MX9605895A - Anticuerpos monoclonales humanos especificos para antigeno de superficie de glioma independiente del ciclo celular. - Google Patents
Anticuerpos monoclonales humanos especificos para antigeno de superficie de glioma independiente del ciclo celular.Info
- Publication number
- MX9605895A MX9605895A MX9605895A MX9605895A MX9605895A MX 9605895 A MX9605895 A MX 9605895A MX 9605895 A MX9605895 A MX 9605895A MX 9605895 A MX9605895 A MX 9605895A MX 9605895 A MX9605895 A MX 9605895A
- Authority
- MX
- Mexico
- Prior art keywords
- cell cycle
- monoclonal antibodies
- human monoclonal
- glioma
- antibodies specific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
- Y10S530/864—Monoclonal
- Y10S530/865—Human
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Las cadenas variables de dos anticuerpos monoclonales humanos (HMAbs) del isotipo IgM que están caracterizadas por la elucidacion de cDNAs que codifican dichas cadenas. Las HMAbs son específicas contra antígenos asociados a un glioma, independientes del ciclo celular y los anticuerpos no reconocen astrocitos humanos normales cultivados. Los inmunoconjugados basados en las secuencias identificadas debería atacar las células de gliomas in vivo, ya sean proliferantes o no proliferantes, proveyendo por lo tanto, una terapia auxiliar valiosa en el tratamiento de estos tumores.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/264,093 US5639863A (en) | 1994-06-21 | 1994-06-21 | Human monoclonal antibodies specific to cell cycle independent glioma surface antigen |
PCT/CA1995/000361 WO1995035374A1 (en) | 1994-06-21 | 1995-06-16 | Human monoclonal antibodies specific to cell cycle independent glioma surface antigen |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9605895A true MX9605895A (es) | 1997-12-31 |
Family
ID=23004543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9605895A MX9605895A (es) | 1994-06-21 | 1995-06-16 | Anticuerpos monoclonales humanos especificos para antigeno de superficie de glioma independiente del ciclo celular. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5639863A (es) |
EP (1) | EP0766736B1 (es) |
JP (1) | JPH10501411A (es) |
CN (1) | CN1074458C (es) |
AT (1) | ATE205532T1 (es) |
AU (1) | AU686394B2 (es) |
CA (1) | CA2192079C (es) |
DE (1) | DE69522689T2 (es) |
MX (1) | MX9605895A (es) |
NO (1) | NO965395L (es) |
NZ (1) | NZ288157A (es) |
WO (1) | WO1995035374A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69738868D1 (de) * | 1996-05-22 | 2008-09-11 | Viventia Biotech Inc | Odieren, und deren verwendung zur vorbeugung und zum nachweis von krebs |
US7115722B1 (en) | 1997-05-22 | 2006-10-03 | Viventia Biotech, Inc. | Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers |
WO1999006834A2 (en) * | 1997-08-04 | 1999-02-11 | Ixsys, Incorporated | Methods for identifying ligand specific binding molecules |
US7109170B2 (en) * | 1999-06-16 | 2006-09-19 | Saint Louis University | Region of factor IXa protease domain that interacts with factor VIIIa and methods therefor |
EP1214352A2 (en) * | 1999-09-07 | 2002-06-19 | Viventia Biotech Inc. | Enhanced phage display libraries of human vh fragments and methods for producing same |
US8372954B2 (en) * | 2000-12-22 | 2013-02-12 | National Research Council Of Canada | Phage display libraries of human VH fragments |
DE10210427A1 (de) * | 2002-03-09 | 2003-10-09 | Hans Konrad Mueller-Hermelink | Humaner monoklonaler Antikörper |
CA2491669A1 (en) * | 2002-07-04 | 2004-01-15 | Oncomab Gmbh | Neoplasm specific antibodies and uses thereof |
DE10311248A1 (de) | 2003-03-14 | 2004-09-30 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper |
AU2004317819A1 (en) * | 2003-11-12 | 2005-10-13 | Patrys, Limited | Methods of identifying neoplasm-specific antibodies and uses thereof |
EP1531162A1 (en) * | 2003-11-14 | 2005-05-18 | Heinz Vollmers | Adenocarcinoma specific antibody SAM-6, and uses thereof |
DE10353175A1 (de) | 2003-11-14 | 2005-06-16 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper mit fettsenkender Wirkung |
DE102004015179A1 (de) * | 2004-03-25 | 2005-10-13 | Oncomab Gmbh | Antigen des PM-2 Antikörpers und dessen Verwendung |
CL2007002668A1 (es) * | 2006-09-20 | 2008-05-09 | Amgen Inc | Proteina de union a antigeno que se une al receptor de glucagon humano; acido nucleico que la codifica; metodo de produccion; composicion farmaceutica que la comprende; y su uso para tratar o prevenir la diabetes tipo 2. |
CA2663243A1 (en) | 2006-09-28 | 2008-04-03 | Merck Serono S.A. | Junctional adhesion molecule-c (jam-c) binding compounds and methods of their use |
US20080199475A1 (en) * | 2006-11-27 | 2008-08-21 | Patrys Limited | Novel glycosylated peptide target in neoplastic cells |
EP2393836A4 (en) * | 2009-02-09 | 2012-09-26 | Patrys Ltd | SAM-6 VARIANTS, TARGET AND USE PROCESS |
CN103127528B (zh) * | 2012-09-14 | 2016-04-20 | 苏州大学 | 人类dcx基因在制备胶质瘤放疗增敏剂中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2035088A1 (en) * | 1990-01-29 | 1991-07-30 | Michael D. Dan | Human monoclonal antibodies for brain tumor diagnosis and therapy |
-
1994
- 1994-06-21 US US08/264,093 patent/US5639863A/en not_active Expired - Lifetime
-
1995
- 1995-06-16 CA CA002192079A patent/CA2192079C/en not_active Expired - Fee Related
- 1995-06-16 JP JP8501432A patent/JPH10501411A/ja active Pending
- 1995-06-16 MX MX9605895A patent/MX9605895A/es unknown
- 1995-06-16 AU AU27092/95A patent/AU686394B2/en not_active Ceased
- 1995-06-16 CN CN95193668A patent/CN1074458C/zh not_active Expired - Fee Related
- 1995-06-16 EP EP95922373A patent/EP0766736B1/en not_active Expired - Lifetime
- 1995-06-16 WO PCT/CA1995/000361 patent/WO1995035374A1/en active IP Right Grant
- 1995-06-16 NZ NZ288157A patent/NZ288157A/en unknown
- 1995-06-16 AT AT95922373T patent/ATE205532T1/de not_active IP Right Cessation
- 1995-06-16 DE DE69522689T patent/DE69522689T2/de not_active Expired - Fee Related
-
1996
- 1996-12-13 NO NO965395A patent/NO965395L/no unknown
Also Published As
Publication number | Publication date |
---|---|
CA2192079C (en) | 2001-01-09 |
WO1995035374A1 (en) | 1995-12-28 |
CN1151184A (zh) | 1997-06-04 |
CN1074458C (zh) | 2001-11-07 |
US5639863A (en) | 1997-06-17 |
DE69522689D1 (de) | 2001-10-18 |
DE69522689T2 (de) | 2002-08-08 |
CA2192079A1 (en) | 1995-12-28 |
JPH10501411A (ja) | 1998-02-10 |
NO965395L (no) | 1996-12-17 |
EP0766736A1 (en) | 1997-04-09 |
AU686394B2 (en) | 1998-02-05 |
EP0766736B1 (en) | 2001-09-12 |
ATE205532T1 (de) | 2001-09-15 |
NO965395D0 (no) | 1996-12-13 |
NZ288157A (en) | 1999-09-29 |
AU2709295A (en) | 1996-01-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX9605895A (es) | Anticuerpos monoclonales humanos especificos para antigeno de superficie de glioma independiente del ciclo celular. | |
DE3687736D1 (de) | Monoklonale antikoerper gegen humanen brustkrebs, korrespondierende hybridome, deren herstellung und verwendung. | |
ES8705975A1 (es) | Un metodo de deteccion o localizacion de celulas de carcinoma humano. | |
DK69890D0 (da) | Monoklonale antistoffer, der er reaktive med cachetin | |
DK25084A (da) | Human-human hybridoma mod neoplasmer | |
EP0597829A4 (en) | NEW MONOCLONAL ANTIBODY DRESSES AGAINST A NEW ANTIGEN ASSOCIATED WITH HUMAN TUMORS. | |
ZA811384B (en) | Labeled antibodies and antibody fragments specific to tumor-associated markers, compositions thereof and use thereof in tumor localization an therapy | |
NZ210867A (en) | Tumour-specific monoclonal antibodies, production thereof and use | |
EP0212403A3 (en) | Monoclonal antibodies to mucin-like human differentiation antigens | |
GB2182949A (en) | Monoclonal antibodies and antigens for human non-small cell lung carcinomas | |
ES8704082A1 (es) | Procedimiento para preparar un agente terapeutico a base de celulas tumorales humanas y eventualmente, neuraminidasa. | |
ES8502547A1 (es) | Un metodo para determinar la presencia de una neoplasia. | |
EP0166458A3 (en) | Monoclonal antibody capable of specifically distinguishing human hepato-carcinoma cells | |
ZA941645B (en) | Antibodies specifically reactive against human prostate specific antigen. | |
EP0278160A3 (en) | Human monoclonal anti cancer antibodies, hybridoma cell lines producing them and their uses | |
IL67944A0 (en) | Antibodies and antigens useful in the diagnosis and treatment of cancer,methods for the production thereof and methods for testing for the presence of cancer cells using the same |