MX9604047A - Secrecion aumentada de polipeptidos. - Google Patents
Secrecion aumentada de polipeptidos.Info
- Publication number
- MX9604047A MX9604047A MX9604047A MX9604047A MX9604047A MX 9604047 A MX9604047 A MX 9604047A MX 9604047 A MX9604047 A MX 9604047A MX 9604047 A MX9604047 A MX 9604047A MX 9604047 A MX9604047 A MX 9604047A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptides
- enhanced secretion
- sequence
- ngf polypeptides
- secretion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se proporciona una secuencia peptídica de señalizacion y los ácidos nucléicos que codifican esta secuencia, los cuales son utiles para mejorar la eficiencia de la secrecion de los polipéptidos NGF. También se proporciona un método para preparar los polipéptidos NGF sin Met.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/215,138 US5470719A (en) | 1994-03-18 | 1994-03-18 | Modified OmpA signal sequence for enhanced secretion of polypeptides |
PCT/US1995/003175 WO1995025743A1 (en) | 1994-03-18 | 1995-03-16 | Enhanced secretion of polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9604047A true MX9604047A (es) | 1997-09-30 |
Family
ID=22801818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9604047A MX9604047A (es) | 1994-03-18 | 1995-03-16 | Secrecion aumentada de polipeptidos. |
Country Status (15)
Country | Link |
---|---|
US (2) | US5470719A (es) |
EP (1) | EP0750634A1 (es) |
JP (1) | JPH09510611A (es) |
AU (1) | AU689569B2 (es) |
CA (1) | CA2185343A1 (es) |
CZ (1) | CZ284204B6 (es) |
FI (1) | FI963655A (es) |
HU (1) | HUT76674A (es) |
IL (1) | IL112982A0 (es) |
MX (1) | MX9604047A (es) |
NO (1) | NO963818L (es) |
NZ (1) | NZ283214A (es) |
SK (1) | SK116896A3 (es) |
WO (1) | WO1995025743A1 (es) |
ZA (1) | ZA952218B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5747662A (en) * | 1995-03-01 | 1998-05-05 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
US5888796A (en) * | 1996-01-31 | 1999-03-30 | St. Louis University | Clone of a nucleotide sequence encoding a protein having two functions |
US20020065394A1 (en) * | 1998-03-18 | 2002-05-30 | Kenneth Jacobs | Secreted proteins and polynucleotides encoding them |
KR100360594B1 (ko) * | 2000-01-19 | 2002-11-13 | 한미약품공업 주식회사 | 인간 인터페론 알파의 발현 분비벡터 및 이를 이용한인터페론 알파의 생산 방법 |
DE60118370T2 (de) | 2000-06-05 | 2006-12-07 | Corixa Corp., Seattle | Leader-anteile zur erhöhung der sekretion von rekombinanten proteinen aus einer wirtzelle |
US20060239966A1 (en) * | 2003-10-20 | 2006-10-26 | Tornoee Jens | In vivo gene therapy of parkinson's disease |
WO2007137300A2 (en) | 2006-05-23 | 2007-11-29 | Bellicum Pharmaceuticals, Inc. | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
US8097422B2 (en) | 2007-06-20 | 2012-01-17 | Salk Institute For Biological Studies | Kir channel modulators |
US20090280103A1 (en) * | 2008-04-04 | 2009-11-12 | Martin Flueck | Regulation of muscle repair |
WO2010033229A2 (en) * | 2008-09-22 | 2010-03-25 | Calmune Corporation | Methods and vectors for display of molecules and displayed molecules and collections |
JP2012531903A (ja) | 2009-07-02 | 2012-12-13 | バーデザイン, インコーポレイテッド | アジピン酸を調製する生物学的方法 |
BRPI1011934A8 (pt) | 2009-07-09 | 2017-10-03 | Verdezyne Inc | Composição |
US8889394B2 (en) * | 2009-09-07 | 2014-11-18 | Empire Technology Development Llc | Multiple domain proteins |
US8343752B2 (en) | 2011-05-03 | 2013-01-01 | Verdezyne, Inc. | Biological methods for preparing adipic acid |
US8728798B2 (en) | 2011-05-03 | 2014-05-20 | Verdezyne, Inc. | Biological methods for preparing adipic acid |
MY166952A (en) | 2011-07-06 | 2018-07-25 | Verdezyne Inc | Biological methods for preparing a fatty dicarboxylic acid |
SG10201705057QA (en) | 2012-12-19 | 2017-07-28 | Verdezyne Inc | Biological methods for preparing a fatty dicarboxylic acid |
US9909151B2 (en) | 2012-12-19 | 2018-03-06 | Verdezyne, Inc. | Biological methods for preparing a fatty dicarboxylic acid |
HUE056155T2 (hu) | 2014-04-09 | 2022-01-28 | Scripps Research Inst | Nem-természetes vagy módosított nukleozid-trifoszfátok sejtekbe importálása nukleinsav-trifoszfát transzporterekkel |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US20180148744A1 (en) | 2015-03-20 | 2018-05-31 | Verdezyne, Inc. | Biological methods for preparing 3-hydroxypropionic acid |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
EP3652316A4 (en) | 2017-07-11 | 2021-04-07 | Synthorx, Inc. | INTEGRATION OF NON-NATURAL NUCLEOTIDES AND METHOD FOR THEREFORE |
WO2019014309A1 (en) | 2017-07-13 | 2019-01-17 | Verdezyne (Abc), Llc | BIOLOGICAL METHODS FOR MODIFYING A CELL CARBON FLOW |
TWI757528B (zh) | 2017-08-03 | 2022-03-11 | 美商欣爍克斯公司 | 用於增生及感染性疾病治療之細胞激素結合物 |
CN108610398B (zh) * | 2018-01-15 | 2020-08-11 | 武汉海特生物制药股份有限公司 | 一段功能序列及在分泌蛋白表达中的应用 |
WO2020060948A1 (en) | 2018-09-17 | 2020-03-26 | Levadura Biotechnology, Inc. | Production of cannabinoids in yeast using a fatty acid feedstock |
BR112021014415A2 (pt) | 2019-02-06 | 2021-09-21 | Synthorx, Inc. | Conjugados de il-2 e métodos de uso dos mesmos |
US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4338397A (en) * | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
US4757013A (en) * | 1983-07-25 | 1988-07-12 | The Research Foundation Of State University Of New York | Cloning vehicles for polypeptide expression in microbial hosts |
US5235043A (en) * | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
WO1992005254A1 (en) * | 1990-09-25 | 1992-04-02 | Genentech, Inc. | Novel neurothrophic factor |
WO1993008300A1 (en) * | 1991-10-18 | 1993-04-29 | The University Of Calgary | Expression-secretion vectors for the production of biologically active fv fragments |
JPH07509600A (ja) * | 1992-06-12 | 1995-10-26 | リジェネロン ファーマシューティカルズ,インコーポレーテッド | ニューロトロフィン−4発現に基づく治療および診断法 |
US5474914A (en) * | 1992-07-29 | 1995-12-12 | Chiron Corporation | Method of producing secreted CMV glycoprotein H |
-
1994
- 1994-03-18 US US08/215,138 patent/US5470719A/en not_active Expired - Lifetime
-
1995
- 1995-03-13 IL IL11298295A patent/IL112982A0/xx unknown
- 1995-03-16 WO PCT/US1995/003175 patent/WO1995025743A1/en not_active Application Discontinuation
- 1995-03-16 SK SK1168-96A patent/SK116896A3/sk unknown
- 1995-03-16 JP JP7524693A patent/JPH09510611A/ja active Pending
- 1995-03-16 HU HU9602548A patent/HUT76674A/hu unknown
- 1995-03-16 NZ NZ283214A patent/NZ283214A/en unknown
- 1995-03-16 EP EP95914033A patent/EP0750634A1/en not_active Withdrawn
- 1995-03-16 MX MX9604047A patent/MX9604047A/es unknown
- 1995-03-16 CA CA002185343A patent/CA2185343A1/en not_active Abandoned
- 1995-03-16 CZ CZ962644A patent/CZ284204B6/cs unknown
- 1995-03-16 AU AU21198/95A patent/AU689569B2/en not_active Ceased
- 1995-03-17 ZA ZA952218A patent/ZA952218B/xx unknown
- 1995-03-20 US US08/407,344 patent/US5608036A/en not_active Expired - Lifetime
-
1996
- 1996-09-12 NO NO963818A patent/NO963818L/no unknown
- 1996-09-16 FI FI963655A patent/FI963655A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
AU2119895A (en) | 1995-10-09 |
EP0750634A1 (en) | 1997-01-02 |
NO963818L (no) | 1996-11-15 |
NO963818D0 (no) | 1996-09-12 |
US5608036A (en) | 1997-03-04 |
HUT76674A (en) | 1997-10-28 |
US5470719A (en) | 1995-11-28 |
AU689569B2 (en) | 1998-04-02 |
NZ283214A (en) | 1998-03-25 |
FI963655A (fi) | 1996-11-15 |
CZ264496A3 (en) | 1997-05-14 |
JPH09510611A (ja) | 1997-10-28 |
CA2185343A1 (en) | 1995-09-28 |
SK116896A3 (en) | 1997-08-06 |
WO1995025743A1 (en) | 1995-09-28 |
HU9602548D0 (en) | 1996-11-28 |
FI963655A0 (fi) | 1996-09-16 |
ZA952218B (en) | 1995-12-12 |
IL112982A0 (en) | 1995-06-29 |
CZ284204B6 (cs) | 1998-09-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX9604047A (es) | Secrecion aumentada de polipeptidos. | |
HUT54177A (en) | Process for producing new fluor-containing peptides inhibitors | |
GB2183661B (en) | Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique | |
EP0805857A4 (en) | METHOD FOR PRODUCING PROTEOLYTIC ENZYMES WITH SPECIFICITY AGAINST A SELECTED PEPTIDE SEQUENCE | |
IL81798A0 (en) | Method of sequencing peptides | |
GR871290B (en) | Enzymatic membrane method for the synthesis and separation of peptides | |
AU1884297A (en) | Recombinant protein containing a c-terminal fragment of plasmodium msp-1 | |
EP0222412A3 (en) | Method of producing peptides | |
AU7452096A (en) | Novel grb2 associating polypeptides and nucleic acids encoding therefor | |
IL116973A0 (en) | Extraction of recombinant proteins | |
GB9714680D0 (en) | Recombinant production of proteins | |
AU1704988A (en) | Peptide production by protein engineering | |
HU895908D0 (en) | Process for producing recombinant interleukin-2 hybrid proteins | |
HU9403070D0 (en) | Improved method for recombinant protein production | |
NZ304789A (en) | Genes encoding lymphocyte interferon regulatory factory (lsirf) polypeptides that are transcription factors and specific antibodies to them | |
IL94526A0 (en) | Method for c-terminal modification of proteins | |
DE3568298D1 (en) | Process for hydrolysis of peptide or protein | |
CZ135099A3 (cs) | Nalfa-2-(4-Nitrofenylsulfonyl)ethoxykarbonylované aminokyseliny | |
GB9218037D0 (en) | Method for enhancing recovery of recombinant proteins | |
IL139272A0 (en) | New peptide fragments for protein purification | |
GB8806571D0 (en) | Supports for proteins & amino acids | |
GB8511710D0 (en) | N-benzyloxycarbonyl amino acids | |
AU4410689A (en) | Method for sequencing peptides or proteins | |
GB9714681D0 (en) | Recombinant production of proteins | |
IL118112A0 (en) | Method for the production of recombinant glucocerobrosidase protein |