF)
PCT/US1995/014575 WO1996015244A2 (en) 1994-11-14 1995-11-08 Sensory and motor neuron derived factor (smdf)

Publications (1)

Publication Number Publication Date
MX9703476A true MX9703476A (es) 1997-07-31

Family

ID=23329369

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9703476A MX9703476A (es) 1994-11-14 1995-11-08 Factor derivado de neuronas sensoriales y motoras (smdf).

Country Status (7)

Country Link
US (4) US5770567A (es)
EP (1) EP0792362A2 (es)
JP (1) JPH10509149A (es)
CA (1) CA2204379A1 (es)
IL (1) IL115960A0 (es)
MX (1) MX9703476A (es)
WO (1) WO1996015244A2 (es)

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Also Published As

Publication number Publication date
IL115960A0 (en) 1996-01-31
US5756456A (en) 1998-05-26
CA2204379A1 (en) 1996-05-23
WO1996015244A3 (en) 1996-08-08
US5667780A (en) 1997-09-16
JPH10509149A (ja) 1998-09-08
US5763213A (en) 1998-06-09
WO1996015244A2 (en) 1996-05-23
US5770567A (en) 1998-06-23
EP0792362A2 (en) 1997-09-03

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