MX9700888A - Ligandos de receptor de urocinasa. - Google Patents

Ligandos de receptor de urocinasa.

Info

Publication number
MX9700888A
MX9700888A MX9700888A MX9700888A MX9700888A MX 9700888 A MX9700888 A MX 9700888A MX 9700888 A MX9700888 A MX 9700888A MX 9700888 A MX9700888 A MX 9700888A MX 9700888 A MX9700888 A MX 9700888A
Authority
MX
Mexico
Prior art keywords
lower alkyl
aryl
halo
cycloalkyl
alkyl
Prior art date
Application number
MX9700888A
Other languages
English (en)
Inventor
Steven Rosenberg
Kerry L Spear
Eric J Martin
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of MX9700888A publication Critical patent/MX9700888A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Los compuestos de la invencion inhiben al activador de plasminogeno o uPAR, representado por la formula general (I), en la que R10 es -CH(R9)XCH(R1) (R11) o un grupo de terminacion o de remate, en el que X es NR12CR12R15, O, S, SR12, o SR12R15; R1, R9, R11, R12, R15 y cada H, alquilo inferior, alquenilo inferior, arilo, aralquilo, aril-alquenilo, aril-alquinilo, arilcicloalquilo sustituido con 0-3 halo, OH, NH2, alquilo inferior, haloalquilo inferior, alcoxi inferior, alquilamino inferior, alquiltio inferior, CN o NO2; R16 es -CH(R5)C(=O)NH2, H, alquilo inferior, cicloalquilo o alquenilo inferior, R2 es arilo o aralquilo, no sustituido u sustituido con 1-3 de halo, OH, NH2, CN, NO2, alquilo inferior, alcoxi inferior, alquilamino inferior, alquiltio inferior, o cicloalquilo; R3 y R5 son cada uno independientemente H, o alquilo inferior, R4 es -CH2C(=O)NR13R14, en la que R13 es H, alquilo inferior, fenilo o bencilo, y R14 es H, arilo o aralquilo, en el que R6 y R7 son cada uno independientemente H, OH, NH2, CN NO2, alquilo inferior, haloalquilo inferior, alcoxi inferior, alquilamio inferior o cicloalquilo y n y m son cada uno independientemente el numero entero de 1 a 3, y sales de adicion de ácido farmacéuticamente aceptables de los mismos.
MX9700888A 1995-06-07 1996-06-06 Ligandos de receptor de urocinasa. MX9700888A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/485,021 US5747458A (en) 1995-06-07 1995-06-07 Urokinase receptor ligands
PCT/US1996/009648 WO1996040747A1 (en) 1995-06-07 1996-06-06 Urokinase receptor ligands

Publications (1)

Publication Number Publication Date
MX9700888A true MX9700888A (es) 1997-04-30

Family

ID=23926620

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700888A MX9700888A (es) 1995-06-07 1996-06-06 Ligandos de receptor de urocinasa.

Country Status (14)

Country Link
US (2) US5747458A (es)
EP (1) EP0777680B1 (es)
JP (1) JPH10503784A (es)
AT (1) ATE214711T1 (es)
AU (1) AU6164096A (es)
BR (1) BR9606429A (es)
CA (1) CA2196334A1 (es)
DE (1) DE69619940T2 (es)
FI (1) FI970446A (es)
HU (1) HUP9702220A3 (es)
IL (1) IL120101A0 (es)
MX (1) MX9700888A (es)
NO (1) NO970513D0 (es)
WO (1) WO1996040747A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519120A (en) * 1989-04-07 1996-05-21 Cancerforskningsfondet Af 1989 Urokinase-type plasminogen activator receptor antibodies
EP1012147B1 (en) * 1997-07-31 2005-11-02 F. Hoffmann-La Roche Ag O-substituted hydroxycumaranone derivatives as antitumor and antimetastatic agents
WO1999055688A1 (en) * 1998-04-27 1999-11-04 Warner-Lambert Company Substituted diarylalkyl amides as calcium channel antagonists
US6228985B1 (en) 1998-05-21 2001-05-08 Schering Corporation Derivatives of aminobenzoic and aminobiphenylcarboxylic acids useful as anti-cancer agents
ES2169690B1 (es) * 2000-10-06 2004-03-16 Diverdrugs Sl Trimeros de n-alquilglicina capaces de proteger a neuronas contra agresiones excitotoxicas, y composiciones que los contienen.
ES2169691B1 (es) * 2000-10-11 2004-03-16 Diverdrugs Sl Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales, y composiciones que los contienen.
AU2004230207A1 (en) * 2003-04-15 2004-10-28 Merck Patent Gmbh Identification of N-alkylglycine trimers for induction of apoptosis
PT2611775E (pt) 2010-08-31 2016-06-07 Consejo Superior De Investig Científicas Agonistas dos recetores de neurotrofina e sua utilização como medicamentos
WO2012073375A1 (ja) 2010-12-03 2012-06-07 富士通株式会社 新規化合物、並びに、キネシンスピンドルタンパク質阻害剤及びその応用
IT202100023357A1 (it) 2021-09-09 2023-03-09 Cheirontech S R L Peptidi con attività anti-angiogenica

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138854B1 (en) * 1983-03-08 1992-11-04 Chiron Mimotopes Pty. Ltd. Antigenically active amino acid sequences
CA1255586A (en) * 1984-07-24 1989-06-13 Hendrik M. Geysen Method of determining mimotopes
NZ215865A (en) * 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
IE66205B1 (en) * 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
WO1994006451A1 (en) * 1992-09-24 1994-03-31 Chiron Corporation Synthesis of n-substituted oligomers
US5536853A (en) * 1994-04-11 1996-07-16 Chiron Corporation Opiate receptor ligands
ZA953361B (en) * 1994-04-26 1996-01-12 Selectide Corp Factor Xa inhibitors

Also Published As

Publication number Publication date
NO970513L (no) 1997-02-05
JPH10503784A (ja) 1998-04-07
US6121240A (en) 2000-09-19
AU6164096A (en) 1996-12-30
FI970446A0 (fi) 1997-02-03
BR9606429A (pt) 1997-09-02
EP0777680A1 (en) 1997-06-11
DE69619940D1 (de) 2002-04-25
US5747458A (en) 1998-05-05
NO970513D0 (no) 1997-02-05
WO1996040747A1 (en) 1996-12-19
ATE214711T1 (de) 2002-04-15
DE69619940T2 (de) 2002-12-19
EP0777680B1 (en) 2002-03-20
HUP9702220A2 (hu) 1998-05-28
CA2196334A1 (en) 1996-12-19
HUP9702220A3 (en) 1998-06-29
IL120101A0 (en) 1997-04-15
FI970446A (fi) 1997-03-26

Similar Documents

Publication Publication Date Title
MX9709951A (es) Derivados de benzamida y su uso como antagonistas de vasopresina.
IL147651A0 (en) Isoxazoline derivative and herbicide containing the same as the active ingredient
ATE152712T1 (de) Phenoxyessigsäurederivate und diese enthaltende pharmazeutische zusammenstellungen
EP0849256A4 (en) AMIDE COMPOUNDS AND THEIR USE
EP0669324A4 (en) CHINAZOLIN DERIVATIVES.
TW200420542A (en) A compound having TGF β inhibition activity and a medicinal composition containing the same
MX9700888A (es) Ligandos de receptor de urocinasa.
CA2360360A1 (en) Piperidyl benzamide compounds, composition containing same and their use thereof
GR3029355T3 (en) New azolidinediones as antihyperglycemic agents
GR3035277T3 (en) Thiazolidines and oxazolidines substituted by a pyridine ring and their use as hypoglycemic agents
DE69507293D1 (de) Benzamid-derivate als vasopressin-antagonisten
HUP0105039A2 (hu) Fungicid hatású propargil-éter-származékok, előállításuk és alkalmazásuk
KR890016017A (ko) 치환된 1-(1h-이미다졸-4-일)알킬-벤즈아미드
EP1304324A4 (en) SEROTONIN RECAPTURE INHIBITORS
EP0436734A4 (en) New aminopiperazine derivatives
EP0375223A3 (en) Novel compounds
TW200505446A (en) Inhibitor of cox
MY131762A (en) Pharmaceutical compounds
NO951080D0 (no) Benzenalkansyrer for kardiovaskulære sykdommer
EP0552489A3 (es)
TW340844B (en) Amide derivatives
AU9426098A (en) Azetidinone derivatives for the treatment of hcmv infections
MX9303976A (es) Derivados de 2-amino-n-{{((4-(aminocarbonil)-pirimidin-2-il-amino)-alquil}-pirimidi n-4-carboxamida, su preparacion y su aplicacion en terapeutica.
AU6312694A (en) 2-aminopyrazine-5-carboxamide derivatives, their preparation and their application in therapeutics
HUP9903096A3 (en) Bicyclic pyrimidine derivatives, their use as anti-coagulants and pharmaceutical compositions containing these compounds